[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elbow-dislocation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elbow-dislocation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100612884","neuro-inflammation-in-extremity-trauma-risk-verification-in-elbow-trauma-the-nerve-study-100612884",false,"NCT07259382","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Study","Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study","NERVE","Inclusion Criteria:\n\n* Adults 18 years or older with an acute elbow fracture and\u002For dislocation less than a week old\n* Open surgery as the chosen treatment\n\nExclusion Criteria:\n\n* Patient with a history of ipsilateral upper limb trauma or pathology, neurological disorder.\n* Patient unable to answer questionnaires.\n* Patient unavailable for a one-year follow-up, for example from another country.\n* Patient with vascular injury or open fracture\n* Patient with an active inflammatory disease (ex: rheumatoid arthritis)\n* Patient using anti-inflammatory drugs or immunosuppressants at the time of the injury.\n* Patient with another acute ipsilateral injury to the upper limb\n* Polytrauma patients with other injuries than the elbow fracture and concomitant central or peripheral neurological injury.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","OBSERVATIONAL","The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations. The specific objectives are as follows for elbow fractures:\n\n1\\) To describe NI mechanisms using biomarkers; 2) To identify factors related to increased NI biomarkers level; 3) To describe the associations between NI and outcomes; 4) To use these findings to refine a larger fully powered prognostic cohort study Hypotheses\n\n1. Level of neuro-inflammation (NI) biomarkers\\* will be significantly higher in patients presenting with both elbow fracture and CNS injury or PNI.\n2. Consumption of opioid in mg of morphine equivalent will be higher in patients with a higher level of NI biomarkers.\n3. Function, assessed by validated joint and limb specific functional questionnaires and QoL will be worse in patients with a higher level of NI biomarkers.\n4. Chronic pain at 3 months will be higher (McGill Pain questionnaire V2, Neuropathic pain questionnaire, NPRS) in patients with a higher level of NI biomarkers.\n5. Duration of tourniquet use and nerve dissection will be correlated to elbow fracture outcome with a higher level of NI biomarkers.\n\n   * Target biomarkers based on preliminary study will include, but not be limited to: TNFa, IL6, Substance P, IL-1B, TREM-2, IL-16, CCL22, VEGF-a, BMPs (table 1).",[25,26,27,28,29],"Elbow Dislocation","Elbow Fractures","Inflammation Biomarkers","TBI Traumatic Brain Injury","Nerve Injury",[31,32,33,34,35],"Biomarkers","Elbow fracture","elbow dislocation","Nerve injury","TBI","NOT_YET_RECRUITING","2026-04-27",{"date":39,"type":40},"2026-04-28","ACTUAL",{"date":42,"type":21},"2026-06-01",{"date":44,"type":21},"2030-12-31",{"name":46,"class":47},"Université de Montréal","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":91},"100609243","the-utilization-of-ultrasound-to-diagnose-pediatric-elbow-fractures-100609243","NCT07212036","The Utilization of Ultrasound to Diagnose Pediatric Elbow Fractures","The Utilization of Ultrasound to Diagnose Pediatric Elbow Fractures: Evaluation of Cost Savings, Radiation Exposure, and Patient Satisfaction","Inclusion Criteria:\n\n• Pediatric patient with elbow pain\n\nExclusion Criteria:\n\n* Polytrauma (more than one injury)\n* Deformity of the arm including the elbow\n* Pain in any other location than the elbow\n* Pain in other parts of the same limb including the, wrist, forearm, shoulder, hand\n* Pain in other limbs,\n* Puckering of the skin (skin indentation)\n* Obvious fracture\n* Open wound at or around the elbow\n* Pain and swelling without trauma\n* Concerns for tumor or infection\n* Suspected nursemaid's elbow",true,{"count":57,"type":21},225,"INTERVENTIONAL",[60],"NA","The goal of this intervention trial is to learn if a ultrasound diagnosis of elbow fractures can improve care in pediatric patients seen in the emergency room. The main questions it aims to answer are:\n\nThe primary outcomes measured are cost of the emergency visit, radiation exposure, time spent in the emergency department and patient satisfaction.\n\nPatients who are evaluated with ultrasounds of the elbow will be compared to patients who have x-rays of the elbow.\n\nParticipants will be assigned either to the ultrasound group or x-rays group when they present with elbow pain.",[63,64,65,66,25,67,68],"Elbow Pain","Supracondylar Humerus Fracture","Radial Head Fractures","Radial Head or Neck Fractures","Humerus Fractures","Jakob II Classification",[70,71,72,73,74,75,76,77,33,78,79,80],"elbow pain","elbow fracture","supracondylar humerus fracture","pediatric","lateral humeral condyle fracture","radial head fracture","radial neck fracture","monteggia fracture","radial head dislocation","emergency department","ultrasound","RECRUITING","2026-01-27",{"date":84,"type":40},"2026-01-29",{"date":86,"type":40},"2025-07-22",{"date":88,"type":21},"2027-09-02",{"name":90,"class":47},"Nemours Children's Clinic",1]