[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"edentulism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:edentulism":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,47,76,104,135,156,177,206,227,254,278,305,331,355,379,403,431,452,482,508,532,559],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100643148","pmcf-study-on-the-effectiveness-and-safety-of-biodentoss-and-dwc-dental-implants-and-superstructures-100643148",false,"NCT07633665","PMCF Study on the Effectiveness and Safety of BIODENTOSS® and DWC® Dental Implants and Superstructures","Post-Market Clinical Follow-Up (PMCF) Study on the Effectiveness and Safety of BIODENTOSS® and DWC® Dental Implants and Superstructures","Inclusion Criteria:\n\n* 18 years of age or older,\n* Male or female,\n* Subjects with missing tooth who require dental implant treatment,\n* At least 2 months elapsed since tooth extraction,\n* General health status suitable for implantation,\n* Not legally restricted (e.g., soldier, convict),\n* Provision of signed Informed Consent Form (ICF)\n\nExclusion Criteria:\n\n* Suspected or confirmed pregnancy or breastfeeding,\n* Disorders preventing adequate daily oral hygiene,\n* Hypersensitivity\u002Fallergy to titanium or implant components,\n* Inappropriate interarch relationship or parafunction (e.g., bruxism),\n* Bone\u002Fsoft tissue deficiency requiring augmentation,\n* Active periodontal infection or untreated oral pathologies,\n* Unstable systemic diseases affecting wound healing (e.g., diabetes),\n* Use of immunosuppressive drug therapy due to systemic disorders, organ transplantation, or any other medical conditions,\n* Hematological disorders or current use of anticoagulants (such as Warfarin, dabigatran or related therapies),\n* Presence of osteoporosis and\u002For any disease condition affecting bone metabolism,\n* Presence of an active systemic infection, or any health condition or ongoing treatment (e.g., radiotherapy, bisphosphonate therapy) that contraindicates elective surgery,\n* Recent myocardial infarction or cerebrovascular event,\n* Individuals who consume high doses of alcohol, cigarettes, or tobacco products and are unable to control their usage,\n* Participation in another interventional clinical study.","ALL","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","This prospective, single-center, interventional post-market clinical follow-up (PMCF) study aims to evaluate the early-term (24 months post-implantation) safety and efficacy of CE-marked BIODENTOSS® and DWC ® Dental Implants and Superstructures in patients requiring dental restoration for tooth loss.",[26,27],"Tooth Loss","Edentulism",[29,30,31,32,33],"Post-Market Clinical Follow-Up (PMCF)","Dental Implants","Osseointegration","Implant Stability","Marginal Bone Loss (MBL)","RECRUITING","2026-06-04",{"date":37,"type":38},"2026-06-08","ACTUAL",{"date":40,"type":38},"2024-12-11",{"date":42,"type":20},"2028-07-31",{"name":44,"class":45},"Değirmenci Otomotiv ve Metal Endüstri A.Ş.","INDUSTRY",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100595563","phase-2-the-impact-of-palatal-rugae-addition-to-complete-dentures-on-patients-satisfaction-and-oral-health-related-quality-of-life-100595563","NCT07034079","The Impact of Palatal Rugae Addition to Complete Dentures on Patients' Satisfaction and Oral Health Related Quality of Life","The Impact of Palatal Rugae Addition to Complete Dentures on Patients' Satisfaction and Oral Health Related Quality of Life: A Randomized Crossover Clinical Trial","Palatal rugae","Inclusion Criteria:\n\n* Patients aged 45-80 years.\n* Completely edentulous for at least 3 months.\n* Seeking new complete maxillary dentures for the first time.\n* Provided written informed consent\n* Motivated and compliant patients, willing to return for follow-up (helps reduce attrition bias)\n* Patients with Class I maxillomandibular relationship\n\nEXCLUSION CRITERIA\n\n* Patients with severe systemic diseases or neuromuscular dysfunction.\n* Presence of mental or auditory impairment.\n* History of oral pathology, xerostomia, or ankyloglossia (tied tongue).\n* Previous or experienced complete denture wearers.\n* Patient with strong gag reflex",true,"40 Years","80 Years",{"count":59,"type":20},60,[61],"PHASE2","In conventional maxillary complete dentures, the palatal surface is typically smooth and polished, lacking the natural anatomy of the palatal rugae. While this design facilitates ease of cleaning, it may compromise the functional feedback required for speech and other oral functions. Since the palatal rugae contain mechanoreceptors essential for guiding the tongue during phonation and mastication, replicating these structures may enhance oral function and patient adaptation.\n\nGiven the variation in clinical outcomes reported in prior studies, a randomized crossover clinical trial is warranted to assess the impact of adding anatomically replicated palatal rugae to complete dentures.",[27],[53,65,27,66],"Oral health impact profile","complete denture","NOT_YET_RECRUITING",{"date":37,"type":38},{"date":70,"type":20},"2026-07-01",{"date":72,"type":20},"2026-12-31",{"name":74,"class":75},"Pakistan Institute of Medical Sciences","OTHER_GOV",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":46},"100557496","dental-implant-healing-with-tnf-alpha-inhibitors-100557496","NCT06538870","Dental Implant Healing With TNF-Alpha Inhibitors","Dental Implant Healing in Patients Taking Tumor Necrosis Factor (TNF)-Alpha Inhibitors","Inclusion Criteria:\n\n* Over the age of 18\n* Require placement of implants to assist with dental restoration.\n* Half of the patients (15) will be recruited with the key criteria of a TNF-alpha inhibitor medication that they have been taking consistently without dose adjustment or other changes for at least 6 months. The other half will be recruited without a target medical condition but will be recruited to match the patients taking TNF-alpha inhibitors in age and gender.\n* All patients will be medically fit to withstand implant placement as judged by best practice applied by the study team.\n* The patients will be required to read and speak English\n* All patients must either provide their own independent consent for medical procedures or to attend study visits with a surrogate decision maker.\n\nExclusion Criteria:\n\nPatients will not be excluded on the basis of age (within the adult population), race, economic status, sex or gender, or other demographic factors. Patients will be excluded if:\n\n* They have periodontal disease (periodontal pockets above 4mm in the applicable arch or radiographic evidence of horizontal bone loss more than mild severity)\n* There is other evidence of pathology in the treated arch on pre-treatment review including radiographs, such as any evidence of cyst or tumor formation in the mandible.\n* They have uncontrolled diabetes (HbA1c \\>8.0) as confirmed by evaluating labs taken on anyone with diagnosed diabetes in the 6 months before the study enrollment.\n* They have history of head and neck radiation for any reason\n* They are taking any antiresorptive or antiangiogenic agents for any reason including osteoporosis, multiple myeloma, bone metastasis of other primary cancers\n* They are unable to seek outpatient medical care or are not medically fit to withstand implant placement, including those with critical findings or lab values. Medical exclusion of patients will be completed by the investigators based on standard of care for surgical procedures in dental medicine and based on specific implant guidelines.