[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"e-cig-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:e-cig-use":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,62,88,119,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100582237","the-impact-of-chronic-e-cigarette-usage-on-microvascular-health-100582237",false,"NCT06860698","The Impact of Chronic E-Cigarette Usage on Microvascular Health","e-Cig users arm\n\nInclusion Criteria:\n\n* Between 18 and 29 years of age\n* Used e-cigarettes with nicotine (≥3 times\u002Fweek for ≥6 months)\n\nExclusion Criteria:\n\n* 17 years old and younger or 30 years old or older.\n* Former combustible tobacco user\u002F former smoker\n* Use of cigarettes for 15 days or more in the past 60 days\n* Use of other tobacco products (cigars, hookah, smokeless), marijuana and\u002For illicit or prescription drugs weekly or more frequently in the past 60 days\n* Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders\n* Disorder or use of medication that affects cardiopulmonary health\n* Evidence of pregnancy or current nursing\n\nNon e-Cig using arm\n\nInclusion\n\n\\- Between 18 and 29 years of age\n\nExclusion\n\n* 17 years old and younger or 30 years old and older\n* Use of cigarettes or other tobacco products more than 50 times in their lifetime.\n* Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders\n* Disorder or use of medication that affects cardiopulmonary health\n* Evidence of pregnancy or current nursing",true,"ALL","18 Years","29 Years",{"count":20,"type":21},44,"ESTIMATED","OBSERVATIONAL","The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.",[25],"E-Cig Use",[27],"Microvascular Health","RECRUITING","2026-06-15",{"date":31,"type":32},"2026-06-17","ACTUAL",{"date":34,"type":32},"2023-07-14",{"date":36,"type":21},"2026-07-28",{"name":38,"class":39},"Virginia Commonwealth University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":40},"100605800","carcinogen-and-toxicant-exposure-among-young-adults-who-co-use-e-cigarettes-and-cannabis-co-tox-study-100605800","NCT07167225","Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)","Inclusion Criteria:\n\n* Young adult (18-25 years old).\n* Ability to read and write in English.\n* Participants must fall into one of the following groups (based on self-report):\n* Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.\n* Predominant cannabis consumer: defined as using cannabis at least 3x\u002Fweek for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.\n* E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x\u002Fweek, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly.\n* No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).\n* Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.\n\nExclusion Criteria:\n\n* Individuals under the age of 18 or over the age of 25.\n* Currently pregnant or breastfeeding (female participants).\n* Unwilling or unable to follow protocol requirements","25 Years",{"count":49,"type":21},150,"This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and\u002For cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.",[52,25],"Cigarette Smoking-Related Carcinoma","2026-05-04",{"date":55,"type":32},"2026-05-08",{"date":57,"type":32},"2025-04-03",{"date":59,"type":21},"2028-10-01",{"name":61,"class":39},"Roswell Park Cancer Institute",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":15,"sex":16,"minAge":68,"maxAge":4,"enrollmentInfo":69,"targetDuration":4,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":40},"100536386","the-role-of-flavor-in-the-substitutability-of-e-cigarettes-for-combustible-cigarettes-among-persistent-smokers-100536386","NCT06264154","The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers","Inclusion Criteria:\n\n1. Able to communicate fluently in English (i.e. speaking, writing, and reading)\n2. Male and female smokers who are \\> 21 years of age and self-report smoking at least 5 cigarettes (menthol and\u002For non-menthol) per day for at least the last 12 months\n3. 5 or more failed quit attempts and the use of smoking cessation medication on at least one prior attempt.\n4. Ever use of an e-cigarette\n5. Have a carbon monoxide (CO) greater than 10 ppm\n6. Not using any forms of nicotine regularly other than cigarettes\n7. Be willing to switch to e-cigarettes for 6 weeks and use the assigned flavors\n8. Plan to live in the area for the duration of the study\n9. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form.\n\nExclusion Criteria:\n\nSmoking Behavior Regular use of nicotine-containing products other than cigarettes (e.g., chewing tobacco, snuff, snus, cigars, e-cigs, etc.). Regular e-cigarette use is defined as greater than 5 days\u002Fpast 30 days\n\n1. Participants agreeing to abstain from using nicotine-containing products other than cigarettes for the duration of the study will be considered eligible.