[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysphagia-after-stroke\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysphagia-after-stroke":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,75,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100630826","effect-of-visual-biofeedback-assisted-oropharyngeal-exercises-in-post-stroke-dysphagia-100630826",false,"NCT07492719","Effect of Visual Biofeedback-Assisted Oropharyngeal Exercises in Post-Stroke Dysphagia","Effectiveness of Visual Biofeedback-Assisted Oropharyngeal Exercises Combined With Neuromuscular Electrical Stimulation in Patients With Post-Stroke Dysphagia: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Clinical diagnosis of dysphagia, defined by at least one of the following: presence of cough or throat clearing during the 90 mL water swallow test, reduced laryngeal elevation on clinical examination, or at least one symptom related to dysphagia\n* Ability to initiate reflex swallowing\n* History of cerebrovascular event within the previous 6 months\n* Stable vital signs\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Severe cognitive impairment (Mini-Mental State Examination \\[MMSE\\] score \\\u003C 20), dementia, or severe communication difficulties due to aphasia\n* Contraindications to electrical stimulation, including the presence of an\n* implantable cardioverter-defibrillator (ICD), impaired skin integrity or open wounds at the electrode placement site, or active epilepsy\n* History of cervical surgery or presence of respiratory distress\n* Diagnosis of malignancy","ALL","18 Years",{"count":19,"type":20},34,"ESTIMATED","INTERVENTIONAL",[23],"NA","Post-stroke dysphagia is a common complication that negatively affects nutritional status, quality of life, and morbidity. Conventional swallowing rehabilitation, including oropharyngeal exercises and neuromuscular electrical stimulation (NMES), is widely used to improve swallowing function. This randomized controlled clinical study aims to investigate the effectiveness of visual biofeedback-assisted oropharyngeal exercises combined with NMES in patients with post-stroke dysphagia. Participants will be randomly assigned to either a visual biofeedback-assisted exercise group or a conventional exercise group, with both groups receiving NMES. Treatment will be administered five days per week for four weeks. Changes in swallowing function, suprahyoid muscle activity assessed by surface electromyography, and muscle stiffness evaluated by shear wave elastography will be analyzed to determine the effectiveness of the intervention.",[26,27,28,29],"Dysphagia After Stroke","Stroke","Dysphagia","Swallowing Disorders",[31,32,33,34,35,36,37],"Post-Stroke Dysphagia","Swallowing Rehabilitation","Oropharyngeal Exercises","Neuromuscular Electrical Stimulation (NMES)","Visual Biofeedback","Surface Electromyography (sEMG)","Shear Wave Elastography","RECRUITING","2026-03-19",{"date":41,"type":42},"2026-03-25","ACTUAL",{"date":44,"type":42},"2026-02-16",{"date":46,"type":20},"2028-01",{"name":48,"class":49},"Gazi University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100609288","cerebellar-transcranial-direct-current-stimulation-for-dysphagia-after-supratentorial-stroke-100609288","NCT07212634","Cerebellar Transcranial Direct Current Stimulation for Dysphagia After Supratentorial Stroke","Efficacy and Mechanisms of Cerebellar Transcranial Direct Current Stimulation for Treating Dysphagia After Supratentorial Stroke","Inclusion Criteria:\n\n1. Patients with supratentorial stroke, confirmed by cranial MRI or CT as having cerebral infarction or hemorrhage;\n2. Stable vital signs after conventional treatment, with disease duration between 1 and 6 months;\n3. 30 ≤ age ≤75 years, male or female;\n4. Presence of dysphagia, drinking-induced coughing, and a Kubota Water Drinking Test grade of 3-5;\n5. Signed informed consent form.\n\nExclusion Criteria:\n\n1. MRI-confirmed lesion involving the cerebellum;\n2. Unstable vital signs;\n3. Significant cognitive impairment (MMSE score ≤ 24);\n4. Presence of swallowing apraxia;\n5. Unwilling or unable to cooperate with treatment, or taking any medication that may affect swallowing function or nervous system activity.","30 Years","75 Years",{"count":61,"type":20},76,[23],"It is estimated that 400,000 to 800,000 people worldwide develop neurogenic dysphagia annually. Stroke represents the most common etiology, with approximately 65% of acute stroke patients experiencing pharyngeal swallowing difficulties. Clinical manifestations of dysphagia vary widely in severity and may include residue, reflux, delayed swallowing initiation, aspiration, and cricopharyngeal muscle dysfunction. Due to its detrimental effects on nutrition, respiration, and psychosocial well-being, dysphagia significantly impairs patients' quality of life. Furthermore, the inability to swallow safely and efficiently can lead to serious complications such as aspiration pneumonia, malnutrition, and depression. The traditional swallowing rehabilitation treatment has limited effect in clinical practice, which makes it necessary to search for new effective swallowing methods.