\n* Patients who have routinely used tobacco or tobacco products in the last 1 year will be excluded, as tobacco use is a known contributor to poor prognosis after implant placement. For this reason, dental implant placement is only recommended in patients who have quit or never used tobacco products.\n\n  * Pregnant women are unlikely to meet inclusion criteria as dental implant placement is considered an elective procedure and typically deferred in dentistry until after delivery.",{"count":84,"type":20},30,[23],"The goal of this pilot study is to learn about healing after dental implant placement in patients taking a class of biologic drug called Tumor Necrosis Factor or TNF-alpha antagonist or inhibitor. The main questions it aims to answer are:\n\nDo patients taking TNF-alpha inhibitors have any complications after the placement of dental implants? Do patients taking TNF-alpha inhibitor experience increased pain after dental implant placement compared to the expected levels when healing from this procedure? Researchers will recruit patients both taking these drugs and those not taking these drugs to compare the outcomes between the two groups.\n\nParticipants missing teeth will be recruited to receive dental implants to meet ideal dental status and will be followed before and after the implant placement to determine levels of health and ensure proper healing. Participants will be followed for a total of one year and follow up visits will consist of both clinical examination and radiographs (x-rays) to evaluate bone level and implant status. Participants will also be asked to rate their pain during clinic visits and at home on a diary and record the amount of pain control medication they take after the implant procedure.",[27,30,88],"TNF-alpha Inhibitors",[90,91,92,93],"Dental implants","TNF-alpha inhibitors","Biologic agents","Missing teeth","2026-05-18",{"date":96,"type":38},"2026-05-20",{"date":98,"type":38},"2025-06-28",{"date":100,"type":20},"2026-12",{"name":102,"class":103},"University of Pennsylvania","OTHER",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":21,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100640713","printow-occlusal-wear-of-denture-teeth-in-digitally-fabricated-complete-dentures-100640713","NCT07585162","PRINTOW: Occlusal Wear of Denture Teeth in Digitally Fabricated Complete Dentures","A Randomized, Double-Blind, Three-Arm Superiority Trial Comparing Occlusal Wear of 3D-Printed, CAD\u002FCAM-Milled, and Prefabricated Denture Teeth in Digitally Fabricated Complete Dentures in Edentulous Patients","Printow","Inclusion Criteria:\n\n* Written informed consent provided by the participant\n* Age ≥ 18 years\n* Fully edentulous maxilla and mandible requiring rehabilitation with new complete removable dental prostheses\n* Patients with or without mandibular implants (implant overdenture or conventional denture)\n* Clinical indication for fabrication of new maxillary and mandibular complete removable dental prostheses\n* Currently wearing complete dentures, or a maxillary denture combined with a mandibular denture or overdenture\n* Ability and willingness to attend all scheduled follow-up visits for the duration of the study\n\nExclusion Criteria:\n\n* Contraindications to the medical devices used, e.g. known hypersensitivity or allergy;\n* Known or suspected non-compliance, drug or alcohol abuse; Inability to follow the procedures of the investigation;\n* Enrolment of the investigator, his\u002Fher family members, employees and other dependent persons;\n* Reported severe bruxism or clenching habits, identified through patient interview and clinical examination, including self-reported grinding or clenching, partner reports, morning jaw discomfort, and other signs of parafunctional activity;\n* Width of the edentulous maxilla \\>80 mm;\n* Width of the edentulous mandible \\>80 mm; Vertical prosthetic space \\\u003C38 mm (maxilla or mandible);\n* Depression: Geriatric Depression Scale \\>9;\n* Xerostomia: UFR ≤ 0.2ml\u002F2min;\n* Dementia: Clock-Drawing Test ≤5;\n* Active peri-implant disease or instability of the two mandibular implants at baseline when implants are present;\n* Presence of an implant-retained prosthesis in the maxilla;\n* Planned implant-related surgical intervention during the study period.",{"count":113,"type":20},45,[23],"This randomized controlled trial evaluates the occlusal wear of denture teeth fabricated using three digital workflows: 3D-printed denture teeth, CAD\u002FCAM-milled double cross-linked denture teeth, and prefabricated denture teeth. Occlusal wear will be assessed over 24 months using digital superimposition techniques. The study aims to determine whether 3D-printed denture teeth demonstrate superior wear resistance compared to CAD\u002FCAM-milled denture teeth.",[117,27],"Edentulism Complete",[27,119,120,121,122,123,124,125],"Complete dentures","Digital dentistry","3D printing","CAD\u002FCAM","Occlusal wear","Denture teeth","Randomized controlled trial","2026-05-08",{"date":128,"type":38},"2026-05-13",{"date":130,"type":20},"2026-09-01",{"date":132,"type":20},"2032-12-30",{"name":134,"class":103},"Najla Chebib",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":143,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":46},"100640075","the-effect-of-palatal-rugae-design-in-complete-denture-on-patient-satisfaction-and-quality-of-life-100640075","NCT07579377","The Effect of Palatal Rugae Design in Complete Denture on Patient Satisfaction and Quality of Life","Inclusion Criteria:\n\n1. Patients seeking conventional complete dentures.\n2. Aged 40-80 years.\n3. Both genders (male and female).\n4. Patient's must be willing to participate in the study and able to attend follow-up appointments\n\nExclusion Criteria:\n\n1. Patients with severe underlying medical conditions and mental conditions.\n2. Neuromuscular dysfunction.\n3. Oral diseases such as denture stomatitis and oral submucous fibrosis\n4. Xerostomia and tied tongue condition.\n5. Flabby and Atrophic Ridges.",{"count":142,"type":20},90,[23],"The goal of this clinical trial is to learn whether different palatal rugae designs in complete dentures can improve comfort, function, and overall oral health-related quality of life in edentulous adults aged 40 to 80 years. The main questions it aims to answer are:\n\nDo roughened or vacuum-formed thermoplastic sheet palatal rugae designs lead to higher patient satisfaction than the traditional polished design?\n\nDo these designs improve oral health-related quality of life, including chewing, speaking, and overall comfort?\n\nResearchers will compare three denture designs-a polished palatal surface, a roughened palatal surface, and a vacuum-formed thermoplastic sheet rugae design-to see which design provides better comfort, function, and quality of life for patients.