[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elderly-people-aged-65-or-more\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elderly-people-aged-65-or-more":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,30,0,25,[9,46,75,106,130,150,176,217,243,274,298,324,349,384,408,432,457,480,508,537,560,580,605,627,650],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100604278","turkish-validation-of-the-aloc-screening-scale-in-older-adults-100604278",false,"NCT07147439","Turkish Validation of the ALOC Screening Scale in Older Adults","Turkish Validity and Reliability of the Appetite Loss in Older Adults With and Without Cognitive Impairment (ALOC) Screening Scale","ALOC","Inclusion Criteria:\n\n* Elderly over 65 years, with or without cognitive impairment\n\nExclusion Criteria:\n\n\\-",true,"ALL","65 Years",{"count":22,"type":23},300,"ESTIMATED","OBSERVATIONAL","As the elderly population increases, health problems related to aging are also increasing. Loss of appetite negatively affects public health by causing malnutrition and related health problems in elderly individuals. Loss of appetite is a common problem in older adults, both in individuals with and without cognitive impairment. This can lead to serious health problems such as malnutrition, weight loss, muscle loss, weakening of the immune system and decreased quality of life. Cognitive disorders such as Alzheimer's and dementia can trigger loss of appetite, or loss of appetite can be a symptom of these disorders. Factors such as metabolic changes during the aging process, decreased sense of taste and smell, loneliness and depression contribute to loss of appetite. However, there is no valid and reliable scale in Turkey for the early diagnosis and assessment of loss of appetite. A scale being valid and reliable means that it can measure the concept it is intended to measure accurately and consistently. The aim of this study was to determine the validity and reliability of the Turkish version of the Loss of Appetite Scale in older adults with and without cognitive impairment .",[27,28],"Elderly (People Aged 65 or More)","With or Without Cognitive Impairment",[30,16,31,32],"Elderly","SNAQ","TURKISH VALIDITY AND RELIABILITY","NOT_YET_RECRUITING","2026-06-08",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":23},"2026-09-01",{"date":41,"type":23},"2026-12-01",{"name":43,"class":44},"Toros University","OTHER",1,{"id":47,"slug":48,"hasResults":12,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100638819","the-effects-of-somatic-based-chair-exercises-in-the-elderly-100638819","NCT07618143","The Effects of Somatic-Based Chair Exercises in the Elderly","The Effects of Somatic-Based Chair Exercises on Balance, Pain, and Quality of Life in the Elderly","Inclusion Criteria:\n\n1. 65 years of age or older\n2. To be volunteered to participate\n3. To be able to speak and understand Turkish at a good level\n\nExclusion Criteria:\n\n1. Scoring \\\u003C24 on the Mini-Mental State Examination\n2. Any neurological or orthopedic problem that would prevent the implementation of assessment and exercise methods",{"count":54,"type":23},70,"INTERVENTIONAL",[57],"NA","The primary aim of this study is to investigate the effects of easily applicable somatic-based chair exercises on balance and pain in the elderly. Additionally, the study aims to reveal the impact of exercise on functionality and cognitive level, and the resulting changes in quality of life.\n\nThe main research questions addressed in this study are:\n\n* What are the most suitable exercise models that can be applied to improve pain control and balance in the elderly?\n* How do the results of different approaches aimed at improving the quality of life in the elderly differ?",[27],[61,62,63,64,65],"elderly","somatic exercises","balance","quality of life","chair exercises","2026-05-25",{"date":68,"type":37},"2026-06-01",{"date":70,"type":23},"2026-06-25",{"date":72,"type":23},"2027-09-30",{"name":74,"class":44},"Istanbul Gedik University",{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":12,"sex":19,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":55,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":45},"100627452","dynamic-and-isometric-strength-training-in-older-adults-with-hypertension-100627452","NCT07448818","Dynamic and Isometric Strength Training in Older Adults With Hypertension","Effects of Dynamic Strength Training and Isometric Strength Training on Cardiovascular Health Indicators, Mental Health, and Neuromuscular Fitness in Older Adults With Hypertension: A Feasibility Study","Dynamic and Is","Inclusion criteria:\n\n* Diagnosis of arterial hypertension and currently taking antihypertensive medication\n* Age 60 years or older\n* Resting blood pressure below 160\u002F95 mmHg\n* No high cardiovascular risk according to the American College of Sports Medicine criteria (for participants with type 2 diabetes, glycemic control with fasting glucose \\\u003C100 mg\u002FdL and postprandial glucose \\\u003C140 mg\u002FdL)\n* Not participating in a structured exercise program for more than three months\n* No cognitive or functional limitations that prevent participation in the exercise program\n\nExclusion Criteria\n\n* Presence of acute illnesses, such as influenza, sinusitis, gastroenteritis, urinary tract infection, fever, inflammatory processes, or any clinical condition requiring rest or that may compromise safety during assessments or training.\n* Decompensated clinical conditions, including: Blood pressure spikes, Chest pain, Uncontrolled arrhythmias, Shortness of breath at rest, Asthma exacerbations, Decompensated diabetes mellitus, characterized by Persistently elevated blood glucose levels (fasting glucose \\> 180 mg\u002FdL or postprandial glucose \\> 250 mg\u002FdL)\n* Irregular use of medication\n* Any unstable clinical condition or condition that represents additional risk for the practice of physical exercise.","60 Years",{"count":85,"type":23},60,[57],"This feasibility study aims to evaluate the effects of dynamic strength training and isometric strength training on cardiovascular health indicators, mental health, and neuromuscular fitness in older adults with hypertension. Participants will be randomly assigned to one of the two training modalities and will complete supervised exercise sessions throughout the intervention period. The study will provide preliminary evidence regarding the safety, acceptability, and potential impact of each training modality on health outcomes in this population.",[89,27],"Hypertension",[89,91,92,93,94,95],"Strength training","Resistance training","Cardiovascular health","blood pressure","old age","RECRUITING","2026-04-27",{"date":99,"type":37},"2026-05-01",{"date":101,"type":37},"2026-03-01",{"date":103,"type":23},"2027-12-31",{"name":105,"class":44},"Raphael Mendes Ritti