[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dystonia-focal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dystonia-focal":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100605924","focused-ultrasound-unilateral-pallidotomy-for-medication-refractory-limb-dystonia-100605924",false,"NCT07168850","Focused Ultrasound Unilateral Pallidotomy for Medication-Refractory Limb Dystonia","Focused Ultrasound Pallidotomy for Medication-Refractory Limb Dystonia (FUTURE Study)","FUTURE","Inclusion Criteria:\n\n* Age 18-80 years\n* Able and willing to consent and attend visits\n* Idiopathic or hereditary limb dystonia (focal, segmental, or multifocal; isolated or combined)\n* Refractory to oral therapy and botulinum toxin\n* Stable medication for ≥30 days and ≥90 days since last BoNT\n* Capable of communicating during Exablate procedure\n\nExclusion Criteria:\n\n* Acquired secondary dystonia\n* Dementia or other neurodegenerative disorders\n* Any clinically significant or unstable medical condition, which, in the opinion of the principal investigator or the clinician delegated by the principal investigator, may put the participant at risk when participating in the study (e.g., unstable heart disease or coagulopathy; uncontrolled psychiatric comorbidity)\n* Prior deep brain stimulation or other brain surgery\n* Any contraindication to MRI\n* Skull Density Ratio (SDR) \\\u003C 0.40\n* Significant brain lesions (eg brain tumor, significant white matter lesions or globus pallidus interna lesions on baseline MRI)\n* Pregnancy","ALL","18 Years","80 Years",{"count":21,"type":22},34,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to find out if a non-invasive procedure called focused ultrasound can safely and effectively treat limb dystonia in adults who have not improved with medications or botulinum toxin injections.\n\nThe main questions it aims to answer are:\n\n* Does focused ultrasound reduce the severity of limb dystonia symptoms?\n* Is the procedure safe and well tolerated?\n\nResearchers will compare people who receive focused ultrasound treatment to those who receive a sham procedure (a look-alike procedure without active treatment) to see if the treatment works.\n\nFocused ultrasound works by producing a very small (millimeter-size) lesion in a deep brain region. In this study, the lesion is located in a region called globus pallidus, which helps control movement.\n\nParticipants will:\n\n* Be randomly assigned to one of two groups: focused ultrasound or sham\n* Undergo a procedure using MRI and focused ultrasound to target a part of the brain called the globus pallidus\n* Be followed for 6 months after treatment to assess changes in symptoms, quality of life, and brain function\n* Participants in the sham group will be offered the real treatment after 3 months\n\nThis study may offer a new non-surgical treatment option for people with dystonia affecting the arm or leg, whose pharmacological control is unsatisfactory.",[28,29,30,31],"Limb Dystonia","Idiopathic Dystonia","Medication-refractory Dystonia","Dystonia, Focal",[33,34,35,36,37,38,39,40],"Focused Ultrasound","MRgFUS","Pallidotomy","Dystonia","Exablate","Neuromodulation","fMRI","TMS","RECRUITING","2026-02-09",{"date":44,"type":45},"2026-02-11","ACTUAL",{"date":47,"type":45},"2025-01-27",{"date":49,"type":22},"2027-02-28",{"name":51,"class":52},"Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta","OTHER",4,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100616709","local-field-potentials-in-dystonia-100616709","NCT07309133","Local Field Potentials in Dystonia","Optimising Deep Brain Stimulation for Dystonia Using Local Field Potentials","LFP-DYT","Inclusion Criteria:\n\n* Age 18 years or older at screening.\n* Clear clinical diagnosis of primary dystonia (idiopathic or genetic forms).\n* Candidate for GPi DBS surgery for dystonia treatment.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Significant neurological or psychiatric disorder (including dementia) that would interfere with outcome evaluation.\n* Participation in a therapeutic research trial within the last year.\n* Diagnosis of functional (psychogenic) dystonia.",{"count":63,"type":22},25,"OBSERVATIONAL","The goal of this clinical trial is to learn whether local field potential (LFP) signals recorded from the globus pallidus interna (GPi) using the Medtronic Percept™ deep brain stimulation (DBS) device can help optimize DBS programming for people with dystonia. The study will also explore whether LFP patterns can serve as a biomarker of disease activity and predict treatment response.\n\nThe main questions it aims to answer are:\n\nDo LFP peaks in the alpha-theta range reliably correlate with dystonia severity and clinical characteristics? Can LFP-based programming achieve similar or better clinical outcomes compared to traditional programming methods? How do LFP profiles change with stimulation and other treatments such as botulinum toxin or oral medications?