\n\nParticipants will:\n\nReceive complete maxillary dentures made with one of the three palatal rugae designs\n\nAttend follow-up assessments at 1 week, 1 month, and 3 months after denture insertion (in person or by phone)\n\nComplete the OHIP-EDENT questionnaire and a Visual Analog Scale (VAS) to report satisfaction, comfort, and oral health-related quality of life.",[27,146],"Complete Dentures","2026-05-07",{"date":149,"type":38},"2026-05-12",{"date":151,"type":38},"2025-10-20",{"date":153,"type":20},"2026-12-30",{"name":155,"class":103},"Dow University of Health Sciences",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":165,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":46},"100629424","comparing-cleaning-tools-for-full-arch-implant-supported-fixed-prostheses-100629424","NCT07474493","Comparing Cleaning Tools for Full-Arch Implant-Supported Fixed Prostheses","Comparison of Cleaning Efficacy of Different Cleaning Aids for Full-arch Implant Supported Fixed Protheses: A Self-controlled Crossover Clinical Trial","Inclusion Criteria:\n\n1. Age ≥18 years;\n2. Patients with single-arch or full-arch edentulism \u002F terminal dentition who have completed implant placement and immediate restoration and are scheduled to receive the definitive prosthesis;\n3. Patients with good compliance who provide informed consent.\n\nExclusion Criteria:\n\n1. Smoking (≥10 cigarettes per day);\n2. Lack of self-care ability and unable to perform prosthesis cleaning independently;\n3. Uncontrolled periodontitis in remaining teeth or unstable periodontal condition;\n4. Presence of failed implants in the full-arch implant restoration and requiring second implantation.",{"count":164,"type":20},18,[23],"For patients with complete edentulism, full-arch implant-supported fixed prostheses can effectively restore functions such as mastication, esthetics, and speech. Their long-term clinical outcomes are predictable, and patient satisfaction is generally high. However, the probability of biological complications associated with full-arch implant-supported fixed prostheses within 10 years can be as high as 91.2%. Poor oral hygiene and plaque accumulation are important risk factors for these biological complications.\n\nProper cleaning and maintenance are crucial for the long-term success of full-arch implant-supported fixed prostheses. However, the most effective cleaning method remains unclear. Superfloss, interdental brushes, and water floss are commonly used auxiliary cleaning tools, but in vivo studies evaluating their cleaning efficacy are limited. Therefore, a randomized controlled study with a relatively long observation period is needed to better evaluate the cleaning effectiveness of different methods-superfloss, interdental brushes, and water floss-in patients with full-arch implant-supported fixed prostheses.\n\nThis study adopts a self-controlled, three-phase crossover design. Participants will sequentially use superfloss (S), interdental brushes (I), and a water flosser (W) to clean the surface of full-arch implant-supported fixed prostheses. Each cleaning method will be used for three months, after which a follow-up examination will be conducted. The participants will then switch to the second cleaning method, followed by another evaluation after three months. Finally, they will switch to the third cleaning method, and a final examination will be performed after an additional three months, completing the study.",[27],"2026-03-11",{"date":170,"type":38},"2026-03-16",{"date":172,"type":38},"2026-01-14",{"date":174,"type":20},"2027-01-31",{"name":176,"class":103},"Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":185,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":199,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":4},"100629421","mandibular-biological-drilling-at-different-speeds-for-dental-implant-placement-100629421","NCT07474454","Mandibular Biological Drilling at Different Speeds for Dental Implant Placement","Radiographic Assessment of Mandibular Biological Drilling at Different Drilling Speeds: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 20-60 years.\n* Partially edentulous patients requiring a single dental implant in the mandible.\n* Adequate bone height and width at the implant site to accommodate the planned implant dimensions without the need for advanced grafting.\n* Good oral hygiene (full-mouth plaque and bleeding scores within acceptable limits).\n* Patients willing to participate, available for 12-month follow-up, and able to sign informed consent.\n\nExclusion Criteria:\n\n* Systemic diseases or conditions that may compromise bone healing (e.g. uncontrolled diabetes, immunosuppression, recent radiotherapy in head and neck region).\n* Smoking more than 10 cigarettes\u002Fday or heavy vaping.\n* Pregnant or lactating women.\n* History of bisphosphonate or other anti-resorptive therapy affecting bone metabolism.\n* Active periodontal disease or poor oral hygiene.\n* Acute infection or pathology at the planned implant site.\n* Need for simultaneous major bone grafting at the same site.\n* Bruxism or severe parafunctional habits.","20 Years","60 Years",{"count":187,"type":20},39,[23],"This randomized controlled clinical trial aims to evaluate the effect of different biological drilling speeds (50, 150, and 300 rpm) during implant osteotomy preparation in the mandible on marginal bone level changes and implant stability. Thirty-nine patients requiring a single dental implant in the mandible will be randomly allocated into three groups according to drilling speed. All implants will be placed using a biological drilling protocol without irrigation. Implant stability will be measured using resonance frequency analysis at implant placement and follow-up visits. Marginal bone levels will be evaluated radiographically using standardized periapical radiographs during the follow-up period up to 12 months. The study aims to determine whether different low-speed drilling protocols influence peri-implant bone remodeling and implant stability.",[27,26],[192,193,194,195,196,197,198],"dental implants","biological drilling","low speed drilling","marginal bone loss","implant stability","mandible","randomized clinical trial",{"date":170,"type":38},{"date":201,"type":20},"2026-03-15",{"date":203,"type":20},"2027-04-01",{"name":205,"class":103},"Cairo University",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":184,"maxAge":185,"enrollmentInfo":213,"targetDuration":4,"studyType":21,"phases":215,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":223,"startDateStruct":224,"completionDateStruct":225,"leadSponsor":226,"locationsCount":4},"100629495","effect-of-mandibular-drilling-speed-on-implant-stability-and-osteogenic-potential-a-randomized-clinical-trial-100629495","NCT07475416","Effect of Mandibular Drilling Speed on Implant Stability and Osteogenic Potential: A Randomized Clinical Trial","Impact of Mandibular Biological Drilling Speeds on Implant Stability and Osteogenic Potential of Autogenous Bone Particles: A Randomized Clinical Trial","Inclusion Criteria:\n\nAdult patients requiring single dental implant placement in the mandible\n\nAdequate bone volume for implant placement without need for bone grafting\n\nGood general health\n\nAbility to provide informed consent\n\nExclusion Criteria:\n\nSystemic diseases affecting bone metabolism or healing\n\nHistory of radiotherapy in the head and neck region\n\nUncontrolled diabetes mellitus\n\nActive periodontal disease\n\nHeavy smoking\n\nPregnancy or lactation",{"count":214,"type":20},36,[23],"This randomized clinical trial aims to evaluate the effect of different low-speed biological drilling protocols on implant stability and the osteogenic potential of autogenous bone particles collected during implant osteotomy. Patients requiring single dental implant placement in the mandible will be randomly assigned to different drilling speed protocols without irrigation. Implant stability will be measured clinically, while collected bone particles will be analyzed for osteogenic markers. The study aims to determine whether biological drilling improves implant stability and preserves the regenerative potential of autogenous bone.",[27,26],[193,194,192,196,219,220,221,222],"autogenous bone particals","BMP-2","VEGF","mandibular implants",{"date":170,"type":38},{"date":201,"type":20},{"date":203,"type":20},{"name":205,"class":103},{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":234,"targetDuration":4,"studyType":21,"phases":236,"briefSummary":237,"conditions":238,"keywords":240,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":46},"100628984","influence-of-implant-insertion-depth-on-peri-implant-bone-changes-around-short-implants-100628984","NCT07468747","Influence of Implant Insertion Depth on Peri-implant Bone Changes Around Short Implants","\"Influence Of Crestal Versus Subcrestal Implant Placement Levels On Peri-Implant Health And Radiographic Bone Changes Around Short Implants: A Randomized Controlled Clinical Trial.