[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"eating-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:eating-disorders":36},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,65,0,25,[9,55,88,125,158,180,204,231,253,284,311,338,363,395,426,448,473,496,525,564,596,618,638,662,693],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":37,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100053868","halo-trial-high-medium-and-low-intensity-psychotherapy-for-binge-eating-disorder-100053868",false,"NCT07698132","HALO-TRIAL: High, Medium And LOw Intensity Psychotherapy for Binge Eating Disorder","HALO","Inclusion Criteria:\n\n* Binge Eating Disorder according to DSM-5 criteria\n* 18-65 years of age\n* Fluent Danish speaker\n\nExclusion Criteria:\n\n* Concurrent psychotherapeutic treatment\n* Use of weight loss medications within the last month (i.e., GLP-1 receptor antagonists)\n* Suicidal ideation or suicidality\n* Psychosis or psychotic disorders\n* Mania or bipolar disorder\n* Drug misuse disorder\n* Alcohol misuse disorder\n* Cluster B personality disorders in the severe range (diagnosed)\n* Dosage of Antidepressants, Antipsychotics and Stimulants must be stable for at least 6 months","ALL","18 Years","65 Years",{"count":21,"type":22},256,"ESTIMATED","INTERVENTIONAL",[25],"NA","The HALO trial is designed as a four-armed, assessor-blinded, fidelity-monitored randomized clinical trial. The goal of this randomized controlled study is to investigate the effectiveness of four different psychotherapy programs and to determine which one is most effective in reducing the number of binge-eating episodes in people with the eating disorder Binge Eating Disorder (BED), by directly comparing three intensities of Cognitive Behavioral Therapy-Enhanced against a manualized treatment as usual.\n\nParticipants will be asked to complete a 21-weeks randomized intervention and participate in follow up assesments.",[28,29,30,31,32,33,34,35,36],"Binge Eating Disorder","Binge Eating Episodes","Binge Eating\u002FLoss of Control Eating","Binge Eating Disorders","Binge Eating","Binge Eating Behaviour","Binge Eating Disorder Associated With Obesity","Eating Disorder Binge","Eating Disorders",[28,36,38,39,40,41],"Cognitive Behavioral Therapy","Psychotherapy","Randomized Controlled Trial","Evidence-based Psychiatry","RECRUITING","2026-07-07",{"date":45,"type":46},"2026-07-13","ACTUAL",{"date":48,"type":46},"2024-06-10",{"date":50,"type":22},"2032-12",{"name":52,"class":53},"Herlev and Gentofte Hospital","OTHER",1,{"id":56,"slug":57,"hasResults":12,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":72,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":84,"leadSponsor":86,"locationsCount":54},"100639845","eating-disorder-dynamic-intervention-100639845","NCT07600671","Eating Disorder Dynamic Intervention","Rapid Innovation of Precision Psychiatry Interventions Using Dynamic Systems Modeling and Ecological Quasi-Experiments","EDDI","Inclusion Criteria:\n\n1. Age 18-70\n2. At least 12 ED behaviors from the same behavioral category in the past 12 weeks (i.e., at least 12 binge eating episodes, at least 12 compensatory behaviors, and\u002For at least 12 instances of dietary restriction)\n3. Ownership of a smartphone\n4. Willingness to complete ecological momentary assessment (EMA) and sensor data collection\n5. Live in the United States\n6. Has a primary care provider or is willing to establish a primary care provider\n\nExclusion Criteria:\n\n1. Inability to fluently speak, read, and write in English\n2. Body mass index \\\u003C 17.5 kg\u002Fm2\n3. Medical complications of ED symptoms requiring immediate treatment\n4. Current ED-focused therapy\n5. Severe psychopathology (i.e., active suicidal ideation, psychosis, bipolar disorder, or substance use disorder) or intellectual disability inhibiting engagement in study protocols","70 Years",{"count":65,"type":22},170,[25],"The goal of this study is to develop and test a digital program to help people with eating disorders in their everyday lives. The program uses brief surveys and sensor data collected by smartphones to understand when someone may be at higher risk for behaviors like restricting food, binge eating, or using unhealthy weight control behaviors.",[36,69,70,28,71],"Anorexia Nervosa","Bulimia Nervosa","Other Specified Feeding or Eating Disorder",[73,74,75,76,77,78,79],"binge eating","eating problem","eating disorder","purging","restriction","weight control behavior","dieting","2026-06-29",{"date":82,"type":46},"2026-07-01",{"date":80,"type":46},{"date":85,"type":22},"2030-07-31",{"name":87,"class":53},"Trustees of Dartmouth College",{"id":89,"slug":90,"hasResults":12,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":23,"phases":101,"briefSummary":102,"conditions":103,"keywords":108,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":121,"leadSponsor":123,"locationsCount":54},"100645213","overvaluation-of-weight-and-shape-intervention-vs-the-body-project-100645213","NCT07678554","Overvaluation of Weight and Shape Intervention vs The Body Project","Pilot Testing Overvaluation of Weight and Shape Intervention vs The Body Project","Inclusion Criteria:\n\n* Female-identifying\n* High School\n* College Adolescents\n* Ages 14-22\n\nExclusion Criteria:\n\n* Non-female identifying\n* Outside of the United States",true,"FEMALE","14 Years","22 Years",{"count":100,"type":22},90,[25],"Priorities aims to reduce body image concerns, prevent eating disorders, bolster self-esteem, and promote mental and emotional health by helping participants identify and nurture alternative sources of self-worth. Priorities would use group discussions, role-plays \\& behavioral challenges, homework assignments \\& letter-writing, and self-worth activism to achieve this. The Priorities intervention will be compared to The Body Project (an existing and successful harm reduction and eating disorder prevention program) for its effectiveness of reducing body image concerns and eating disorder outcomes. This study aims to evaluate whether there is a more effective eating disorder prevention program than The Body Project.",[104,105,36,106,107],"Body Image","Mental Health Outcomes","Body Dysmorphic Disorders","Self-esteem",[109,110,111,112,113,114,115,116],"Eating disorder","Female","Body project","Priorities","self-esteem","adolescent mental health","Body dysmorphia","Disordered eating","NOT_YET_RECRUITING","2026-06-28",{"date":82,"type":46},{"date":82,"type":22},{"date":122,"type":22},"2027-06-01",{"name":124,"class":53},"Stanford University",{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":130,"eligibilityCriteria":131,"healthyVolunteers":95,"sex":17,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":23,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":54},"100636395","preved-mr-improving-emotion-dysregulation-through-mixed-reality-based-dialectical-behavioral-therapy-in-adolescents-and-young-adults-at-risk-of-developing-eating-disorders-100636395","NCT07565129","PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.","PrevED MR","Inclusion Criteria:\n\n* Adolescents and young adults aged 13 to 35 years.\n* Spanish-speaking participants who are able to understand the study procedures and complete the assessment instruments.\n* Students recruited from participating schools, universities, or related recruitment settings.\n* Participants at mid-to-high risk of developing eating disorders, as assessed by the Eating Attitudes Test-26 (EAT-26) and selected subscales of the Eating Disorder Inventory-3 (EDI-3).\n* Participants who provide informed consent. For minors, informed consent from a parent or legal guardian will also be required, together with the minor's assent when applicable.\n\nExclusion Criteria:\n\n* Current or past self-reported diagnosis of an eating disorder.\n* Current severe psychiatric symptoms or diagnosis that could interfere with participation, including suicidal, manic, or psychotic symptoms.\n* Severe neurodevelopmental disorder, intellectual disability, or other cognitive impairment that could interfere with understanding or completing the study procedures.\n* Physical, motor, or sensory impairment that could interfere with the assessment procedures or the use of the mixed\u002Fvirtual reality intervention.\n* Current psychological or pharmacological treatment for a mental health disorder delivered on a weekly or biweekly basis.\n* Inability to understand Spanish.