Dias",{"id":107,"slug":108,"hasResults":12,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":113,"targetDuration":115,"studyType":24,"phases":4,"briefSummary":116,"conditions":117,"keywords":119,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":45},"100636225","comparison-of-physical-performance-balance-and-functional-mobility-parameters-according-to-walking-speed-in-geriatric-individuals-100636225","NCT07562919","Comparison of Physical Performance, Balance, and Functional Mobility Parameters According to Walking Speed in Geriatric Individuals","Comparison of Physical Performance, Balance, and Functional Mobility Parameters According to Walking Speed Threshold Values in Geriatric Individuals","Inclusion Criteria:\n\n* Being 65 years of age or older\n* Being able to perform walking functions\n* Having sufficient mobility to perform the physical performance tests included in the research, such as 5 sit-stand tests, TUG (Trip and Go) tests, and stair climbing\u002Fdescending tests. • Having a walking speed of at least 0.4 m\u002Fs or more as a result of the 4 Meter Walking Test (having limited or independent mobility within the community).\n* Voluntarily agreeing to participate in the study and providing informed consent.\n\nExclusion Criteria:\n\n1. Having a history of advanced cognitive impairment or diagnosed dementia that would impair the ability to understand and follow test instructions.\n2. Those diagnosed with moderate or severe cognitive impairment (MMSE \\\u003C 24 and\u002For MoCA \\\u003C 21)\n3. Having a walking speed below 0.4 m\u002Fs on the 4-Meter Walk Test (individuals who are wheelchair-bound or bedridden).\n4. Advanced Parkinson's disease, active stroke sequelae, lower extremity fracture within the last 6 months, or a history of acute orthopedic surgery that primarily affects motor performance and balance.\n5. Those with severe hearing or vision loss\n6. Individuals experiencing significant difficulty communicating\n7. Participants who did not sign the voluntary consent form",{"count":114,"type":23},76,"1 Week","The aim of this study is to examine the determining role of walking speed on physical performance parameters in individuals aged 65 and over. The study aims to compare flexibility, lower extremity muscle strength (5-count sit-stand test), static balance (single-leg balance), upper extremity muscle strength (hand grip), dynamic balance (FUT), functional mobility (TUG), and stair climbing\u002Fclimbing skills in individuals with walking speeds of 0.4-0.8 m\u002Fs (limited community mobility) and above 0.8 m\u002Fs (independent community mobility).",[118,27],"Geriatric",[120,121,122,61],"walkinp speed","physical fıtness","geriatric","2026-04-25",{"date":99,"type":37},{"date":99,"type":23},{"date":127,"type":23},"2026-08-30",{"name":129,"class":44},"Istanbul University - Cerrahpasa",{"id":131,"slug":132,"hasResults":12,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":18,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":137,"targetDuration":115,"studyType":24,"phases":4,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":145,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":149,"locationsCount":45},"100636223","evaluating-the-clinical-suitability-of-microsoft-xbox-one-games-in-geriatric-rehabilitation-100636223","NCT07562893","Evaluating the Clinical Suitability of Microsoft Xbox One Games in Geriatric Rehabilitation","Evaluating the Clinical Suitability of Microsoft Xbox One Games in Geriatric Rehabilitation: A Delphi Study","Inclusion Criteria:\n\n1. To be a Physiotherapist with at least 5 years of clinical\u002Facademic experience in geriatric rehabilitation or neurological rehabilitation,\n2. To be a researcher in game technologies, Exergame applications, or Kinect systems, and to be a Physiotherapist with clinical\u002Facademic experience,\n3. To approve the 'Informed Consent Form' regarding participation in the study.\n\nExclusion Criteria:\n\n1. Not having conducted research\u002Facademic activities in the specified areas of expertise (Physiotherapy, Gerontology, Play Technologies),\n2. Failure to provide feedback within the specified timeframes,\n3. Withdrawing voluntarily at any stage of the study.",{"count":138,"type":23},20,"This study aims to determine the potential for 'safe' and 'effective' use of Microsoft Xbox One-based motion games for the geriatric population through expert consensus using a unique set of assessments, and to provide clinicians with an evidence-based guide to game selection.",[118,27],[142,122,143,144],"exergame","Kinect sensory","security",{"date":99,"type":37},{"date":147,"type":23},"2026-04-30",{"date":127,"type":23},{"name":129,"class":44},{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":157,"targetDuration":4,"studyType":55,"phases":158,"briefSummary":159,"conditions":160,"keywords":165,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":45},"100596423","effect-of-exergaming-program-versus-neuromuscular-exercise-in-elderly-people-with-motor-cognitive-risk-syndrome-100596423","NCT07045259","Effect of Exergaming Program Versus Neuromuscular Exercise in Elderly People With Motor Cognitive Risk Syndrome","Effect of Exergaming Program Versus Neuromuscular Exercise on Locomotor and Cognitive Functions in Elderly People With Motor Cognitive Risk Syndrome","Inclusion Criteria:\n\n* Being over 65 years of age\n* Having a Barthel Daily Living Activities Index score of ≥ 90\n* Having a Mini Mental Status Score (MMSE) of ≥24\n* Having the ability to walk with or without a walking aid\n* Having a slow walking speed\n* Having subjective memory complaints\n\nExclusion Criteria:\n\n* Presence of Dementia\n* Major Depression\n* Generalized Anxiety Disorder and Delirium\n* Parkinson's Disease\n* Anemia\n* Thyroid Disease\n* Vitamin B12 Deficiency\n* Malnutrition\n* Terminal Illness\n* Hearing or Visual Impairment",{"count":85,"type":23},[57],"The primary aim of our study is to compare the effects of neuromuscular exercise training versus structured exergaming program on locomotor and cognitive functions in elderly individuals with Motor Cognitive Risk (MCR), which defines the transition state between typical aging and dementia and mild cognitive impairment. This study aims to present for the first time the effects of neuromuscular exercise training and exergaming program on locomotor and cognitive functions in elderly individuals with MCR with comparative results.",[161,27,162,163,164],"Motoric Cognitive Risk Syndrome","Geriatric Patient","Exergaming","Neuromuscular Exercise",[161,30,166,167],"neuromuscular exercise","exergaming","2026-04-23",{"date":170,"type":37},"2026-04-24",{"date":172,"type":37},"2025-12-25",{"date":174,"type":23},"2026-06-30",{"name":129,"class":44},{"id":177,"slug":178,"hasResults":12,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":55,"phases":186,"briefSummary":188,"conditions":189,"keywords":192,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":216},"100629606","phase-4-effect-of-intravenous-iron-on-quality-of-life-in-older-patients-with-acute-coronary-syndrome-100629606","NCT07476859","Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome","Phase IV, Open-label, Randomized Clinical Trial on the Effect of Intravenous Iron on Quality of Life in Elderly Patients With Acute Coronary Syndrome","HI-COR-65","Inclusion Criteria:\n\n1. Age ≥ 65 years.