\n\nConventional swallowing rehabilitation often yields limited clinical benefits, highlighting the urgent need for more effective therapeutic strategies. Transcranial direct current stimulation (tDCS) is a non-invasive and safe neuromodulation technique that has shown promise in the field of neurorehabilitation. Its mechanisms extend beyond immediate cortical modulation and cerebral blood flow changes to include the regulation of synaptic plasticity, neurotransmitters such as glutamate and GABA, and excitability in remote subcortical regions. In recent years, tDCS has been increasingly applied to various neurological disorders, including post-stroke motor impairment, dysphagia, aphasia, depression, addiction, and spinal cord injury-related movement disorders. Currently, tDCS is being explored to elucidate its regulatory effects on cerebellar swallowing control, positioning it as a potential innovative treatment for neurogenic dysphagia.",[26],"NOT_YET_RECRUITING","2025-10-01",{"date":68,"type":42},"2025-10-08",{"date":70,"type":20},"2025-12-01",{"date":72,"type":20},"2027-12-31",{"name":74,"class":49},"Zhejiang Provincial People's Hospital",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":88,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":50},"100584324","enhancing-post-stroke-dysphagia-rehabilitation-100584324","NCT06887855","Enhancing Post-Stroke Dysphagia Rehabilitation","Enhancing Post-Stroke Dysphagia Rehabilitation Via the Synergistic Effects of Neuromuscular Electrical Stimulation, Neuromuscular Taping, and Swallowing Exercises: a Randomized Controlled Trial","Not exist","Inclusion Criteria:\n\n* Patients aged 18 - 75 years old,\n* Diagnosed with swallowing disorders between one day and six months post-stroke,\n* Able to attend 10 therapy sessions,\n* Have never received any swallowing treatment before participating in this study.\n\nExclusion Criteria:\n\n* Post-stroke patients with severe cognitive impairment,\n* Patients who have swallowing disorders due to other etiologies,\n* Patients who need traditional swallowing therapy other than Expiratory Muscle Strength Training (EMST) and Chin Tuck Against Resistance (CTAR). - Skin disorders in the submental area and anterior neck,\n* Medical conditions that may affect participation,\n* A defibrillator and use precision electrical biomedical devices (e.g. pacemaker, etc.).",{"count":84,"type":20},10,[23],"The goal of this clinical trial is to investigate the effects of a combined swallowing intervention (Neuromuscular Electrical Stimulation (NMES) + Neuromuscular Taping (NMT) + swallowing exercises) on swallowing function and quality of life in post-stroke dysphagia patients. The main questions it aims to answer are:\n\n• Does the combination of swallowing exercises, NMES \\& NMT have a greater improvement in dysphagia rehabilitation when compared to either NMES or NMT alone? Researchers will compare the effects of intervention between the three groups (NMES and swallowing exercises, NMT and swallowing exercises, and NMES with NMT and swallowing exercises).\n\nParticipants will:\n\n* Receive a combined dysphagia rehabilitation comprised of swallowing exercises, Neuromuscular Electrical stimulation, and\u002For Neuromuscular Taping.\n* Visit the clinic once every 5 days a week for 10 therapy sessions.\n* Undergo baseline and post-intervention evaluation procedures.",[26],[89,90,91,92,93,94,95,96],"post-stroke","dysphagia","combined rehabilitation","neuromuscular electrical stimulation","kinesiology taping","neuromuscular taping","chin tuck against resistance","expiratory muscle strength training","2025-03-15",{"date":99,"type":42},"2025-03-20",{"date":101,"type":42},"2024-11-01",{"date":103,"type":20},"2025-12-30",{"name":105,"class":106},"Hamad Medical Corporation","INDUSTRY",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":17,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":117,"phases":4,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":4},"100559481","to-explore-the-functional-connectivity-pattern-of-cortical-swallowing-network-in-the-oral-phase-of-post-stroke-dysphagia-based-on-dynamic-causal-modelling-100559481","NCT06564688","To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling","Inclusion Criteria:\n\n1. Inclusion criteria of patients with post-stroke oral dysphagia:\n\n   * Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * Oral dysphagia caused by stroke;\n   * FOIS level ≤ 5; WST level ≥3;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke course and dysphagia duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n2. Inclusion criteria of patients without dysphagia after stroke:\n\n   * Patients with first-ever stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI;\n   * No dysphagia, FOIS level =7; WST level =1;\n   * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment;\n   * Clear consciousness and stable vital signs;\n   * Patients in the recovery stage with stroke duration between 0 and 6 months;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n3. Inclusion criteria of healthy control group:\n\n   * Normal cognitive function and swallowing function, FOIS level =7; WST level =1;\n   * Gender and age matched with patients with dysphagia in the oral phase after stroke;\n   * Right-handed;\n   * Voluntary participants with informed consent.\n\nExclusion Criteria:\n\n* Dysphagia not caused by stroke or non-oral dysphagia;\n* History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases;\n* Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression;\n* Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses;\n* Patients with metal implants and\u002For spatial claustrophobia who are not suitable for MRI scanning;\n* Visual\u002Fhearing disorders affecting training and assessment;\n* Persons who are participating in other research trials that may influence the results of this study.",true,"80 Years",{"count":116,"type":20},72,"OBSERVATIONAL","Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.",[26,120,121,122,123],"Cortical Swallowing Network","Functional Magnetic Resonance Imaging","Oral Phase","Dynamic Causal Modelling","2024-08-19",{"date":126,"type":42},"2024-08-21",{"date":128,"type":20},"2024-08-20",{"date":130,"type":20},"2025-07-01",{"name":132,"class":49},"Fujian University of Traditional Chinese Medicine"]