\n* Failure to provide informed consent. For minors, lack of parent or legal guardian consent will also be an exclusion criterion.","13 Years","35 Years",{"count":135,"type":22},72,[25],"The aim of this study is to evaluate the feasibility and preliminary effects of PrevED MR, a group-based preventive intervention for adolescents and young adults at risk of developing eating disorders. PrevED MR is based on dialectical behavior therapy skills and uses mixed reality and virtual reality activities to support emotion regulation, mindfulness, distress tolerance, and body-related acceptance.\n\nParticipants will be randomly assigned to either the PrevED MR intervention group or a waiting-list control group. The intervention will be delivered over 6 weeks, with two sessions per week, for a total of 12 sessions. Assessments will be conducted at baseline and after the intervention to examine changes in eating disorder symptoms, body image acceptance, emotion regulation strategies, rumination, usability, sense of presence, cybersickness, satisfaction, and adherence.",[36,139],"Emotion Dysregulation",[141,142,143,144,145,146,147,148],"Eating disorders","Eating disorder prevention","Emotion regulation","Dialectical behavior therapy","Mixed reality","Adolescents","Young adults","Body image","2026-06-22",{"date":151,"type":46},"2026-06-25",{"date":153,"type":46},"2026-04-28",{"date":155,"type":22},"2027-09",{"name":157,"class":53},"Universitat Internacional de Catalunya",{"id":159,"slug":160,"hasResults":12,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":168,"phases":4,"briefSummary":169,"conditions":170,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":4},"100619907","inpatient-care-of-patients-with-difficult-to-treat-anorexia-nervosa---factors-affecting-treatment-outcome-100619907","NCT07350720","Inpatient Care of Patients With Difficult to Treat Anorexia Nervosa - Factors Affecting Treatment Outcome.","Inpatient Care of Patients With Difficult to Treat Eating Disorders - What Affects Treatment Outcome?","Inclusion Criteria:\n\n* Anorexia Nervosa diagnosis (ICD F50.0)\n* Admitted to inpatient care at department 5 at Region Skåne Eating Disorders Center\n\nExclusion Criteria:\n\n* Confidential identity\n* Inability to read or write in Swedish or English\n* Condition or treatment that, according to the study team, makes participation in the study inappropriate","64 Years",{"count":167,"type":22},100,"OBSERVATIONAL","The overall aim of the project is to investigate factors that may influence treatment outcomes in people with difficult-to-treat anorexia nervosa who are enrolled in inpatient care at the Region Skåne Eating Disorders Centre in Lund. Treatment expectations, sense of autonomy, and patient participation, will be investigated, as well as caregivers' attitudes towards, and experiences of working with, autonomy and patient participation in the inpatient setting. The research project is expected to contribute to increased knowledge about the treatment of difficult-to-treat anorexia nervosa, and what part patient participation and autonomy may play when treating severe eating disorders. The overall objectives of the research program are:\n\n1. To contribute to increased knowledge about factors that influence the treatment of people with difficult-to-treat anorexia nervosa\n2. To highlight the role of autonomy and patient participation in inpatient care of severe eating disorders\n3. To use the research results for clinical improvement work at Region Skåne Eating Disorders Center",[36,69],"2026-06-15",{"date":173,"type":46},"2026-06-16",{"date":175,"type":22},"2026-09",{"date":177,"type":22},"2029-12",{"name":179,"class":53},"Region Skane",{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":186,"eligibilityCriteria":187,"healthyVolunteers":12,"sex":17,"minAge":188,"maxAge":98,"enrollmentInfo":189,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":4},"100642332","evaluation-of-a-day-hospital-program-for-adolescents-and-young-adults-with-eating-disorders-100642332","NCT07648108","Evaluation of a Day Hospital Program for Adolescents and Young Adults With Eating Disorders","Evaluation of the Contribution of a Specialized Day Hospital for Adolescents and Young Adults With Eating Disorders: Long-Term Clinical Outcomes and Cross-Reported Experiences","UDJ-TCA","Inclusion Criteria:\n\n* Adolescents and young adults aged 12 to 22 years\n* Diagnosed with an eating disorder\n* Referred for admission to the day hospital program between October 2019 and December 2023\n* Provided informed consent (and parental consent for minors)\n\nExclusion Criteria:\n\n* Refusal to participate\n* Age below 12 years or above 22 years","12 Years",{"count":190,"type":22},307,[25],"This study aims to evaluate the clinical, psychological, and functional outcomes of adolescents with anorexia nervosa receiving multidisciplinary care in hospital settings. Participants are treated either in a day hospitalization program or in a full-time inpatient program, in accordance with the French national guidelines (Haute Autorité de Santé, HAS) for the management of anorexia nervosa.\n\nThe study seeks to better understand the evolution of patients' health status over time, including nutritional, psychological, and social dimensions, and to identify factors associated with treatment response. Data will be collected as part of routine clinical care without modification of the standard therapeutic management.\n\nThe results of this study may help improve clinical practices and optimize care pathways for adolescents with anorexia nervosa.",[36,194,195],"Nervosa Adolescent","Adolescent Eating Disorders","2026-06-12",{"date":171,"type":46},{"date":199,"type":22},"2026-05-25",{"date":201,"type":22},"2027-02-24",{"name":203,"class":53},"Fondation Santé des Étudiants de France",{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":17,"minAge":211,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":223,"lastUpdatePostDateStruct":224,"startDateStruct":226,"completionDateStruct":227,"leadSponsor":229,"locationsCount":54},"100643268","a-study-testing-a-digital-gamified-early-intervention-for-eating-disorders-flexed-100643268","NCT07632248","A Study Testing a Digital, Gamified Early Intervention for Eating Disorders (\"FlexED\")","A Randomized Controlled Trial Testing Mechanism Engagement and Clinical Impact of FlexED: A Digital, Gamified Early Intervention for Eating Disorders","Inclusion Criteria:\n\n* Female between the age of 15-25 years old.\n* Weight Concerns Scale score of \\>=47.\n* Endorses one or more eating disorder behaviors (e.g., extreme dieting or exercise, subjective or objective binge eating, purging behaviors).\n\nExclusion Criteria:\n\n* Currently meets the DSM-5 diagnostic criteria for full threshold anorexia nervosa, bulimia nervosa or binge eating disorder, or for an eating or feeding disorder that does not include body-image or weight related distress and is not the focus of study (e.g., ARFID, PICA) or a past diagnosis of one of these disorders.\n* Change in psychotropic medications in the past month.\n* Active suicidal ideation, current substance use disorder or diagnosed psychotic disorder.\n* Bipolar disorder not being treated with medication.\n* Currently in treatment for an eating disorder.\n* Non-English speaking.","15 Years","25 Years",{"count":214,"type":22},128,[25],"The goal of this clinical trial is to test whether a new digital intervention decreases eating disorder symptoms in young women and girls at risk by changing how they experience thoughts and feelings about their body.\n\nThe digital intervention is based on Acceptance and Commitment Therapy (ACT). Participants will be randomly assigned (like a coin toss) to either the new digital intervention or education modules completed online.\n\nThe main questions are:\n\nDoes the digital intervention change how participants experience thoughts and feelings about their body or how they react to eating disorder triggers (e.g., images of idealized bodies)? Do these changes lead to decreases in eating disorder symptoms? Is the intervention acceptable and at the right dose?\n\nParticipants will:\n\nComplete seven brief digital sessions over about 8 weeks. Complete interviews, surveys and lab assessments of reaction to body-related words and images.