[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"e-cigarette-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:e-cigarette-use":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,42,71,107,136,159,182,209,231,252,278,299,321],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100587525","the-development-and-evaluation-of-a-culturally-grounded-ends-intervention-for-rural-hawaiian-youth-100587525",false,"NCT06929520","The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth","Inclusion Criteria:\n\n* 6th-8th grade students attending a public or public-charter school on Hawaii Island.\n\nExclusion Criteria:\n\n* K-5th grade students and 9th-12th grade students on Hawaii Island.",true,"ALL","10 Years","14 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims. AIM 1 (Years 1-3) are focused on pre-intervention and intervention development. In Year 1, youth focus groups will be conducted to assess the environmental demands related to ENDS use in rural Hawai'i. In Year 2, specific ENDS-related problem situations (i.e., situations that increase risk for ENDS use) will be extracted from the Year 1 focus groups and prioritized through survey methods with 200-250 predominately Native Hawaiian youth across 16 different middle\u002Fintermediate schools on Hawai'i Island. In Year 3, five situations found to be the most frequently experienced and\u002For difficult to manage by youth surveyed in Year 2 will serve as the foundation for the development of narrative scripts. Three of these scripts will be cast and filmed on location on Hawai'i Island by a professional film director, and will be edited into three short films, 6-8 video clips, and 6-8 professional photos or production stills. Similar to the investigators' prior drug prevention research in rural Hawai'i, classroom-based lessons will be created to support the short films. Additional lessons and videos from an evidence-based, culturally grounded substance abuse prevention curriculum for Hawaiian youth (Ho'ouna Pono) will be used to create a modular classroom curriculum. The video clips and professional photography\u002Fproduction stills will be embedded with prevention messaging, and will be used for a social and print media campaign to reinforce the classroom curriculum. AIM 2 (Years 4-5) is to evaluate the ENDS prevention intervention (classroom curriculum plus social\u002Fprint media campaign) across all middle\u002Fintermediate public or public-charter schools (N = 16) and up to 11 different cultural immersion charter schools on Hawai'i Island using a dynamic wait-listed control group design.",[27,28],"E-cigarette Use","Substance Use","RECRUITING","2026-06-03",{"date":32,"type":33},"2026-06-05","ACTUAL",{"date":35,"type":33},"2025-10-15",{"date":37,"type":21},"2027-05-15",{"name":39,"class":40},"University of Hawaii","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100640642","an-online-intervention-to-reduce-e-cigarette-use-and-cigarette-smoking-risk-in-adolescents-100640642","NCT07624292","An Online Intervention to Reduce E-cigarette Use and Cigarette Smoking Risk in Adolescents","An Online Intervention to Reduce E-cigarette Use and Potential for Cigarette Smoking in Adolescents","Inclusion Criteria:\n\n* be between the ages of 12 to 17\n* be able to read English\n* be a current resident of California\n* report vaping at least one day per week in the past month\n* report no history of cigarette use at screening and baseline\n* have access to a computer or mobile device with internet access\n\nExclusion Criteria:\n\n* currently receiving nicotine cessation services","12 Years","17 Years",{"count":52,"type":21},150,[24],"The goal of this clinical trial is to learn if a brief digital intervention can reduce e-cigarette use and prevent cigarette smoking initiation in teenagers ages 12-17. The main questions it aims to answer are:\n\n* Compared to the control condition, does the intervention reduce e-cigarette use frequency in teenagers?\n* Compared to the control condition, does the intervention reduce risk to start smoking cigarettes in teenagers? Researchers will compare the digital intervention to see if it leads to greater reductions in e-cigarette use and smoking risk than a waitlist control condition.