[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysmenorrhea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysmenorrhea":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,47,95,129,156,180,210,239,278,303,327,353,381,404,432,453,477,505,526,551],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100546749","the-effect-of-cognitive-exercise-therapy-approach-and-yoga-in-adolescents-with-dysmenorrhoea-100546749",false,"NCT06398990","The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea","The Effect of Telerehabilitation-Based Cognitive Exercise Therapy Approach and Yoga on Pain, Physical Function and Quality of Life in Adolescents With Dysmenorrhoea","Inclusion Criteria:\n\n* Between the ages of 10 and 19,\n* Having had a menstrual cycle for at least 6-12 months (ACOG, 2018),\n* Having menstrual pain intensity of ≥4 cm according to the Visual Analog Scale (VAS, 0-10 cm) (Kannan, P. 2015; Yonglitthipagon, P. 2017),\n* To have been diagnosed with primary dysmenorrhea according to the clinical characteristics and diagnostic approach defined in international dysmenorrhea guidelines (ACOG 2018; JOGC 2017),\n* Nulliparous (having never given birth),\n* Able to read and write in Turkish,\n* Willing to participate in the study and having provided informed consent.\n\nExclusion Criteria:\n\n* History or clinical findings suggestive of secondary dysmenorrhea,\n* Presence of serious comorbidities, including neurological, cardiovascular, musculoskeletal, psychiatric, gastrointestinal, or autoimmune disorders,\n* History of surgery involving the abdominal, pelvic, or spinal regions within the past 12 months,\n* Current pregnancy or suspected pregnancy,\n* Use of intrauterine devices (IUDs),\n* Having participated in a regular exercise, sports, or physiotherapy program within the last 6 months,\n* Concurrent participation in another clinical study.","FEMALE","10 Years","19 Years",{"count":20,"type":21},42,"ESTIMATED","INTERVENTIONAL",[24],"NA","Dysmenorrhoea is a condition that negatively affects the quality of life in women of many age groups. In girls with dysmenorrhoea in adolescence, there is an effect on school performance, self-confidence-depression problems and a decrease in quality of life due to pain. In order to eliminate these negative effects, they should receive a good treatment. Medical treatment usually tries to minimise and balance this situation. Considering the fact that families do not want to use drugs such as oral contraceptives in their children at this age and the risks of oral contraceptives, parents are in different searches. Considering that the approach to pain should always be from a holistic perspective, yoga and cognitive exercise therapy approaches are both biopsychosocial treatment methods within the scope of mind-body integrity. Yoga and cognitive exercise therapy approach is thought to reduce symptoms, improve physical functions and quality of life in adolescent girls. With these positive effects, school absenteeism decreases, depression and self-confidence improve. Health costs will also be reduced to some extent.",[27,28],"Dysmenorrhea","Primary Dysmenorrhea",[30,31,32,33],"dysmenorrhea","mind-body exercises","cognitive exercise therapy approach","yoga","RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-02","ACTUAL",{"date":40,"type":38},"2025-12-01",{"date":42,"type":21},"2026-12",{"name":44,"class":45},"Acibadem University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":46},"100645235","crest-samphire-guided-care-program-on-wellbeing-work-productivity-and-quality-of-life-100645235","NCT07679074","CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life","A 12-Week Prospective Cohort Study Evaluating the Efficacy of the Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life in Individuals With Menstrual and Pelvic Health Conditions","CREST","Inclusion Criteria:\n\n* Self-identified female, aged 18-65 years at the time of enrollment\n* Basic English literacy\n* Able and willing to provide informed consent electronically\n* Residing in the United States\n* Reporting mood or cognitive symptoms associated with menstruation, perimenopause, or menopause (must endorse a minimum of three of the following: irritability, emotional dysregulation, brain fog, fatigue, reduced concentration, sleep disruption, or low mood)\n* Symptoms present for at least 3 months and sufficiently severe to interfere with daily functioning, work performance, quality of life, or interpersonal relationships\n* Currently in full-time employment with medical benefits as part of compensation package\n* Access to a smartphone with internet access compatible with the Samphire mobile application\n* Able to safely operate the study device in the home environment\n* Willing to complete baseline, mid-program, and end-of-program questionnaires and engage with the 12-week guided care program\n\nExclusion Criteria:\n\n* Pregnancy, breastfeeding, or actively planning pregnancy during the study period\n* History of epilepsy or seizure disorder\n* Severe or unstable neurological disease that, in the opinion of the study team, may increase risk or interfere with participation\n* Implanted electronic or metal devices in the head, neck, or brain region contraindicated for tDCS use\n* Active scalp lesions, open wounds, or dermatologic conditions at electrode sites that may interfere with safe device use\n* Current diagnosis of schizophrenia, bipolar disorder, or other severe psychiatric condition that would make participation inappropriate, as determined by screening\n* Active suicidal ideation, recent suicidal behavior, or clinically significant self-injurious behavior, as determined by participant self-report during screening\n* Inability to provide informed consent or safely use the device in the home environment\n* Current participation in another interventional neurotechnology or drug study",true,"18 Years","65 Years",{"count":59,"type":21},50,"OBSERVATIONAL","This study evaluates the feasibility and efficacy of the Samphire Guided Care (SGC) program\n\n* a 12-week structured digital health program combining clinician-led onboarding, at-home neuromodulation using the Lutea tDCS device, neuromodulation coach support, and app-based symptom tracking - on work productivity, employee wellbeing, and quality of life in individuals experiencing mood and cognitive symptoms associated with menstruation, perimenopause, or menopause.",[63,64,27,65,66,67,68],"Premenstrual Syndrome","Premenstrual Dysphoric Disorder","Endometriosis","Perimenopause","Menopause","Pelvic