\n\nParticipants are followed for about 1 year.",[36,104],[36,219,220,221,222],"Body Image Flexibility","Acceptance and Commitment Therapy","Psychological Flexibility","Early Intervention","2026-06-01",{"date":225,"type":46},"2026-06-08",{"date":223,"type":22},{"date":228,"type":22},"2028-07-31",{"name":230,"class":53},"Duke University",{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":4,"eligibilityCriteria":237,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":238,"targetDuration":4,"studyType":23,"phases":240,"briefSummary":241,"conditions":242,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":249,"leadSponsor":251,"locationsCount":54},"100637872","safety-behavior-fading-versus-progressive-muscle-relaxation-for-appearance-concerns-100637872","NCT07589621","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns","Safety Behavior Fading Versus Progressive Muscle Relaxation for Appearance Concerns: A Randomized Clinical Trial of Digital Interventions","Inclusion Criteria:\n\n* being between the ages of 18 and 65 years old\n* having an internet-capable smart-phone\n* scoring at or above the empirical cutoff for appearance concerns measured by the Social Appearance Anxiety Scale (i.e., 52)\n\nExclusion Criteria:\n\n* changes in psychotropic medication in the last 4 weeks\n* failing attention checks in baseline data collection",{"count":239,"type":22},300,[25],"The current study aims to explore the efficacy of a text message based safety behavior fading intervention compared to a progressive muscle relaxation intervention for appearance concerns.",[243,36,244],"Body Dysmorphic Disorder","Social Anxiety Disorder","2026-05-29",{"date":247,"type":46},"2026-06-02",{"date":245,"type":46},{"date":250,"type":22},"2026-12",{"name":252,"class":53},"Florida State University",{"id":254,"slug":255,"hasResults":12,"nctId":256,"briefTitle":257,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":270,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":54},"100489298","a-precision-medicine-approach-to-target-engagement-for-emotion-regulation-100489298","NCT05651295","A Precision Medicine Approach to Target Engagement for Emotion Regulation","Inclusion Criteria:\n\n* Elevated emotion dysregulation\n\nExclusion Criteria:\n\n* Lack of proficiency in English\n* No access to smartphone\n* Conditions requiring greater than outpatient care",{"count":260,"type":22},390,[25],"The proposed study is designed to first test whether teaching people personalized or standardized emotion regulation skills leads to greater decreases in daily negative emotion intensity. Second, using data from an initial sample, the investigators will prospectively assign an independent sample of participants to receive their predicted optimal or non-optimal skills to determine if it is feasible and efficacious to match participants to the most appropriate training condition. Results of these studies may identify the mechanisms by which emotion regulation interventions impact emotional functioning and allow for the development of personalized, evidence-based, and scalable emotion regulation interventions.",[264,265,266,267,268,269,36],"Emotional Regulation","Depression","Anxiety","Borderline Personality Disorder","Obsessive-Compulsive Disorder","Posttraumatic Stress Disorder",[271,272,273,274],"cognitive-behavior therapy","mechanism","ecological momentary assessment","personalization","2026-05-07",{"date":277,"type":46},"2026-05-11",{"date":279,"type":46},"2023-09-29",{"date":281,"type":22},"2026-12-31",{"name":283,"class":53},"Matthew Southward, PhD",{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":297,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":308,"locationsCount":310},"100577661","impact-of-a-mobile-app-based-waitlist-intervention-on-readiness-for-eating-disorder-treatment-100577661","NCT06801197","Impact of a Mobile App-Based Waitlist Intervention on Readiness for Eating Disorder Treatment","Impact of a Mobile App-Based Waitlist Intervention (MI-Coach: ED) on Readiness for Eating Disorder Treatment: A Randomized Controlled Trial","MI-Coach: ED","Inclusion Criteria:\n\n* Must self-identify as a woman, including cisgender or transgender individuals.\n* Must be at least 18 years old at the time of enrollment.\n* Currently on a waitlist to receive treatment for an eating disorder at provincially funded eating disorder programs in British Columbia.\n* Meets criteria for a threshold or subthreshold eating disorder, including anorexia nervosa (restricting or binge\u002Fpurge subtype), bulimia nervosa, binge eating disorder, or other specified feeding or eating disorder (OSFED).\n* Able to read and understand English fluently.\n* Owns or has regular access to a smartphone or mobile device capable of running the MI-Coach: ED app.\n\nExclusion Criteria:\n\n* Does not identify as a woman, regardless of sex assigned at birth.\n* Currently receiving active treatment for an eating disorder, such as outpatient therapy, inpatient care, or day programs.\n* Diagnosed with a schizophrenia-spectrum disorder or other psychotic disorder.\n* Presence of a cognitive impairment or sensory deficit (e.g., severe visual or hearing impairment) that would interfere with the ability to use the app or complete study assessments.\n* History of a recent traumatic brain injury or neurological condition that might impact participation.\n* Any condition that, in the opinion of the investigators, would interfere with the participant's ability to comply with the study protocol or complete the intervention.",{"count":293,"type":22},74,[25],"The goal of this randomized controlled trial is to evaluate whether a mobile app-based motivational interviewing intervention (MI-Coach: ED) can improve motivation and readiness for treatment in adults with eating disorders who are currently on waitlists for provincially funded eating disorder services in British Columbia. The main questions it aims to answer are:\n\n* Does the use of MI-Coach: ED improve overall motivation, confidence, and readiness for treatment compared to treatment-as-usual (waitlist with no intervention)?\n* Does the app help mitigate declines in motivation over time among waitlisted individuals?\n\nResearchers will compare participants using the MI-Coach: ED app to a delayed treatment control group to assess differences in motivation, readiness for treatment, and associated clinical outcomes.\n\nParticipants will:\n\n* Treatment group: Use the MI-Coach: ED app for four weeks, completing interactive modules focused on motivation and readiness for change, while also completing weekly brief assessments of motivation.\n* Delayed treatment group: Remain on the waitlist with no intervention for four weeks while completing weekly brief assessments of motivation. After this period, they will receive access to the MI-Coach: ED app and be integrated into the treatment group.\n* Complete pre-test and post-test questionnaires at 0, 4, 8, and 12 weeks assessing motivation, eating pathology, anxiety, and depressive symptoms.\n\nThis study aims to inform evidence-based practices for reducing the adverse effects of long waitlist durations on individuals with eating disorders.",[36],[298,299,300,301],"eating disorders","digital interventions","motivational interviewing","treatment barriers","2026-05-05",{"date":304,"type":46},"2026-05-08",{"date":306,"type":46},"2025-10-21",{"date":155,"type":22},{"name":309,"class":53},"University of British Columbia",3,{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":12,"sex":17,"minAge":188,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":23,"phases":321,"briefSummary":322,"conditions":323,"keywords":324,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":333,"completionDateStruct":334,"leadSponsor":336,"locationsCount":54},"100581512","guided-self-help-for-eating-disorders-implementation-study-100581512","NCT06851273","Guided Self Help for Eating Disorders Implementation Study","National Implementation of Highly Efficient Evidence-Informed Treatment for Youth With Eating Disorders","GSHimplement","Inclusion Criteria:\n\n* Family including an adolescent with a confirmed diagnosis of Anorexia nervosa according to DSM-5-TR criteria.