[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"edentulous-mouth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:edentulous-mouth":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,41,68,97,127,153,186],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100527578","changes-in-microbial-status-from-dentate-edentulous-and-after-dental-implant-placement-100527578",false,"NCT06149585","Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement","Inclusion Criteria:\n\n1. At least 21 years of age\n2. Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays\n3. Planned for full mouth extraction and replacement by dental implants.\n4. Rehabilitation with Implant supported restorations either maxilla and\u002F or mandible.\n5. At least 2 implants available for examination.\n6. No bone augmentation required.\n\nExclusion Criteria:\n\n1. Conditions requiring chronic routine prophylactic use of antibiotics.\n2. Conditions requiring prolonged use of steroids.\n3. History of leukocyte dysfunction and deficiencies\n4. Bleeding disorders\n5. History of neoplastic disease requiring use of radiation or chemotherapy\n6. Metabolic bone disorders\n7. Uncontrolled endocrine disorder\n8. Use of any investigational drug or device within the 30 day period prior to implant surgery.\n\n10\\. Alcoholism or drug abuse 11. Patient infected with HIV 12. Condition or circumstances, in the opinion of the investigator, which would prevent completion of study participation or interfere with analysis of study results, such as history of non-compliance, unreliability.\n\nLocal Exclusion Criteria\n\n1. Local inflammation\n2. Mucosal disease such as erosive lichen planus\n3. History of local irradiation therapy\n4. Osseous lesion.\n5. Active infection with suppuration or fistula track.\n6. Persistent intraoral infection different than periodontitis",true,"ALL","21 Years",{"count":19,"type":20},12,"ESTIMATED","OBSERVATIONAL","The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material\u002Fsurface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.",[24,25,26,27],"Edentulous Mouth","Periodontal Diseases","Periodontitis, Adult","Microbial Colonization","RECRUITING","2026-06-29",{"date":31,"type":32},"2026-07-01","ACTUAL",{"date":34,"type":32},"2023-08-16",{"date":36,"type":20},"2028-05-01",{"name":38,"class":39},"Case Western Reserve University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":40},"100642830","clinical-outcomes-of-3d-printed-and-milled-complete-dentures-100642830","NCT07586774","Clinical Outcomes of 3D Printed and Milled Complete Dentures","An Open, Single-center, Prospective, Randomized, Two-armed, Interventional, Post-market Clinical Investigation of 3D Printed Complete Dentures and Milled Complete Dentures During a 5-year Follow-up Period","Inclusion Criteria:\n\n* Adult aged 18 years or above at time of informed consent.\n* Subject willing to participate in the clinical investigation and able to understand the content of the clinical investigation.\n* Subject willing to comply with investigational related procedures and to return for follow-up visits for a period of 5 years.\n* Subject has signed and dated the informed consent form.\n* Subjects in need of complete dentures in maxilla and mandible.\n* Prosthodontic Diagnostic Index (PDI) Completely edentulous classification (Class 1-3).\n* History of edentulism of at least 1 year.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to any of the components.\n* Subjects with significant systemic health issues or chronic conditions (American Society of Anesthesiologists (ASA) class 3-6 ).\n* Known pregnancy at time of enrolment.\n* Subjects unlikely to comply with investigational procedures, or unlikely to come back for follow-up visits, as judged by the Investigator.\n* Previous enrolment in the present clinical investigation.\n* Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n* PDI Completely edentulous classification (Class 4)\n\n  * Presence of severely atrophied ridge.\n  * Presence of severe ridge undercuts.\n  * Clinically severe Xerostomia.\n  * Absence of hard or soft tissue pathology that precludes denture therapy.\n  * Maxillofacial defects.\n* Uncontrolled pathological process in the oral cavity, as judged by the Investigator.