Pain",[70,71,72,73,74,75,76,77,78,79,80,81,82,83,84],"tDCS","neuromodulation","hormonal health","menstrual symptoms","perimenopause","menopause","PMDD","PMS","work productivity","brain fog","mood","cognitive function","digital health","decentralized clinical trial","guided care","2026-06-25",{"date":87,"type":38},"2026-07-01",{"date":89,"type":38},"2026-06-01",{"date":91,"type":21},"2027-03-01",{"name":93,"class":94},"Samphire Group, Inc.","INDUSTRY",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":22,"phases":105,"briefSummary":106,"conditions":107,"keywords":108,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":128},"100642530","effects-of-physiotherapy-on-ultrasound-and-clinical-parameters-in-women-with-dysmenorrhea-100642530","NCT07645196","Effects of Physiotherapy on Ultrasound and Clinical Parameters in Women With Dysmenorrhea","Effects of Physiotherapy on Ultrasound and Clinical Parameters in Women With Dysmenorrhea With or Without Endometriosis","Inclusion Criteria:\n\n* female sex\n* aged 18 to 50 years\n* clinical diagnosis of dysmenorrhea (cyclic pelvic pain during menstruation)\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Delivery less than 1 year prior to enrollment\n* History of abdominal or pelvic surgery within the past 3 months\n* Diagnosis of fibromyalgia, diabetes, or cancer\n* Ongoing manual therapy treatment of the abdominal or genital area","50 Years",{"count":104,"type":21},80,[24],"Dysmenorrhea affects up to 90% of women of reproductive age and represents a significant public health concern. Beyond prostaglandin-mediated uterine contractions, dysmenorrhea involves central sensitization mechanisms and myofascial components, including abdominal trigger points. Despite growing interest in physiotherapy for chronic pelvic pain, objective data on tissue-level changes induced by manual therapy remain scarce.\n\nThis randomized single-blind sham-controlled trial aims to evaluate the effects of abdominal manual mobilization techniques on (1) tissue stiffness measured by shear wave elastography at the uterine cervix and bilateral abdominal regions, and (2) clinical outcomes including pain intensity and quality of life in women with dysmenorrhea, with or without endometriosis.\n\nParticipants will be randomly assigned to either a treatment group receiving standardized abdominal manual therapy or a sham group receiving superficial manual contact. Assessments will be conducted over three menstrual cycles using shear wave elastography, the Numeric Rating Scale (NRS), and the SF-36 questionnaire.",[27,65],[27,109,110,111,112,113,114,115,116,117],"endometriosis","Shear wave elastography","Manual therapy","Physiotherapy","Abdominal mobilization","Tissue stiffness","Chronic pelvic pain","Central sensitization","Menstrual pain","NOT_YET_RECRUITING","2026-06-08",{"date":121,"type":38},"2026-06-12",{"date":123,"type":21},"2026-09",{"date":125,"type":21},"2028-09",{"name":127,"class":45},"Vrije Universiteit Brussel",2,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":143,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":154,"locationsCount":46},"100639157","comparative-effects-of-aerobic-exercises-and-jacobsons-progressive-relaxation-technique-in-primary-dysmenorrhea-100639157","NCT07628452","Comparative Effects of Aerobic Exercises and Jacobson's Progressive Relaxation Technique in Primary Dysmenorrhea","Comparative Effects of Aerobic Exercises and Jacobson's Progressive Relaxation Technique on Pain, Fatigue and Quality of Life in Primary Dysmenorrhea","Inclusion Criteria:\n\n* Pain on numeric rating pain scale,\n* Menarche range 12-16,\n* BMI less than 30,\n* Having a regular menstrual cycle (28-32) days,\n* Normal bleeding days (3 to 1) and diagnosed with mild PD according to WaLiDD score\n\nExclusion Criteria:\n\n* Athletes,\n* married women with gynaecological abnormalities were excluded,\n* Medical treatment during the study (e.g., oral contraceptives, antidepressants)\n* Recent musculoskeletal trauma or surgery, or chronic musculoskeletal disorders\n* affecting pain perception (e.g., fibromyalgia, pelvic floor dysfunction)\n* secondary dysmenorrhea-related conditions (e.g., endometriosis, fibroids, ovarian cysts),\n* consumption of painkillers\n* No mental or physical diseases, which reduce the abilities to exercise","17 Years","24 Years",{"count":139,"type":21},58,[24],"The study will focus on the comparative effects of aerobic exercises and Jacobson's progressive relaxation technique on pain, fatigue and quality of life in primary dysmenorrhea.\n\nThis study will be a randomized clinical trial and will be conducted in, Superior college depalpur and Army public schools and college Lahore (APSACS). Non probability convenience sampling will be used to collect the data.64 participants will be selected on the basis of inclusion and exclusion criteria and will be equally divided into two groups by sealed opaque enveloped .Participants having age group between 17-24 years and diagnosed with WaLiDD score are included.",[27],[144,145,146,147,148],"aerobic exercise","quality of life,","dysmenorrhea,","female,","Jacobson's progressive relaxation technique",{"date":150,"type":38},"2026-06-05",{"date":152,"type":38},"2025-10-01",{"date":87,"type":21},{"name":155,"class":45},"Riphah International University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":55,"sex":16,"minAge":163,"maxAge":18,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":178,"leadSponsor":179,"locationsCount":46},"100638285","effects-of-sacral-release-technique-and-lumbar-mobilization-in-primary-dysmenorrhea-100638285","NCT07576231","Effects of Sacral Release Technique and Lumbar Mobilization in Primary Dysmenorrhea.","Comparative Effects of Sacral Release Technique and Lumbar Mobilization in Pain, Symptoms Severity and Quality of Life in Primary Dysmenorrhea.","Inclusion Criteria:\n\n* Unmarried female\n* Diagnosed with primary dysmenorrhea through WaLIDD Score\n* Regular menstrual cycles (21-35 days)\n* Pain score of \\> 4 on the Numerical Pain Rating Scale (NPRS) during menstruation\n\nExclusion Criteria:\n\n* Any pelvic inflammatory disease\n* Obesity\n* PCOS\n* Spinal deformity\n* Lumber radiculopathy\n* Heavy menstrual bleeding (menorrhagia)\n* Irregular menstrual cycles\n* Spine trauma and coccyx pain\n* History of pelvic or spinal surgery currently on hormonal therapy or other ongoing physiotherapy for dysmenorrhea","13 Years",{"count":165,"type":21},46,[24],"The aim of this study is to determine the comparative effects of sacral release technique and lumbar mobilization in pain, symptoms severity and quality of life in primary