[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"early-mobilization\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:early-mobilization":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,72],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100621727","nurse-led-early-mobilization-after-colorectal-surgery-100621727",false,"NCT07374380","Nurse-Led Early Mobilization After Colorectal Surgery","Effect of a Nurse-Led Early Mobilization Protocol on Colorectal Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Scheduled for elective colorectal surgery (e.g., procedures related to\n* colorectal cancer, diverticulitis, or inflammatory bowel disease \\[IBD\\])\n* Able to ambulate independently preoperatively\n* Medically and cognitively able to participate in a mobilization protocol\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Undergoing emergency colorectal surgery\n* Patients requiring postoperative intensive care unit (ICU) admission\n* Severe cognitive impairment or psychiatric disorders that may affect participation\n* Musculoskeletal or neurological conditions that impair mobility\n* Inability to understand study instructions due to language or communication barriers","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study was designed to evaluate the effectiveness of a nurse-led early mobilization protocol on postoperative recovery outcomes in patients undergoing elective colorectal surgery. The outcomes assessed include walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, incidence of postoperative complications, and length of hospital stay.\n\nResearch Question:\n\nIn patients undergoing colorectal surgery (P), does a nurse-led early mobilization protocol (I), compared with standard mobilization practices (C), improve postoperative recovery outcomes (O), including walking distance, mobility levels, gastrointestinal function (time to first flatus and first defecation), nausea, vomiting, comfort, fatigue, time to initiation of oral intake, patient satisfaction, postoperative complication rates, and length of hospital stay?",[26,27,28,29],"Colorectal Surgery","Early Mobilization","Postoperative Care","Postoperative Recovery",[31,32,33],"colorectal surgery","early mobilization","Nurse-Led Intervention","NOT_YET_RECRUITING","2026-01-25",{"date":37,"type":38},"2026-01-28","ACTUAL",{"date":40,"type":20},"2026-01-05",{"date":42,"type":20},"2026-12-29",{"name":44,"class":45},"Ege University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":56,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100603125","sedation-and-analgesia-bundled-strategies-among-icu-nurses-100603125","NCT07132450","Sedation and Analgesia Bundled Strategies Among ICU Nurses","Current Practice of Sedation and Analgesia Bundled Strategies Among ICU Nurses: A National Cross-sectional Survey","Inclusion Criteria:\n\n1. possessing a valid nurse professional qualification certificate,\n2. having worked in an ICU for a minimum of one year.\n\nExclusion Criteria:\n\n1. nurses who were not working in the ICU during the study period\n2. those in rotation or undergoing advanced training. All subjects must sign the online informed consent form before filling out the questionnaire.",{"count":55,"type":20},228,"1 Day","OBSERVATIONAL","This is a prospective observational study to investigate the current clinical practice status of sedation and analgesia bundled strategies among ICU nurses",[60,61,62,27],"Sedation and Analgesia","Delirium","Family Invlovement\u002FEmpowerment","2025-08-13",{"date":65,"type":38},"2025-08-20",{"date":67,"type":20},"2025-08-30",{"date":69,"type":20},"2026-01-01",{"name":71,"class":45},"Ruijin Hospital",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":16,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100547250","rehabilitation-of-patients-from-the-icu-to-the-post-hospital-phase-100547250","NCT06405529","Rehabilitation of Patients From the ICU to the Post-hospital Phase","Rehabilitation of Patients Submitted to Mechanical Ventilation, From the ICU to the Post-hospital Phase: Blinded Randomized Controlled Clinical Trial, With Economic and Multicenter Evaluation","Inclusion Criteria:\n\n* Both sexes\n* Age greater than or equal to 21 years\n* Be on invasive mechanical ventilation (IMV) for at least 48 hours\n* Sufficient cardiovascular stability for mobilization\n\n  1. Absence of bradyarrhythmia (\\\u003C 50 bpm);\n  2. Heart rate ≥ 150 bpm;\n  3. Most recent lactate measurement ≤ 4.0mmol\u002FL;\n  4. Combined adrenaline\u002Fnoradrenaline infusion rate ≤ 0.2mcg\u002FKg\u002Fmin, OR if the adrenaline\u002Fnoradrenaline infusion was increased by more than 25% in the last 6 hours;\n  5. Cardiac index ≥ 2.0L\u002Fmin\u002Fm2; when evaluated\n* Respiratory stability sufficient for mobilization f) Respiratory rate ≤ 45rpm; g) FiO2 ≤ 0.6; h) PEEP ≤ 16 cmH2O; i) No need for NO (nitric oxide), prone position, neuromuscular blocker, ECMO (extracorporeal membrane oxygenation) or HFOV (high frequency ventilation).