\n\nParticipants will complete 5 brief online surveys across 12 weeks, and some will be selected to do a post-intervention virtual interview. In this interview, participants will be asked to share their opinions about the intervention and identify areas that need refinement.",[27,56],"Cigarette Smoking Risk",[58,59,60,61],"E-cigarette","Tobacco","Nicotine addiction","mHealth","NOT_YET_RECRUITING","2026-05-31",{"date":30,"type":33},{"date":66,"type":21},"2026-07-01",{"date":68,"type":21},"2027-03-30",{"name":70,"class":40},"University of Southern California",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":93,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":41},"100608922","parents-helping-parents-for-youth-vaping-cessation-100608922","NCT07207850","Parents Helping Parents for Youth Vaping Cessation","Parents Helping Parents for Youth Vaping Cessation (PhP-VX)","PhP-VX","ADOLESCENT INCLUSION:\n\n* 15-18\n* Report vaping in the previous 30 days\n* English literacy\n\nPARENT INCLUSION:\n\n* Biological, adoptive, stepparents, or adult guardian of adolescent participating\n* Have face-to-face contact with the adolescent at least one day per week during the study period\n* Access to a computer or mobile phone at home\n* Interested in helping adolescent quit e-cigarette\u002Fvape use","15 Years","18 Years",{"count":82,"type":21},200,[24],"The goal of this randomized controlled study is to test if this new intervention works to help adolescents quit vaping. A key feature of the program is the use of peer support for parents, delivered by trained parent coaches. Participants will complete baseline and follow up surveys. Parents in the intervention arm will receive peer support as part of the program.",[86,87,88,89,90,91,92],"Implementation Science","Engagement, Patient","E Cigarette Use","Peer Support","Vaping Teens","Vaping Cessation","Parent Support",[94,59,95,96,97],"Vaping","vaping cessation","Parent support","adolescent vaping","2026-05-20",{"date":100,"type":33},"2026-05-26",{"date":102,"type":33},"2026-05-18",{"date":104,"type":21},"2027-08-31",{"name":106,"class":40},"University of Nebraska",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":15,"sex":16,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":118,"briefSummary":119,"conditions":120,"keywords":122,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":41},"100623618","sex-differences-in-e-cigarette-perception-100623618","NCT07398976","Sex Differences in E-Cigarette Perception","Sex Differences in E-Cigarette Perception: Study 2","Inclusion Criteria:\n\n* Able to read\u002Fwrite in English\n* Current cigarette smoking\n* Prior e-cigarette exposure\n* Biochemically verified cigarette use\n* Not trying to quit tobacco use\n\nExclusion Criteria:\n\n* Significant medical concerns that would increase study risk\n* Use of psychoactive drugs unless prescribed and stable\n* Allergy to menthol or other e-liquid ingredients\n* Dislike of menthol\n* Pregnant, trying to get pregnant, breastfeeding","21 Years","44 Years",{"count":117,"type":21},60,[24],"This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.",[121,27],"Nicotine Dependence",[123,124,125,126,127,94],"Sex Differences","Females","E-cigarettes","Menthol","Nicotine",{"date":129,"type":33},"2026-05-19",{"date":131,"type":21},"2026-06-15",{"date":133,"type":21},"2027-04-01",{"name":135,"class":40},"Yale University",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":15,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":22,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":41},"100544746","noncombustible-nicotine-delivery-systems-as-potential-harm-reduction-tools-for-persistent-cigarette-smokers-100544746","NCT06372899","Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers","Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers","Inclusion Criteria:\n\n1. Able to communicate fluently in English (i.e. speaking, writing, and reading)\n2. Male and female smokers who are \\> 21 years of age and self-report smoking at least 5 cigarettes (menthol and\u002For non-menthol) per day for at least the last 6 months.\n3. 5 or more failed quit attempts and the use of smoking cessation medication on at least one prior attempt.\n4. Have a carbon monoxide (CO) greater than 10 ppm.\n5. Not using any forms of nicotine regularly other than cigarettes\n6. Be willing to switch to e-cigarettes or nicotine pouches for 6 weeks.\n7. Plan to live in the area for the duration of the study.\n8. Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the combined consent and HIPAA form.\n\nExclusion Criteria:\n\nSmoking Behavior\n\n1. Regular use of nicotine-containing products other than cigarettes (e.g., chewing tobacco, snuff, snus, cigars, e-cigs, etc.). Regular e-cigarette and nicotine pouch use is defined as greater than 5 days\u002Fpast 30 days.\n\n   a. Participants agreeing to abstain from using nicotine-containing products other than cigarettes for the duration of the study will be considered eligible.\n2. Current enrollment or plans to enroll in a smoking cessation program over the duration of the study.\n3. Current use of smoking cessation medication\n4. Provide a CO breath test reading less than 10 ppm at Intake.\n\nAlcohol and Drug\n\n1. History of substance abuse (other than nicotine dependence) in the past 12 months.