[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"effort\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:effort":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100626608","impact-of-peep-on-respiratory-effort-during-assisted-ventilation-100626608",false,"NCT07437846","Impact of PEEP on Respiratory Effort During Assisted Ventilation","Impact of Positive End-Expiratory Pressure on the Modulation of Respiratory Effort During Assisted Ventilation: A Physiological Randomized Crossover Study","PEEP-EFFORT","Inclusion criteria:\n\n* Age ≥18 years.\n* ICU patients receiving invasive mechanical ventilation (endotracheal tube or tracheostomy).\n* Ventilated in an assisted mode with spontaneous breathing\n* Clinically stable to undergo protocolized PEEP changes.\n* Sedation level compatible with spontaneous breathing and ventilator triggering\n* Informed consent from the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Contraindication to esophageal balloon placement (if applicable).\n* Significant hemodynamic instability or unstable vasopressor requirements.\n* Unstable arrhythmia or active myocardial ischemia.\n* Undrained pneumothorax or major air leak.\n* Controlled ventilation without effective spontaneous effort (apnea, neuromuscular blockade, deep sedation).\n* Pregnancy\n* Acute or chronic neurological conditions that may impair respiratory drive or interfere with the regulation of spontaneous breathing.","ALL","18 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure. However, during assisted ventilation, excessive inspiratory effort may develop and contribute to lung injury, diaphragmatic overload, and patient self-inflicted lung injury.\n\nOptimizing ventilator settings to modulate respiratory effort therefore represents a major physiological and clinical challenge.\n\nPositive end-expiratory pressure (PEEP) is a key determinant of lung recruitment and respiratory system mechanics and may influence inspiratory effort by modifying lung volume, compliance, and respiratory drive. Despite its widespread use, PEEP titration in clinical practice is still mainly guided by oxygenation parameters, while its direct effects on inspiratory effort during assisted mechanical ventilation remain insufficiently characterized.\n\nThis physiological randomized crossover study aims to evaluate the effect of four predefined levels of positive end-expiratory pressure (0, 5, 10, and 15 cmH₂O) on the respiratory system and inspiratory effort in adult patients receiving assisted mechanical ventilation. Patients will be exposed to each PEEP level in randomized order, with stabilization and washout periods between conditions, while ventilatory support settings other than PEEP are kept constant.",[27,28,29],"Mechanical Ventilation","Respiratory Failure","Effort",[31,32,33],"Assisted mechanical ventilation","Inspiratory Effort","Breathing effort","RECRUITING","2026-02-23",{"date":37,"type":38},"2026-02-27","ACTUAL",{"date":40,"type":38},"2025-01-01",{"date":42,"type":21},"2026-07",{"name":44,"class":45},"Pontificia Universidad Catolica de Chile","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":79,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":46},"100617476","evaluation-of-the-impact-of-a-nutritional-formulation-on-cognitive-performance-following-stress-exposure-100617476","NCT07319117","Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure.","A Double-blind, Placebo-controlled, Randomised, Acute, Repeated Measures Cross-over Study to Evaluate the Impact of Skoshify 'Think Tank' Nutritional Formulation on Cognitive Performance Following Stress Exposure.","Inclusion Criteria:\n\n1. Willing and able to provide written informed consent (in English)\n2. Aged 40-60\n3. Female\n4. Daily caffeine drinkers\n5. Healthy and free from significant physical and psychiatric disorders\n\nExclusion Criteria:\n\n1. Current cigarette smokers\u002Fvapers.\n2. Known food allergy or intolerance to the investigational products or control products.\n3. Not willing to consume coffee.\n4. Individuals diagnosed with psychiatric\u002Fmental health conditions.\n5. Individuals engaging in recreational drug use.\n6. Individuals with diagnosed cardiovascular conditions (e.g. heart disease, high blood pressure)\n7. Individuals taking prescribed medication except contraceptives\u002Fhormone replacement therapy\n8. Individuals suffering from Raynaud's or circulatory issues\n9. Individuals who have suffered an injury or infection in their hand\u002Farm in the last month\n10. Individuals who have suffered from chronic pain conditions or experience extreme numbness or pain in response to cold temperatures.\n11. Previous brain injury\u002Fbrain surgery\n12. Individuals who work night shifts.\n13. Currently pregnant or breastfeeding.\n14. Previous participants in a laboratory stress protocol.",true,"FEMALE","40 Years","60 Years",{"count":59,"type":21},40,[24],"The proposed project will evaluate the synergistic effects of a nutritional formulation, 'Think Tank' on cognitive performance following exposure to a psychological and physical stressor. Adopting a double-blind repeated measures cross-over design, middle-aged females (40-60 years) will be recruited to take part in a two-stage research study that will examine whether the formulation enhances cognitive performance and subjective well-being following the challenge of a stressor, compared to placebo. Cognitive assessments will examine the impact of the nutritional formulation on working memory, sustained attention, cognitive flexibility and inhibitory control. The study will also assess physiological (heart rate, blood pressure and cortisol) and subjective (well-being, anxiety, positive and negative mood, stress) markers of stress reactivity. The study will also explore levels sleep quality, mental and physical fatigue, effort, productivity, and perceived impact of the intervention.",[63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,29],"Cognitive Assessment","Working Memory","Executive Function (Cognition)","Sustained Attention","Inhibitory Control","Cognitive Flexibility","Cortisol","Stress","Anxiety","Depression","Sleep Quality","Blood Pressure","Heart Rate","Mental Fatigue","Physical Fatigue","Productivity",[80,81,82,83,84,85,86,87,88],"Cognitive Performance","Stress Response","Creatine","Magnesium","L-Tyrosine","L-Theanine","Rhodiola","Phosphatidylserine","Citicoline","2025-12-19",{"date":91,"type":38},"2026-01-06",{"date":93,"type":21},"2025-12-15",{"date":95,"type":21},"2026-08-31",{"name":97,"class":45},"Leeds Beckett University"]