\"","Inclusion Criteria:\n\n1. Adults aged 18 years or older requiring dental implant therapy for replacement of a missing tooth in the posterior maxilla or mandible.\n2. Presence of sufficient bone volume to receive a short dental implant without the need for bone augmentation procedures.\n3. Patients in good general health or with controlled systemic conditions that do not contraindicate implant surgery.\n4. oral hygiene, defined as a plaque score ≤25%.\n5. Presence of healthy or treated periodontal tissues prior to implant placement.\n6. Patients willing and able to return for follow-up visits at 3, 6, and 12 months.\n7. Patients who provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus, immunosuppressive disorders).\n2. History of radiotherapy in the head and neck region.\n3. Patients currently receiving bisphosphonate therapy or other medications affecting bone metabolism.\n4. Active periodontal disease or untreated oral infections.\n5. Heavy smokers (≥10 cigarettes per day).\n6. Presence of parafunctional habits such as severe bruxism or clenching.\n7. Patients requiring simultaneous bone grafting or sinus augmentation at the implant site.\n8. Pregnant or lactating women.\n9. Patients unable or unwilling to comply with the study protocol or follow-up schedule.",{"count":235,"type":20},58,[23],"Dental implants are widely used to replace missing teeth and restore oral function and aesthetics. One of the key factors affecting the long-term success of dental implants is the stability of the bone surrounding the implant, particularly the crestal bone around the implant neck. Implant insertion depth relative to the alveolar crest may influence peri-implant tissue health and marginal bone remodeling.\n\nThis randomized controlled clinical trial aims to evaluate the influence of implant placement depth on peri-implant health and radiographic bone changes around short dental implants placed using guided surgical protocol. All implants will be placed using the Bicon Implant System following computer-guided implant planning and surgical guide fabrication to ensure precise implant positioning.\n\nParticipants requiring implant therapy will be randomly allocated into two groups. In the test group, implants will be placed 2 mm below the crestal bone level (subcrestal placement). In the control group, implants will be placed at the crestal bone level (crestal placement). Implant placement will be performed using guided implant surgery to standardize surgical positioning and minimize variability in implant angulation and depth.\n\nClinical parameters related to peri-implant health, including Modified Plaque Index, Implant Mucosal Index, Peri-implant Mucosal Tissue Index and Probing Depth during follow-up visits at 3, 6 and 12 months. In addition, standardized radiographic examinations will be performed to measure peri-implant Crestal bone level changes at 12 months.\n\nThe primary objective of this study is to determine whether subcrestal implant placement (2 mm below the bone crest) results in improved preservation of peri-implant crestal bone compared with crestal implant placement. Secondary outcomes will include assessment of peri-implant soft tissue health and overall implant stability.\n\nThe findings of this study may help clarify the optimal implant insertion depth for short implants placed using guided surgery and may contribute to improving long-term implant success and peri-implant tissue stability.",[26,27,239],"Peri-implant Bone Loss",[30,241,242,243,244],"Short Implants","Subcrestal Implant Placement","Peri-Implant Health","Radiographic Bone Changes","2026-03-09",{"date":247,"type":38},"2026-03-13",{"date":249,"type":20},"2026-03-30",{"date":251,"type":20},"2027-05-30",{"name":253,"class":103},"Gulf Medical University",{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":21,"phases":263,"briefSummary":264,"conditions":265,"keywords":266,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":274,"leadSponsor":276,"locationsCount":46},"100624372","single-implant-versus-two-implant-mandibular-overdentures-100624372","NCT07408778","Single-implant Versus Two-implant Mandibular Overdentures","Patient-reported Outcomes and Masticatory Performance of Mandibular Overdentures Retained by One Parasymphyseal Implant or Two Implants: Randomized Clinical Trial","Inclusion Criteria:\n\n* Men and women ≥40 years.\n* ASA I-II; favorable general health or adequately controlled systemic disease (e.g., hypertension, diabetes).\n* Skeletal Class I relationship.\n* Completely edentulous mandible and maxilla.\n* Technically acceptable complete dentures in both jaws for ≥3 and ≤24 months; dissatisfaction limited to mandibular retention\u002Fstability.\n* Adequate anterior mandibular bone for implant ≥3.5×10 mm confirmed on CBCT; no bone augmentation needed.\n* Normal mucosal resilience (\\~2 mm displacement).\n* Implant sites healed ≥4 months since extraction.\n* Willingness to be randomized and attend follow-ups; written informed consent.\n* Primary stability target ≥25 N-cm.\n\nExclusion Criteria:\n\n* Uncontrolled systemic disease; neurodegenerative disease; osteoporosis requiring antiresorptives.\n* Chronic systemic antibiotics\u002Fsteroids; bleeding disorders; active cancer therapy; metabolic bone disease; HIV.\n* Investigational drug use within 30 days.\n* Alcohol dependence\u002Fillicit drug use; xerostomia (stimulated flow \\\u003C0.7 mL\u002Fmin).\n* Heavy smoking \\>20 cigarettes\u002Fday.\n* TMD\u002Forofacial pain; severe bruxism; moderate\u002Fsevere cognitive impairment.\n* Prior implant therapy.\n* Non-adherence risk or inability to attend longitudinal visits.\n* Insufficient prosthetic space for attachment housing: inter-arch vertical distance \\\u003C8.5 mm at parasymphyseal\u002Fcanine region.\n* Concurrent participation in another interventional study.\n* Erosive lichen planus or other significant oral mucosal disease; head-and-neck irradiation history.\n* Mandibular pathology on CBCT (e.g., cyst, tumor).\n* Ridge dimensions \\\u003C6 mm width or \\\u003C10 mm height at planned sites.