dysmenorrhea.",[27],[30,170,171,172,173],"adolescent","girls","female","quality of life","2026-05-04",{"date":176,"type":38},"2026-05-08",{"date":152,"type":38},{"date":87,"type":21},{"name":155,"class":45},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":186,"maxAge":102,"enrollmentInfo":187,"targetDuration":4,"studyType":22,"phases":189,"briefSummary":190,"conditions":191,"keywords":196,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":46},"100608750","the-good-pain-consultation-in-endometriosis-100608750","NCT07205614","The Good Pain Consultation in Endometriosis.","Inclusion Criteria:\n\n* biological women\n\nExclusion Criteria:\n\n* not speaking norwegian","16 Years",{"count":188,"type":21},110,[24],"This PhD project investigates the effect of \"the good pain consultation\" and early integration of biopsychosocial pain education with current standard management of endometriosis. Our goal is to facilitate self-management of pain and improve health-related quality of life (HRQOL) using limited resources.\n\nOur research question is: Does a good pain consultation improve pain self-efficacy and HRQOL, compared to usual care at 3 months and 1 year.?\n\nResearchers will compare a good pain consultation to a control group that will receive usual care.\n\nParticipants will:\n\nAttend a consultation and biopsychososial pain education plus usual care or usual care alone.\n\nThey will answer questions in an internet-based questionnaires three times point during the study.",[192,65,27,193,194,195],"Pelvic Pain Syndrome","Adenomyosis","Period Pain","Menstrual Pain",[197,198,199],"pain education","biopsychosocial","randomised controlled trial","2026-04-22",{"date":202,"type":38},"2026-04-28",{"date":204,"type":38},"2025-11-01",{"date":206,"type":21},"2028-06-01",{"name":208,"class":209},"Sorlandet Hospital HF","OTHER_GOV",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":216,"eligibilityCriteria":217,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":218,"enrollmentInfo":219,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":46},"100632028","phase-1-vaginal-sildenafil-for-primary-dysmenorrhea-100632028","NCT07508358","Vaginal Sildenafil for Primary Dysmenorrhea","Vaginal Sildenafil for Primary Dysmenorrhea: A Randomized, Double-Blind, Placebo-Controlled, Two-Period Crossover Mechanistic Study","SILDYS","Inclusion Criteria:\n\n* Female sex assigned at birth\n* Age 18 to 35 years\n* History of moderate-to-severe primary dysmenorrhea\n* Regular menstrual cycles of approximately 21 to 35 days\n* Willing and able to complete 2 menstrual treatment visits in separate menstrual cycles\n* Able to provide informed consent\n* Able to comply with study procedures, including MRI procedures and vaginal self-administration of study product\n\nExclusion Criteria:\n\n* Known hypersensitivity to sildenafil or any formulation component\n* Current use of nitrates or nitric oxide donors\n* Current use of potent CYP3A4 inhibitors or potent CYP3A4 inducers\n* Current use of another phosphodiesterase type 5 inhibitor\n* Uncontrolled hypertension, near-hypotension, or other clinically significant hemodynamic instability\n* Clinically significant cardiovascular disease\n* Clinically significant electrocardiographic abnormality, as judged by the investigator\n* Clinically significant laboratory abnormality, as judged by the investigator\n* Severe hepatic impairment or severe renal impairment\n* Active pelvic infection\n* Contraindication to MRI or factors that would impair MRI safety or interpretability, including certain metallic implants, metallic injury, claustrophobia, or intrauterine device-related artifact\n* Pregnant or breastfeeding\n* Any condition that, in the opinion of the investigator, would increase risk or interfere with study participation","35 Years",{"count":59,"type":21},[221],"PHASE1","This phase 1 randomized, double-blind, placebo-controlled, two-period crossover trial will evaluate whether a single 100 mg vaginal sildenafil citrate suppository reduces uterine hypercontractility during menstruation in adults with moderate-to-severe dysmenorrhea. Uterine contractility will be measured using cine magnetic resonance imaging (MRI). Key secondary objectives are to evaluate acute menstrual pain reduction over 4 hours, characterize limited systemic exposure using a single 4-hour plasma sildenafil concentration, and assess short-term safety and tolerability.",[27,195],[225,226,227,228,30,229],"sildenafil","vaginal sildenafil","uterine contractility","cine MRI","pelvic pain","2026-03-31",{"date":232,"type":38},"2026-04-02",{"date":234,"type":21},"2026-05",{"date":236,"type":21},"2027-10",{"name":238,"class":45},"Kevin Hellman",{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":245,"eligibilityCriteria":246,"healthyVolunteers":55,"sex":16,"minAge":247,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":22,"phases":251,"briefSummary":252,"conditions":253,"keywords":265,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":46},"100628155","effectiveness-of-an-mhealth-innovation-on-the-impact-of-menstrual-complaints-in-adolescents-100628155","NCT07457957","Effectiveness of an mHealth Innovation on the Impact of Menstrual Complaints in Adolescents","The Effectiveness of an mHealth Innovation on the Impact of Menstrual Complaints in Adolescents - A Randomised Controlled Trial","MGA","Inclusion Criteria:\n\n* Dutch, English, Turkish or Moroccan-Arabic speaking\n* Post menarche\n* Access to a smartphone or tablet with iOS or Android operating system\n\nExclusion Criteria:\n\n* Amenorrhea\n* Pregnancy\n* No menstrual bleeding or withdrawel bleeding in the 3 months prior to inclusion.