\n* Access to computer and internet connection\n* Have the capacity to speak, write, and understand English or French\n* Therapist\u002Fcoaches are licensed mental health clinician with experience in eating disorder treatment\n\nExclusion Criteria:\n\n* Adolescent has a current physical or mental disorder that requires hospitalization and\u002For prohibits the use of psychotherapy\n* Adolescent has a current dependence on drugs or alcohol\n* Adolescent has a current physical condition known to influence weight or eating (pregnancy, diabetes mellitus)\n* Adolescent has expected body weight of less than 75%\n* Adolescent\u002Ffamily has undergone four or more sessions of FBT for anorexia nervosa at any time\n* Does not have the capacity to speak, write, and understand English or French\n* Does not have access to computer and internet connection\n* Professionals are not licensed mental health professionals with experience in eating disorder treatment.","100 Years",{"count":100,"type":22},[25],"Eating disorders are amongst the most understudied illnesses affecting young women in Canada. Further, mortality rates are amongst the highest of all psychiatric illnesses. Despite their high prevalence and mortality rates, research into adolescent eating disorders is underfunded in Canada. In addition to the problem of research underfunding, healthcare system underfunding exists - creating long waiting lists and fragmented care for children and youth with eating disorders. More efficient treatments are urgently needed to reduce wait times and provide expedited care to adolescents on eating disorder waitlists. The current study aims to assess whether implementing a virtual parent-lead therapy, Guided Self Help Family-Based Therapy (GSH FBT) might alleviate wait times for eating disorder services and also reduce eating disorder symptomatology in young people with anorexia nervosa. This study also aims to determine the experiences of both families and medical teams of GSH FBT implementation as an intervention.",[36],[325,326,327,328,329,330],"Anorexia nervosa","Mental disorders","Adolescent eating disorders","Psychotherapy intervention","Guided self help therapy","Family-based treatment","2026-05-01",{"date":275,"type":46},{"date":153,"type":46},{"date":335,"type":22},"2027-12-30",{"name":337,"class":53},"McMaster University",{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":12,"sex":17,"minAge":346,"maxAge":347,"enrollmentInfo":348,"targetDuration":4,"studyType":23,"phases":350,"briefSummary":351,"conditions":352,"keywords":353,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":54},"100570787","treatment-of-adolescent-anorexia-nervosa-100570787","NCT06711783","Treatment of Adolescent Anorexia Nervosa","VISAN - vårdkedja i Samverkan för Unga Patienter Med Anorexia Nervosa (Collaborative Chain of Care in Adolescnt Anorexia Nervosa Treatment)","VISAN","Inclusion Criteria:\n\n* Having been diagnosed with f500 or f501 and being planned for family based therapy at the unit.\n\nExclusion Criteria:\n\n* being subjected to care by the social welfare system","11 Years","17 Years",{"count":349,"type":22},60,[25],"VISAN is a naturalistic study of family based treatment of Anorexia nervosa in adolescnet girls.",[36],[354],"anorexia nervosa","2026-04-30",{"date":331,"type":46},{"date":358,"type":46},"2024-08-01",{"date":360,"type":22},"2029-12-31",{"name":362,"class":53},"Region Örebro County",{"id":364,"slug":365,"hasResults":12,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":371,"enrollmentInfo":372,"targetDuration":4,"studyType":23,"phases":373,"briefSummary":374,"conditions":375,"keywords":379,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":388,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":54},"100531301","targeting-social-function-in-anxiety-and-eating-disorders-100531301","NCT06198023","Targeting Social Function in Anxiety and Eating Disorders","Targeting Social Function to Improve Outcomes in Anxiety and Eating Disorders","SF","Inclusion Criteria:\n\n* In the past 12 months, has met DSM-5 criteria met for an eating disorder (Anorexia Nervosa, Atypical Anorexia Nervosa, Bulimia Nervosa, Avoidant-Restrictive Food Intake Disorder, or Other Specified Feeding or Eating Disorder) and\u002For an anxiety disorder (Generalized Anxiety Disorder, Social Anxiety Disorder)\n* Between the ages of 18-30\n\nExclusion Criteria:\n\n* Current inpatient or residential treatment\n* Medical instability or safety\u002Fsuicide risk as determined by the PI","30 Years",{"count":349,"type":22},[25],"Social processing and cognition are often altered in patients with eating disorders. The goal of this clinical trial is to assess two different social therapeutic interventions -- one educational, one interactive -- for their effectiveness in improving clinical outcomes in patients with eating disorders. Patients in both interventions will receive education about social function in eating disorders, but those in the interactive treatment group will complete an additional collaborative art task.\n\nParticipants will:\n\n* attend a baseline study visit to complete clinical interviews, cognitive testing, and behavioral tasks\n* complete a pre-intervention assessment with questionnaires\n* attend eight sessions of their assigned treatment group over the course of 12 weeks\n* complete three virtual follow-up assessments 4, 8, and 12 months from their baseline\n* attend a final study visit to repeat some clinical interviews, cognitive testing, and behavioral tasks\n\nResearchers will compare changes in eating disorder, mood, and anxiety symptoms as well as test results from baseline and final study visits for each group to see if\n\n* patients can be treated effectively with education alone or if an interactive group component produces additional benefits\n* cognitive and behavioral task performance are associated with recovery or illness state.",[36,69,70,376,377,71,244,378],"Atypical Anorexia Nervosa","Purging (Eating Disorders)","Generalized Anxiety Disorder (GAD)",[380,381,382,383,384,385,386,387],"social function","social cognition","social processing","psychoeducation","group therapy","group intervention","art therapy","social anxiety",{"date":302,"type":46},{"date":390,"type":46},"2024-02-28",{"date":392,"type":22},"2028-09",{"name":394,"class":53},"University of Texas Southwestern Medical Center",{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":402,"targetDuration":4,"studyType":23,"phases":404,"briefSummary":405,"conditions":406,"keywords":411,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":417,"lastUpdatePostDateStruct":418,"startDateStruct":420,"completionDateStruct":422,"leadSponsor":424,"locationsCount":54},"100628166","the-step-mied-trial-digital-stepped-care-for-emotional-disorders-100628166","NCT07458100","The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders","Effectiveness and Cost-effectiveness of a Digital Stepped-care Mindfulness Intervention for Recovery From Emotional Disorders: a Multicentre Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age: 18-65 years.\n2. Diagnosed with an emotional disorder by a outpatient psychiatrist, including depressive disorders, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, agoraphobia, social anxiety disorder), obsessive-compulsive disorder, post-traumatic stress disorder, and eating disorders (e.g., anorexia nervosa, bulimia nervosa).\n3. Symptom severity meeting the threshold: PHQ-9 score ≥10 or GAD-7 score ≥8.\n\nExclusion Criteria:\n\n1. Current diagnosis of psychotic disorders or bipolar disorder.\n2. Current organic mental disorders, pervasive developmental disorders, severe cognitive impairment, or substance use disorders.\n3. Current suicide risk (PHQ-9 item 9 score \\>2).\n4. Antisocial personality disorder.\n5. Severe medical illnesses that may affect intervention participation or require recent hospitalization.\n6. Previous participation in a systematic 8-week mindfulness course.\n7. Inability to access the internet.",{"count":403,"type":22},464,[25],"The goal of this clinical trial is to evaluate the effectiveness and cost-effectiveness of a digital mindfulness-based intervention in adults (aged 18-65) diagnosed with emotional disorders like depression or anxiety. The main questions it aims to answer are:\n\n* Does adding a digital mindfulness intervention to usual care help people recover from emotional disorders faster and more sustainably over two years?\n* Is this combined approach more cost-effective than usual care alone? Researchers will compare the group receiving the digital mindfulness intervention plus their usual treatment to the group receiving only their usual treatment to see if the intervention leads to better long-term recovery and represents good value for money.\n\nParticipants in the intervention group will:\n\n* Attend eight weekly 2-hour online group mindfulness sessions.\n* Use a WeChat mini-program for 49 days of guided mindfulness exercises and daily tasks.