\n* Active intraoral infection.",{"count":262,"type":20},32,[23],"This randomized controlled trial compares a mandibular overdenture retained by one implant placed in the parasymphyseal or canine region with a mandibular overdenture retained by two implants placed in the interforaminal region in completely edentulous adults. Primary outcomes are oral health-related quality of life, patient satisfaction, and masticatory performance measured by a two-color chewing gum mixing test, assessed at baseline before implant surgery and at 3, 6, and 12 months after overdenture insertion.",[27],[267,268,269],"mandibular denture instability","poor denture retention","implant-retained overdenture","2026-02-16",{"date":272,"type":38},"2026-02-17",{"date":270,"type":38},{"date":275,"type":20},"2027-07",{"name":277,"class":103},"Rola Shadid",{"id":279,"slug":280,"hasResults":11,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":55,"sex":16,"minAge":285,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":21,"phases":288,"briefSummary":289,"conditions":290,"keywords":291,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":46},"100608996","3d-printed-implant-overdentures-comparing-impression-techniques-100608996","NCT07208812","3D-Printed Implant Overdentures: Comparing Impression Techniques","Impact of Impression Techniques on Patient Satisfaction and Chewing Efficiency in 3D-Printed Implant Overdentures: A Crossover Study","Inclusion Criteria:\n\n* Healthy patients, free from systemic diseases that affect bone resorption (e.g., uncontrolled diabetes, osteoporosis)\n* Residual alveolar ridges covered with healthy, firm mucosa\n* Adequate mandibular bone length and width to accommodate standard implant sizes.\n* Angle's Class I maxillo-mandibular relationship.\n\nExclusion Criteria:\n\n* Absolute contraindications to implant placement (e.g., active cancer, immune system diseases)\n* History of head and neck irradiation or chemotherapy within the past 3 years\n* Metabolic bone diseases such as uncontrolled diabetes, osteoporosis, or hyperparathyroidism\n* Parafunctional habits such as bruxism or clenching\n* Smoking or alcoholism\n* Any physical or medical condition that may interfere with study follow-up or implant success","45 Years",{"count":287,"type":20},16,[23],"This randomized crossover clinical trial aims to compare three different impression techniques for the construction of 3d-printed mandibular implant overdentures in completely edentulous patients. Sixteen patients will receive two mandibular implants and three overdentures fabricated using:(1) conventional open-tray implant level impression (2) functionally generated reline impression, and (3)mucostatic base with functional borders impression. Each overdenture will be worn for three months with a washout period between interventions.\n\nThe primary outcome is masticatory efficiency, assessed using a color -mixing ability test at 3,6, and9 months.\n\nSecondary outcome is patient satisfaction, assessed using a Visual Analog Scale (VAS) at the same intervals. the study hypothesis is that the impression technique influences both chewing efficiency and patient satisfaction",[27],[292,293,294,295],"3D-Printed Implant Overdenture","Impression Techniques","Chewing Efficiency","Patient Satisfaction","2026-01-27",{"date":298,"type":38},"2026-01-29",{"date":300,"type":38},"2026-01-06",{"date":302,"type":20},"2027-05-31",{"name":304,"class":103},"Mansoura University",{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":11,"sex":16,"minAge":312,"maxAge":57,"enrollmentInfo":313,"targetDuration":4,"studyType":21,"phases":315,"briefSummary":316,"conditions":317,"keywords":318,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":323,"lastUpdatePostDateStruct":324,"startDateStruct":325,"completionDateStruct":327,"leadSponsor":329,"locationsCount":46},"100588626","platelet-rich-fibrinogen-in-extraction-socket-healing-of-the-aged-100588626","NCT06943846","Platelet-Rich Fibrinogen in Extraction Socket Healing of the Aged","Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen","Inclusion Criteria:\n\n* Patient at University of Nebraska Medical Center (UNMC) College of Dentistry\n* Requires extraction of posterior tooth\n* Able and willing to provide consent\u002Fassent\n\nExclusion Criteria:\n\n* Systemic conditions that delay wound healing\n* Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy","14 Years",{"count":314,"type":20},12,[23],"The purpose of this study is to better understand oral wound healing in the aged participant following placement of platelet-rich fibrinogen (PRF). In this study, 12 participants requiring a posterior tooth extraction will be enroll: 6 participants aged 14-18, 6 participants aged 50-80. All will undergo a posterior tooth extraction with a small tissue specimen taken from the extraction site. Half of the participants will also have their blood drawn and platelet-rich fibrinogen placed in the extraction socket. Participants will return in 2 weeks for suture removal and another soft tissue sample. Participants will return at 3 months for a final post-operative radiograph. All soft tissue samples will undergo immunofluorescence.",[27],[319,320,321,322],"extraction","platelet-rich","fibrin","healing","2026-01-23",{"date":296,"type":38},{"date":326,"type":38},"2025-05-01",{"date":328,"type":20},"2027-05",{"name":330,"class":103},"University of Nebraska",{"id":332,"slug":333,"hasResults":11,"nctId":334,"briefTitle":335,"officialTitle":336,"acronym":4,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":338,"enrollmentInfo":339,"targetDuration":4,"studyType":21,"phases":341,"briefSummary":342,"conditions":343,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":349,"completionDateStruct":351,"leadSponsor":353,"locationsCount":46},"100621997","accuracy-of-digital-vs-conventional-denture-impressions-an-in-vivo-study-100621997","NCT07377890","Accuracy of Digital vs Conventional Denture Impressions: An In Vivo Study","Accuracy of Intraorally Scanned Denture Impressions Compared to Conventional Border-Molded Impressions: An In Vivo Study","Inclusion Criteria:\n\n* Patients attending DDH for complete dental prosthesis.\n* Fully edentulous patients\n* All alveolar ridge classifications of Cawood and Howell 1988 (Cawood and Howell, 1988)\n* Above 18 years old\n* Arabic and English-speaking patients\n* Good physical health (ASA class 1 or 2)\n* Willing to provide informed consent.\n\nExclusion Criteria:\n\n* Dentate patients\n* Implant-attachment-supported complete denture.\n* Patients un-willing to participate (non-consented patients)\n* Patients with severe gag reflex\n* Patients who are mentally unstable, drug users or alcoholics","85 Years",{"count":340,"type":20},10,[23],"The goal of this clinical trial is to compare the accuracy of two denture impression techniques, digital intraoral scanning and conventional border-molded impressions, in adults who have lost all their teeth (fully edentulous patients).\n\nThe main questions it aims to answer are:\n\nIs a digital intraoral scan as accurate as a conventional impression for capturing the shape of the mouth, including movable gum areas? Are repeated digital scans consistent (precise) when taken multiple times on the same patient? Researchers will compare digital impressions taken with an intraoral scanner to conventional impressions made with custom trays and border molding to see if digital scans can match the accuracy of the traditional \"gold standard\" method.\n\nParticipants will:\n\nAttend Dubai Dental Hospital for two study visits. Have their mouth scanned three times using a digital intraoral scanner. Have a conventional impression taken using a custom tray and high-accuracy material after border molding.