[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"edentulous-alveolar-ridge\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:edentulous-alveolar-ridge":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,46,75,96,116,144,172,196,214],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100517017","two-piece-zirconia-implants-with-two-various-platforms-100517017",false,"NCT06012071","Two-piece Zirconia Implants With Two Various Platforms","Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial","ZircImpl","Inclusion Criteria:\n\n* Single missing maxillary premolar\n* Occlusal stability\n* Good oral hygiene\n* Good general health\n\nExclusion Criteria:\n\n* Oral mucosa pathology\n* Dental caries\n* Active periodontitis (non-treated)\n* Systemic diseases and conditions that affect healing or immune capacity",true,"ALL","25 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","24 patients with missing premolar teeth and healed sockets will be recruited. They will be randomized into two groups to supplied with tissue-level (n=12) or bone-level (n=12) 10-mm long 4-mm wide zirconia implants. Primary and secondary stabilities will be measured with International Stability Quotient (ISQ) device. After 3 months, ceramic crowns will be supplied. Implant survival rates and parameters in relation to periimplant soft-tissues and bone health and anatomy will be recorded and evaluated after 1, 3 and 5 years.",[28],"Edentulous Alveolar Ridge",[30,31,32],"dental implants","zirconia","two-piece","RECRUITING","2026-05-05",{"date":36,"type":37},"2026-05-06","ACTUAL",{"date":39,"type":37},"2022-07-03",{"date":41,"type":22},"2027-12-03",{"name":43,"class":44},"University of Ljubljana","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":18,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":71,"leadSponsor":73,"locationsCount":45},"100600967","freeze-dried-bone-allograft-vs-autologous-bone-blocks-in-the-lateral-augmentation-of-the-jaws-100600967","NCT07104370","Freeze-dried Bone Allograft vs Autologous Bone Blocks in the Lateral Augmentation of the Jaws","Comparison of Freeze-dried Bone Allograft and Autogenous Bone Blocks in the Surgical Reconstruction of Horizontally Atrophied Jaws for Implant Placement: Randomized Clinical Trial","Inclusion Criteria:\n\n* over 18 years old\n* require lateral augmentation for implant rehabilitation\n\nExclusion Criteria:\n\n* Smoking\n* Pregnancy\n* Poor oral hygiene\n* Failure to attend follow-up visits\n* Therapeutic-dose irradiation to the head and neck region\n* Local bone tumors, cysts, or inflammatory processes\n* Decompensated systemic diseases contraindicate surgery\n* Use of medications affecting bone metabolism (steroids, antiresorptive medications such as bisphosphonates, RANKL inhibitor antibodies, VEGF antagonists)\n* Psychiatric disorders contraindicate implant rehabilitation","18 Years",{"count":55,"type":22},30,[25],"After tooth loss, the alveolar ridge undergoes various modeling and remodeling processes, resulting in overall bone resorption. In case of extensive alveolar atrophy, bone volume must be restored before or during implant placement to achieve successful dental rehabilitation and maximize implant survival and success rates. One possible method for reconstructing severe bone resorption is block bone augmentation.\n\nDue to its biological properties, autologous bone is considered the \"gold standard\" among bone graft materials, as it possesses osteoinductive, osteoconductive, and osteogenic properties.\n\nThe advantages of using allografts over autologous bone grafts include reduced postoperative morbidity, decreased surgical time, and the absence of anatomical limitations regarding the amount of bone that can be harvested. The disadvantage of allografts is the loss of viable osteogenic cells and osteoinductive factors during processing.\n\nThe aim of the study is:\n\n* to compare the success of the bone augmentation surgery depending on whether freeze-dried bone allograft blocks or autologous bone blocks are used,\n* compare the microarchitecture of the augmented bone depending on the bone graft material applied,\n* to evaluate the success of dental implants placed in the augmented bone and that of the prostheses delivered on the dental implants.",[28,59],"Edentulous Alveolar Ridge Atrophy",[61,62,63,64,65,66],"autologous bone","retromolar area","bone block","bone augmentation","dental implant","freeze-dried bone allograft","2025-09-29",{"date":69,"type":37},"2025-10-03",{"date":67,"type":37},{"date":72,"type":22},"2033-09-01",{"name":74,"class":44},"Semmelweis University",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":18,"minAge":53,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":45},"100602508","the-impact-of-the-adequacy-of-keratinized-mucosa-on-peri-implant-tissue-health-and-patient-reported-outcomes-100602508","NCT07124416","The Impact of the Adequacy of Keratinized Mucosa on Peri-implant Tissue Health and Patient-reported Outcomes","Inclusion Criteria:\n\n* Individuals aged 18 to 70 years (inclusive of 18 and 70 years), of any gender;\n* Patients who have undergone dental implant restoration是（single crown or fixed bridge restorations） at the Stomatology Hospital, Zhejiang University School of medicine and have had their final restoration for at least 6 months;\n* Patients who voluntarily participate and sign the informed consent form after being fully informed, and who cooperate with relevant examinations.