\n2. Current alcohol consumption that exceeds 20 standard drinks\u002Fweek.\n3. Current use of recreational drugs (other than nicotine and cannabis)\n4. Breath alcohol reading (BrAC) greater than .000 at Intake.\n\nMedical\n\n1. Women, including all individuals assigned as \"female\" at birth, who are pregnant, breastfeeding, or planning a pregnancy over the duration of the study period.\n2. Serious or unstable disease within the past year (e.g. cancer, heart disease). Applicable conditions will be evaluated on a case-by-case basis by the Principal Investigator.\n\nPsychiatric\n\n1\\. Lifetime history of schizophrenia or psychosis.\n\nGeneral Exclusion\n\n1. Past, current, anticipated, or pending enrollment in another research program over the study period that could potentially impact subject safety, study data, and\u002For the study design as determined by the Principal Investigator.\n2. Any medical condition, illness, disorder, adverse event (AE), or concomitant medication that could compromise participant safety or significantly impact study performance as determined by the Principal Investigator. Subjects may be deemed ineligible for any of the aforementioned reasons at any point throughout the study, as well as during the initial telephone screen.\n3. Significant non-compliance with protocol and\u002For study design as determined by the Principal Investigator. Subjects may be deemed ineligible at any point throughout the study.",{"count":82,"type":21},[24],"This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to ECIGS or ONPS and be instructed to switch (versus smoking cigarettes) over a 6-week period. Relative reductions in biomarkers of exposure will be measured. ECIG- and ONP-associated subjective reward and the reinforcing value of ECIGS and ONPS relative to combustible cigarettes will be assessed as mechanisms.",[27,147,148,149],"Cigarette Smoking","Harm Reduction","Tobacco Use","2026-03-11",{"date":152,"type":33},"2026-03-12",{"date":154,"type":33},"2024-10-02",{"date":156,"type":21},"2028-03-31",{"name":158,"class":40},"Abramson Cancer Center at Penn Medicine",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":114,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":22,"phases":167,"briefSummary":168,"conditions":169,"keywords":170,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":41},"100605325","effects-of-a-low-nicotine-standard-and-tobacco-prices-on-illegal-cigarette-purchasing-100605325","NCT07161050","Effects of a Low Nicotine Standard and Tobacco Prices on Illegal Cigarette Purchasing","Inclusion Criteria:\n\n* Provide informed consent Be at least 21 years of age or older Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm) Stable tobacco use patterns for at least two months\n\nExclusion Criteria:\n\nFor exclusive cigarette smokers:\n\nSmoke at least 10 cigarettes daily and do not use NVPs regularly (no more than 9 times in the last month).\n\nFor dual cigarette\u002FNVP users:\n\nSmoke at least 10 cigarettes daily and use NVPs at least 3 times in a week (report use of closed nicotine salt system)\n\nFor both groups:\n\nHave plans to move out of the area Have a serious or unstable physical or mental health condition Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement Report concrete, immediate plans to alter\u002Fquit using their usual nicotine products at the beginning of the study Being pregnant or lactating",{"count":166,"type":21},70,[24],"This study will investigate the effects of a very-low-nicotine cigarette (VLNC) standard, e-cigarette price, and illegal cigarette price on illegal product purchasing and alternative product use in a virtual marketplace.",[147,27],[171,172],"Experimental Tobacco Marketplace","Illegal cigarette","2026-01-14",{"date":175,"type":33},"2026-01-16",{"date":177,"type":33},"2025-12-01",{"date":179,"type":21},"2026-10-07",{"name":181,"class":40},"Virginia Polytechnic Institute and State University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":22,"phases":192,"briefSummary":193,"conditions":194,"keywords":195,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":41},"100531184","adapting-an-intervention-for-vaping-in-young-veterans-100531184","NCT06196489","Adapting an Intervention for Vaping in Young Veterans","Nicotine Cessation: Adapting a Counseling Program for Emerging Adults","Inclusion Criteria:\n\n* daily e-cigarette user for at least the past 6 months\n* 18-30 years old\n* willing to enroll in a program to quit nicotine use within 30 days\n* owns smartphone or computer\u002Ftablet with camera and internet connectivity\n* English speaker\n\nExclusion Criteria:\n\n* ICD-10 diagnosis of dementia\n* current use of combustible tobacco products at least weekly","30 Years",{"count":191,"type":21},20,[24],"The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA).\n\n1. Examine factors related to e-cigarette use, barriers to cessation, and facilitators of use of cessation services among an EA population.\n2. Beta-test an initial version of the intervention, delivered via video telehealth and telephone, to examine usability and acceptability.",[88],[196,197,198,199],"Veteran","e-cigarette","vaping","young adult","2026-01-06",{"date":202,"type":33},"2026-01-08",{"date":204,"type":33},"2024-01-01",{"date":206,"type":21},"2026-06",{"name":208,"class":40},"Veterans Medical Research Foundation",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":4,"enrollmentInfo":216,"targetDuration":4,"studyType":22,"phases":218,"briefSummary":220,"conditions":221,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":229,"locationsCount":230},"100596062","phase-2-a-trial-of-varenicline-for-e-cigarette-cessation-100596062","NCT07040566","A Trial of Varenicline for E-cigarette Cessation","Investigating Efficacious E-Cigarette Interventions and Cessation Effects on Cancer-Related Biomarkers: A Randomized Trial of Varenicline in Adults","Inclusion Criteria:\n\n* report daily use of an e-cigarette containing nicotine\n* live in Connecticut or South Carolina\n\nExclusion Criteria:\n\n* regular use of other tobacco products besides e-cigarettes\n* medical contraindications for varenicline use\n* current treatment for tobacco cessation\n* lack proficiency in English",{"count":217,"type":21},326,[219],"PHASE2","This is randomized, placebo-controlled clinical trial in treatment-seeking adults who report regular e-cigarette use to test the hypothesis that varenicline is efficacious for quitting e-cigarettes.",[27,94,121],"2025-12-15",{"date":224,"type":33},"2025-12-17",{"date":226,"type":33},"2025-10-14",{"date":228,"type":21},"2030-10-30",{"name":135,"class":40},2,{"id":232,"slug":233,"hasResults":11,"nctId":234,"briefTitle":235,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":15,"sex":16,"minAge":80,"maxAge":237,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":242,"conditions":243,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":41},"100528349","early-phase-1-sex-differences-in-the-vascular-effects-of-e-cigarette-use-100528349","NCT06159608","Sex Differences in the Vascular Effects of E-cigarette Use","Inclusion Criteria:\n\n* 18-24 years old\n* one of the following:\n\n  1. have no history of e-cigarette use\n  2. be a current e-cigarette user who has been using e-cigarettes for 6 months or longer\n\nExclusion Criteria:\n\n* history of cardiovascular, metabolic, and\u002For skin diseases\n* body mass index \\>30 kg\u002Fm2\n* blood pressure ≥140 systolic and\u002For ≥ 90 diastolic\n* current or history of tobacco cigarette use\n* current antihypertensive or cholesterol-lowering medication\n* current use of cannabis, marijuana, and\u002For other illegal substances\n* current use of stimulant drugs\n* currently pregnant or breastfeeding\n* allergy to materials used during the experiment (e.g. latex),\n* known allergy to study drugs\n* healthy control subjects will also be excluded if they have ever used e-cigarettes in the past","24 Years",{"count":239,"type":21},80,[241],"EARLY_PHASE1","The use of electronic nicotine delivery systems, or e-cigarettes - colloquially referred to as \"vaping\" - in the United States has increased exponentially since their introduction to the US market in 2007. Prevalence of ever and current e-cigarette use is highest among teenagers and young adults with 16-28% of this population having reported vaping. While the majority of e-cigarette users are current tobacco smokers, 32.5% of current e-cigarette users are never- or former-smokers, representing a growing population of young adults who exclusively vape. While e-cigarettes have been marketed as a safer alternative to tobacco cigarettes, clinical studies examining these claims are limited. Cardiovascular disease (CVD) is the primary cause of premature death among tobacco cigarette smokers and reductions in vascular endothelial function, a significant predictor of future CVD, are detectible in otherwise healthy young adults who smoke. Despite the explosion in e-cigarette use among young adults, the health effects - especially the effects on mechanisms of vascular function - of these devices remain relatively unexplored.