\n\nProvide informed consent and allow their impression data to be analyzed for accuracy.",[27,146,344,345],"Digital Impression Accuracy","Dental Impression Techniques","2026-01-22",{"date":348,"type":38},"2026-01-30",{"date":350,"type":38},"2025-10-01",{"date":352,"type":20},"2026-06-01",{"name":354,"class":103},"Mohammed Bin Rashid University of Medicine and Health Sciences",{"id":356,"slug":357,"hasResults":11,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":21,"phases":364,"briefSummary":365,"conditions":366,"keywords":367,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":372,"lastUpdatePostDateStruct":373,"startDateStruct":374,"completionDateStruct":375,"leadSponsor":377,"locationsCount":46},"100620929","accuracy-of-metal-sleeve-free-fully-guided-implant-surgery-100620929","NCT07364006","Accuracy of Metal Sleeve-Free Fully Guided Implant Surgery","Evaluation of Accuracy in Fully Guided Dental Implant Surgery Using 3D-Printed Surgical Guides Without Metal Sleeves: A Split-Mouth In Vivo Study","Inclusion Criteria:\n\n* Partially or fully edentulous patients requiring fixed complete-arch rehabilitation with dental implants.\n* Patients classified as ASA I or ASA II.\n* Adult patients aged 18 years or older.\n* Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Patients classified as ASA III or ASA IV.\n* Patients with medical conditions that contraindicate dental implant surgery.\n* Inability or unwillingness to provide informed consent.",{"count":363,"type":20},15,[23],"This clinical trial aims to evaluate the in vivo accuracy of fully guided dental implant surgery using 3D-printed surgical guides without metal sleeves. The study is designed as a split-mouth clinical trial and will be conducted in partially or fully edentulous adult patients requiring complete-arch rehabilitation with dental implants.\n\nThe primary objective of the study is to assess the accuracy of implant placement by comparing the virtually planned implant positions with the actual clinical positions achieved after guided surgery. Accuracy will be evaluated by analyzing linear and angular deviations between planned and placed implants.\n\nParticipants will undergo a fully guided implant placement procedure using metal sleeve-free surgical guides. Two different drilling channel diameters (standard and reduced) will be randomly assigned in a split-mouth manner. Postoperative intraoral scans and cone-beam computed tomography (CBCT) scans with scan bodies will be obtained to register the final implant positions.\n\nThe planned and achieved implant positions will be compared using three-dimensional analysis software to quantify deviations and determine whether the use of metal sleeve-free guides and reduced drilling diameters influences implant placement accuracy.",[27],[368,90,369,370,371],"Guided implant surgery","Surgical guide accuracy","Metal sleeve-free surgical guides","3D-printed surgical guides","2026-01-16",{"date":323,"type":38},{"date":350,"type":38},{"date":376,"type":20},"2026-08-01",{"name":378,"class":103},"Universidad Complutense de Madrid",{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":383,"acronym":4,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":385,"targetDuration":4,"studyType":387,"phases":4,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":4},"100602103","multicentric-prospective-observational-study-of-neodent-implantable-devices-of-helix-short-system-100602103","NCT07119151","Multicentric Prospective Observational Study of Neodent Implantable Devices of Helix Short System","Inclusion Criteria:\n\n* Patients with atrophic maxilla and mandible, who need of one or more dental implants with opposing dentition (natural teeth or teeth\u002Fimplant-supported fixed restorations) and who qualify for placement of Helix Short implants.\n* Collaborative patient.\n* Patient with opposing dentition (natural teeth or fixed and\u002For removable restorations)\n\nExclusion Criteria:\n\n* Contraindication according to the IFU: This product is contraindicated for patients who show signs of allergy or hypersensitivity to the chemical components of titanium. Implants with a length of 4 mm are contraindicated for single and overdenture rehabilitations, and they are contraindicated for total and multiple restorations when not associated with implants with lengths greater than or equal to 5.5 mm.\n* Patients with periodontal disease, severe alcohol\u002Ftobacco consumption, bruxism, high use of bisphosphonates or proton pump inhibitors (PPI), radiotherapy to the neck and head in the last 3 years, uncontrolled systemic diseases.\n* Pregnant patient.",{"count":386,"type":20},94,"OBSERVATIONAL","This is a post-market prospective observational study to prospectively collect clinical data to confirm the long-term safety and clinical performance of implants and abutments Helix Short in a daily dental practice setting, by means of success and survival rates of these devices. Additionally, from the collected data, the study aims to identify previously unknown side-effects and monitor the known side-effects and contraindications stated on the IFU, identify and analyze emerging risks on the basis of factual evidence, and ensure the continued acceptability of the benefit-risk ratio with the intent to verify that the intended purpose is correct for all JJGC products involved in the procedure that get in contact with the patient.",[27,390,391,392,393],"Dental Implant","Atrophy of Edentulous Alveolar Ridge","Atrophy of Edentulous Mandibular Alveolar Ridge","Atrophy of Edentulous Maxillary Alveolar Ridge","2025-08-05",{"date":396,"type":38},"2025-08-12",{"date":398,"type":20},"2025-09-01",{"date":400,"type":20},"2028-12",{"name":402,"class":45},"Neodent",{"id":404,"slug":405,"hasResults":11,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":409,"eligibilityCriteria":410,"healthyVolunteers":11,"sex":16,"minAge":411,"maxAge":412,"enrollmentInfo":413,"targetDuration":4,"studyType":21,"phases":415,"briefSummary":416,"conditions":417,"keywords":418,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":4},"100595678","assessment-of-wear-and-muscular-efficiency-of-3d-printed-versus-conventional-denture-teeth-a-cross-over-in-vivo-study-100595678","NCT07035574","Assessment of Wear and Muscular Efficiency of 3D Printed Versus Conventional Denture Teeth: A Cross-Over In Vivo Study","Assessment of the Amount of Wear and Muscular Efficiency of 3D Printed Denture Teeth Versus Conventionally Fabricated Denture Teeth: A Cross-Over In Vivo Study","3D-DENTURE","Inclusion Criteria:\n\nCompletely edentulous patients. Aged 21-70 years old. Able to read and sign the informed consent document. Class Ι maxilla-mandibular relationship. Free from temporomandibular disorders. Free from systemic diseases that could affect neuromuscular behaviors or muscular activities.\n\nEdentulous condition falls within Class I and II cases based on the Prosthodontic Diagnostic Index (PDI) classification system for complete edentulism.\n\nExclusion Criteria:\n\nPresence of major medical problems or severe chronic diseases. Poor residual ridge anatomy. Any intra-oral soft or hard tissue abnormalities. Flat, flabby, or knife-edge ridge anatomy.