\n* Participation in another clinical investigation that may interfere with the present clinical investigation.","18 Years",{"count":50,"type":20},68,"INTERVENTIONAL",[53],"NA","This is a two-armed, single-center clinical study evaluating performance, efficacy and safety of three dimensional (3D) printed complete dentures and milled complete dentures during a 5-year follow-up period. The primary objective of this clinical investigation is to evaluate survival rate, i.e. subjects with survived dentures in both upper and lower jaw, of 3D printed complete dentures and milled complete dentures after 1 year (in each of the groups separately).",[24,56],"Edentulous Jaw","NOT_YET_RECRUITING","2026-06-05",{"date":60,"type":32},"2026-06-08",{"date":62,"type":20},"2026-05-30",{"date":64,"type":20},"2032-10-30",{"name":66,"class":67},"Dentsply Sirona Implants and Consumables","INDUSTRY",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":51,"phases":79,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100639347","comparasion-of-dental-anxiety-in-first-time-complete-denture-patients-100639347","NCT07597057","Comparasion of Dental Anxiety in First Time Complete Denture Patients","Comparison of Dental Anxiety Level in Edentulous Patients Before and After Seeking Complete Denture Treatment for the First Time: A Quasi-Experimental Study","Inclusion Criteria: Edentulous patients (missing all teeth) requiring first-time complete dentures.\n\nExclusion Criteria: History of previous denture use, severe cognitive impairment, or systemic diseases contraindicating dental procedures.","40 Years","70 Years",{"count":78,"type":20},70,[53],"This quasi-experimental study compares dental anxiety levels in edentulous patients at two specific clinical points: the primary impression appointment and the denture insertion appointment. The study aims to determine if the process of receiving first-time complete dentures significantly impacts patient anxiety levels. Data will be collected from 70 participants at the Khyber College of Dentistry over a five-week interval between the two appointments",[24,82],"Dental Anxiety",[84,85,86,87],"complete denture","dental anxiety scale","prosthodontics","edentulism","2026-05-13",{"date":90,"type":32},"2026-05-19",{"date":92,"type":20},"2026-05-01",{"date":94,"type":20},"2026-12-30",{"name":96,"class":39},"Khyber College of dentistry",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100636635","changes-in-oral-health-related-quality-of-life-ohrqol-during-full-arch-implant-treatment-a-prospective-study-100636635","NCT07568249","Changes in Oral Health-related Quality of Life (OHRQoL) During Full Arch Implant Treatment: A Prospective Study","Inclusion Criteria:\n\n* Systemically good health and absence of contraindications for implant therapy, with indication to be rehabilitated with at least one FASISR - maxilla or mandible.\n\nExclusion Criteria:\n\n\\-",{"count":104,"type":20},100,"Full arch implant-supported fixed dental prosthesis is widely accepted as a treatment modality for edentulous patients, presenting high long-term implant survival rates, although further research is necessary to evaluate patient satisfaction on a longer term and the psycho-social impact of this treatment on the daily life and functioning of patients. Patient-related outcome measures evaluated through oral health-related quality of life (OHRQol) parameters, patient satisfaction and patient preference allows to evaluate the impact of the prosthodontic needs.",[24,107,108,109],"Quality of Life","Tooth Loss","Oral Health Quality of Life (OHQoL) Was Assessed",[111,112,113,114,115,116],"dental implant","oral health","outcome studies","oral quality of life","OHIP-14","Implant-supported prosthesis","2026-04-28",{"date":119,"type":32},"2026-05-05",{"date":121,"type":32},"2025-11-01",{"date":123,"type":20},"2028-10-01",{"name":125,"class":39},"Implantology Institute",2,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":15,"sex":16,"minAge":134,"maxAge":76,"enrollmentInfo":135,"targetDuration":4,"studyType":51,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":126},"100612632","occlusion-and-dis-occlusion-time-in-mandibular-overdentures-supported-by-conventional-versus-mini--dental-implants-100612632","NCT07256106","Occlusion and Dis-Occlusion Time in Mandibular Overdentures Supported by Conventional Versus Mini- Dental Implants","Evaluation of The Occlusion and Dis-Occlusion Time in Mandibular Single Overdentures Supported by Conventional Versus Mini- Dental Implants; A Parallel Blinded Randomized Clinical Trial","Inclusion Criteria:\n\n* patients with completely edentulous mandibular ridges and fully dentate or partially dentate maxillary arch restored with fixed restoration,\n\n  * enough inter-arch space to allow for prosthetic rehabilitation with lower implant-retained overdentures\n  * good oral hygiene and motivation.\n\nExclusion Criteria:\n\n* The excluded patients will be patients with major systemic diseases that may affect osseointegration as uncontrolled diabetes mellitus, pregnancy, patients under bisphosphonate treatment.","55 Years",{"count":136,"type":20},28,[53],"The aim of the study will be comparing between the occlusion and disocclusion time in mandibular single overdenture supported with immediately loaded two conventional implants versus immediately loaded four mini-implants.