\n* Patients who have not achieved reliable recovery after group retraining voluntarily participate in individual UP\\&MIED counseling.\n* Complete regular questionnaires and interviews over two years to track their progress.\n\nAll participants will continue to receive their usual medical care from their doctors throughout the study.",[407,408,409,268,410,36],"Emotional Disorders","Depressive Disorder","Anxiety Disorders","Post-Traumatic Stress Disorder, PTSD",[412,413,414,415,416,407],"Cost-effectiveness","Mindfulness","Recovery","randomized controlled trial","stepped-care","2026-04-18",{"date":419,"type":46},"2026-04-21",{"date":421,"type":46},"2026-03-23",{"date":423,"type":22},"2028-05",{"name":425,"class":53},"Peking University",{"id":427,"slug":428,"hasResults":12,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":12,"sex":17,"minAge":188,"maxAge":433,"enrollmentInfo":434,"targetDuration":4,"studyType":23,"phases":436,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":440,"lastUpdatePostDateStruct":441,"startDateStruct":443,"completionDateStruct":444,"leadSponsor":446,"locationsCount":54},"100611209","developing-an-artificial-intelligence-ai-chatbot-for-adolescents-and-young-adults-with-eating-disorders-100611209","NCT07237607","Developing an Artificial Intelligence (AI) Chatbot for Adolescents and Young Adults With Eating Disorders","Developing an Artificial Intelligence (AI)-Powered Exposure Therapy Chatbot for Adolescents and Young Adults With Eating Disorders","Inclusion Criteria:\n\n* Age is between or equal to 12-26 years\n* Admitted to the Penn State Health Eating Disorder Partial Hospital Program (PHP) or Intensive Outpatient Program (IOP)\n* Have a personal smartphone\n* Have a diagnosis of anorexia nervosa (AN), bulimia nervosa (BN), binge-eating disorder (BED), or other specified feeding or eating disorder (OSFED)\n* Be English speaking\n\nExclusion Criteria:\n\n* Diagnosis of avoidant\u002Frestrictive food intake disorder (ARFID)\n* Have acute suicidality\n* Diagnosis of an intellectual disability","26 Years",{"count":435,"type":22},20,[25],"The goal of this study is to develop and refine an artificial intelligence (AI)-powered Exposure Therapy for Eating Disorders chatbot web-app that effectively engages adolescents and young adults and decreases anxiety about weight gain. Participants will use the web-app as a supplemental therapeutic tool during their first six weeks of treatment in a Partial Hospitalization Program. Participants will complete assessments every two weeks, including: (1) semi-structured interviews about their experience with the chatbot web-app; (2) implementation outcome measures (e.g., feasibility, usability, acceptability); and (3) anxiety about weight gain.",[36,69,70,439],"Binge-Eating Disorder","2026-04-14",{"date":442,"type":46},"2026-04-15",{"date":421,"type":46},{"date":445,"type":22},"2027-06-30",{"name":447,"class":53},"Milton S. Hershey Medical Center",{"id":449,"slug":450,"hasResults":12,"nctId":451,"briefTitle":452,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":454,"targetDuration":4,"studyType":168,"phases":4,"briefSummary":455,"conditions":456,"keywords":460,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":472},"100582952","psychotropic-drug-induced-qt-prolongation-and-ecg-monitoring-in-the-pediatric-population-100582952","NCT06870006","Psychotropic-Drug-induced QT Prolongation and ECG Monitoring in the Pediatric Population","Inclusion Criteria:\n\n* Admitted to psychiatry ward\n* Starting a psychotropic drug acting on QT interval\n\nExclusion Criteria:\n\n* Age \\>18aa\n* History of administration of drug acting on QT interval in the 3 months prior",{"count":167,"type":22},"Electrocardiogram (ECG) Q-T prolongation is a cardiac electrophysiological disorder associated with the occurrence of arrhythmias potentially fatal. Several psychotropic drugs are associated with an increased risk of QT prolongation, which is why in clinical practice a baseline ECG is performed before a psychotropic drug is prescribed. However, there are no validated protocols establishing when to repeat this examination or describing clinical events when this examination should be repeated in clinical follow-up.\n\nThe study aims to investigate the incidence of QTc prolongation events as a side effect of chronic psychotropic drug administration. For this purpose, ECGs will be recorded and confounding factors of patients at the beginning of psychotropic therapy and after 3, 6 and 12 months will be analyzed.",[36,457,458,459],"Mood Disorders in Children and Adolescents","Psychotic Disorder","QTc Intervals Changes",[461,462],"QTc interval","psychotropic drugs","2026-03-17",{"date":465,"type":46},"2026-03-18",{"date":467,"type":46},"2024-01-01",{"date":469,"type":22},"2027-01",{"name":471,"class":53},"Meyer Children's Hospital IRCCS",6,{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":96,"minAge":18,"maxAge":480,"enrollmentInfo":481,"targetDuration":4,"studyType":23,"phases":483,"briefSummary":484,"conditions":485,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":487,"lastUpdatePostDateStruct":488,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":54},"100628941","diabetes-body-project-2-100628941","NCT07468188","Diabetes Body Project 2","Development of a T2D-Specific, Virtually-Delivered Disordered Eating Prevention Intervention - Diabetes Body Project 2","Inclusion Criteria:\n\n* 1.) Female sex 2) self-reported gender identity of \"woman\"; 3) age 18-40 years old; 4) diagnosed with T2D for at least 6 months; 5) experiencing at least one body image concern.\n\nExclusion Criteria:\n\n* Recent hospitalization for eating disorder within the last 12 months\n* Eating disorder related diabetic ketoacidosis within the last 12 months\n* unwillingness to be video-recorded,\n* restricted English proficiency\n* developmental, cognitive, or psychiatric limitations that compromise participation in the intervention sessions and study.","40 Years",{"count":482,"type":22},42,[25],"The purpose of this study is to test the feasibility and effectiveness of an eating disorder prevention program specifically targeted for women with type 2 diabetes (T2D) called the Diabetes Body Project 2 (DBP2).\n\nThe Diabetes Body Project 2 (DBP2) will be adapted from the Diabetes Body Project, which is an eating disorder prevention program developed to improve satisfaction with body image and diabetes management for young women with type 1 diabetes (DBP).\n\nThe study is looking to see if the DBP is effective in improving body image concerns, reducing disordered eating behaviors and improving glycemic control in women with T2D.",[36,486],"Type 2 Diabetes","2026-03-11",{"date":489,"type":46},"2026-03-12",{"date":491,"type":46},"2025-01-24",{"date":493,"type":22},"2027-05-31",{"name":495,"class":53},"Joslin Diabetes Center",{"id":497,"slug":498,"hasResults":12,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":4,"eligibilityCriteria":502,"healthyVolunteers":12,"sex":17,"minAge":503,"maxAge":97,"enrollmentInfo":504,"targetDuration":4,"studyType":23,"phases":506,"briefSummary":507,"conditions":508,"keywords":512,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":518,"lastUpdatePostDateStruct":519,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":523,"locationsCount":54},"100628778","lifestyle-intervention-for-obesity-and-eating-disorder-prevention-in-transgender-adolescents-100628778","NCT07466069","Lifestyle Intervention for Obesity and Eating Disorder Prevention in Transgender Adolescents","Lifestyle Intervention to Prevent Obesity and Eating Disorders in Transgender and Gender-Diverse Adolescents: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 10-14 years\n* Self-identified as transgender or gender-diverse\n\nExclusion Criteria:\n\n* Current diagnosis of eating disorder requiring specialized treatment\n* Severe psychiatric instability\n* Cognitive impairment limiting participation","10 Years",{"count":505,"type":22},24,[25],"Transgender and gender-diverse adolescents are at increased risk for obesity, disordered eating behaviors, body dissatisfaction, and reduced quality of life due to minority stress and structural inequities. However, no structured lifestyle interventions specifically tailored to this population have been developed.\n\nThis randomized controlled trial aims to evaluate the effectiveness of a 6-month interdisciplinary lifestyle intervention designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14 years. Participants will be randomized (1:1) to either an intervention group receiving monthly group sessions (for adolescents and caregivers separately) and weekly supportive messages, or a control group receiving standard outpatient care and general health recommendations.