\n2. Hospitalization for confirmed acute coronary syndrome (ACS) within 15 days prior to enrollment.\n3. Iron deficiency diagnosed at admission or within 15 days after the index ACS event, defined as:\n\n   * Serum ferritin \\\u003C 100 ng\u002FmL, OR\n   * Transferrin saturation (TSAT) \\\u003C 20%.\n4. Ability to provide written informed consent prior to participation.\n\nExclusion Criteria:\n\n1. Active malignancy.\n2. End-stage or terminal illness as determined by the IDC-Pal score.\n3. Known heart failure with left ventricular ejection fraction (LVEF) \\\u003C 40% prior to enrollment, or development of LVEF \\\u003C 40% during hospitalization or within 15 days after ACS.\n4. Chronic dialysis or advanced renal or hepatic failure.\n5. Severe anemia (hemoglobin \\\u003C 10 g\u002FdL) at the time of ACS or within 15 days after the event.\n6. Prior treatment with intravenous or oral iron within 12 months before the index ACS.\n7. Known hypersensitivity to ferric carboxymaltose, other parenteral iron products, or any component of the formulation.\n8. Evidence of iron overload or disorders of iron metabolism.\n9. Ongoing bacteremia or active systemic infection.\n10. Participation in another interventional clinical trial involving an investigational medicinal product.\n11. Any condition that, in the investigator's opinion, would compromise safety, protocol compliance, or study integrity.",{"count":185,"type":23},538,[187],"PHASE4","The goal of this phase IV, open-label, randomized clinical trial is to evaluate whether intravenous iron improves quality of life in adults aged 65 years and older with iron deficiency after an acute coronary syndrome (ACS).\n\nThe main questions it aims to answer are:\n\n* Does intravenous iron improve quality of life at 6 and 12 months?\n* Does it reduce frailty and adverse clinical outcomes?\n\nResearchers will compare intravenous ferric carboxymaltose with standard of care.\n\nParticipants will:\n\n* Be randomly assigned to receive intravenous iron or standard care\n* Attend three study visits over 12 months\n* Complete questionnaires and undergo blood tests",[190,191,27],"Acute Coronary Syndromes (ACS)","Iron Deficiencies",[193,194,195,196,197,198,199,200,201,202,203,204,205,206],"Acute coronary syndrome","Iron deficiency","Intravenous iron","Ferric carboxymaltose","Quality of life","Older adults","Myocardial infarction","Frailty","Cardiovascular outcomes","Biological aging","ELOVL2 methylation","Telomere length","Klotho","FGF23","2026-03-20",{"date":209,"type":37},"2026-03-24",{"date":211,"type":37},"2026-03-05",{"date":213,"type":23},"2028-05",{"name":215,"class":44},"Fundación para la Investigación del Hospital Clínico de Valencia",9,{"id":218,"slug":219,"hasResults":12,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":55,"phases":226,"briefSummary":227,"conditions":228,"keywords":230,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":241,"locationsCount":45},"100618620","effect-of-biofeedback-activation-on-balance-in-osteoporotic-elderly-100618620","NCT07333989","Effect of Biofeedback Activation on Balance in Osteoporotic Elderly","Effect of Biofeedback Activation on Balance in Osteoporotic Elderly Patients","Inclusion Criteria:\n\n* All patients included in this study met the following criteria:\n\n  1. Sixty patients of both sexes were diagnosed with osteoporosis confirmed by bone density test through Dual-energy X-ray absorptiometry (DEXA) scan (A T-score equal to or less than - 2.5) (Sheu and Diamond, 2016).\n  2. Their age ranged between 65 - 75 years.\n  3. Their BMI ranged between 25 - 29.9 kg\u002Fm2.\n  4. They had good mentality and cognitive function.\n\nExclusion Criteria:\n\n* The potential patients were excluded if they have one of the following criteria:\n\n  1. Patients with endocrine disorders likely to be related to metabolic bone disease, such as premature ovarian failure, hypogonadism, untreated hyperthyroidism, hyperparathyroidism, adrenal insufficiency or Cushing's syndrome.\n  2. Patients with active contagious skin conditions.\n  3. Patients with implant devices such as pacemaker or electrical prosthesis.\n  4. Any cardiopulmonary disorders.\n  5. Any neuromuscular disorders.\n  6. Any acute viral infection.\n  7. Patients with ascites or end stage liver or kidney failure.\n  8. Leg discrepancy.","75 Years",{"count":85,"type":23},[57],"This study aimed to investigate the effect of gluteus medius activation using electromyography (EMG) biofeedback combined with balance training on balance, physical performance, gluteus medius muscle activity, and quality of life in osteoporotic elderly patients.",[229,27],"Balance Problems",[231,30,232,233,234,197,235],"Osteoporosis","Balance training","Gluteus medius","Electromyography biofeedback","performance.","2026-03-18",{"date":207,"type":37},{"date":239,"type":37},"2026-01-02",{"date":99,"type":23},{"name":242,"class":44},"Mohamed Said Alsafy Alhamrawy",{"id":244,"slug":245,"hasResults":12,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":12,"sex":19,"minAge":83,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":55,"phases":251,"briefSummary":252,"conditions":253,"keywords":260,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":45},"100628425","effects-of-continuous-monitoring-and-progressive-regulation-of-inflatable-laryngeal-mask-airway-cuff-pressure-on-postoperative-pharyngolaryngeal-complications-in-elderly-patients-100628425","NCT07461467","Effects of Continuous Monitoring and Progressive Regulation of Inflatable Laryngeal Mask Airway Cuff Pressure on Postoperative Pharyngolaryngeal Complications in Elderly Patients","Inclusion Criteria:\n\n* Aged ≥ 60years;\n* Non-cardiac, non-thoracic, and non-head and neck surgery;\n* Non-laparoscopic surgery;\n* Elective surgery;\n* Surgical position: supine position ;\n* American Society of Anesthesiologists (ASA) physical status classification Ⅰ-Ⅲ;\n* New York Heart Association (NYHA) cardiac function classification Ⅰ-Ⅱ;\n* Expected surgical duration ≥30 minutes and ≤ 2 hours;\n* Body mass index (BMI) 18.5-30.0 kg\u002Fm2.