\n\nIn this study, we use the blood vessels in the skin as a representative vascular bed for examining mechanisms of microvascular dysfunction in humans. Using a minimally invasive technique (intradermal microdialysis for the local delivery of pharmaceutical agents) we examine the blood vessels in a dime-sized area of the skin in otherwise healthy young (18-24yrs) chronic e-cigarette users. Local heating of the skin at the microdialysis sites is used to explore differences in mechanisms governing microvascular control. As a compliment to these measurements, we also draw blood from the subjects to measure circulating factors that may contribute to cardiovascular health and examine markers of inflammatory activation. We will also collect urine from female participants to measure estradiol.",[27],"2025-12-08",{"date":222,"type":33},{"date":247,"type":33},"2023-12-02",{"date":249,"type":21},"2026-12",{"name":251,"class":40},"Anna Stanhewicz, PhD",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":15,"sex":16,"minAge":259,"maxAge":4,"enrollmentInfo":260,"targetDuration":4,"studyType":261,"phases":4,"briefSummary":262,"conditions":263,"keywords":264,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":41},"100409809","novel-pulmonary-imaging-of-lung-structure-and-function-in-e-cigarette-smokers-100409809","NCT04616313","Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers","Novel Pulmonary Imaging of Lung Structure and Function in Symptomatic and Asymptomatic E-cigarette Smokers","Inclusion Criteria:\n\n* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.\n* Male and female participant age ≥16 years.\n* Participant has recently started vaping, \\>1 and \\\u003C5 years weekly use.\n* 70 participants will be c-cigarette never users.\n* 70 participants will be former or current c-cigarette users.\n* 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.\n\nExclusion Criteria:\n\n* Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.\n* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.\n* Participant unable to perform spirometry or plethysmography maneuvers.","16 Years",{"count":52,"type":21},"OBSERVATIONAL","This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.",[88],[265,266,267,268],"e-cigarette smoking","pulmonary function","Xenon-129","Magnetic Resonance Imaging","2025-08-08",{"date":271,"type":33},"2025-08-14",{"date":273,"type":33},"2023-01-17",{"date":275,"type":21},"2027-12",{"name":277,"class":40},"Western University, Canada",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":15,"sex":16,"minAge":80,"maxAge":237,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":288,"conditions":289,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":41},"100508873","vape-free-text-messaging-pilot-study-100508873","NCT05906082","Vape-Free Text-Messaging: Pilot Study","Text-messaging E-cigarette Cessation Intervention for Young Adults in Rural Areas: A Pilot Study","Inclusion Criteria:\n\n* English speaking\n* 18-24 years\n* everyday e-cigarette use in the past month\n* ownership of a mobile phone or smartphone with texting and internet access abilities\n* knowledge of how to use text messages\n* plan on quitting e-cigarette use within one month\n* home address in a rural county of Wisconsin, Minnesota, North Dakota, and South Dakota\n\nExclusion Criteria:\n\n* Individuals who reported use of other tobacco products (e.g., cigarettes, smokeless tobacco) than e-cigarettes in the past month",{"count":286,"type":21},50,[24],"This is a small pilot randomized controlled trial to evaluate the feasibility, acceptability, and preliminary efficacy of the e-cigarette cessation text-messaging intervention with young adults in rural areas.",[27],"2025-08-03",{"date":292,"type":33},"2025-08-07",{"date":294,"type":33},"2023-05-25",{"date":296,"type":21},"2026-12-31",{"name":298,"class":40},"Jovan Gwon, PhD, RN, FIAAN",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":15,"sex":16,"minAge":114,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":22,"phases":308,"briefSummary":309,"conditions":310,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":41},"100521238","early-phase-1-evaluation-of-the-electronic-cigarette-withdrawal-syndrome-100521238","NCT06066996","Evaluation of the Electronic Cigarette Withdrawal Syndrome","Evaluation of the Electronic Cigarette Withdrawal Syndrome: Mechanistic Targets for Intervention","Inclusion criteria:\n\n1. 21-55 years old\n2. good general health as reviewed by study medical team\n3. vital signs in normal range as reviewed by study medical team\n4. negative urine test for illicit drug use (excluding THC) and negative breath alcohol test\n5. daily use of a nicotine-containing e-cigarette for at least 6 months\n6. no regular use of other tobacco products (e.g., smokeless products) for at least 6 months\n7. urine cotinine \\>100ng\u002FmL (i.e., recommended cutoff for confirming current nicotine use)\n8. exhaled breath carbon monoxide (CO) \\\u003C6ppm\n9. Penn State E-cigarette Dependence (PSED) score \\>=4, indicating mild dependence or greater\n10. have an interest in reducing e-cigarette use\n\nExclusion criteria:\n\n1. psychoactive drug use (aside from cannabis, nicotine, alcohol, caffeine) in past month\n2. current use of over-the-counter (OTC) or