\n\nThe primary outcome is quality of life measured by the WHOQOL-BREF. Secondary outcomes include eating disorder symptoms, body image, diet quality, physical activity levels, sedentary behavior, body composition, and anthropometric measures.",[509,36,510,511],"Obesity & Overweight","Body Image Disturbance","Gender Diverse Populations",[513,514,515,516,141,517],"Transgender","Adolescent","Gender-diverse","Lifestyle","Obesity","2026-03-06",{"date":489,"type":46},{"date":521,"type":22},"2026-03",{"date":250,"type":22},{"name":524,"class":53},"University of Sao Paulo",{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":532,"enrollmentInfo":533,"targetDuration":4,"studyType":23,"phases":535,"briefSummary":536,"conditions":537,"keywords":548,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":54},"100493968","neurostimulation-versus-therapy-for-problems-with-emotions-100493968","NCT05712057","Neurostimulation Versus Therapy for Problems With Emotions","Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis","Inclusion Criteria:\n\n* age 18 to 55\n* elevated overall score on Difficulties with Emotion Regulation Scale (DERS total score \\>=90)\n* has been in the same type of psychotherapy (including none) for the last 4 weeks\u002F1mo (\\*except for current CBT) and is willing to stay on the same regimen throughout the study.\n* low self-reported use of cognitive restructuring (ERQ restructuring subscale average score \\\u003C 4.7)\n* meets criteria for at least one mood (including Bipolar II w\u002Fo current hypomania), anxiety, stressor, OCD, Impulse Control, ADHD, or eating DSM-5 disorder (except exclusionary diagnoses such as severe anorexia). Note: Both current or partial remission of the disorder will be ok for inclusion into the study.\n* verbal agreement to maintain dose of prescribed psychotropic medication (if any) constant throughout the study, provided they are stable on it for the past 4 weeks (except exclusion medication and except if there is a medical emergency requiring changes in medication).\n* Naïve to rTMS\n\nExclusion Criteria:\n\n* current hypomania (Note: Bipolar II w\u002Fo current hypomanic episode is ok for inclusion)\n* meets diagnostic criteria for current or history of psychotic disorder, or psychotic features,\n* meets diagnostic criteria for Bipolar I disorder\n* meets diagnostic criteria on SCID5 for current alcohol or substance use disorder (moderate and high severity) or meets past history of severe alcohol use disorder\n* unable to read, blind, or deaf, or unwilling to give consent\n* non-English speaker,\n* verbal IQ \\\u003C 90 on the North American Adult Reading Test (NART).\n* current uncontrolled anorexia or other condition requiring hospitalization\n* high risk for suicide defined as either having attempted suicide in past 6 months or reporting current suicidal ideation that includes a method, plan, or intent to die\n* current serious medical illness, including current severe migraine headaches\n* started\u002Fchanged psychotropic medications in the prior 4 weeks, or plans to change medication during the study\n* history of seizure except those therapeutically induced by ECT (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesions that are contraindications for TMS, devices that may be affected by TMS (pacemaker, medication pump, cochlear implant, implanted brain stimulator), have left elbow\u002Fhand\u002Fwrist tendonitis\n* conditions associated with increased intracranial pressure, space occupying brain lesion (considered significant and unsafe for TMS by the study MD), transient ischemic attack, cerebral aneurysm, dementia, Parkinson's or Huntington's disease, multiple sclerosis\n* Wellbutrin \\>300mg per day or on daily stimulant\u002FADHD medications above the recommended FDA daily recommendations\n* use of investigational drug or devices within 4 weeks of screening\n* cochlear implants\n* Pregnancy\n* metal in body that would exclude them from the MRI scan; severe claustrophobia\n* is a prisoner or in police custody at time of screening, or has pending court case jeopardizing the participation in the study\n* has had TMS in their lifetime\n* has had CBT in the past 4 weeks or plans to start therapy during the study\n* weighs over 300 pounds (could not fit in MRI scanner)","55 Years",{"count":534,"type":22},240,[25],"The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for response to emotion regulation training.\n\nParticipants will undergo brain imaging while engaging in an emotional regulation task. Participants will be randomly assigned to learn one of two emotion regulation skills. Participants will be reminded of recent stressors and will undergo different types of neurostimulation, targeted using fMRI (functional MRI) results. Participants who may practice their emotion regulation skills during neurostimulation in a one-time session. Following this training, participants will undergo another fMRI and an exit interview to assess for immediate neural and behavioral changes. Measures of emotion regulation will be assessed at a one week and a one month follow up visit.",[538,539,540,409,541,542,36,543,544,545,546,547,268,139,267],"Emotion Regulation","Mood Disorders","Stress Disorder","OCD","Impulse Control Disorder","Emotional Dysfunction","Emotional Instability","Emotional Distress","Emotional Maladjustment","Emotional Impulsivity",[139,549,550,551,552,553,554,555,143],"Distress Intolerance","Neuromodulation","Neurostimulation","TMS","cognitive restructuring","regulation skills","neuroimaging","2026-03-02",{"date":558,"type":46},"2026-03-04",{"date":560,"type":46},"2023-05-15",{"date":562,"type":22},"2027-12-01",{"name":230,"class":53},{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":569,"acronym":4,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":17,"minAge":571,"maxAge":572,"enrollmentInfo":573,"targetDuration":4,"studyType":23,"phases":575,"briefSummary":576,"conditions":577,"keywords":580,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":594,"locationsCount":595},"100480801","study-comparing-acceptance-and-commitment-therapy-to-supportive-diabetes-counseling-and-a-waitlist-control-for-eating-disorders-in-type-1-diabetes-100480801","NCT05540704","Study Comparing Acceptance and Commitment Therapy to Supportive Diabetes Counseling and a Waitlist Control for Eating Disorders in Type 1 Diabetes","Changing the T1DE (Type 1 Diabetes Eating Disorders): A Randomized Controlled Trial Comparing Acceptance and Commitment Therapy (ACT) to Supportive Diabetes Counseling and a Waitlist Control","Primary Cohort\n\nInclusion Criteria:\n\n* 16-50 years of age\n* Diagnosis of Type 1 diabetes\n* Eating disorder characterized by binge eating and\u002For problematic weight control behaviors, including withholding insulin (Bulimia Nervosa, Binge Eating and Purging Disorder spectrum diagnoses)\n* Independently manages diabetes (not reliant on a caregiver)\n\nExpansion Cohort\n\nInclusion Criteria:\n\n* 16-50 years of age\n* Diagnosis of Type 1 diabetes\n* DEPR-R score \\>=20 but does not meet criteria for the primary cohort\n\nPrimary and Expansion Cohort\n\nExclusion Criteria:\n\n* Active suicidal ideation\n* Diagnosis of Avoidant Restrictive Food Intake Disorder or Anorexia Nervosa spectrum diagnoses\n* Hypoglycemic unawareness as assessed by the Gold Method and multiple severe episodes of hypoglycemia requiring 3rd party assistance in the last 2 years\n* Current substance abuse disorder or current or past psychotic disorder\n* NonEnglish speaking","16 Years","50 Years",{"count":574,"type":22},235,[25],"The goal of this clinical trial is to test whether a new intervention works to treat eating disorders in type 1 diabetes. Participants are assigned to one of the following: (1) Acceptance and Commitment Therapy (ACT), (2) Supportive Diabetes Counseling, or (3) a 6-month Waitlist Control. Participants in the ACT and Supportive Diabetes Counseling conditions complete 12 sessions over 12-16 weeks and use their mobile phone between sessions to increase engagement and reinforce learning.\n\nThe main questions are:\n\nDoes treatment improve glycemic levels, eating disorder symptoms, diabetes management and diabetes distress?\n\nDoes one treatment do better than the other?\n\nHow do the treatments work, if they work, and for whom?