\n\nExclusion Criteria:\n\n* Preoperative predictable difficult airways, such as trismus, limited neck mobility, and other related conditions;\n* Preoperative pharyngeal and laryngeal complications including sore throat, hoarseness, blood-tinged sputum, and dysphagia;\n* Preexisting conditions such as loose teeth, laryngeal obstruction, laryngeal edema, acute airway inflammation, and gastrointestinal bleeding;\n* Comorbidities of respiratory diseases like chronic obstructive pulmonary disease (COPD) and asthma;\n* Allergies to ILMA materials (e.g., silicone, polyvinylchloride \\[PVC\\]);\n* Inability to cooperate with the study for any reason;\n* Participation in other clinical trials within 3 months prior to enrollment in this study;\n* Any other circumstances deemed inappropriate for inclusion by the investigators.",{"count":250,"type":23},146,[57],"Currently, research on laryngeal mask airway (LMA) has been continuously deepened both domestically and internationally, which has greatly promoted the optimization process of clinical application and related management strategies. Numerous domestic and foreign research findings have consistently emphasized the key role of LMA cuff pressure monitoring in reducing postoperative complications, especially in alleviating sore throat and dysphagia. Foreign studies have extensively covered the research and development innovation of LMA devices, as well as comprehensive comparative analyses with other airway management methods such as endotracheal intubation, providing rich perspectives for expanding the application of LMA and improving its application effects. In contrast, domestic studies have distinct pertinence, focusing on application exploration in specific populations and clinical practice scenarios, and have provided important evidence for the safe and effective use of LMA in specific groups through in-depth research. However, it is undeniable that there are obvious deficiencies in both domestic and foreign research regarding the application of continuous monitoring and progressive regulation of LMA cuff pressure in elderly patients-a crucial field. Due to the natural decline of physiological functions, elderly patients face an increased risk of complications such as pulmonary and extrapulmonary complications, as well as pharyngolaryngeal complications, when using LMA during the perioperative period. Therefore, it is particularly urgent to carry out continuous pressure monitoring and progressive regulation of LMA cuff pressure, and to further explore the optimal range of LMA cuff pressure. This study will not only fill the current research gap but also provide solid support for the safe and efficient airway management of elderly patients during the perioperative period.",[27,254,255,256,257,258,259],"LMA","Randomized Controlled Trial","Laryngeal Mask Airways","Pharyngolaryngeal Postoperative Pain","Cuff Pressure","Oropharyngeal Leak Pressure",[261,262,263,264,255],"Elderly people","Laryngeal mask airways","pharyngolaryngeal complications","cuff pressure","2026-03-06",{"date":267,"type":37},"2026-03-10",{"date":269,"type":37},"2025-11-02",{"date":271,"type":23},"2027-03-01",{"name":273,"class":44},"First Affiliated Hospital of Chongqing Medical University",{"id":275,"slug":276,"hasResults":12,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":281,"targetDuration":4,"studyType":55,"phases":283,"briefSummary":284,"conditions":285,"keywords":286,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":45},"100622249","the-effect-of-nhaler-training-and-reminders-on-medication-on-adherence-in-elderly-individuals-100622249","NCT07381166","The Effect of İnhaler Training and Reminders on Medication on Adherence in Elderly Individuals","The Effect Of Metered-Dose İnhaler Training And Reminders On Medication Adherence In Elderly Individuals: A Randomized Controlled Study","Inclusion criteria for the study:\n\n* Age ≥ 65 years old\n* Having at least basic literacy,\n* Receiving metered-dose inhaler therapy for at least 6 months,\n* Being hospitalized in the pulmonary ward,\n* Presenting to the pulmonary function test unit,\n* Presenting to the pulmonary outpatient clinic,\n* Signing the informed consent form for participation in the study,\n* Having internet access and a mobile device with Android\u002FiOS operating system,\n* Being able to use a telephone,\n* Having no communication barriers,\n* Being able to use the inhaler without needing assistance,\n* Making an error in at least one of the usage steps according to the MDI usage skills chart.\n\nExclusion criteria for the study:\n\n* Age \\\u003C65\n* Illiteracy\n* Receiving metered-dose inhaler therapy for \\\u003C6 months\n* Outpatient treatment\n* Being hospitalized in the intensive care unit\n* Being hospitalized in wards other than the pulmonary ward (such as surgery, physical therapy)\n* Visiting outpatient clinics other than the pulmonary clinic (such as surgery, physical therapy)\n* Not signing the informed consent form for participation in the study\n* Not having internet access and a mobile device with Android\u002FiOS operating system\n* Not having telephone skills\n* Having communication barriers\n* Requiring assistance while using the inhaler\n* Not making any errors in the usage steps according to the MDI usage skills chart\n* Wanting to withdraw from the study\u002Fwithdrawing from participation during the research process\n* Not completing the questionnaire",{"count":282,"type":23},64,[57],"This study will evaluate the effect of metered-dose inhaler training and reminders on treatment adherence in elderly individuals.",[27],[61,287,288,289],"Metered Dose Inhalers","reminder","adherence to treatment",{"date":291,"type":37},"2026-03-09",{"date":293,"type":37},"2026-01-21",{"date":295,"type":23},"2026-07-30",{"name":297,"class":44},"Çanakkale Onsekiz Mart University",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":302,"acronym":303,"eligibilityCriteria":304,"healthyVolunteers":12,"sex":19,"minAge":83,"maxAge":4,"enrollmentInfo":305,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":307,"conditions":308,"keywords":311,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":320,"leadSponsor":322,"locationsCount":45},"100624428","assessment-of-informal-support-provided-by-caregivers-at-different-stages-of-alzheimers-disease-100624428","NCT07409506","Assessment of Informal Support Provided by Caregivers at Different Stages of Alzheimer's Disease","ICAD","Inclusion Criteria:\n\n* Patients from Charpennes Hospital included in the MEM-AURA cohort\n* Patients aged 60 years and older at inclusion\n* Patients with dementia due to clinically probable Alzheimer's disease, regardless of stage\n* Patients with a Mini-Mental State Evaluation (MMSE) score ≤ 26 at inclusion\n* Patients accompanied by a caregiver at inclusion\n\nExclusion Criteria:\n\n* \\- Patients or caregivers who have expressed their opposition to the study\n* Patients living in institutions or nursing homes\n* Patients protected by law (under legal protection, guardianship, or conservatorship)\n\nEarly termination Criteria :\n\n\\- Patients or caregivers withdrawing their consent to participate during the study",{"count":306,"type":23},312,"In France, approximately 1,200,000 people aged 65 and over suffer from Alzheimer's disease or related disorders, of which Alzheimer's disease (AD) accounts for 70% of cases. This prevalence could double by 2050. The cognitive decline and progression to functional dependence that accompany AD are associated with a decline in quality of life, an increased risk of comorbidities, institutionalization, and mortality, as well as high care costs, placing a burden on the patient, their family and friends, and the healthcare system.