prescription medications that may impact safety\n3. use cannabis \\>2 times per week\n4. history of or current significant medical condition that would impact participation or safety according to the study investigators and medical staff\n5. current psychiatric condition or substance use disorder (aside from tobacco use disorder) that would impact participation or safety according to the study investigators and medical staff\n6. enrollment in another trial\n7. positive pregnancy test\n8. currently using a nicotine\u002Ftobacco cessation product\n9. seizure disorder or traumatic brain injury (TBI)","55 Years",{"count":52,"type":21},[241],"The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome.",[27,311],"Withdrawal","2025-07-09",{"date":314,"type":33},"2025-07-14",{"date":316,"type":33},"2023-11-28",{"date":318,"type":21},"2028-06-30",{"name":320,"class":40},"Johns Hopkins University",{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":16,"minAge":80,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":22,"phases":331,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":4},"100507827","phase-3-impact-of-aversive-warnings-on-e-cigarette-cessation-100507827","NCT05892445","Impact of Aversive Warnings on E-Cigarette Cessation","Impact of Aversive Visual Health Warnings on E-Cigarette Cessation Intentions and Behaviors Among Young Adults","* Age 18-29 years\n* Basic understanding of English\n* Not institutionalized\n* Currently use e-cigarettes at least once per week","29 Years",{"count":330,"type":21},1000,[332],"PHASE3","This project aims to evaluate the effectiveness of aversive visual health warnings on e-cigarette cessation among young adults through a randomized controlled trial, as e-cigarette use among this population has been steadily increasing, posing significant public health concerns. While traditional tobacco products have long featured health warnings, e-cigarettes lack similarly aversive visual warnings, and this study seeks to inform the development of targeted e-cigarette cessation strategies and contribute to a deeper understanding of how visual health warnings can be utilized to reduce e-cigarette use and ultimately improve public health. The project has three main aims, which include a rigorous assessment of the academic literature on e-cigarette risks and adverse effects to develop evidence-based mock visual health warnings for e-cigarettes; assessing the effectiveness of aversive visual health warnings in increasing intent to cessate e-cigarettes, with a particular focus on individuals who have experienced adverse events; and examining the long-term impacts of visual health warnings on e-cigarette cessation. This study will also investigate the underlying mechanisms that may explain the relationship of the intervention on cessation. To generate visual warnings, the research team will conduct a thorough review of the scientific literature on e-cigarette risks and adverse effects and collaborate with a graphic designer. Experimental warnings will be annotated and categorized in order to understand the influence of different imagery on variations in participant response. The study will be conducted as a randomized controlled trial, recruiting participants through market research firms that will distribute an online survey to their panels of e-cigarette users. Participants will be eligible for inclusion if they are 18-29 years old and currently use e-cigarettes at least once per week. A quota will be included to ensure sufficient responses from individuals who have experienced at least one adverse event related to e-cigarette use in the past 12 months. The intervention group will be exposed to a series of aversive visual health warnings about the potential health risks of e-cigarette use, delivered through the online survey platform, while the control group will not receive any intervention and will complete the same survey as the intervention group. Data will be analyzed using appropriate statistical techniques, including logistic regression and mediation\u002Fmoderation analysis, to assess the effectiveness of the aversive visual health warnings in reducing e-cigarette use and the moderating effects of prior adverse event experience. Participants will be contacted for follow-up assessments at 3-months post-intervention to investigate the impact of aversive visual health warnings on e-cigarette cessation among young adults, including the moderating effects of prior adverse event experience, and assess the underlying mechanisms that may explain the relationship between the intervention and e-cigarette cessation.",[88],"2024-06-03",{"date":337,"type":33},"2024-06-05",{"date":339,"type":21},"2025-05-01",{"date":341,"type":21},"2025-09-30",{"name":343,"class":40},"University of California, San Diego"]