[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"early-onset-colorectal-cancer\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:early-onset-colorectal-cancer":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100572506","care-crc-microbiome-insights-and-correlations-for-risk-and-outcomes-in-colorectal-cancer-100572506",false,"NCT06734156","CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer","CARE-CRC","Inclusion Criteria:\n\n* Be willing and able to provide written informed consent\n* Resident in Portugal\n* Age from 40 to 74 years\n* Have a recent diagnosis of CRC without initiating any treatment.\n\nExclusion Criteria:\n\n* Age \\\u003C 40 years or ≥ 75 years\n* Unable to provide informed consent\n* Refusal to provide stool samples\n* Previous or current treatment for CRC\n* First-degree family history of CRC\n* Previous diagnosis of inflammatory bowel disease (ulcerative colitis, Crohn's disease or indeterminate colitis), inflammatory bowel syndrome, recurrent infection by Clostridioides difficile\n* Pregnancy","ALL","40 Years","74 Years",{"count":20,"type":21},400,"ESTIMATED","OBSERVATIONAL","Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths globally, with increasing incidence rates. While predominantly affecting older adults, CRC cases among individuals under 50 (early-onset CRC, or EoCRC) are rising. This age group rarely undergoes routine screening, resulting in delayed diagnoses and more advanced disease at presentation. In the USA, EoCRC accounts for 10% of CRC cases and is the leading cause of cancer-related deaths in men under 50.\n\nDespite the increase in EoCRC incidence, the causes remain unclear. Only 25% of cases have a CRC family history, suggesting environmental factors. Diets low in fibre and rich in fat and red meat, obesity, alcohol consumption, sedentary lifestyle, stress, and chronic inflammation of the GI tract are estimated to account for 70-90% of CRC risk. According to the World Cancer Research Fund, 47% of all CRC cases could be prevented through lifestyle changes, particularly in diet and physical activity.\n\nThese lifestyle factors are also strongly linked to changes in the gut microbiome, which differs markedly between CRC patients and healthy individuals. The microbiome may influence tumour development by producing metabolites that regulate immune responses or create anti-tumour environments. Thus, the gut microbiome is a promising target for early CRC detection and prevention.\n\nThis study aims to develop a non-invasive, microbiome-based diagnostic tool for CRC, identifying biomarkers to improve early detection, personalise treatment, and reduce healthcare costs.",[25,26,27],"Colorectal Cancer (CRC)","Microbiome","Early Onset Colorectal Cancer",[29,30,26,31,32,33,34,35],"Colorectal Cancer","Gut Microbiota","Early-onset Colorectal Cancer","Biomarkers","Diet","Risk factors","Metagenomics","RECRUITING","2026-05-11",{"date":39,"type":40},"2026-05-12","ACTUAL",{"date":42,"type":40},"2026-03-02",{"date":44,"type":21},"2029-12-02",{"name":46,"class":47},"Gulbenkian Institute for Molecular Medicine","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":62,"studyType":22,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100495547","exogenous-and-endogenous-risk-factors-for-early-onset-colorectal-cancer-100495547","NCT05732623","Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer","Diet obEsity sMoking Epigenetics geneTics biomaRkers Physical Activity: An International Multicenter Case-control Study on Endogenous and Exogenous Risk Factors in Early-onset Colorectal Cancer","DEMETRA","Inclusion Criteria:\n\n* All sexes eligible\n* (for Cases) eoCRC diagnosed between 18 and 49 years and confirmed by histology (biopsy or surgical specimen in case of surgery)\n* (for Controls) negative past and present history of cancer; negative fecal occult blood test (FOBT), or negative colonoscopy.\n\nExclusion Criteria:\n\n* CRC diagnosed at ≥ 50 years\n* Diseases that can modify the dietary regimen (celiac disease, diabetes)\n* Diseases that are known to predispose to eoCRC (personal past or recent history of inflammatory bowel disease, past history of pelvic irradiation)\n* Unable to give written consents and to fill in the electronic questionnaire",true,"18 Years","49 Years",{"count":61,"type":21},2300,"10 Years","An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally.\n\nCRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants, obesity, alcohol, physical activity, red meat, and a Western diet).\n\nDesign: an international, multicenter, retrospective case-control study of prospectively enrolled patients; low-risk intervention study as it will perform a fecal occult blood test Endpoint: predictive power of a semi-quantitative food frequency questionnaire (SQFFQ) developed for eoCRC.\n\nCases: Patients with a recent diagnosis of eoCRC (within 2 years from enrollment).\n\nControls: matched by age (matching range ± 5 years) and sex. Healthy volunteers will be mainly enrolled among workers within the participating hospital center. The enrolled healthy volunteers will perform a fecal occult blood test.\n\nVariables of interest: age, sex, ethnicity, BMI at the time of eoCRC diagnosis and at 18 years old, country, tobacco smoking at the time of eoCRC diagnosis and at 18 years old, sitting time, TV-viewing time, moderate-to-vigorous physical activity (MVPA), waist circumference (cm), home blood pressure levels (mmHg), fasting blood glucose (mg\u002Fdl), regular consumption of aspirin\u002FNSAID, calcium and folate supplements, oral contraceptive agents, post-menopausal hormones and years of consumptions, if the filled questionnaire reflects diet for the last 5-10 years before.\n\nCases only: date of eoCRC diagnosis, symptoms at diagnosis, eoCRC localization, eoCRC stage, histological diagnosis, type of surgery, and date (if performed), chemotherapy and radiotherapy (if performed), vital status and duration of follow-up, family history of CRC and other cancers (uterus, ovary, stomach, small intestine, urinary tract\u002Fbladder\u002Fkidney, bile ducts, brain, pancreas, skin tumors), type of germline pathogenetic variant (if performed).\n\nBefore the case-control study, three non-consecutive 24-hour Dietary Recalls (24hDRs) will validate the SQFFQ.\n\nThe SQFFQ will be administered to the validation study group during three non-consecutive calls, including one non-weekday (30-minute 24-h-recall computer-aided personal interview).\n\nPrimary Objective To measure the relative risk of specific dietary and lifestyle factors (smoking habit, alcohol intake, physical activity) for early-onset colorectal cancer in countries where eoCRC incidence is increasing versus stable\u002Fdecreasing",[29,27,65,66],"Diet Habit","Risk Reduction",[68,69,70,71,72,73,74,33],"Early onset","Young onset","Young adult","Colon cancer","Rectal cancer","Cancer genetics","Cancer risk factors","2026-04-21",{"date":77,"type":40},"2026-04-24",{"date":79,"type":40},"2022-12-05",{"date":81,"type":21},"2035-01",{"name":83,"class":47},"San Raffaele University",8,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100559787","earlier-detection-and-optimization-of-treatment-and-prognosis-for-patients-with-early-onset-colorectal-cancer-100559787","NCT06568679","Earlier Detection and Optimization of Treatment and Prognosis for Patients With Early-onset Colorectal Cancer","Striving for Earlier Detection and Optimization of Treatment and Prognosis for Patients With Early-onset Colorectal Cancer (EOCRC); BIO-EOCRC Study","BIO-EOCRC","Inclusion Criteria:\n\n* Patients with locoregional or metastatic colorectal cancer (CRC)\n* Histologically proven CRC\n* Age 18 - 49 years at time of first CRC diagnosis\n* Able to understand the informed consent form\n* Provide written informed consent.\n\nExclusion Criteria:\n\n* Mentally incompetent patients based on the opinion of treating physician\n* Inability to understand the Dutch language",{"count":94,"type":21},300,"The study aims to collect high quality clinical data on lifestyle and patient biomaterials prior to start or during \u002F after treatment of early-onset colorectal cancer (EOCRC) and to inform on treatment and survival outcomes of EOCRC patients.",[31],"2025-07-31",{"date":99,"type":40},"2025-08-05",{"date":101,"type":40},"2025-01-27",{"date":103,"type":21},"2038-12-01",{"name":105,"class":47},"The Netherlands Cancer Institute",1]