\n* Previously or currently under treatment by a health care provider for menstrual complaints","12 Years","21 Years",{"count":250,"type":21},874,[24],"The aim of this study is to improve menstrual health-related quality of life in adolescents by using a mobile menstrual health tracker. We will perform a randomized controlled trial to evaluate the (cost)-effectiveness of this mHealth intervention.",[27,254,255,256,257,258,259,260,261,262,263,264],"Heavy Menstrual Bleeding","Menstrual Cramps","Menstrual Bleeding, Heavy","Menstrual Discomfort","Menstrual Cycle Abnormal","Menstrual Disorder","Menstrual Health","Mobile Application","mHealth","Menstrual Health Intervention","Adolescent",[266,262,267,264,268],"randomized clinical trial","Menstrual health","Menstrual Tracker App","2026-03-04",{"date":271,"type":38},"2026-03-09",{"date":273,"type":21},"2026-02-16",{"date":275,"type":21},"2029-05-31",{"name":277,"class":45},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":284,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":218,"enrollmentInfo":286,"targetDuration":4,"studyType":22,"phases":288,"briefSummary":289,"conditions":290,"keywords":291,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":46},"100612050","iv-magnesium-in-the-treatment-of-acute-dysmenorrhea-100612050","NCT07248540","IV Magnesium in the Treatment of Acute Dysmenorrhea","Evaluation of Intravenous Magnesium Administration in the Treatment of Dysmenorrhea","IVMAG","Inclusion Criteria:\n\nFemale patients aged 18 to 35 years\n\nPresenting to the obstetrics and gynecology emergency department with a diagnosis of primary dysmenorrhea\n\nHaving regular menstrual cycles within the last 6 months\n\nHaving a Visual Analog Scale (VAS) pain score of ≥6 at emergency admission\n\nProviding written informed consent for participation in the study\n\nExclusion Criteria:\n\nPatients with secondary dysmenorrhea or underlying gynecological pathology\n\nPregnancy or breastfeeding\n\nUse of analgesics or muscle relaxants within the last 3 days\n\nKnown allergy to magnesium sulfate or dexketoprofen trometamol\n\nHistory of renal failure, cardiac arrhythmia, or serious systemic disease\n\nInability to assess pain due to mental disability or communication disorder\n\nFailure to provide informed consent for participation in the study",{"count":287,"type":21},60,[24],"This prospective, randomized, double-blind clinical trial aims to evaluate the analgesic efficacy of intravenous magnesium sulfate in women presenting to the emergency department with acute dysmenorrhea. Participants will be randomized into two groups receiving either 2 ampoules of magnesium sulfate or intravenous dexketoprofen. Pain levels will be assessed using the Visual Analog Scale (VAS) before and after treatment.",[27],[27,292,293],"Magnesium Therapy","Pain Management","2025-11-18",{"date":296,"type":38},"2025-11-25",{"date":298,"type":38},"2025-07-01",{"date":300,"type":21},"2026-01-01",{"name":302,"class":209},"Havva Betül Bacak",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":308,"acronym":4,"eligibilityCriteria":309,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":218,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":311,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":46},"100609054","a-research-study-exploring-how-musculoskeletal-function-and-the-autonomic-nervous-system-relate-to-visceral-pain-in-women-with-and-without-dysmenorrhea-painful-periods-100609054","NCT07209566","A Research Study Exploring How Musculoskeletal Function and the Autonomic Nervous System Relate to Visceral Pain in Women With and Without Dysmenorrhea (Painful Periods).","The Effect of Vaginal Somatovisceral Pain on Hip Extension Mobility and Strength in Women at Mid-cycle With Dysmenorrhea vs. Controls: A Case-control Study","Inclusion Criteria: Non-pregnant women, not taking hormonal birth control, between the ages of 18 and 36 who report regular menstrual cycles are eligible for the study Exclusion Criteria: Participants will be excluded if they are currently pregnant or, have given birth within the preceding six months, are breastfeeding, or are undergoing in-vitro fertilization treatments. Exclusions also include those who have had abdominal, lumbar, or pelvic surgery within the preceding 12 months, suffer from a chronic pain condition, have an active genitourinary infection, are incontinent of bowel or bladder, or have been diagnosed with prolapse of a pelvic organ, severe labral pathology, femoral acetabular impingement (FAI), interstitial cystitis, endometriosis, pelvic inflammatory disease, irritable bowel syndrome, or other pelvic pathology. Participants reporting a cycle length of less than 28 days or longer than 35 days, those with a history of sexual assault, and those who are anovulatory without hormonal BC or amenorrheic will also be excluded.\n\n\\-",{"count":287,"type":21},[24],"The purpose of this clinical trial is to determine if women with dysmenorrhea demonstrate an increased musculoskeletal and autonomic nervous system response to a painful visceral stimulus compared to controls. A secondary aim is to determine if interoceptive awareness moderates this relationship. The designed methodology aims to elucidate the intricate connections between the interoceptive and musculoskeletal systems in pain perception among female participants, providing valuable insights into the underlying mechanisms of interoceptive pain and functional musculoskeletal changes.",[27,314,315,195],"Dysmenorrhea Primary","Visceral Pain",[317],"Effect of visceral organ pain on musculoskeletal and autonomic nervous system","2025-09-29",{"date":320,"type":38},"2025-10-07",{"date":322,"type":38},"2025-08-01",{"date":324,"type":21},"2027-04-01",{"name":326,"class":45},"Azusa Pacific University",{"id":328,"slug":329,"hasResults":11,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":351,"locationsCount":46},"100606542","doppler-ultrasound-guided-angiopuncture-for-dysmenorrhea-pain-a-clinical-trial-100606542","NCT07176910","Doppler Ultrasound-Guided Angiopuncture for Dysmenorrhea Pain: A Clinical Trial","Inclusion Criteria:\n\nPrimary dysmenorrhea diagnosis (≥6 months of menstrual pain scoring ≥2 on numerical rating scale) Regular menstrual cycles (28-32 days), menstrual period lasts 4 to 7 days No pelvic pathology on transvaginal ultrasound.\n\nExclusion Criteria:\n\ncoagulopathy (INR \\>1.5) recent analgesic use (48-hour washout) secondary dysmenorrhea confirmed by laparoscopy.","25 Years",{"count":335,"type":21},30,[24],"the study is to evaluated dopplar guided angiopuncture efficacy and safety in patients with dysmenorrhea",[339,27,340],"Angiopuncture","Dopplar Ultrasound",[27,342,343,344],"angiopuncture","dopplar","ultrasound","2025-09-12",{"date":347,"type":38},"2025-09-16",{"date":349,"type":38},"2024-09-01",{"date":204,"type":21},{"name":352,"class":45},"City University of Hong Kong",{"id":354,"slug":355,"hasResults":11,"nctId":356,"briefTitle":357,"officialTitle":358,"acronym":359,"eligibilityCriteria":360,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":361,"enrollmentInfo":362,"targetDuration":4,"studyType":22,"phases":363,"briefSummary":364,"conditions":365,"keywords":368,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":375,"completionDateStruct":377,"leadSponsor":379,"locationsCount":4},"100604882","menstrual-pain-intervention-among-students-100604882","NCT07155291","Menstrual Pain Intervention Among Students","Evaluation of Easy-to-Implement Intervention for Menstrual Pain in a