\n2. Current enrollment or plans to enroll in a smoking cessation program over the duration of the study.\n3. Current use of smoking cessation medication\n4. Provide a CO breath test reading less than 10 ppm at Intake.\n\nAlcohol and Drug\n\n1. History of substance abuse (other than nicotine dependence) in the past 12 months.\n2. Current alcohol consumption that exceeds 20 standard drinks\u002Fweek.\n3. Current use of recreational drugs (other than nicotine and cannabis)\n4. Breath alcohol reading (BrAC) greater than .000 at Intake.\n\nMedical\n\n1. Women, including all individuals assigned as \"female\" at birth, who are pregnant, breastfeeding, or planning a pregnancy over the duration of the study period.\n2. Serious or unstable disease within the past year (e.g. cancer, heart disease). Applicable conditions will be evaluated on a case-by-case basis by the Principal Investigator.\n3. Allergies to either propylene glycol or flavor additives\n\nPsychiatric\n\n1\\. Lifetime history of schizophrenia or psychosis.\n\nGeneral Exclusion\n\n1. Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact subject safety, study data, and\u002For the study design as determined by the Principal Investigator.\n2. Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the Principal Investigator. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen.\n3. Significant non-compliance with protocol and\u002For study design as determined by the Principal Investigator and\u002Fo. Subjects may be deemed ineligible at any point throughout the study.","21 Years",{"count":70,"type":21},210,"INTERVENTIONAL",[73],"NA","This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.",[76,77,78,25],"Smoking","Tobacco Use","Cigarette Smoking","2026-02-17",{"date":81,"type":32},"2026-02-19",{"date":83,"type":32},"2024-08-26",{"date":85,"type":21},"2027-12",{"name":87,"class":39},"Abramson Cancer Center at Penn Medicine",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":15,"sex":16,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":71,"phases":98,"briefSummary":99,"conditions":100,"keywords":104,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":40},"100605410","a-hybrid-program-to-prevent-substance-use-risk-among-upper-elementary-school-students-using-a-positive-youth-development-approach-100605410","NCT07162155","A Hybrid Program to Prevent Substance Use Risk Among Upper Elementary School Students Using a Positive Youth Development Approach","Inclusion Criteria: Students will be eligible for participation if they attend a school enrolled in the trial and they are between ages 7-11.\n\nExclusion Criteria: All students will be eligible to participate in intervention implmentation, but survey responses will be excluded from the formal analysis with documentation of significant cognitive impairment as determined by school officials.","7 Years","11 Years",{"count":97,"type":21},3000,[73],"The goal of this randomized controlled trial is to evaluate a psychosocial school-based hybrid intervention which includes traditional classroom sessions and online e-learning modules to reduce risk of vaping and prescription drug misuse as part of a broader positive youth development substance use prevention model. Upper elementary schools (N=30) will be randomized to either an intervention group that will receive a hybrid intervention or a treatment-as-usual control group that will receive existing health education programming. At the end of the intervention period, and at 6- and 12-month follow-up assessments, both groups will be compared on changes in behaviors, norms, attitudes, and knowledge regarding vaping and prescription medication use.\n\nThe main questions the trial aims to answer are:\n\n* Does the intervention lower risk of vaping and prescription drug misuse?\n* Does the intervention increase pro-health norms, attitudes, and knowledge regarding vaping and prescription drug misuse?\n\nParticipants will:\n\n* Attend 1 classroom session per week for 6 weeks (lecture, discussion, small group activities, skills practice).\n* Complete 1 e-learning module per week for 6 weeks (animated didactic content).