[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dysphagia-oropharyngeal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dysphagia-oropharyngeal":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,76,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100521694","k01-impacts-of-lingual-endurance-exercise-100521694",false,"NCT06072924","K01 Impacts of Lingual Endurance Exercise","Impact of Lingual Endurance Exercise on Rehabilitation of Swallowing Impairments After Ischemic Stroke","Inclusion Criteria:\n\n* 1\\) 3-6 months since most recent diagnosis of ischemic, confirmed from clinical imaging) with or without small hemorrhagic transformation (HI-1)\n* 2\\) Have some indication of on-going swallowing issues\n* 3\\) English Speaking\n\nExclusion Criteria:\n\n* 1\\) ≤18 years of age\n* 2\\) history of dysphagia prior to or after the stroke caused by any of the following conditions: gastrointestinal disease, traumatic brain injury, head and neck cancer, surgery involving the pharynx or larynx\n* 3\\) history of other neurological disease (i.e. multiple sclerosis, ALS, Parkinson's, dementia).\n* 4\\) Medium to large hemorrhagic transformation\u002Finvolvement documented on clinical stroke imaging 5) 5) History of temporomandibular joint and muscle disorders (also known as TMJ).","ALL","18 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn whether a tongue endurance exercise program can improve swallowing function in adults with dysphagia after a stroke. It also aims to explore how this exercise may affect brain structure and connectivity involved in swallowing. The main questions it aims to answer are:\n\nPrimary Aim: Does lingual endurance exercise improve swallowing function compared to a sham therapy? Secondary Aim: Does lingual endurance exercise lead to changes in brain structure or neuroplasticity, as measured by MRI?\n\nResearchers will compare a group receiving tongue endurance exercises to a sham therapy group to see whether the treatment improves tongue function, swallowing.\n\nParticipants will:\n\n* Complete a baseline swallowing assessment and MRI\n* Be randomly assigned to either the lingual exercise or sham therapy group\n* Complete 8 weeks of home-based tongue exercise therapy\n* Return for follow-up swallowing assessments\n* A subgroup of participants will complete a pre-treatment and post-treatment MRI.",[26,27,28,29],"Dysphagia","Dysphagia, Oropharyngeal","Ischemic Stroke","Stroke",[31,32,33],"swallowing trouble","difficulty swallowing","swallow rehab","RECRUITING","2025-12-16",{"date":37,"type":38},"2025-12-18","ACTUAL",{"date":40,"type":38},"2023-09-01",{"date":42,"type":20},"2028-08-31",{"name":44,"class":45},"University of Cincinnati","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100505546","liposomal-bupivacaine-and-transoral-robotic-surgery-100505546","NCT05862792","Liposomal Bupivacaine and Transoral Robotic Surgery","Impact of Liposomal Bupivacaine on Post-operative Pain, Opioid Use, and Swallow Function in Transoral Robotic Surgery","Inclusion Criteria:\n\n* Adult patients, greater than or equal to 18 years of age; Patients of all genders; Patients undergoing transoral robotic surgery; Patient who are able and willing to give consent\n\nExclusion Criteria:\n\n* Patients with an allergy to Bupivacaine or other amide anesthetics; Patients with a carnitine deficiency",{"count":55,"type":20},80,"OBSERVATIONAL","This study is for patients with oropharyngeal squamous cell carcinoma. We want to learn more about how we can optimize pain control in patients who undergo transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma. Our goal is to determine if a local anesthetic called EXPAREL® (Liposomal Bupivacaine) impacts postsurgical pain and swallow function in patients with oropharyngeal squamous cell carcinoma undergoing TORS. EXPAREL® is an FDA-approved anesthetic drug that provides long-lasting and precise pain relief when injected into the surgical wound. Our study team wants to determine if injecting EXPAREL® into the surgical wound will provide better pain relief and swallow function when compared to patients who do not undergo postoperative EXPAREL® injection. Both options for postoperative pain control are considered standard of care for patients undergoing TORS.",[59,27,60,61],"Oropharyngeal Cancer","Post Operative Pain","Transoral Robotic Surgery",[63,64,65,66],"oropharyngeal cancer","squamous cell carcinoma","postoperative pain","transoral robotic surgery","2025-09-05",{"date":69,"type":38},"2025-09-09",{"date":71,"type":38},"2023-06-01",{"date":73,"type":20},"2026-01-15",{"name":75,"class":45},"Geisinger Clinic",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":46},"100511144","occupational-therapy-rehabilitation-for-frail-elders-with-dysphagia-100511144","NCT05935618","Occupational Therapy Rehabilitation for Frail Elders with Dysphagia","No Food or Drink Does Any Good Until It is Swallowed: a Proof-of-concept Study on Occupational Therapy Rehabilitation for Frail Elders with Dysphagia","Inclusion Criteria:\n\n* A score of 5-18 on the Gugging Swallowing Screen.\n* Speaks and understands Danish.\n* Are able to cooperate in the intervention and give written informed consent; i.e. is oriented in time, place and own data, and able to perform four simple oral motor movements on request.\n\n  * Has given written informed consent.\n\nExclusion Criteria:\n\n* Esophageal dysphagia.\n* Progressive neurologenic dysphagia.\n* Psychiatric illness.\n* Delirious.\n* Infections that requires isolation.