\n\nParticipants complete assessments that include wearing a continuous glucose sensor and activity watch, and get a blood draw to determine HbA1c. They also complete diagnostic interviews, surveys and computer tests of attention and things like heart rate and reaction time. These assessments help us better understand the types of changes that are happening and how they might influence health and well-being.",[578,36,579,377,439],"Type 1 Diabetes","Disordered Eating Behaviors",[581,582,298,583,584,585,586,587],"glycemic control","disordered eating behavior","type 1 diabetes","acceptance and commitment therapy","diabetes counseling","mhealth","psychological flexibility","2026-02-23",{"date":590,"type":46},"2026-02-25",{"date":592,"type":46},"2023-04-04",{"date":155,"type":22},{"name":230,"class":53},2,{"id":597,"slug":598,"hasResults":12,"nctId":599,"briefTitle":600,"officialTitle":601,"acronym":4,"eligibilityCriteria":602,"healthyVolunteers":12,"sex":96,"minAge":18,"maxAge":19,"enrollmentInfo":603,"targetDuration":4,"studyType":23,"phases":605,"briefSummary":606,"conditions":607,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":54},"100625068","cognitive-behavioral-and-digital-therapy-for-suicide-risk-in-eating-disorders-100625068","NCT07417826","Cognitive-Behavioral and Digital Therapy for Suicide Risk in Eating Disorders","Efficacy of Cognitive-behavioral Therapy (CBT) and Digital Therapy (DT) in the Prevention of Suicide Risk in Patients With Eating Disorders (ED): a Randomized Clinical Trial.","Inclusion Criteria:\n\n* Gender: Female.\n* Age between 18 and 65 years old.\n* Clinically stable and able to provide written informed consent.\n* Subjects included in the \"Suicide Risk Code\" (Codi Risc Suïcidi - CRS) program due to recent suicidal ideation or suicide attempts.\n* Patients with a diagnosis of an Eating Disorder (ED).\n\nExclusion Criteria:\n\n* Presence of intellectual disability or cognitive impairment that prevents understanding the therapy or the study requirements.\n* Diagnosis of Bipolar Disorder or any Psychotic Disorder.\n* Current active substance abuse or dependence.\n* Any medical condition that, in the investigator's opinion, makes participation unsafe or unfeasible.",{"count":604,"type":22},150,[25],"The purpose of this study is to determine if adding a digital intervention to standard cognitive-behavioral therapy (CBT) is more effective in preventing suicide risk and reducing eating disorder symptoms. Participants will be women between 18 and 65 years old who have recently experienced suicidal ideation or attempts. One group will receive standard group therapy, while the other will receive group therapy plus a mobile application and digital monitoring devices. The goal is to see if digital tools can improve clinical outcomes and safety for patients.",[36,608],"Suicide Risk","2026-02-13",{"date":611,"type":46},"2026-02-18",{"date":613,"type":46},"2025-10-22",{"date":615,"type":22},"2028-10",{"name":617,"class":53},"Universitat Autonoma de Barcelona",{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":622,"acronym":4,"eligibilityCriteria":623,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":165,"enrollmentInfo":624,"targetDuration":4,"studyType":23,"phases":626,"briefSummary":627,"conditions":628,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":634,"leadSponsor":636,"locationsCount":54},"100564634","targeting-transdiagnostic-self-regulatory-factors-and-eating-disorder-pathology-among-adults-with-binge-spectrum-eating-disorders-a-mhealth-interoceptive-exposure-intervention-the-bio-health-study-100564634","NCT06631729","Targeting Transdiagnostic Self-regulatory Factors and Eating Disorder Pathology Among Adults With BInge-spectrum Eating disOrders: A mHEALTH Interoceptive Exposure Intervention (the Bio-HEALTH Study)","Inclusion Criteria:\n\n* ages 18-64;\n* no changes to ED treatment in the past 4-weeks;\n* agree not to access other eating disorder treatments throughout the studies (unless warranted by a worsening of participants' symptoms during the study period; see Monitoring Participant Safety for more information);\n* no bariatric surgery (prior or planned during the study period);\n* no pregnancy or lactation (current or planned during the study);\n* own an Apple or Android-brand iOS smartphone (which is required for compatibility with the apps used in this study;\n* reside in the continental U.S.;\n* meet Diagnostic and Statistical Manual of Mental Disorders-5-TR (DSM-5-TR) criteria for binge eating disorder (BED) or bulimia nervosa (BN), both of which include objective binge eating (i.e., consuming a larger amount of food than most people would eat in a similar period of time under similar circumstances with loss of control over eating during the episode) ≥1x\u002Fweek over the past 3 months (APA, 2022). Single-item questions will determine eligibility via criteria 1-7. Criterion 8 for will be determined via the Eating Disorder Diagnostic Scale for the DSM-5 (EDDS-5; Stice et al., 2000, 2004), which has exhibited good sensitivity (.88), specificity (.98), and positive predictive power (.74) for detecting EDs among community samples (Stice et al., 2000, 2004).\n\nExclusion Criteria:\n\n* not between the ages of 18 and 64;\n* had changes to ED treatment in the past 4 weeks;\n* plan to access other eating disorder treatments throughout the study;\n* received or are planning to undergo bariatric surgery during the study period;\n* currently pregnant or lactating, or planning to become pregnant or lactate during the study period;\n* no Apple or Android-brand iOS smartphone;\n* do not live in the continental U.S.;\n* do not currently experience BN or BED.",{"count":625,"type":22},144,[25],"The present study will be fully remote (virtual) and include observational design features (assessments) plus a clinical trial. All assessments will be completed using HIPAA-approved platforms (e.g., Qualtrics, MindLogger EMA platform). After screening via Qualtrics to determine eligibility (described below), participants will complete a cross-sectional survey via Qualtrics, followed by a baseline EMA period. During the baseline EMA period, participants will receive brief (3-5 minutes) surveys on their mobile devices 6 times per day for 7-days via the MindLogger app. During the baseline EMA period, participants will also be asked to wear non-invasive chest-worn Holter monitors (Polar H10 Holter monitors) that will capture their heartrate variability data.\n\nThey will then complete the 4-week intervention (HRV bio or ED-JITAI treatment arms; see below), followed by a post-intervention 7-day EMA assessment period while they also wear the Holter monitors. Recruitment is expected to last for 1.5 years. In HRV-bio, participants will also complete a HRV biofeedback task via the Elite HRV app. In this intervention, participants will learn how to use their HRV data that they will see in real-time via the Elite HRV app to improve their HRV by engaging in an app-guided diaphragmatic breathing exercise. They will complete this exercise twice daily (morning, night). In ED-JITAI, participants will be prompted to complete focused, guided body scan tasks that will be sent to them via the MindLogger app. These guided tasks will be sent to them in the form of 1 of 3 brief (3-5 minute) videos via the MindLogger app. The body scans will be designed to promote participants' connection with, vs.\n\ndistancing\u002Fdistraction from, feared ED sensations (e.g., hunger, satiety, bloating).\n\nParticipants will receive prompts to complete the body scans at times when they report via EMA that they are experiencing worse interoception than usual. \"Worse interoception than usual\" will be defined as participants' EMA-reported interoception scores during the intervention period that fall 1 SD or more above their baseline EMA-reported interoception levels.",[36],"2026-02-10",{"date":631,"type":46},"2026-02-12",{"date":633,"type":46},"2025-01-15",{"date":635,"type":22},"2026-07-15",{"name":637,"class":53},"University of Minnesota",{"id":639,"slug":640,"hasResults":12,"nctId":641,"briefTitle":642,"officialTitle":643,"acronym":644,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":646,"targetDuration":4,"studyType":23,"phases":648,"briefSummary":649,"conditions":650,"keywords":651,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":660,"locationsCount":54},"100624605","study-of-the-effectiveness-of-a-systematic-minimal-early-intervention-on-care-engagement-in-adults-with-eating-disorders-requesting-specialized-treatment-100624605","NCT07411807","Study of the Effectiveness of a Systematic Minimal Early Intervention on Care Engagement in Adults With Eating Disorders Requesting Specialized Treatment.","Study of the Effectiveness of a Systematic Minimal Early Intervention on Care Engagement in Adults With Eating Disorders Requesting Specialized Treatment: A Monocentric Pilot Study.","AGIS-TCA","Inclusion Criteria:\n\n* Individual who has submitted a request for care to the CMME for an eating disorder (anorexia nervosa or bulimia)\n* Adult (18 years or older) Resident of the Île-de-France region\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²: these patients will be directed, from the first telephone contact, to structures or care networks that can offer appropriate treatment.