\n* Students attending schools randomized to the control group will attend existing health education programming.",[101,102,103],"Vaping","E Cig Use","Prescription Drug Misuse",[105,106,107],"prevention","school-based","positive youth development","NOT_YET_RECRUITING","2025-08-29",{"date":111,"type":32},"2025-09-09",{"date":113,"type":21},"2026-01",{"date":115,"type":21},"2028-08",{"name":117,"class":118},"Christopher Williams","INDUSTRY",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":71,"phases":129,"briefSummary":130,"conditions":131,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":40},"100582341","breathe-free-a-pilot-feasibility-trial-100582341","NCT06862050","BREATHE Free: a Pilot Feasibility Trial","BREATHE Free: Character Strength and Resilience-Based Curriculum for Successful Tobacco Treatment: a Pilot Feasibility Trial","BF","Inclusion Criteria:\n\n* Daily use of one or more tobacco products\n* Valid home address in Augusta or the CSRA\n* Functioning telephone number\n* Speak, read, write in English\n\nExclusion Criteria:\n\n* Current use of tobacco cessation medications\n* Enrolled in tobacco treatment program",{"count":128,"type":21},90,[73],"The overall purpose of this pilot study is to assess the feasibility and acceptability of an in-person faith-based intervention to help people stop tobacco use. The study will address use of different types of tobacco products, such as smoking combustible cigarettes, cigarillos and little filtered cigars, and using\u002Fvaping electronic nicotine delivery systems (vape pens, e-cigs, and JUUL).\n\nThe intervention consists of 12 weekly meetings in which participants will go through BREATHE Free, a study guide curriculum designed to teach character strengths and promote resilience. This pilot research will provide information and practical lessons on how to improve Breathe Free implementation, increase engagement of the local people, and maximize their benefit.\n\nThe main questions it aims to answer are:\n\n* Do participants find BREATHE Free curriculum acceptable, engaging and helpful to stop tobacco use?\n* Do participants who complete BREATHE Free curriculum smoke fewer cigarettes per day?\n\nResearchers will assign participants to either BREATHE Free curriculum or usual care.\n\nParticipants will:\n\n* Be taught BREATHE Free curriculum or be given information and referral to tobacco quit line\n* BREATHE Free group will attend 12 group meetings held on the university campus\n* All participants will answer interview questions related to tobacco use, character strengths and resilience\n* Expired Carbon Monoxide (CO) will be assessed in all participants.",[132,25,133],"Smoking Cessation; Tobacco Dependence","Nicotine Dependence, Other Tobacco Product","2025-03-03",{"date":136,"type":32},"2025-03-06",{"date":138,"type":21},"2025-03-01",{"date":140,"type":21},"2026-12-25",{"name":142,"class":39},"Augusta University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":71,"phases":153,"briefSummary":156,"conditions":157,"keywords":158,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":40},"100413367","phase-1-hyperpolarized-xenon-129-mr-imaging-of-the-lung-100413367","NCT04662658","Hyperpolarized Xenon-129 MR Imaging of the Lung","Hyperpolarized Xenon-129 MR Imaging of the Lung:E-cigarette Sub-study","e-cigarette","Inclusion Criteria:\n\n1. Male and female subjects 21-30 years of age\n2. At baseline health with no recent illnesses or medical conditions that would preclude enrollment as assessed by the Principal Investigator\n3. Ability to understand a written informed consent form and comply with the requirements of the study.\n4. E-cigarette use for more than 6 months preceding the date of enrollment and less than a 5 pack year smoking history (e-cigarette users) OR less than a 5 pack year smoking history (non-smoker group).\n5. No diagnosis of any lung disease (pre-bronchodilator FEV1\u002FFVC normal on the day of screening defined by \\> 95thCI of NHANES III, ATS\u002FERS guideline)\n\nExclusion Criteria:\n\n1. History of any lung disease\n2. Control (non-smoking) group: History of illegal drug use by inhalation\n3. History of CNS disease including stroke and dementia, end-stage liver disease, coronary artery disease, renal failure\n4. Acute infection of any kind in the previous 6 weeks\n5. Pregnancy or a possibility of pregnancy\n6. Anemia\n7. Inability to undergo MR imaging based on the standard clinical criteria for MRI",{"count":152,"type":21},24,[154,155],"PHASE1","PHASE2","Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as a \"less harmful\" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine phenotypes similar to those of human COPD. Recently, \"spiked\" vape juice has been linked to severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still poorly understood, especially in healthy young adults. Therefore, establishing the health effects of e-cigarettes in humans is of paramount importance to guide medical and regulatory decision making. Its widespread use and immense popularity among teenagers and young adults have caused major concern given potentially significant addictive and detrimental long-term health effects.",[25],[159],"e-cigarette use with young adults","2020-12-09",{"date":162,"type":32},"2020-12-10",{"date":164,"type":32},"2020-11-05",{"date":166,"type":21},"2025-12",{"name":168,"class":39},"University of Virginia"]