[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"dystussia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:dystussia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100638430","transcutaneous-superior-laryngeal-nerve-stimulation-to-upregulate-swallowing-frequency-and-urge-to-swallow-in-patients-living-with-als-100638430",false,"NCT07606235","Transcutaneous Superior Laryngeal Nerve Stimulation to Upregulate Swallowing Frequency and Urge to Swallow in Patients Living With ALS","Inclusion Criteria:\n\n* Confirmed diagnosis of ALS (El-Escorial Criteria)\n* ALS FRS Bulbar Subscore of ≤ 10 and ≥ 3.\n* Functional Oral Intake scale score ≥ 2\n\nExclusion Criteria:\n\n* A diagnosis of significant cognitive impairment or frontotemporal dementia per the treating neurologist or neuropsychologist,\n* Current nasogastric tube placement\n* Current head and neck carcinoma\n* Pacemaker or implanted defibrillator or history of diagnosed arrhythmia, bradycardia, or repeated attacks of hypotension,\n* Implanted vagal nerve stimulator\n* Current pregnancy\n* History of epilepsy\n* Infected, broken or inflamed skin on the neck, or impaired sensation at the site of sEMG or TENS placement\n* Living greater than 50 miles from the NSU clinic round trip\n* Any clinical reason that this stimulation may not be a suitable treatment according to the principal investigator.","ALL","18 Years","90 Years",{"count":19,"type":20},5,"ESTIMATED","INTERVENTIONAL",[23],"NA","Prospective, single-arm pilot study evaluating transcutaneous electrical nerve stimulation of the superior laryngeal nerve (TENS-SLN) in individuals with ALS.\n\nUp to 5 participants with confirmed ALS and bulbar involvement will be enrolled.\n\nPrimary outcomes: swallowing frequency and perceived urge to swallow. Participants complete a baseline visit, followed by two supervised treatment sessions within one week, and a final post-treatment evaluation.\n\nOptional visits (up to 2) may be used to individualize stimulation parameters prior to treatment.\n\nSwallowing function will be assessed using physiological monitoring, fiberoptic endoscopy, and videofluoroscopic swallow study (VFSS).\n\nTENS-SLN is a non-invasive neuromodulation approach targeting sensory pathways to facilitate swallowing without inducing muscle contraction.\n\nThis pilot study is designed to assess feasibility, safety, and preliminary effect sizes to inform future randomized trials, and is not powered to determine efficacy.",[26,27,28],"Amyotrophic Lateral Sclerosis (ALS)","Dysphagia","Dystussia","NOT_YET_RECRUITING","2026-05-18",{"date":32,"type":33},"2026-05-26","ACTUAL",{"date":35,"type":20},"2026-06",{"date":37,"type":20},"2026-12",{"name":39,"class":40},"Nova Southeastern University","OTHER"]