Series of N-of-1 Trials: Study Protocol of the Menstrual Pain Intervention Among Students Study (MPIS)","MPIS","Inclusion Criteria:\n\n* Female students living in Germany\n* Have consistently experienced menstrual pain and other symptoms primarily during menstruation for at least the last three cycles\n* Regular access to a smartphone on which the StudyU (https:\u002F\u002Fwww.studyu.health\u002F) application can be installed\n* Informed consent\n* Proficiency in English or German\n\nExclusion Criteria:\n\n* Age under 18 or over 45 years\n* Participation in a different intervention study during the duration of this study\n* Use of hormonal treatments affecting the menstrual cycle\n* Confirmed or suspected pregnancy\n* Presence of contraindicated disorders or diseases for massage\n* Severe psychiatric conditions impairing informed consent or reliable participation\n* Substance abuse (e.g., alcohol, drugs)\n* Planned surgery within the next four to five months\n* Doctor's advice against proceeding with the intervention","45 Years",{"count":165,"type":21},[24],"Dysmenorrhea, or menstrual pain, is a prevalent issue among female students, which negatively influences students' productivity, academic performance, and quality of life.\n\nThis study explores a non-pharmaceutical physiotherapy method that has shown potential to decrease menstrual cramping, but research on its efficacy remains limited. The intervention is a visceral abdominal self-massage.\n\nBecause individuals tend to respond differently to physiotherapy methods, the investigators aim to assess the effect of performing the self-massage regularly on the self-reported perception of menstrual pain and related symptoms of female students in Germany, with a series of N-of-1 trials.\n\nN-of-1 trials lasting up to 60 days are conducted with participants who regularly experience dysmenorrhea. Participants undergo a control (A) and an intervention phase (B), with a probable second control phase (A) depending on the individual cycle lengths and study start. Daily symptoms are recorded via the StudyU smartphone application. The baseline questionnaire collects demographic, lifestyle, and menstrual history information to identify potential effect modifiers. The intervention's effects will be estimated across individual and population levels. Participants will receive access to an analysis of their data.\n\nThe results may benefit individual well-being and contribute to the exploration of a more holistic approach to menstrual health.",[27,314,366,367],"Dysmenorrhea Secondary","Dysmenorrhea Symptom",[369,370,260,371],"Abdominal Self-Massage","Massage Physiotherapy","N-of-1 Trial","2025-08-31",{"date":374,"type":38},"2025-09-04",{"date":376,"type":21},"2025-09",{"date":378,"type":21},"2026-01",{"name":380,"class":45},"University of Potsdam",{"id":382,"slug":383,"hasResults":11,"nctId":384,"briefTitle":385,"officialTitle":385,"acronym":4,"eligibilityCriteria":386,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":387,"targetDuration":4,"studyType":22,"phases":389,"briefSummary":390,"conditions":391,"keywords":393,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":401,"leadSponsor":402,"locationsCount":46},"100600422","the-effect-of-sensory-awareness-training-given-to-women-of-reproductive-age-on-dysmenorrhea-and-kinesiophobia-100600422","NCT07097285","The Effect of Sensory Awareness Training Given to Women of Reproductive Age on Dysmenorrhea and Kinesiophobia","Inclusion Criteria:\n\n* Volunteering to participate in research\n* Having a complaint of dysmonea\n* Being of childbearing age\n* Being over 19 years old\n* Having internet access\n* Having a smart mobile phone\n\nExclusion Criteria:\n\n* Be pregnant\n* Having any disease that affects the menstrual period\n* Using oral contraceptives\n* Using intrauterine device",{"count":388,"type":21},40,[24],"This research investigates the use of web-based sensory awareness training given to women of reproductive age. It was planned to examine the effect of dysmenorrhea level and kinzeophobia status.H0a = Body weight of women of reproductive age who received and did not receive sensory awareness training. There is no difference between awareness levels.\n\nH1a = Body size of women of reproductive age who receive and do not receive sensory awareness training. There is a difference between awareness levels.\n\nH0b = Dysmenorrhea of women of reproductive age who received or did not receive sensory awareness training. There is no difference between the levels.\n\nH1b = Dysmenorrhea among women of reproductive age who received and did not receive sensory awareness training. There is a difference between the levels.\n\nH0c = Kinesiophobia in women of childbearing age who received or did not receive sensory awareness training. There is no difference between the situations.\n\nH1c = Kinesiophobia in women of reproductive age who receive and do not receive sensory awareness training. There is a difference between situations Sensory awareness training was given to women in the intervention group of the study for 4 weeks. will be given. Training contents, Sensory System Training Presentation, Proprioception and Kinesthesia Sensory Training Presentation, Interoception Sense Training Presentation will be given, then Graded Sensory Discrimination, Graded Motor Imagery (DMI), interoception awareness training, body training with training consisting of interoceptive awareness exercises and home exercise programs. A protocol for awareness training will be implemented.",[27,392],"Kinesiophobia",[394,27,392,395,396],"Sensory Awareness","Reproductive","Women","2025-08-16",{"date":399,"type":38},"2025-08-22",{"date":40,"type":21},{"date":89,"type":21},{"name":403,"class":45},"Saglik Bilimleri Universitesi",{"id":405,"slug":406,"hasResults":11,"nctId":407,"briefTitle":408,"officialTitle":409,"acronym":410,"eligibilityCriteria":411,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":218,"enrollmentInfo":412,"targetDuration":4,"studyType":22,"phases":414,"briefSummary":416,"conditions":417,"keywords":419,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":46},"100582331","phase-4-nsaid-use-for-treating-dysmenorrhea-and-preventing-chronic-pelvic-pain-nsaid-heal-100582331","NCT06861920","NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)","Targeting Interindividual Variability in NSAID Responses to Mitigate Chronic Pelvic Pain Risk in Dysmenorrhea (NSAID HEAL)","NSAIDHEAL","Inclusion Criteria:\n\n* aged 18-35\n* individuals who menstruate, with painful periods\n* regular menstrual cycles (every 22-35 days)\n\nExclusion