\n\nInformal care, i.e., care provided by a family member or caregiver, plays an important role in the overall management of major neurocognitive disorders (NCDs) associated with AD at home. In France, the annual cost of informal care for AD was estimated in 2008 at around €14 billion per year, or approximately 50% of the total annual cost of AD. The economic valuation of informal care serves to inform public decision-makers not only about the cost of this resource, but also about its usefulness. The issue of resource allocation (particularly the daily allowance for family caregivers - AJPA in French) at the societal level and the sharing of private (role of caregivers) and public (role of the state and local authorities) responsibilities leads us to question the determinants of this usefulness, particularly the clinical determinants in AD patients at different stages of the disease.\n\nThe main hypothesis is that informal care varies according to cognitive decline and loss of autonomy, independently or in interaction with the number and type of the patient's comorbidities, their behavioral disorders, and the caregiver's burden.",[27,309,310],"Neurocognition","Alzheimer s Disease",[312,313,314],"informal care","cost of alzheimer's disease","caregiver","2026-02-12",{"date":317,"type":37},"2026-02-13",{"date":319,"type":37},"2025-09-09",{"date":321,"type":23},"2027-09-09",{"name":323,"class":44},"Hospices Civils de Lyon",{"id":325,"slug":326,"hasResults":12,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":4,"eligibilityCriteria":330,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":331,"targetDuration":333,"studyType":24,"phases":4,"briefSummary":334,"conditions":335,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":45},"100624649","predictive-factors-for-functional-and-quality-of-life-decline-in-patients-65-years-with-a-gastrointestinal-tract-cancer-diagnosis-taken-to-curative-resectable-surgery-100624649","NCT07412379","Predictive Factors for Functional and Quality of Life Decline in Patients >65 Years With a Gastrointestinal Tract Cancer Diagnosis Taken to Curative Resectable Surgery","Predictive Factors Associated With Functional Decline and Quality of Life Decline at 12 Months Follow-up and 5 Year Oncological Follow-up in Patients >65 Yares With a Gastrointestinal Tract Cancer Diagnosis Taken to Resectable Surgery With a Curative Intent in Hospital Universitario Mayor-Méderi, Bogotá, Colombia","Inclusion Criteria:\n\n* Gastrointestinal cancer tract diagnosis (oesophagus, stomach, duodenum, pancreas, liver, biliary tract, small bowel, appendix, colon and rectum)\n* Have resectable disease by surgery\n* Taken to surgery by curative intent\n* Willingness to participate and enrollment by informed consent\n* Attended in the Mederi Hospital Networn\n\nExclusion Criteria:\n\n* Mortality\n* Loss to follow-up\n* Not taken to surgery\n* Emergency surgery\n* Taken to surgery as an oncological relapse or due to complications previous to an index procedure\n* Endoscopical treatment\n* Second primary tumor without a minimum 5 year disease free period from the primary one\n* Basal functionality 0\u002F6 by Katz score.",{"count":332,"type":23},327,"5 Years","Introduction: Human life expectancy has increased significantly, leading to a transformation in the global demographic structure. Cancer is considerably more common among older adults compared to younger populations, as age is one of the main risk factors for its development. In fact, most solid tumors are considered age-related diseases. For this reason, the incidence of cancer among older individuals is expected to continue rising. Oncological care for this population group is particularly complex and represents a significant challenge, as comorbidities and the social aspects of aging create clinical scenarios that differ greatly from those seen in younger patients.\n\nObjective: To identify the predictive factors of functional decline and quality of life at 12 months of follow-up, as well as oncological outcomes at 5 years of follow-up, in patients aged 65 years and older with gastrointestinal cancer who undergo curative-intent resective surgery at Hospital Universitario Mayor - Méderi, Bogotá, Colombia.\n\nMethodology: Longitudinal and analytical observational study of prospective prognostic cohort type.\n\nExpected Results: Predictive model of functional decline and quality of life, as well as oncological outcomes, in patients with gastrointestinal cancer undergoing curative-intent surgical procedures.",[336,27,337,338,339],"Cancer Abdomen","Quality of Life","Sarcopenia in Elderly","Functional Autonomy Level","2026-02-09",{"date":342,"type":37},"2026-02-17",{"date":344,"type":37},"2026-01-13",{"date":346,"type":23},"2029-12-15",{"name":348,"class":44},"Hospital Universitario Mayor Méderi",{"id":350,"slug":351,"hasResults":12,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":356,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":358,"conditions":359,"keywords":366,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":45},"100592034","frailty-and-muscle-strength-tests-in-older-adults-undergoing-major-surgery-100592034","NCT06988176","Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery","Feasibility and Correlation of Functional Muscle Strength Tests and Objective Frailty Measures With Clinical Frailty Scale in Patients Undergoing Major Surgery","Inclusion Criteria:\n\nParticipants may be eligible for this study if they meet the following conditions:\n\n* Age 65 years or older.\n* Scheduled for elective (planned, non-emergency) major abdominal surgery, including colorectal, hepatobiliary, gynecologic, or urologic procedures.\n* Able to attend a routine preoperative evaluation visit.\n* Able and willing to complete brief assessments for muscle strength, walking, breathing strength, memory, and nutrition.\n\nExclusion Criteria:\n\nParticipants will not be eligible for the study if they have any of the following conditions:\n\n* Surgery is an emergency procedure.\n* Unable to walk independently (for example, dependent on a wheelchair or bed-bound).\n* Significant cognitive impairment that prevents understanding or completing study tests.",{"count":357,"type":23},100,"The goal of this observational study is to learn if simple tests for frailty and muscle strength can help predict which older adults (age 65 and older) are at higher risk for problems after major abdominal surgery.