\n\nResearchers will compare two programming approaches:\n\nTraditional programming based on clinical assessment and imaging. LFP-guided programming based on the site and characteristics of LFP peaks\n\nParticipants will:\n\nUndergo DBS surgery for dystonia as part of standard clinical care. Attend regular follow-up visits for DBS programming and outcome assessments. Complete clinical rating scales for dystonia severity, quality of life, cognition, and mood.\n\nTake part in neurophysiological assessments, including surface EMG, EEG, and reaction time tasks.\n\nHave LFP recordings collected using the Medtronic Percept™ device during clinic visits and, where possible, at home using device sensing features.\n\nThis study will help determine whether LFP analysis can shorten the time to optimal DBS settings and improve outcomes for people with dystonia.",[36,31,67],"Dystonia, Primary",[69,70,71,72,73,74],"Deep Brain Stimulation","DBS","Globus Pallidus Interna","Local Field Potentials","Neurostimulation","Neurophysiology","2025-12-15",{"date":77,"type":45},"2025-12-30",{"date":79,"type":45},"2025-09-04",{"date":81,"type":22},"2028-12",{"name":83,"class":52},"Newcastle-upon-Tyne Hospitals NHS Trust",1,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":17,"minAge":93,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":96,"conditions":97,"keywords":117,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":84},"100318611","dystonia-genotype-phenotype-correlation-100318611","NCT03428009","Dystonia Genotype-Phenotype Correlation","Dystonia Genotype-Phenotype Correlation: A Study to Identify Additional Genetic Associations That Contribute to Specific Dystonic Phenotypes","General Exclusion (both Dystonia and Control groups):\n\n* Metal in any part of the body (including metal injury to the eye) OR carrying a medical device incompatible with MRI (e.g., metal implants such as surgical clips or pacemakers) OR positive screening per UTSW MRI screening form\n* Claustrophobia\n* Non-fluent English\n* Weight incompatible with MRI safety\n* History of head trauma with neurological sequelae, including multiple concussions and\u002For history of stroke\n* Pregnancy\n* Serious medical illness or history of serious medical illness, including cancer that was treated with radiation or chemotherapy, heart attack, or a known history of HIV-1 + status\n* Subjects with Hepatitis C (by Hepatitis C+ titer)\n* Subjects with insulin dependent diabetes mellitus (IDDM)\n* Severe respiratory compromise\n* In the opinion of the investigator, not able to safely participate in this study\n\nInclusion Criteria:\n\n* Dystonia group\n\nPrevious diagnosis of dystonia which include but is not limited to:\n\n* cervical dystonia (50 subjects)\n* blepharospasm (25 subjects)\n* limb dystonia (50 subjects)\n* spasmodic dysphonia (25 subjects)\n* segmental dystonia\n* multi-focal dystonia\n* Any childhood-onset dystonia (25 subjects) Age \\> 11 years\n\n  * Control group:\n\nNo prior dystonia diagnosis (175 subjects) Age \\> 11 years\n\nExclusion Criteria:\n\n* Dystonia group Prior history of or concurrent neurological or psychiatric diagnosis - depression and\u002For anxiety accepted Current use of non-dystonia neuroactive medications - SSRI\u002Fmedication for depression and\u002For anxiety accepted Current use of cervical brace designed for dystonia treatment Prior structural brain injury\n\nControl group:\n\nHistory of or current neurological or psychiatric diagnosis - depression and\u002For anxiety accepted, but must not be in active phase Current use of any neuroactive medication, SSRI\u002Fmedication for depression and\u002For anxiety accepted",true,"11 Years",{"count":95,"type":22},200,"The purpose of this study is to (1) investigate the effect of known dystonia-causing mutations on brain structure and function, to (2) identify structural brain changes that differ between clinical phenotypes of dystonia, and to (3) collect DNA, detailed family history, and clinical phenotypes from patients with idiopathic dystonia with the goal of identifying new dystonia-related genes. Investigators will be recruiting both healthy control subjects and subjects with any form of dystonia. For this study there will be a maximum of two study visit involving a clinical assessment, collection of medical and family history, task training session, an MRI using the learned tasks, and finally a blood draw for genetic analysis. In total, these visits will take 3-5 hours. If the dystonia subjects receive botulinum toxin injections for treatment, the participants and their matched controls will be asked to come for a second visit.",[36,98,67,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,31,115,116],"Dystonia; Idiopathic","Dystonia, Secondary","Dystonia, Familial","Dystonia Disorder","Dystonias, Sporadic","Dystonia; Orofacial","Dystonia Lenticularis","Dystonia, Paroxysmal","Dystonia 6","Dystonia 5","Dystonia 8","Dystonia 9","Dystonia 19","Dystonia 10","Dystonia 11","Dystonia 20","Dystonia 12","Dystonia of Head","Dystonia, Diurnal",[36,118,119,120,121],"Control","Magnetic Resonance Imagine","Genotype","Phenotype","2025-06-03",{"date":124,"type":45},"2025-06-06",{"date":126,"type":45},"2018-03-01",{"date":128,"type":22},"2027-09",{"name":130,"class":52},"University of Texas Southwestern Medical Center"]