Criteria:\n\n* presence of active pelvic or abdominal malignancies (primary or metastatic)\n* conditions associated with the absence of regular menses such as polycystic ovarian syndrome, pregnancy, or any current use of continuous hormonal medication or contraceptive\n* unable to read or comprehend the informed consent in English\n* presence of other diagnosed chronic back or pelvic pain conditions (including chronic back pain, fibromyalgia, bladder pain syndrome, irritable bowel syndrome, vulvar pain syndrome, and endometriosis-associated pelvic pain)\n* having another diagnosed\u002Fsymptomatic chronic pain condition besides migraines with an average pain score \\>3\u002F10 in the last month when not consuming pain relievers, or that requires daily treatment with opioids (ex. hydrocodone, oxycodone, codeine, morphine, hydromorphone, tapentadol, tramadol) or neuromodulators (also known sometimes as antidepressants \\[ex. amitriptyline, nortriptyline, imipramine, duloxetine, milnacipran, venlafaxine\\] or antiseizure medications \\[ex. topiramate, gabapentin, pregabalin, carbamazepine, lamotrigine\\])\n* current or past history of stomach ulcers\n* current or past history of gastrointestinal (GI) bleeding\n* diagnosis of peptic ulcer disease\n* current or past history of renal disorders\n* current or past history of adrenal dysfunction\n* diagnosis of liver disorders\n* diagnosis of chronic acid reflex (i.e. GERD)\n* Diagnosis of Crohn's disease or ulcerative colitis\n* Coagulopathy\n* Prolactinoma\n* Von Willebrand disease\n* Platelet disorders\n* High blood pressure that is difficult to manage\n* gastrointestinal conditions or surgeries that affect naproxen absorption\n* bleeding disorders\n* heart failure\n* a history of stroke\n* a history of heart attack\n* active genitourinary or sexually transmitted infection\n* allergy to non-steroidal anti-inflammatory drugs (NSAIDs) or their ingredients\n* individuals who take the following medications: anticoagulants (i.e. warfarin), lithium, diuretics, antacids, angiotensin-converting enzyme (ACE) inhibitors, methotrexate, cholestyramine, or probenecids.\n* Unmanaged diabetes (i.e. Fasting Blood Glucose: ≥ 126 mg\u002FdL (≥ 7.0 mmol\u002FL), Non-Fasting\u002FRandom Blood Glucose: ≥ 200 mg\u002FdL (≥ 11.1 mmol\u002FL), Hemoglobin A1c (HbA1c): ≥ 6.5%)\n* Uncontrolled thyroid function (i.e. Hypothyroidism (Underactive Thyroid): Thyroid-Stimulating Hormone (TSH): \\> 4.5 mIU\u002FL (mild) or \\> 10 mIU\u002FL (severe) Free T4: Below the lower end of the reference range (usually \\\u003C 0.9 ng\u002FdL)\n* Hyperthyroidism (overactive thyroid) (i.e. TSH: \\\u003C 0.4 mIU\u002FL (Suppressed or undetectable), Free T4: Above the upper end of the reference range (usually \\> 2.0 ng\u002FdL)\n* Liver dysfunction (i.e. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) or bilirubin (unless known diagnosis of Gilbert's syndrome) ≥ 1.5 times the upper limit of the reference range)\n* Kidney dysfunction (i.e. Serum creatinine \\> 1.1 mg\u002FdL.)",{"count":413,"type":21},600,[415],"PHASE4","The goal of this clinical trial is to learn if NSAIDs (i.e. naproxen sodium) can treat menstrual pain and prevent the development of chronic pelvic pain in menstruating adults with painful periods. The main questions it aims to answer are:\n\n* Can non-menstrual pelvic pain reduction be predicted by menstrual pain response to NSAIDs?\n* Will participants with the largest reductions in multi-site sensitivity following NSAID therapy have the largest reductions in non-menstrual pelvic pain?\n\nResearchers will compare naproxen sodium to a placebo (a look-alike substance that contains no drug) to see if naproxen sodium works to treat painful periods.\n\nParticipants will:\n\n* Take naproxen sodium or placebo during several days of their menstrual period every month for 1 year.\n* Complete computer questionnaires and tests from home every 3 months.\n* Complete at-home urine tests to measure hormones every few days for 1-year.\n* Use a pin-prick to collect a small spot of blood, and use a pad or tampon to collect a sample of menstrual blood, and bring it to the research site twice over a 1-year period.\n* Come to the research site twice over a 1-year period to complete sensory assessments and undergo a blood draw.\n\nThe major goal of the study is to develop a multivariable statistical model (see https:\u002F\u002Fgrants.nih.gov\u002Fgrants\u002Fguide\u002Frfa-files\u002FRFA-NS-24-021.html ) describing the factors that effectiveness of pain medication and risk for chronic pain",[27,418,68],"Chronic Pelvic Pain",[420,421,418,68,422],"Painful Periods","NSAIDs","Periods","2025-08-04",{"date":425,"type":38},"2025-08-07",{"date":427,"type":38},"2025-04-07",{"date":429,"type":21},"2030-07",{"name":431,"class":45},"Endeavor Health",{"id":433,"slug":434,"hasResults":11,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":4,"eligibilityCriteria":438,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":102,"enrollmentInfo":439,"targetDuration":4,"studyType":22,"phases":440,"briefSummary":441,"conditions":442,"keywords":444,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":322,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":46},"100544108","electroacupuncture-for-dysmenorrhea-secondary-to-adenomyosis-100544108","NCT06364592","Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis","Effect of Electroacupuncture for Dysmenorrhea Secondary to Adenomyosis: an Exploratory Pilot Study","Inclusion Criteria:\n\n* Meeting the diagnosis criteria of dysmenorrhea secondary to adenomyosis.\n* Female patients aged between 18 and 50.\n* Dysmenorrhea lasting for 3 consecutive menstrual cycles or more.\n* At least three consecutive menstrual cycles with an interval of 24 to 38 days, differing by less than 7 days, and menstrual periods lasting 2 to 8 days before screening.\n* At least 2 days of worst pain score ≥4 on Numerical Rating Scale during the screening period.\n* Having not used medications, other than rescue medicine, or therapies for dysmenorrhea secondary to adenomyosis for at least 1 month before randomization, and consenting not to use throughout the process of the research.\n* Volunteering to participate the trial and signing written informed consent.