\n\nExclusion Criteria:\n\n* Patients who are unwilling to participate in the follow-up of this study for various reasons","90 Years",{"count":83,"type":22},150,"OBSERVATIONAL","This study aims to conduct a cross-sectional study to compare the differences in clinical indices, patient-reported outcomes, and levels of inflammatory factors in peri-implant gingival crevicular fluid between sites with adequate (≥ 2 mm) and inadequate (\\\u003C 2 mm) keratinized mucosa after implant restoration, in order to explore the impact of the presence of keratinized mucosa on peri-implant soft and hard tissue health.",[28],"2025-08-08",{"date":89,"type":37},"2025-08-15",{"date":91,"type":37},"2025-07-10",{"date":93,"type":22},"2026-12",{"name":95,"class":44},"The Dental Hospital of Zhejiang University School of Medicine",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":18,"minAge":53,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":45},"100578240","clinical-influence-of-different-surface-treatments-on-implant-stabiity-100578240","NCT06808724","Clinical Influence of Different Surface Treatments on Implant Stabiity","Clinical Influence of Different Surface Treatments on Implant Stabiity: a Prospective Observational Clinical Study","Inclusion Criteria:\n\n* Age older than 18 years old;\n* Indication for an implant-supported rehabilitation in the left and right upper premolar\u002Ffirst molar areas;\n* The area in which the implants will be placed must have had at least 6 months of healing;\n* No use of grafts or bone substitutes following tooth extraction;\n* Bone volume measuring at least 10 mm in height and 6 mm in width;\n* Absence or decision to not wear a removable prosthesis during the healing period;\n* Patients with good and stable oral hygiene;\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Acute myocardial infarction within the previous six months;\n* Uncontrolled bleeding disorders;\n* Uncontrolled diabetes (HBA1c \\> 7.5%);\n* Radiotherapy in the head-neck area in the previous 48 months;\n* Immunocompromised patients (es. AIDS \u002F chemotherapy);\n* Current or previous treatment with antiresorptive drugs via intravenous injection;\n* Psychological or psychiatric disease;\n* Alcohol and \u002For drugs abuse;\n* Heavy smokers (more than 10 cigarettes \u002F day);\n* Plaque index \\>20% and\u002For bleeding on probing \\>10%\n* Pregnant or breastfeeding patients;\n* Patients refusing to participate in follow-up checks.",{"count":104,"type":22},32,"The goal of this observational study is to monitor, within a cohort of patients requiring rehabilitation at two different sites in the premolar area, the primary and secondary stability of implants placed with different surface treatments: vacuum-plasma activation, ozonated oil and non-activated implants.",[28],"2025-02-04",{"date":109,"type":37},"2025-02-05",{"date":111,"type":37},"2025-01-31",{"date":113,"type":22},"2030-12-31",{"name":115,"class":44},"International Piezosurgery Academy",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":17,"sex":18,"minAge":53,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":45},"100421321","phase-4-behavioral-comparison-of-three-different-graft-materials-to-increase-soft-tissue-thickness-around-dental-implants-100421321","NCT04766255","Behavioral Comparison of Three Different Graft Materials to Increase Soft Tissue Thickness Around Dental Implants.","Behavioral Comparison of Three Different Graft Materials to Increase Soft Tissue Thickness Around Dental Implants in Terms of Volume Gain and Stability Over Time: A Randomized Clinical Trial.","Inclusion Criteria:\n\nPatients referred to Department of Periodontology (CUO) in need of a single implant and need of soft tissue augmentation such as buccal defects, thin biotype, lack of keratinized tissue and aesthetic compromised situation.\n\n* The patient must be ≥18 years and able to understand the nature of the proposed surgery and must sign an informed consent.\n* The implant must be located between 2 fixed reference points (i.e. clinical crowns).\n* Anterior and premolar teeth (from premolar to premolar).\n* Enough crestal bone width to leave a minimum thickness of 2mm at the buccal bone plate when placing the implant.\n* Palate must have ≥2mm of thickness at premolar area.\n* Full mouth plaque and bleeding score \\\u003C20%.\n\nExclusion Criteria:\n\n* Pregnant or lactation.\n* Active periodontal disease.\n* Previous soft tissue augmentation in the area.\n* Need of guided bone regeneration (GBR) during or after the placement of the implant.\n* Heavy smokers (\\> 10 cigarettes per day).