\n* Need for palliative care.","65 Years",{"count":85,"type":20},30,[23],"The goal of this proof-of-concept study is to assess the potential of a newly developed intervention with combined skill- and strength-based principles for maximizing swallowing-related outcomes and prevent further weakening of the swallowing muscles in older people with dysphagia (difficulty swallowing).\n\nThe main questions to be answered are:\n\n1. Does the intervention produce clinically significant improvement in ingestive skills during meals in older individuals with dysphagia?\n2. Does the intervention produce clinically significant improvements in tongue strength and orofacial function in older persons with dysphagia?\n3. Does the intervention produce clinically significant improvements in nutritional status and quality of life in older individuals with dysphagia?\n4. Is there an association between perceived autonomy support and intervention engagement when older individuals with dysphagia receive the intervention during hospitalization and continued in community-based rehabilitation after discharge?\n\nParticipants will be asked to perform goal-directed and task-specific swallowing exercises in eating and drinking activities where the intensity variables include advancing steps of an altered bolus volume and consistency according to a 17-level task hierarchy, which are introduced according to predetermined progression rules, as well as increases in swallowing repetitions. The dosage is 2-3 individual, face-to-face therapy sessions per week for up to a maximum of eight weeks. A therapy session lasts up to 45 min. In between therapy sessions, participants integrate the achieved level from therapy into their daily meals as self-training.",[27,89],"Deglutition Disorders","2025-03-11",{"date":92,"type":38},"2025-03-14",{"date":94,"type":38},"2023-08-07",{"date":96,"type":20},"2025-12-31",{"name":98,"class":45},"Hvidovre University Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":83,"enrollmentInfo":106,"targetDuration":108,"studyType":56,"phases":4,"briefSummary":109,"conditions":110,"keywords":112,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100544473","ultrasound-study-of-the-submentonian-musculature-and-its-relationship-in-dysphagia-100544473","NCT06369337","Ultrasound Study of the Submentonian Musculature and Its Relationship in Dysphagia","Ultrasound Study of the Submentonian Musculature and Its Relationship in the Development of Dysphagia After Invasive Mechanical Ventilation: a Single-center Cohort Study","Inclusion Criteria:\n\n* • Subjects \\>18 years old.\n\n  * Having received an episode of orotracheal intubation for \\>48h\n\nExclusion Criteria:\n\n* • Congenital or acquired conditions of the Central Nervous System (CNS) such as stroke, traumatic brain injury, Parkinson's, multiple sclerosis, amyotrophic lateral sclerosis (ALS) or any other condition that may bias the attribution of dysphagia to factors other than exclusively clinical ones.\n\n  * Involvement of the cranial nerves or the Peripheral Nervous System (PNS) as well as diseases of the neuromuscular junction such as Myasthenia Gravis or any other condition that may bias the attribution of dysphagia to other factors that are not exclusively clinical.\n  * Neck morphology incompatible with exploration through ultrasound procedures.\n  * Secondary musculoskeletal injuries, including vertebral fractures, unstable extremity fractures or any condition that requires absolute bed rest as prescribed by a doctor.\n  * Malignant tumor lesions or previous head and\u002For neck surgeries.\n  * Medical-surgical history due to pathology of the larynx, oropharynx and\u002For esophagus.\n  * Diagnosis of dysphagia or swallowing disorders prior to the intubation episode with IMV.\n  * Patients unable to eat orally, at least partially.\n  * Known prior cognitive impairment upon admission to the ICU.",{"count":107,"type":20},150,"1 Year","Acquired dysphagia is one of the most frequent complications suffered by patients in intensive care units (ICU) after orotracheal extubation. Ultrasound has proven to be a useful method in the morphological and kinematic exploration of the main swallowing structures. AIM: to evaluate, through ultrasound procedures, the evolution of the morphology of the tongue and muscles of the floor of the mouth and the hyolaryngeal kinematics in patients intubated \\>48h and to correlate these measurements with the possible development of acquired dysphagia. The incidence of dysphagia and ICU acquired weakness (ICUAW) in subjects with \\>48h of intubation and the relative risk factors associated with baseline characteristics and clinical variables will be described. METHODOLOGY: Design: Single-center cohort study (Ramón y Cajal University Hospital). Participants: subjects \\>18 years old, admitted to an intensive care unit (ICU), with \\>48 hours of orotracheal intubation who meet eligibility criteria. Outcomes: the study of socio-demographic and clinical variables related to ICU admission will be included. The physical function variables will be analyzed through the Medical Research Council (MRC) and Functional Status Score (FSS), as well as swallowing function variables through the Volume-Viscosity Swallow (VVS-T) and Functional Oral Intake Scale scales. (FOIS) and Gugging Swallowing Screen (GUSS). Measurements will be made of the thickness and echogenicity of the submental and tongue muscles, as well as hyolaryngeal kinematics",[27,89,111],"Mechanical Ventilation Complication",[26,113,114,115,116],"Ultrasonography","Deglutition disorders","Diagnostic Imaging","Mechanical ventilation","NOT_YET_RECRUITING","2024-06-27",{"date":120,"type":38},"2024-07-01",{"date":122,"type":20},"2024-06",{"date":124,"type":20},"2025-06",{"name":126,"class":45},"Universidad Europea de Madrid"]