\n\nExclusion Criteria:\n\n* Diagnosed with Endometriosis or having a history of endometriosis-related surgery\n* Currently taking hormonal medications, including: a.use of GnRH agonists within 6 months before the screening period; b. use of progestins or danazol and other long-acting hormones within 3 months before the screening period; c. use of oral contraceptive-like short-acting hormones within one month before the screening period;\n* Having clinically significant gynecologic condition such as clinically significant endometrial pathology, persistent complex ovarian cyst larger than 3 cm or simple ovarian cyst larger than 5 cm, or single fibroid 4 cm or larger or more than 4 fibroids measuring at least 2 cm or symptomatic submucosal fibroid of any size.\n* having an IUD.\n* HB \\\u003C 90G\u002FL.\n* Having any other chronic pain syndrome that required chronic analgesic or other chronic therapy.\n* Having a current history of undiagnosed abnormal genital bleeding.\n* Malignant tumors (including the reproductive system and other systems).\n* Combined with severe diseases in the cardiac, respiratory, renal, liver, and hematopoietic systems, psychiatric disorder and\u002For cognitive disorders.\n* Pregnant, breast feeding, planning a pregnancy within the next 7 months.",{"count":335,"type":21},[24],"The aim of this study is to preliminarily evaluate the is to assess the effects and safety of electroacupuncture for moderate to severe dysmenorrhea secondary to adenomyosis.",[27,193,443],"Electroacupuncture",[27,193,443],{"date":446,"type":38},"2025-08-06",{"date":448,"type":38},"2024-07-21",{"date":450,"type":21},"2026-12-31",{"name":452,"class":45},"Guang'anmen Hospital of China Academy of Chinese Medical Sciences",{"id":454,"slug":455,"hasResults":11,"nctId":456,"briefTitle":457,"officialTitle":458,"acronym":4,"eligibilityCriteria":459,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":22,"phases":462,"briefSummary":463,"conditions":464,"keywords":465,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":46},"100573037","effect-of-tens-on-pain-and-symptoms-in-primary-dysmenorrhea-100573037","NCT06741059","Effect of TENS on Pain and Symptoms in Primary Dysmenorrhea","Determining the Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Pain and Menstrual Symptoms in Primary Dysmenorrhea","Inclusion Criteria:\n\n* Aged 18 and above\n* Have regular menstrual cycles (lasting 3 to 8 days, with a menstrual cycle range of 21 to 35 days)\n* Have dysmenorrhea pain severity rated 4 or higher on the Visual Analog Scale (VAS)\n\nExclusion Criteria: Women with the following conditions were excluded from the study:\n\n* Secondary dysmenorrhea\n* Using oral contraceptives\n* Having impaired tissue integrity in the abdominal area\n* Having previous experience with TENS\n* Having a history of nerve damage or sensory loss\n* Having a pacemaker\n* Having any systemic diseases\n* Being pregnant or in the postpartum period",{"count":461,"type":21},93,[24],"The Effect of Transcutaneous Electrical Nerve Stimulation (TENS) on Pain and Menstrual Symptoms in Primary Dysmenorrhea\n\nThis study aims to investigate the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) in managing pain and alleviating menstrual symptoms in individuals with primary dysmenorrhea. Primary dysmenorrhea is characterized by severe menstrual pain and accompanying symptoms that negatively impact the quality of life and daily functioning. TENS, a non-invasive and drug-free method, is applied to relieve pain by stimulating nerves through electrical impulses. This research evaluates the impact of TENS on both the intensity of menstrual pain and associated symptoms, offering insights into its potential as an alternative or complementary therapeutic approach.",[27],[28,466,195,467],"Transcutaneous Electric Nerve Stimulation","nursing","2025-03-17",{"date":470,"type":38},"2025-03-20",{"date":472,"type":38},"2024-12-20",{"date":474,"type":21},"2025-05-25",{"name":476,"class":45},"Osmaniye Korkut Ata University",{"id":478,"slug":479,"hasResults":11,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":483,"eligibilityCriteria":484,"healthyVolunteers":11,"sex":16,"minAge":247,"maxAge":56,"enrollmentInfo":485,"targetDuration":4,"studyType":22,"phases":487,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":501,"leadSponsor":503,"locationsCount":46},"100580824","the-effect-of-distraction-techniques-used-in-intramuscular-im-injections-on-pain-in-adolescents-presenting-to-the-emergency-department-with-dysmenorrhea-a-randomized-controlled-study-100580824","NCT06842329","The Effect of Distraction Techniques Used in Intramuscular (IM) Injections on Pain in Adolescents Presenting to the Emergency Department With Dysmenorrhea: A Randomized Controlled Study","\"The Effectiveness of Helfer Skin Tap Technique and ShotBlocker in Reducing Pain Severity During Intramuscular Injections in Adolescent Dysmenorrhea: A Randomized Controlled Trial\"","\"HSTT-SB Dysme","nclusion Criteria:\n\n* Adolescents aged 12-18 years.\n* Experience of dysmenorrhea (menstrual pain) during at least one menstrual cycle.\n* Adolescents presenting to the emergency department with dysmenorrhea.\n* Written informed consent from participants or their legal guardians.\n\nExclusion Criteria:\n\n* Individuals with severe cardiovascular, neurological, or other serious medical conditions.\n* Pregnant individuals.\n* Individuals undergoing regular hormonal therapy or using birth control methods.\n* Individuals with significant psychological or physiological conditions related to pain sensitivity (e.g., hyperalgesia).\n* Individuals receiving other pharmacological treatments or pain management medications during the study.",{"count":486,"type":21},90,[24],"Brief Summary:\n\nThis study investigates the effectiveness of non-pharmacological techniques for managing dysmenorrhea (menstrual pain) in adolescents. The study focuses on methods such as Helfer Skin Tap Technique (HSTT) and ShotBlocker, which aim to reduce pain without medication. The goal is to determine how these techniques can help adolescents manage their pain more effectively.\n\nThe study targets adolescents aged 12-18 who experience menstrual pain. Participants will be monitored over several months to assess the impact of these techniques on their pain levels, emotional well-being, and daily activities.