\n* Local or systemic conditions that would interfere with routine periodontal therapy (non-controlled diabetes mellitus, cancer, HIV, Chronic High dose steroid therapy, bone metabolic diseases, radiation, immunosuppressive disorders, liver function disorder, immunosuppressant disease, autoimmune disease).\n* Allergy to non-steroidal anti-inflammatory drugs.\n* Patients taking medications that cause gingival enlargement.",{"count":124,"type":22},60,[126],"PHASE4","The purpose of the study is to compare soft tissue volume changes in terms of volume gain and stability around dental implants and PROMS in cases where a sub-epithelial connective tissue graft (SCTG) from the palate, Porcine collagen matrix (CM) or Porcine Acellular dermal matrix (PADM) is used after 3 and 15 months after implant placement.",[129,130,28],"Soft Tissue Atrophy","Mucogingival Deformity on Edentulous Ridge",[132,133,134],"soft tissue graft","acellular dermal graft","collagen matrix","2024-12-05",{"date":137,"type":37},"2024-12-11",{"date":139,"type":37},"2021-05-01",{"date":141,"type":22},"2026-12-30",{"name":143,"class":44},"Universitat Internacional de Catalunya",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":17,"sex":18,"minAge":53,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":171},"100550620","zero-echo-time-mr-for-the-assessment-of-maxillary-sinus-and-dental-regions-100550620","NCT06449443","Zero Echo Time MR for the Assessment of Maxillary Sinus and Dental Regions","Zero Echo Time MR for the Assessment of Maxillary Sinus, Bone and Soft Tissues in the Maxillary Premolar and Molar Areas","ZTE-DENTAL","Inclusion Criteria:\n\n* Missing teeth in the maxillary premolar and molar regions\n* Cone-beam computed tomography images of the tooth-deficient area\n* Do not have any systemic disease that may affect periodontal tissues (diabetes, rheumatoid arthritis, etc.)\n* Over the age of 18\n* Individuals who approved the informed consent form\n\nExclusion Criteria:\n\n* All maxillary teeth missing\n* With active periodontitis\n* Under 18 years of age\n* Individuals who did not approve the informed consent form.",{"count":153,"type":22},20,"The aim of this study is to evaluate the efficacy of zero echo time magnetic resonance imaging (ZTE MRI) as an ionizing radiation-free diagnostic method to evaluate both hard and soft tissues and maxillary sinus region before dental implants in the posterior maxillary region.",[28],[157,158,159,160,161],"ZTE MRI","CBCT","Intraoral Scanner","Maxillary Posterior Zone","Dental Implant","2024-09-30",{"date":164,"type":37},"2024-10-01",{"date":166,"type":37},"2024-07-01",{"date":168,"type":22},"2025-12-01",{"name":170,"class":44},"Hacettepe University",2,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":17,"sex":18,"minAge":179,"maxAge":180,"enrollmentInfo":181,"targetDuration":4,"studyType":23,"phases":183,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100560761","gfrc-enhance-patient-satisfaction-and-reduce-complications-in-maxillary-implants-with-pekkton-frameworks-100560761","NCT06581354","GFRC Enhance Patient Satisfaction and Reduce Complications in Maxillary Implants With Pekkton Frameworks","The Impact of Provisionalization Using Glass Fiber Reinforced Composite on Patient Satisfaction and Prosthetic Complications in Maxillary Implant-Supported Arches Restored by Definitive Pekkton Frameworks","Inclusion Criteria:\n\n* a. Completely edentulous patients with Angle's Class I maxillomandibular relationship b. Age ranges from 40 to 65 years old. c. Adequate zone of keratinized attached mucosa (≥ 8mm) over the maxillary crest.\n\n  d. Absence of any medical disorder that could complicate the surgical phase or affect osseointegration.\n\n  e. The patient must have enough bone height for implants, a minimum length of bone f. 12 mm, and a minimum diameter of bone 6 mm. g. Patients with good oral hygiene. h. Complete denture wearer. i. Adequate interarch space for screw-retained prosthesis. j. Absence of any intra-oral pathological condition.\n\nExclusion Criteria:\n\n\\- a. Patients with recent extraction (less than three months). b. Patients with an inflamed ridge or candida infection c. Patients with the flabby ridge. d. Para functional habits. e. Cancer patients receiving chemotherapy and\u002For radiotherapy. f. Patients with uncontrolled diabetes, assessed by measuring glycosylated hemoglobin (HbA1c ≥ 7) g. Potentially uncooperative patients who are not willing to go through the proposed interventions.