\n\nExclusion Criteria:\n\n* Dependent for ADLs in the month prior to ICU admission;\n* Diagnosed cognitive deficit;\n* Diagnosis OR suspicion of acute primary brain disease (TBI, stroke);\n* Diagnosis OR suspected spinal cord injury OR other neuromuscular disease that may result in prolonged or permanent muscle weakness (except muscle weakness acquired in the ICU);\n* Need OR instructions to remain in bed OR not to bear weight on the lower limbs bilaterally;\n* Life expectancy of less than 180 days due to acute or chronic clinical conditions;\n* Death considered inevitable due to current clinical condition or if the patient\u002Fclinical guardian is not committed to complete active treatment (e.g. brain death);\n* Inability to communicate in Portuguese;\n* Readmission to the ICU of the same hospital service;\n* Pregnant women;\n* Patients with a permanent pacemaker.",true,"21 Years",{"count":82,"type":20},206,[23],"Introduction: Advances in knowledge have contributed to the increase in the number of patients who survive prolonged hospitalization in an Intensive Care Unit (ICU), and, among them, critically ill patients who develop acute respiratory failure and need for mechanical ventilation. These individuals have their mobility restricted to bed, and may suffer from pulmonary and systemic complications, such as ICU-Acquired Muscle Weakness, which increases the chances of resulting in reduced functional capacity or death. Early mobilization in the ICU has demonstrated benefits, but still with a low level of evidence. However, the type and intensity of exercise still need to be better defined, and previous protocols did not offer continuous monitoring from the ICU to the ward and subsequent outpatient rehabilitation for these patients, which is considered a limitation in some studies.\n\nObjective: To investigate the effects of an early and intensive hospital mobilization and post-hospital rehabilitation program on indicators of functionality, inflammation, cost-effectiveness, and mortality in critically ill patients undergoing invasive mechanical ventilation.\n\nMethods: This is a Blind Randomized Controlled Clinical Trial that will be conducted in the ICUs of the Hospital das Clinicas and the Emergency Unit of the Faculty of Medicine of Ribeirao Preto of the University of São Paulo. Patients of both sexes over 21 years of age who have been under invasive mechanical ventilation for at least 24 hours will be recruited. Patients will be randomized into the Intervention Group (IG), with 30 to 60 minutes of exercise per day, and the Control Group (CG), with 10 minutes of exercise per day, both with the same protocol and based on the ICU Mobility Scale - IMS, with continuity in the ward. After hospital discharge, participants will be allocated to the Guidance Group (GIor and GCor) and the Outpatient Rehabilitation Group (GIreab and GCreab), with functional exercise capacity as the main outcome, assessed by the six-minute walk test (6MWT). Volunteers will be monitored one, three, and six months after hospital discharge. The sample calculation was based on the results of the 6MWT , with a power of 80% for the assessments carried out at the proposing institution (n=206), and with a power of 90% for the multicenter project (n=275), considering a sample loss of 30%. The following will be evaluated: clinical parameters, severity indexes, functionality, lung function and mechanics, functional exercise capacity, mortality, inflammatory markers, energy expenditure, activities of daily living, quality of life, muscle assessment, adherence, barriers and facilitators and cost-effectiveness.",[27,86,87],"Physiotherapy","Rehabilitation",[89,86,90,91,87,92],"Mechanical ventilation","Respiratory function","Functional capacity","Cost-effectiveness","2024-05-06",{"date":95,"type":38},"2024-05-08",{"date":97,"type":20},"2024-07-01",{"date":99,"type":20},"2027-01-31",{"name":101,"class":45},"University of Sao Paulo"]