\n\nParticipation in the study poses minimal risks. However, the effectiveness of these pain management techniques may vary from person to person. By the end of the study, the aim is to improve pain management strategies for adolescents and gain a better understanding of the effectiveness of non-pharmacological treatments for dysmenorrhea.",[27,490,491],"Pain","Distraction Methods",[493,494,495],"helfer skin tap","shotblocker","pain management","2025-02-21",{"date":498,"type":38},"2025-02-24",{"date":500,"type":38},"2024-10-01",{"date":502,"type":21},"2025-04-01",{"name":504,"class":45},"Duygu MEZDE",{"id":506,"slug":507,"hasResults":11,"nctId":508,"briefTitle":509,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":137,"enrollmentInfo":512,"targetDuration":4,"studyType":22,"phases":514,"briefSummary":515,"conditions":516,"keywords":4,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":46},"100572167","effect-of-bioptron-on-primary-dysmenorrhea-100572167","NCT06729749","Effect of Bioptron on Primary Dysmenorrhea","Effect of Bioptron on Primary Dysmenorrhea: a Randomized Controlled Trial","Inclusion Criteria:\n\nAll females will be clinically diagnosed by the gynecologist with primary dysmenorrhea.\n\n* Self-reported history of PD, at least moderate pain due to menstrual cramps (\\>4 on VAS)\n* They have moderate symptoms of PD on the WaILDD questionnaire, (5-12) Teheran et al., 2018).\n* Their ages will be ranged from 18-24 years old.\n* Their BMI will be less than 30 kg\u002Fm².\n* Being a virgin.\n* Having regular menstruation for the last 6 months (every 28-30 days with no intermittent bleeding).\n* Voluntary acceptance to participate in the study.\n\nB) Exclusion Criteria:\n\nParticipants will be excluded if they have:\n\n* Musculoskeletal or neurological disorders.\n* Patients with a history of phototherapy allergy.\n* Professional athletes (Jill et al., 2012).\n* Secondary dysmenorrhea pathology such as (endometriosis, fibroids, adenomyosis, and pelvic inflammatory disease)\n* Menstrual irregularity.\n* Using hormonal contraception (such as contraceptives or injections).",{"count":513,"type":21},56,[24],"This study will be conducted to determine the effect of bioptron on PD through the assessment of serum progesterone level, and pain level measured by pressure algometry in addition to evaluation of the symptoms of PD and its effect on girl's quality of life through valid and reliable questionnaires which will be of valuable benefits in the women's health fields.",[27],"2024-12-07",{"date":519,"type":38},"2024-12-11",{"date":521,"type":21},"2024-12-15",{"date":523,"type":21},"2025-06-30",{"name":525,"class":45},"Cairo University",{"id":527,"slug":528,"hasResults":11,"nctId":529,"briefTitle":530,"officialTitle":531,"acronym":4,"eligibilityCriteria":532,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":218,"enrollmentInfo":533,"targetDuration":4,"studyType":22,"phases":535,"briefSummary":536,"conditions":537,"keywords":538,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":542,"lastUpdatePostDateStruct":543,"startDateStruct":545,"completionDateStruct":547,"leadSponsor":549,"locationsCount":46},"100562212","effect-of-pelvic-floor-based-training-on-dysmenorrhea-100562212","NCT06600230","Effect of Pelvic Floor-Based Training on Dysmenorrhea","The Effect of Pelvic Floor-Based Training on Young Women With Dysmenorrhea","Inclusion Criteria:\n\n* Being diagnosed with primary dysmenorrhea\n* Being between the ages of 18-35\n* Having a regular menstrual cycle\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Not having a history of endometriosis or gynecological pathology •\n* Having a history of gynecological disease or surgery\n* Having a neurological or musculoskeletal problem",{"count":534,"type":21},70,[24],"The aim of this study is to examine the effect of patient education, knowledge levels and dysmenorrhea symptoms in young women with primary dysmenorrhea. The main question it aims to answer is the questions are as follows:\n\n1. Is patient education effective in improving symptoms in young women with primary dysmenorrhea?\n2. Is there a relationship between knowledge level and symptoms in young women with primary dysmenorrhea?\n\nParticipants will:\n\nAfter the training group was given the training in 2 sessions, the participants were asked to apply the exercises in which the training was given. The control group applied conventional self-methods when dysmenorrhea symptoms occurred. The evaluations were made before the training and at the end of the first menstrual cycle.",[27],[30,539,540,541],"pelvic floor","physiotherapy","exercise education","2024-09-12",{"date":544,"type":38},"2024-09-19",{"date":546,"type":38},"2024-08-20",{"date":548,"type":21},"2024-10",{"name":550,"class":45},"Uskudar University",{"id":552,"slug":553,"hasResults":11,"nctId":554,"briefTitle":555,"officialTitle":556,"acronym":557,"eligibilityCriteria":558,"healthyVolunteers":55,"sex":16,"minAge":559,"maxAge":560,"enrollmentInfo":561,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":563,"conditions":564,"keywords":565,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":567,"lastUpdatePostDateStruct":568,"startDateStruct":570,"completionDateStruct":572,"leadSponsor":574,"locationsCount":46},"100543278","adolescent-dysmenorrhoea-as-a-risk-factor-for-chronic-pain-clinical-cohort-study-100543278","NCT06353789","Adolescent Dysmenorrhoea as a Risk Factor for Chronic Pain: Clinical Cohort Study","Understanding the Role of Adolescent Dysmenorrhoea as a Risk Factor for the Transition to Chronic Pain: Clinical Cohort Study","RoADPain","Inclusion Criteria:\n\n* Participant (or parent\u002Fguardian of participant) is willing and able to give informed consent for participation in the study.\n* Female or assigned female at birth.\n* aged 11 - 20 years.\n* At least 6 periods per year since menarche.\n* During the study data collection period will be within one of the following time intervals since menarche:\n* 12 - 15 months\n* 36 - 39 months\n* 60 - 63 months\n* Reports either period pain or no pain with periods and scores appropriately on NRS (period pain: ≥4\u002F10; no period pain: ≤3\u002F10).\n* Not using hormonal therapies (i.e. contraceptives) currently and has not used previously.\n* Reasonably fluent in English.\n\nExclusion Criteria:\n\n* Current or previous chronic pain condition other than dysmenorrhoea, including migraine.\n* Pregnant or breast-feeding.\n* Previous cancer diagnosis.\n* Contraindication to MRI","11 Years","20 Years",{"count":562,"type":21},132,"This study aims to understand whether changes in a variety of body systems which are seen in adult women with period pain are also seen in adolescents in the first few years of having periods. This information will help to understand 1) how quickly any changes occur, informing clinical practice, and 2) how period pain might lead to other types of chronic pain, potentially allowing development of preventative strategies.",[27],[264,566],"chronic pain","2024-06-11",{"date":569,"type":38},"2024-06-14",{"date":571,"type":38},"2024-06-04",{"date":573,"type":21},"2027-05-01",{"name":575,"class":45},"University of Oxford"]