\n\nThe main questions it aims to answer are:\n\n* Do measures of frailty and muscle strength, taken before surgery, predict complications after surgery?\n* Can these tests be easily done during a routine pre-surgical visit?\n\nParticipants will:\n\n* Complete brief tests measuring muscle strength, breathing strength, physical function, nutrition status, body composition, and memory during a regular pre-surgical clinic appointment.\n* Allow researchers to review their medical records 30 and 90 days after surgery to identify any complications or health problems.",[200,360,338,361,362,363,364,27,365],"Sarcopenia","Muscle Strength","Post Operative Complications","Nutrition Assessment","Risk Assessment","Hand Strength",[200,367,368,369,365,370,371,364,363,372,373,374],"sarcopenia","elective abdominal surgery","Muscle strength","Inspiratory muscle strength","Post operative complications","Elderly patients","Cognitive Function","Physical functional performance","2026-01-27",{"date":377,"type":37},"2026-01-28",{"date":379,"type":37},"2025-06-19",{"date":381,"type":23},"2026-08",{"name":383,"class":44},"University of North Carolina, Chapel Hill",{"id":385,"slug":386,"hasResults":12,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":61,"eligibilityCriteria":390,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":391,"enrollmentInfo":392,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":402,"completionDateStruct":404,"leadSponsor":406,"locationsCount":45},"100606782","figure-of-eight-backward-walk-test-in-elderly-100606782","NCT07180030","Figure-of-eight Backward Walk Test in Elderly","Determination of Reliability, Validity, and Minimal Detectable Change (MDC) of the Figure-of-eight Backward Walking Test in Elderly Adults","Inclusion Criteria:\n\n* Healthy elderly individuals over 65 years of age.\n* Elderly individuals who have fluent in Turkish and able to communicate.\n* Elderly individuals who have no cognitive impairment.\n\nExclusion Criteria:\n\n* Elderly individuals who have any neurological problems (Parkinson's, hemiplegia, etc.)\n* Elderly individuals who have any orthopedic problems (fractures, etc., in the last year)\n* Elderly individuals who have a body mass index (BMI) ≥ 40 kg\u002Fm2\n* Elderly individuals who havevision problems\n* Elderly individuals who have had any lower extremity surgery in the last year\n* Elderly individuals who use any mobility aids\n* Elderly individuals who refuse to participate in the study.","85 Years",{"count":393,"type":23},87,"Mobility is a fundamental element of healthy aging. Balance is a necessary function during mobility for all movements throughout life in elderly individuals. Falls due to balance disorders in elderly individuals cause a decrease in the quality of life. Studies in the literature indicate that 13% of individuals aged 65-69 experience falls, and this rate rises to 46% in individuals over 85. Lower extremity muscle volume and strength gradually decrease with aging. This decreased muscle strength directly impacts individuals' activities of daily living.Normal walking speed for elderly individuals is related to balance and overall health performance. However, walking assessments generally focus on walking activities in a forward direction and in a straight line. However, in daily life, we may need to sit on a chair, walk backward to navigate a narrow space, or change direction suddenly due to obstacles or environmental cues. Walking backward requires more complex motor control, and these gait training programs are known to be effective in improving balance and walking skills.Clinically, balance assessments in the elderly persons are commonly measured by using the TUG, 10-meter walk test, functional reach test, 4-square step test, and Berg balance scale. The methods used to assess balance are still not fully standardized. The best test for assessing dynamic balance and fall risk is still up for debate, especially when it comes to elderly individuals who live freely in the community. Further research is needed to determine whether lateral walking tests can identify those at high risk of falling in elderly adults. The purpose of this study was to determine the reliability, validity, and minimal detectable change (MDC) of the Figure-of-8 backward walking test in healthy elderly adults.",[27,396,397,398],"Balance","Dynamic Balance","Backward Walking","2025-12-18",{"date":401,"type":37},"2025-12-19",{"date":403,"type":37},"2025-05-01",{"date":405,"type":23},"2026-01-30",{"name":407,"class":44},"Kahramanmaras Sutcu Imam University",{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":412,"acronym":413,"eligibilityCriteria":414,"healthyVolunteers":18,"sex":19,"minAge":415,"maxAge":416,"enrollmentInfo":417,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":419,"conditions":420,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":45},"100616449","cancan-body-composition-study-100616449","NCT07305753","CanCan Body Composition Study","Cancan","Inclusion Criteria:\n\n* Being either male or female\n* Being an adult \\>20 - \\\u003C40 or \\>70 years of age.\n* Having a body weight of less than 440 pounds\n* Being willing to comply with the study procedures\n* Not having a chronic illness (e.g., diabetes, cancer, etc.)\n* Must be willing to have biospecimens and imaging stored for research use\n\nExclusion Criteria:\n\n* Being pregnant, attempting to become pregnant, or breastfeeding\n* Having medical implants such as a pacemaker or metal joint replacements\n* Having had a mastectomy, breast reduction, or breast implants\n* Having hair that cannot fit in a swim cap\n* Having a body weight greater than 440 pounds\n* Taking medications that alter the body's fluid compartments (ex: diuretics)\n* Not willing to have biospecimens and imaging stored for future research use.","20 Years","90 Years",{"count":418,"type":23},40,"The aim of this study is to develop a dataset with reference body composition measurements using criterion methods. This dataset will be used to develop new protocols to study patients with cancer. Obtaining measurements of sodium bromide (NaBr), deuterium dilution (D2O), and D3-Creatine in a stratified sample of adults will determine the accuracy (and precision) of the available devices for ECW, TBW, and skeletal muscle mass measurements.",[421,422,27],"Healthy Participants","Young Healthy Adults","2025-12-12",{"date":425,"type":37},"2025-12-26",{"date":427,"type":37},"2025-10-15",{"date":429,"type":23},"2026-05-30",{"name":431,"class":44},"Pennington Biomedical Research Center",{"id":433,"slug":434,"hasResults":12,"nctId":435,"briefTitle":436,"officialTitle":437,"acronym":438,"eligibilityCriteria":439,"healthyVolunteers":12,"sex":19,"minAge":440,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":55,"phases":443,"briefSummary":444,"conditions":445,"keywords":446,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":449,"lastUpdatePostDateStruct":450,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":45},"100611742","effects-of-physical-exercise-and-cognitive-training-on-quality-of-life-in-elderly-adults-100611742","NCT07244536","Effects of Physical Exercise and Cognitive Training on Quality of Life in Elderly Adults","Health-related Quality of Life in Elderly Adults Following Physical Exercise and Cognitive Training: a Randomized-controlled Trial","HELIOS","Inclusion Criteria:\n\n* Male and female\n* Age ≥ 70 years\n* Provision of the informed consent form\n\nExclusion Criteria:\n\n* Absolute contraindications to physical exercise (e.g. NYHA class IV heart failure, unstable angina, etc.)