\n\nResearch question Is there a difference in occlusion and disocclusion time between two mandibular single dentures, one supported by immediately loaded two conventional implants and the second one supported by immediately loaded four mini-implants? Primary outcome: occlusion and disocclusion time Secondary outcome: Kapur index The null hypothesis is that there is no difference between both treatment modalities on occlusion and disocclusion time.",[140,24],"Dental Implant",[142,143],"occlusion time","disocclusion time","2025-12-28",{"date":146,"type":32},"2025-12-30",{"date":148,"type":32},"2025-11-29",{"date":150,"type":20},"2026-04-15",{"name":152,"class":39},"Ain Shams University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":4,"eligibilityCriteria":159,"healthyVolunteers":15,"sex":16,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":51,"phases":164,"briefSummary":165,"conditions":166,"keywords":171,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":40},"100571701","evaluation-of-bone-changes-around-implants-in-patients-treated-with-all-on-four-100571701","NCT06723678","Evaluation of Bone Changes Around Implants in Patients Treated With All on Four","Radiographic Evaluation of Crestal Bone Changes Around Implants in Patients Treated With Delayed Loaded All on Four (Randomized Clinical Trail)","Inclusion Criteria:\n\n* All patients' ages must range from 50-65 years old.\n* All patients' ridges should be covered with firm mucosa free from any signs of inflammation or ulceration and exhibit adequate height and width of the residual alveolar ridge.\n* Patients should be free from any metabolic or bone disorders that contraindicate implant installation.\n* All patients must have sufficient inter arch space\n\nExclusion Criteria:\n\n* Patients with oral or systemic diseases.\n* Patients with xerostomia or excessive salivation.\n* Patients with parafunctional habits (bruxism or clenching).\n* Heavy smoker or alcoholic patients.\n* Patients with history of temporo-mandibular dysfunction.\n* Patients with brain disorders or psychiatric disorders","50 Years","65 Years",{"count":163,"type":20},16,[53],"The Goal of the clinical trail is to evaluate the Bone height changes around two axially placed anterior implants and two distally inclined 30-degree angle posterior implants in comparison to two axially placed anterior implants and two distally inclined 45-degree angle posterior implants using cone beam CT (CBCT).\n\nPatients will visit the clinic after the surgery and after the framework and denture insertion for check ups and during the follow up periods ( at denture insertion, 6 months and 12 months)",[167,168,169,140,170,24],"Edentulous Alveolar Ridge In Mandible","Complete Edentulism","All on Four Technique","Edentulous Jaws",[172,173,174,175,176],"Completely edentulous patients","Dental Implants","All on four technique","Fixed Detachable Prosthesis","screw retained prosthesis","2024-12-08",{"date":179,"type":32},"2024-12-12",{"date":181,"type":32},"2024-11-26",{"date":183,"type":20},"2026-01-01",{"name":185,"class":39},"Al-Azhar University",{"id":187,"slug":188,"hasResults":11,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":48,"maxAge":4,"enrollmentInfo":192,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":194,"conditions":195,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":40},"100468074","real-life-evaluation-of-the-safety-and-performance-of-euroteknika-dental-implants-100468074","NCT05375045","Real-life Evaluation of the Safety and Performance of EUROTEKNIKA Dental Implants","Inclusion Criteria:\n\n* Patient aged 18 or over\n* Patient who has completed bone growth\n* Patient informed and agreeing to participate in the study\n* Partially or totally edentulous patient who will be implanted with the EUROTEKNIKA dental implant (for the prospective cohort)\n* Patient to benefit from the placement of an implant for the creation of a single crown (for the prospective cohort)\n* Patient implanted with the EUROTEKNIKA dental implant before 2017 (for the retrospective cohort)\n* Patient having benefited from the placement of an implant for the creation of a single crown (for the retrospective cohort)\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women (for the prospective cohort)\n* Patient with bone disease in the cervico-facial region\n* Patient refusing to participate in the study\n* Patient with at least one contraindication to implantation (for the prospective cohort)\n* Patient to benefit from the placement of an implant with immediate or early loading (for the prospective cohort)\n* Patient to benefit from the placement of an implant for the support of the bridge, piles, attachment (for the prospective cohort)\n* Patient having benefited from the placement of an implant with immediate or early loading (for the retrospective cohort)\n* Patient having benefited from the placement of an implant for the support of the bridge, piles, attachment (for the retrospective cohort)",{"count":193,"type":20},868,"Real-life evaluation of the safety and performance of EUROTEKNIKA dental implants",[24],"2022-05-10",{"date":198,"type":32},"2022-05-16",{"date":200,"type":32},"2022-03-25",{"date":202,"type":20},"2028-02-01",{"name":204,"class":67},"Euroteknika"]