\n\nPoor understanding of the French language\n\nSensory impairment significantly affecting telephone communication\n\nPatient currently receiving care at a specialized eating disorder facility at the time of the call\n\nPatient not consenting to participate in the study\n\nSubject under legal protection measures (guardianship or curatorship)",{"count":647,"type":22},215,[25],"Eating disorders (EDs) are complex psychiatric conditions-such as anorexia nervosa and bulimia nervosa-often emerging in young adulthood and associated with high morbidity and mortality. Despite their severity, access to specialized care remains difficult, delayed by shame, stigma, and a lack of insight among patients, as well as long waiting times and limited specialized resources.\n\nThe AGIS-TCA pilot study aims to evaluate the effectiveness of a systematic minimal early intervention designed to reduce the number of patients lost to follow-up between their request for specialized care and the actual start of treatment.\n\nThis monocentric, low-risk interventional study will be conducted at the Clinique des Maladies Mentales et de l'Encéphale (CMME), GHU Paris Psychiatrie \\& Neurosciences. The intervention includes three early, structured telephone calls and five online support group sessions offered during the waiting period for care.\n\nThe main objective is to determine whether this proactive approach decreases attrition rates (\"lost to follow-up\") compared with a historical cohort. Secondary objectives include assessing the acceptability of early phone contact, adherence to support groups, and describing the clinical and sociodemographic profiles of patients requesting care or lost to follow-up.\n\nThe expected benefit is to facilitate timely access to care for vulnerable patients, prevent symptom worsening, and strengthen engagement in treatment pathways. Risks and constraints are minimal, as participation involves only remote interactions without any invasive procedures.",[36],[652],"Anorexia Nervosa, Bulimia Nervosa","2026-02-09",{"date":655,"type":46},"2026-02-17",{"date":657,"type":46},"2025-12-29",{"date":659,"type":22},"2027-04",{"name":661,"class":53},"Centre Hospitalier St Anne",{"id":663,"slug":664,"hasResults":12,"nctId":665,"briefTitle":666,"officialTitle":667,"acronym":4,"eligibilityCriteria":668,"healthyVolunteers":12,"sex":17,"minAge":571,"maxAge":4,"enrollmentInfo":669,"targetDuration":4,"studyType":23,"phases":671,"briefSummary":672,"conditions":673,"keywords":675,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":685,"lastUpdatePostDateStruct":686,"startDateStruct":688,"completionDateStruct":689,"leadSponsor":691,"locationsCount":54},"100622772","a-brief-cannabis-use-psychoeducation-intervention-for-eating-disorder-patients-100622772","NCT07387965","A Brief Cannabis Use Psychoeducation Intervention for Eating Disorder Patients","A Brief Psychoeducation Intervention to Address Cannabis Use Amongst Patients Seeking Eating Disorder Treatment: A Single Blind Randomized Control Trial","Inclusion Criteria:\n\n* A patient of St. Joseph's Healthcare Hamilton Eating Disorder Program (i.e. is currently seeking eating disorders treatment)\n* Participant has been diagnosed with an eating disorder\n* Aged 16+\n* Understands written and spoken English\n\nExclusion Criteria:\n\n* Has not been diagnosed with an eating disorder\n* Under the age of 17\n* Does not understand written and spoken English",{"count":670,"type":22},80,[25],"The goal of this clinical trial is to learn if providing eating disorder patients with education about the consequences of cannabis (marijuana) use on mental health, gastrointestinal symptoms, eating disorder symptoms, and eating disorder treatment effectiveness increases their knowledge about the cannabis use consequences, intention to reduce cannabis use, and motivation to seek treatment for their cannabis use. The main questions this study aims to answer are:\n\n1. Does education about consequences of cannabis use increase eating disorder patients' knowledge about the risks of cannabis use?\n2. Does education about the consequences of cannabis use increase intention to reduce cannabis use and seek cannabis use treatment among those with eating disorders?\n3. Does cannabis use interfere with how successful eating disorder treatment is for eating disorder patients?\n\nAll participants will receive 20 weeks of eating disorder treatment. In week 1 of treatment, participants will either be assigned to receive education about cannabis use consequences, or be assigned to a control condition where they receive education about consequences of poor sleep. Participants will be asked to complete a number of questionnaires that measure knowledge about cannabis use consequences, intention to reduce use and seek cannabis use treatment, eating disorder symptoms, and cannabis use habits. Researchers will assess how effective providing education about cannabis use consequences is on changing knowledge about cannabis use risks, intention to reduce use, and intention to seek cannabis use treatment. It will also be examined if effectiveness of eating disorder treatment is related to cannabis use habits.",[36,674],"Cannabis Use",[676,677,678,298,679,383,680,681,682,683,354,684],"single blind","single blind randomized control trial","randomized control trial","cannabis use","brief intervention","marijuana","cannabis","binge eating disorder","bulimia nervosa","2026-01-27",{"date":687,"type":46},"2026-02-04",{"date":687,"type":22},{"date":690,"type":22},"2028-02-04",{"name":692,"class":53},"St. Joseph's Healthcare Hamilton",{"id":694,"slug":695,"hasResults":12,"nctId":696,"briefTitle":697,"officialTitle":697,"acronym":698,"eligibilityCriteria":699,"healthyVolunteers":95,"sex":96,"minAge":18,"maxAge":4,"enrollmentInfo":700,"targetDuration":4,"studyType":23,"phases":702,"briefSummary":703,"conditions":704,"keywords":4,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":706,"lastUpdatePostDateStruct":707,"startDateStruct":709,"completionDateStruct":711,"leadSponsor":713,"locationsCount":54},"100507329","detection-of-eating-disorders-in-pregnant-women-100507329","NCT05885971","Detection of Eating Disorders in Pregnant Women","PREGN'ED","Inclusion Criteria:\n\n* Adult pregnant woman\n* Woman with current diagnosed Eating Disorders or without Eating Disorders\n* Having a good command of the French language\n* Having given their consent for their participation in the research\n\nExclusion Criteria:\n\n* Underage pregnant woman\n* Woman who does not have a good command of the French language.\n* Woman with past Eating Disorders",{"count":701,"type":22},50,[25],"Eating disorders (ED) are insufficiently detected and belatedly or not treated during pregnancy.\n\nThere are many screening questionnaires for eating disorders in the literature, but we note the absence of a specific and validated tool for their screening during pregnancy, which would make it possible to differentiate maternal dietary concerns related to pregnancy from symptoms linked to a proven eating disorder.\n\nThe main objective of the study is to evaluate which items of the Sick Control One stone Fat Food (SCOFF-F) and Eating disorders examination questionnaire (EDE-Q) questionnaires could be specific to an ED during pregnancy and not related to the simple state of pregnancy, by comparing the answers of pregnant women, for whom the diagnosis of ED has been made, to those of pregnant women without an ED.",[36,705],"Pregnancy Related","2026-01-12",{"date":708,"type":46},"2026-01-13",{"date":710,"type":46},"2023-06-30",{"date":712,"type":22},"2026-06",{"name":714,"class":53},"Centre Hospitalier Henri Laborit"]