\n* Pregnancy\n* Severe cognitive impairment, defined as a MoCa score ≤ 12\n* Severe visual impairment or blindness","70 Years",{"count":442,"type":23},156,[57],"The aim of the study is to investigate the effectiveness of three different types of intervention, based on physical exercise and\u002For cognitive stimulation or training, on quality of life, cognition and mobility, on a population of older adults, who are most at risk of functional and cognitive decline",[27],[61,447,448,64],"exercise","cognitive training","2025-12-04",{"date":423,"type":37},{"date":452,"type":37},"2025-11-15",{"date":454,"type":23},"2028-10-31",{"name":456,"class":44},"University Hospital of Ferrara",{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":462,"acronym":4,"eligibilityCriteria":463,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":464,"targetDuration":4,"studyType":55,"phases":466,"briefSummary":468,"conditions":469,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":472,"lastUpdatePostDateStruct":473,"startDateStruct":475,"completionDateStruct":476,"leadSponsor":478,"locationsCount":4},"100609040","phase-2-clinical-efficacy-of-transarterial-chemoembolization-in-elderly-patients-with-advanced-unresectable-colorectal-cancer-100609040","NCT07209384","Clinical Efficacy of Transarterial Chemoembolization in Elderly Patients With Advanced Unresectable Colorectal Cancer","CLINICAL EFFICACY OF TRANSARTERIAL CHEMOEMBOLIZATION IN ELDERLY PATIENTS WITH ADVANCED UNRESECTABLE COLORECTAL CANCER","Inclusion Criteria:\n\n* Age ≥ 65 years, gender not restricted Pathologically confirmed advanced colorectal cancer without the opportunity for curative surgery Karnofsky Performance Status (KPS) score ≥ 60, with an estimated survival time ≥ 3 months At least 1 measurable colorectal lesion No prior systemic chemotherapy, or a minimum interval of 6 months between the last chemotherapy and study enrollment Voluntary signing of the informed consent form\n\nExclusion Criteria:\n\n* Concomitant other malignant tumors Presence of gastrointestinal perforation Severe cardiovascular and cerebrovascular diseases Patients with hypersensitivity to study drugs or psychiatric disorders",{"count":465,"type":23},50,[467],"PHASE2","We plan to conduct a prospective, two-arm, open-label phase Ⅱ study to evaluate whether transarterial chemoembolization with FOLFOX plus\u002Fminus intravenous cetuximab\u002Fbevacizumab significantly improves the efficacy and safety compared with systemic FOLFOX therapy plus\u002Fminus cetuximab\u002Fbevacizumab in elderly patients with advanced unresectable colorectal cancer.",[470,471,27],"Unresectable Colorectal Cancer","Advanced Malignancy","2025-10-01",{"date":474,"type":37},"2025-10-07",{"date":472,"type":23},{"date":477,"type":23},"2026-10-01",{"name":479,"class":44},"Junpeng Wang",{"id":481,"slug":482,"hasResults":12,"nctId":483,"briefTitle":484,"officialTitle":485,"acronym":486,"eligibilityCriteria":487,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":55,"phases":490,"briefSummary":492,"conditions":493,"keywords":497,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":45},"100605618","phase-3-safety-and-efficacy-of-very-short-dapt-in-older-patients-undergoing-pci-100605618","NCT07164859","Safety and Efficacy of Very Short DAPT in Older Patients Undergoing PCI","Safety and Efficacy of Very Short Dual Antiplatelet Therapy Followed by P2Y12 Inhibitor Monotherapy in Older Patients Undergoing Percutaneous Coronary Intervention (SOLOPCI)","SOLOPCI","Inclusion Criteria:\n\n* Patients ≥ 65 years\n* Successfully treated with percutaneous coronary intervention (PCI) with ≥ 1 drug-eluting stent (final TIMI 3 flow and visually estimated residual diameter stenosis \\\u003C30%) for acute coronary syndrome (including ST-elevation myocardial infarction, non-ST-elevation myocardial infarction and unstable angina) or chronic coronary syndrome (elective PCI). Inclusion is possible after the last PCI procedure in staged procedure.\n* Randomization must be performed before the discharge from the study site.\n* Written informed consent\n* Social security affiliated\n\nExclusion Criteria:\n\n* PCI without drug-eluting stent implantation or with a bioresorbable scaffold\n* Planned coronary artery bypass grafting or cardiac surgery\n* Any planned surgery within 12 months unless intended antiplatelet therapy could be maintained throughout the peri-surgical period\n* Index PCI for stent thrombosis or chronic total occlusion\n* Need for oral anticoagulation therapy\n* Known hypersensitivity or allergy to aspirin, clopidogrel, ticagrelor or prasugrel\n* Use of fibrinolytic therapy within 24 hours of PCI\n* Severe renal insufficiency (MDRD creatinine clearance \\\u003C 30 ml\u002Fmin\u002Fm2) and\u002For dialysis\n* Increased bleeding risk (prior hemorrhagic stroke; stroke \\\u003C 30 days; brain injury\\\u003C6 months; history of intracranial tumor or intracranial hemorrhage; internal bleeding\\\u003C6 weeks; active bleeding; anemia (hemoglobin ≤ 8 g\u002Fdl) or thrombocytopenia (platelets \\\u003C 100 000 G\u002FL); major surgery\\\u003C3 weeks)\n* increased thrombotic risk related to the patient (previous stent thrombosis, ≥ 2 previous myocardial infarction, symptomatic peripheral artery disease, chronic systemic inflammatory disease treated with corticoids or immunosuppressive drug) or the procedure (left main treated, ≥3 stents\u002Ftreated lesions, total length of stents\\>60mm, bifurcation lesion with stents in each branch, stenting of the last patent vessel)\n* Life expectancy less than 1 year\n* Participation in another interventional trial\n* Patients considered as vulnerable by the investigators because of medical, psychological or social conditions:\n\n  * Patients with known or discovered severe cognitive impairment\n  * Patients with treated or untreated severe psychological or psychiatric conditions\n  * Patients with uncorrected severe hearing or visual handicap\n  * Patients with addictive alcohol, drug or substance abuse\n  * Patients with protective measures (guardianship, tutorship, curatorship)\n  * Any other condition considered by the investigators as not warranting informed consent\n* patients with poor quality of the downstream territory with diffuse distal coronary disease\n* women of childbearing potential: non menopaused -with no menses for 12 months without an alternative medical cause- and not permanently sterilized -hysterectomy, bilateral salpingectomy or bilateral oophorectomy-",{"count":489,"type":23},1700,[491],"PHASE3","The goal of this clinical trial is to learn if reducing the duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (short treatment regimen, stopping aspirin at day 7) is as safe and efficient as the standard DAPT duration (standard treatment regimen) in elderly patients ≥ 65 years.