\n\nh. Moderate-to-heavy daily smokers (more than ten per day)","40 Years","65 Years",{"count":182,"type":22},8,[25],"This study aims to evaluate the effect of provisionalization with a glass fiber composite framework on patient satisfaction and prosthetic complications before the insertion of a definitive PEKKTON framework when used under the screw-retained maxillary implant-supported prostheses at a one-year follow-up period.",[28],"NOT_YET_RECRUITING","2024-08-29",{"date":189,"type":37},"2024-09-03",{"date":191,"type":22},"2024-09-01",{"date":193,"type":22},"2025-11-01",{"name":195,"class":44},"Cairo University",{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":17,"sex":18,"minAge":179,"maxAge":180,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":186,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":4},"100560410","the-effect-of-fiber-reinforced-composites-on-quality-of-life-and-bone-height-in-maxillary-implant-arches-100560410","NCT06576778","The Effect of Fiber-Reinforced Composites on Quality of Life and Bone Height in Maxillary Implant Arches","The Impact of Provisionalization Using Fiber-Reinforced Composite on the Quality of Life and Bone Height Changes in Maxillary Implant Supported Arches Restored by Final PEKKTON Frameworks: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • Completely edentulous patients with Angle's Class I maxillomandibular relationship\n\n  * Age ranges from 40 to 65 years old.\n  * Adequate zone of keratinized attached mucosa (≥ 8mm) over the maxillary crest.\n  * Absence of any medical disorder that could complicate the surgical phase or affect osseointegration.\n  * The patient must have enough bone height for implants, a minimum length of bone\n  * 12 mm, and a minimum diameter of bone 6 mm.\n  * Patients with good oral hygiene.\n  * Adequate inter arch space for screw-retained prosthesis.\n  * Absence of any intra-oral pathological condition.\n\nExclusion Criteria:\n\n* • Patients with recent extraction (less than three months).\n\n  * Patients with an inflamed ridge or candida infection\n  * Patients with the flabby ridge.\n  * Para functional habits.\n  * Cancer patients receiving chemotherapy and\u002For radiotherapy.\n  * Patients with uncontrolled diabetes, assessed by measuring glycosylated hemoglobin (HbA1c ≥ 7)\n  * Potentially uncooperative patients who are not willing to go through the proposed interventions.\n  * Moderate-to-heavy daily smokers (more than ten per day)",{"count":182,"type":22},[25],"The aim of this study is assessing the effect of provisionalization with a glass fiber composite framework on patients' quality of life and bone height changes before the insertion of a definitive PEKKTON framework of screw-retained maxillary implant-supported prosthesis at a one-year follow-up period.",[28],"2024-08-27",{"date":187,"type":37},{"date":210,"type":22},"2024-09",{"date":212,"type":22},"2025-11",{"name":195,"class":44},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":17,"sex":18,"minAge":53,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":229,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":45},"100558662","soft-tissue-response-to-different-restorative-materials-used-in-implant-dentistry-100558662","NCT06554041","Soft Tissue Response to Different Restorative Materials Used in Implant Dentistry","Inclusion Criteria:\n\n* Participants must be 18 years or older.\n* Participants must be edentulous with at least four missing teeth in the posterior region of the mandible or maxillae.\n* Participants must have appropriate oral hygiene and periodontal status of natural teeth, with a pocket depth of 4mm or less and no bleeding.\n* Dental implants must be fully integrated with no bone resorption or inflammation after three months of implant placement, confirmed by X-ray and clinical examination.\n* Implant placement must be into natural bone without additional procedures such as sinus lift or bone augmentation.\n* The procedure must be a standard implantation with no immediate implant placement.\n* The height of the gingiva must be at least 3mm or more.\n\nExclusion Criteria:\n\n* Patients with systemic diseases such as malignancy, diabetes, osteoporosis, or rheumatoid arthritis.\n* Patients with a history of periodontal treatment.\n* Patients who smoke or use tobacco.\n* Patients who have received antibiotic treatment within three months prior to implantation.\n* Pregnant individuals.",{"count":221,"type":22},40,[25],"The goal of this clinical trial is to learn how different materials used in dental implants affect the surrounding gum tissue in adults who need dental implants. The main questions it aims to answer are:\n\nHow do different materials (titanium, PEEK, zirconia, and lithium disilicate) affect inflammation around dental implants? What changes occur in inflammation markers in the gum tissue after 3 and 6 months? Researchers will compare the different materials to see which one causes the least amount of inflammation.\n\nParticipants will:\n\nReceive dental implants made from different materials. Have samples of fluid from around their implants collected for analysis at 3 and 6 months.\n\nUndergo regular dental check-ups to measure gum health, such as bleeding and pocket depth around the implants.",[28,225,226,227,228],"Peri-Implantitis","Peri-implant Mucositis","Prosthetic Infection","Prosthetic Complication",[230,231,232,233,234],"Dental Implants","Peri-Implant Soft Tissue","Prosthetic Materials","Inflammation Markers","Oral Health","2024-08-12",{"date":237,"type":37},"2024-08-14",{"date":239,"type":37},"2023-08-23",{"date":241,"type":22},"2026-01-01",{"name":243,"class":44},"Harvard Medical School (HMS and HSDM)"]