\n\n\\-","21 Years","70 Years",{"count":414,"type":20},13,[23],"This study aims to evaluate the wear resistance and muscular efficiency of denture teeth fabricated using two different methods: 3D printing and conventional techniques. The research is designed as a crossover in vivo study, where completely edentulous patients will receive both types of dentures sequentially. The primary outcome is the amount of wear observed in the denture teeth over time, while the secondary outcome is the muscular efficiency measured using electromyography (EMG). The study seeks to determine whether 3D printed denture teeth offer advantages in durability and functionality compared to conventionally fabricated denture teeth. Results from this study may provide valuable insights into improving the quality and comfort of dentures for edentulous patients.",[27],[419,420,421,422],"3D Printed Denture Teeth","Wear Analysis","Muscular Efficiency","Digital Dentistry","2025-06-16",{"date":425,"type":38},"2025-06-25",{"date":427,"type":20},"2025-07-01",{"date":429,"type":20},"2026-05-30",{"name":205,"class":103},{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":438,"targetDuration":4,"studyType":21,"phases":440,"briefSummary":442,"conditions":443,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":450,"locationsCount":46},"100517527","early-phase-1-a-clinical-trial-of-dental-device-cemented-with-polymethyl-methacrylate-pmma-bone-cement-100517527","NCT06018701","A Clinical Trial of Dental Device Cemented with Polymethyl Methacrylate (PMMA) Bone Cement","A Clinical Trial of Dental Device Made of Zirconia Cemented with PMMA Bone Cement on Partial Edentulous Patients of Kathmandu","Inclusion Criteria:\n\n* Adult patients (18 years old and above) who agrees for the treatment\n* Single\u002Fmultiple missing tooth\u002Fteeth (edentulism)\n* Maxillary\u002Fmandibular bone density of more than 350 Hounsfield Unit (HU)\n* Edentulous region with minimum of 2mm bone width and 5mm of bone height\n* Well controlled diabetes and hypertension\n\nExclusion Criteria:\n\n* Severe\u002FCritical medical conditions\n* Adults above 80 years old",{"count":439,"type":20},48,[441],"EARLY_PHASE1","Conventional bridge and dental implants have been playing a significant role in replacing missing tooth\u002Fteeth. But they come with shortcomings. Hence, to explore the possibility of addressing such shortcomings, a clinical trial study of a new dental device made of zirconia is intended to be studied to see if it could serve as an additional option for fixed prosthodontics. An approach to explore possibilities for cheaper and faster procedure with regards to the treatment of tooth\u002Fteeth loss.",[27],"2025-02-13",{"date":446,"type":38},"2025-02-14",{"date":448,"type":38},"2024-09-03",{"date":201,"type":20},{"name":451,"class":103},"Bluebird International Clinic",{"id":453,"slug":454,"hasResults":11,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":55,"sex":16,"minAge":460,"maxAge":461,"enrollmentInfo":462,"targetDuration":4,"studyType":21,"phases":463,"briefSummary":464,"conditions":465,"keywords":467,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":46},"100571524","evaluation-of-different-attachments-on-implant-retained-mandibular-overdenture-100571524","NCT06721377","Evaluation of Different Attachments on Implant-Retained Mandibular Overdenture.","Clinical and Radiographic Evaluation of Different Attachments on Implant-Retained Mandibular Overdenture.","Overdenture","Inclusion Criteria:\n\n* All patients' ridges should be covered with firm mucosa which is free from any signs of inflammation or ulceration.\n* Patients should be free from any bone disorder and exhibit adequate height and width of the residual alveolar ridge.\n* All patients must have sufficient inter arch space.\n\nExclusion Criteria:\n\n* Patients with oral or systemic diseases.\n* Patients with xerostomia or excessive salivation.\n* Patients with parafunctional habits (bruxism or clenching).\n* Heavy smoker or alcoholic patients.\n* Patients with history of temporo-mandibular dysfunction.\n* Patients with brain disorders or psychiatric disorders.","65 Years","69 Years",{"count":340,"type":20},[23],"Patients will be selected from the outpatient clinic of Removable Prosthodontic Department. Faculty of Dental Medicine for Girls, Al-Azhar University..\n\nEach patient will be assessed for eligibility and Informed consent will be obtained from patient after explanation of the treatment protocols and expected outcomes or alternative management.",[466,27],"Edentulism in Lower Jaw",[468,469,470,471,472],"overdenture","implant placemnent","Novaloc attachment.","Equator attachment","edentulism","2024-12-05",{"date":475,"type":38},"2024-12-06",{"date":477,"type":38},"2023-09-01",{"date":479,"type":20},"2025-01-01",{"name":481,"class":103},"Al-Azhar University",{"id":483,"slug":484,"hasResults":11,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":4,"eligibilityCriteria":488,"healthyVolunteers":11,"sex":16,"minAge":185,"maxAge":4,"enrollmentInfo":489,"targetDuration":491,"studyType":387,"phases":4,"briefSummary":492,"conditions":493,"keywords":496,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":506,"locationsCount":46},"100569009","examining-the-effects-of-removable-denture-use-in-patients-over-60-years-of-age-100569009","NCT06688669","Examining the Effects of Removable Denture Use in Patients Over 60 Years of Age","Examining the Effects of Removable Denture on Behavior and Cognitive Skills in Geriatric Patients","Inclusion Criteria:\n\n* Patients over the age of 60\n* No systemic condition that would prevent the fabrication of removable dentures\n* Need for new removable dentures for both jaws\n* Ability to read and understand the questions in the tests and surveys\n* No barriers to communication or self-expression\n* No significant physical disability affecting functionality\n* No history of cancer or surgical operation in the head and neck region\n* No conditions or medications that could limit test performance (e.g., Parkinson's disease)\n\nExclusion Criteria:\n\n* Patients under the age of 60\n* Patients who do not require new removable dentures\n* Patients whose missing teeth can be restored with fixed prosthetic restorations and who do not need removable dentures\n* Patients who are illiterate\n* Patients with systemic conditions that prevent the fabrication of removable dentures\n* Patients with conditions like Parkinson's disease that could restrict test performance or who use medications with side effects causing unwanted convulsions\n* Patients with significant balance issues, who frequently lose balance while walking\n* Geriatric patients with temporary or permanent memory loss\n* Patients with any history of cancer in the head and neck region\n* Patients with severe difficulty in communication and self-expression\n* Patients who are not willing to participate in the study",{"count":490,"type":20},40,"3 Months","Patients over the age of 60 who do not currently have any removable dentures but require them will be included in the study. Patients who will receive complete dentures and those who will receive partial dentures will be assessed in separate groups. Before the fabrication of the dentures, the Mini-Mental State Examination Test (MMSE), the physical normative value test (TUG), and the Oral Functional Capacity (OFC) scoring will be conducted. No intervention will be made to the treatment during the prosthetic treatment process.\n\nThe same questionnaires will be administered again three weeks after the completion of the prosthetic treatments. The impact of the use of removable dentures on test results will be evaluated. Additionally, during this session, patients will complete a patient satisfaction test regarding their dentures (OHIP-14 for patients with a removable partial denture indication, and OHIP-edent for patients with a complete denture indication). Patients will be called back after three months, and all tests will be repeated. The relationship between the Mini-Mental State Examination, the TUG test, and the OFC test with patient satisfaction will be assessed and any changes in test scores related to denture use will be investigated.",[27,494,495],"Denture, Complete","Denture, Partial, Removable",[66,497,498,499],"removable partial denture","OHIP-14","mini mental state examination","2024-11-12",{"date":502,"type":38},"2024-11-14",{"date":504,"type":38},"2024-10-25",{"date":326,"type":20},{"name":507,"class":103},"Istanbul University",{"id":509,"slug":510,"hasResults":11,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":515,"targetDuration":4,"studyType":387,"phases":4,"briefSummary":517,"conditions":518,"keywords":519,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":4},"100567522","success-and-safety-of-the-implant-placement-using-navigated-surgery-100567522","NCT06669286","Success and Safety of the Implant Placement Using Navigated Surgery","Retrospective Single Cohort Mono-center Study on Success and Safety of Navigated Implant Placement in Proximity of the Alveolar Nerve","Inclusion Criteria:\n\n* Implants placed in 2 mm distance or less of the alveolar nerve\n* Subject was at least 18 years old at the time of surgery\n* Subject signed consent form\n* Subject signed GDPR form\n\nExclusion Criteria:\n\n* 1-year follow-up data on treatment success not available",{"count":516,"type":20},20,"Subjects with severely atrophic mandibles were treated with implants and implant-based restorations. Subjects will be required to consent to study participation and data processing according to General Data Protection Regulation (GDPR). Implant positions were planned digitally in a dental software DTX Studio, and implants placed with navigated surgery (Nobel Biocare X-Guide). Implants eligible for this study must be placed 2 mm or less from the alveolar nerve. Implants placed are NobelParallel TiUnite and NobelActive TiUnite. All subjects were followed up for 1 year after surgery to monitor success and adverse events related to the alveolar nerve. Data analysis will include demographics, medical history, Cone-beam Computed Tomography (CBCT) scans\u002Fperi-apical x-ray data, soft tissue parameters, and adverse events.",[27],[520,521,522],"navigated surgery","alveolar nerve","implant placement","2024-10-30",{"date":525,"type":38},"2024-11-01",{"date":527,"type":20},"2024-12-31",{"date":529,"type":20},"2025-07-30",{"name":531,"class":103},"Roberto Villa",{"id":533,"slug":534,"hasResults":11,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":540,"targetDuration":4,"studyType":21,"phases":541,"briefSummary":543,"conditions":544,"keywords":547,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":46},"100558561","phase-1-pilot-study-on-the-effectiveness-of-a-flexible-hydroxyapatite-based-composite-for-jaw-bone-regeneration-100558561","NCT06552715","Pilot Study on the Effectiveness of a Flexible Hydroxyapatite-Based Composite for Jaw Bone Regeneration","Pilot Clinical Study on the Efficacy of a Flexible Hydroxyapatite-Based Composite for the Regeneration of Jaw Bone Defects","Flexi2024","Inclusion Criteria:\n\n* Patients with partially edentulous and atrophic jaws, requiring implant-prosthetic rehabilitation (from 1 to 3 implants), classified as Seibert Class II or III, and needing a GBR bone regeneration intervention with defects not exceeding 7 mm in height\n* Age 18 years or older\n* Obtaining informed consent\n\nExclusion Criteria:\n\n* Patients who have received radiation therapy to the head and neck with more than 70 Gray.\n* Immunocompromised and immunosuppressed patients.\n* Patients treated with or currently receiving intravenous amino-bisphosphonates.\n* Patients with poor oral hygiene and lack of motivation.\n* Uncontrolled diabetes.\n* Pregnancy or breastfeeding.\n* Drug or alcohol dependence.\n* Psychiatric conditions that contraindicate surgical treatment.\n* Limited mouth opening (less than 3.5 cm distance between the two arches in the anterior area).\n* Patients with acute or chronic inflammation\u002Finfection at the implant site.\n* Patients referred solely for implant placement.",{"count":516,"type":20},[542],"PHASE1","Following a review of the scientific literature, it was found that there are no clinical studies but only in vitro and in vivo studies, which show promising results in terms of bone formation and integration. However, it is necessary to evaluate how well the regenerated bone maintains its structural integrity over time, considering masticatory function and real-life biomechanics. Factors such as mechanical load, remodeling dynamics, and interactions with surrounding tissues could influence the long-term stability of the regenerated bone. Additionally, another important aspect to study is the potential complications and adverse effects associated with the use of the flexible HAp-based composite.",[545,27,546],"Bone Atrophy","Bone Regeneration",[548,192,549],"bone regeneration","jaws atrophy","2024-08-09",{"date":552,"type":38},"2024-08-14",{"date":554,"type":20},"2024-09",{"date":556,"type":20},"2025-09",{"name":558,"class":103},"University of Bologna",{"id":560,"slug":561,"hasResults":11,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":565,"eligibilityCriteria":566,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":567,"targetDuration":569,"studyType":387,"phases":4,"briefSummary":570,"conditions":571,"keywords":572,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":578,"lastUpdatePostDateStruct":579,"startDateStruct":581,"completionDateStruct":583,"leadSponsor":585,"locationsCount":587},"100538170","5-years-pmcf-study-of-ceramic-dental-implants-one-piece-versus-two-piece-100538170","NCT06287346","5-Years PMCF Study of Ceramic Dental Implants One-piece Versus Two-piece.","5-Years Multicentric Prospective Post-Market Clinical Follow-up (PMCF) Comparative Study of CeraRoot Ceramic Dental Implants One-piece Versus Two-piece.","240101","Inclusion Criteria:\n\n* Clinical Diagnosis of partial or total edentulism.\n* Specially indicated for patients with metal allergies and chronic illness due to metal allergies.\n\nExclusion Criteria:\n\n1. General Contraindications:\n\n   1. Local and Systemic contraindications for surgery.\n   2. Poor oral hygiene\n   3. Patients with health problems, disease or any physical or psychological condition to which an oral surgery may be contraindicated.\n2. Relative Contraindications:\n\n   1. Previously irradiated bone\n   2. diabetes\n   3. anticoagulant medication\n   4. hemodynamic problems\n   5. bruxism\n   6. Para functional habits\n   7. bad bone anatomy\n   8. smokers\n   9. none controlled periodontitis\n   10. malocclusions\n   11. TMJ problems\n   12. diseases in the oral cavity\n   13. pregnancy\n   14. insufficient oral hygiene for adequate health.\n3. Local contraindications\n\n   1. insufficient bone quantity or quality\n   2. remaining of roots\n   3. localized periodontal disease\n   4. Any pathology in the neighboring teeth.",{"count":568,"type":20},652,"1 Year","The goal of this cohort observational study is to compare in the survival rate of ceramic dental implants placed in patients with missing or hopeless teeth . The main question\\[s\\] it aims to answer are:\n\n* Are there any significant differences in survival rate between the use of one-piece ceramic implant versus the two-piece (TL) variant?\n* What are the complications associated to the procedure and differences between the two groups.",[27,26],[573,574,575,576,577],"dental implant","ceramic dental implant","zirconia implant","y-tzp","metal-free","2024-02-29",{"date":580,"type":38},"2024-03-01",{"date":582,"type":38},"2024-01-01",{"date":584,"type":20},"2030-01-01",{"name":586,"class":45},"CeraRoot SL",2]