\n\nThe main questions it aims to answer are:\n\nDoes the reduction of the duration of DAPT reduces rates of bleeding without increasing the risk of cardiovascular events? Researchers will compare a short treatment by DAPT (7 days, followed by single antiplatelet therapy) to a standard treatment duration by DAPT (3 to 12 months) after successful percutaneous coronary intervention with ≥ 1 drug-eluting stent.\n\nParticipants will:\n\n* Take aspirin for 7 days in one group or 3 to 12 months in another group\n* Be contacted by phone at 7 days, 14 days, 21 days, 30 days, 3 months, 6 months and 12 months after hospital discharge\n* Keep a diary of any bleeding or cardiovascular events occurring during the study period",[494,495,496,27],"Coronary Artery Disease (CAD)","Percutaneous Coronary Intervention (PCI)","Antiplatelet Therapy",[498,499,61],"antiplatelet therapy","percutaneous coronary intervention","2025-09-25",{"date":472,"type":37},{"date":503,"type":23},"2025-10",{"date":505,"type":23},"2029-10",{"name":507,"class":44},"Vincent ROULE",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":515,"targetDuration":4,"studyType":55,"phases":517,"briefSummary":518,"conditions":519,"keywords":523,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":528,"lastUpdatePostDateStruct":529,"startDateStruct":531,"completionDateStruct":533,"leadSponsor":535,"locationsCount":45},"100603644","the-effect-of-cognitive-behavioral-therapy-cbt-based-psychoeducation-on-cognitive-flexibility-and-rumination-in-the-elderly-100603644","NCT07139197","The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly","The Effect of a Cognitive Behavioral Approach-Based Psychoeducation Program on Cognitive Flexibility and Rumination in Elderly Individuals Living in Nursing Homes","Inclusion Criteria:\n\n* Be 65 years of age or older,\n* Be willing to participate in the study,\n* Not have hearing or vision problems that would prevent understanding the training to be provided,\n* Have communication and comprehension skills,\n* Be literate,\n* Have a Standardized Mini Mental Test score between 25 and 30 points.\n\nExclusion Criteria:\n\n* Having any hearing or vision problems.\n* Having physical, neurological, or psychological health problems that could disrupt group harmony and integrity.\n* Having an illness or problem that could prevent them from responding to the measurement tools used in the study.\n* Having a Standardized Mini Mental Test score below 25.",{"count":516,"type":23},38,[57],"This study aimed to investigate the effect of psychoeducation on rumination and cognitive flexibility in elderly individuals residing in nursing homes. Cognitive Behavioral Therapy (CBT)-based psychoeducation has recently been applied to multiple specific groups around the world and in our country. In general, executive functioning skills and, more specifically, cognitive flexibility appear to be important for the ability to use certain CBT techniques; however, considering that these skills naturally decline with age, further research is needed. It is anticipated that the results of this study will contribute to applications in the field of psychiatric nursing.",[520,521,27,522],"Cognitive Flexibility","Rumination","Psychoeducation",[61,524,525,526,527],"psychoeducation","cognitive flexibility","rumination","cognitive behavioral therapy","2025-08-27",{"date":530,"type":37},"2025-09-04",{"date":532,"type":23},"2025-09-01",{"date":534,"type":23},"2026-06-15",{"name":536,"class":44},"Ataturk University",{"id":538,"slug":539,"hasResults":12,"nctId":540,"briefTitle":541,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":544,"targetDuration":545,"studyType":24,"phases":4,"briefSummary":546,"conditions":547,"keywords":549,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":552,"startDateStruct":554,"completionDateStruct":556,"leadSponsor":558,"locationsCount":45},"100596120","oral-metronomic-vinorelbine-and-pd-1-inhibitors-in-elderly-non-small-cell-lung-cancer-100596120","NCT07041320","Oral Metronomic Vinorelbine and PD-1 Inhibitors in Elderly Non-small Cell Lung Cancer","Effect and Safety of Oral Metronomic Vinorelbine and PD-1 Inhibitors in Elderly Patients With Non-small Cell Lung Cancer","Inclusion Criteria:\n\n* 1\\) All patients are histologically or cytologically confirmed non-small cell lung cancer. Genetic testing identifies no driver gene mutations.\n\n  2\\) Male or female, age ≥ 65 years 3) Patients had not received first-line treatment. 4) KPS score ≥ 70 points (ECOG score 0-1 points), the expected survival ≥3 months; 5) No dysfunction of major organs. EcG, liver function, renal function, and blood count tests before treatment are normal or basically normal, but must meet the following experimental results:\n  1. Blood routine test:\n\n     Leukocyte WBC≥3.5×109\u002FL; Neutrophil count (ANC) ≥ 1.5×109\u002FL; Platelet (PLT) ≥ 80×109\u002FL;\n  2. Blood biochemical test:\n\n     Total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal values; Alanine aminotransferase (ALT\u002FSGPT) and alanine transaminases (AST\u002FSGOT) ≤ 2.5 times the normal high value (ULN), or ≤ 5 times the upper limit of normal value in patients with liver metastases; Serum creatinine (Cr) ≤ 1.5 times the upper limit of normal values;\n  3. Cardiac function test: 50% of the left ventricular ejection function of the heart \\>; 6) The subject has good compliance, and can cooperates with follow-up.\n\n     Exclusion Criteria:\n* previously treated",{"count":418,"type":23},"2 Years","The goal of this observational study is to evaluate the efficacy and safety of oral metronomic vinorelbine and PD-1 inhibitors in elderly patients with unoperable, locally advanced or metastatic non-small-cell lung cancer. The primary end point was objective response rate (ORR), and the second end points included disease control rate (DCR), progression-free survival (PFS), and safety. Participants over 65 years old, received oral metronomic vinorelbine 40mg every week (20mg for patients over 80 years old), combined with PD-1 inhibitors every 3 weeks.",[548,27],"Lung Cancer (NSCLC)",[550,551],"Oral metronomic vinorelbine","PD-1 inhibitors",{"date":553,"type":37},"2025-06-27",{"date":555,"type":37},"2023-06-15",{"date":557,"type":23},"2026-12-31",{"name":559,"class":44},"Anhui Chest Hospital",{"id":561,"slug":562,"hasResults":12,"nctId":563,"briefTitle":564,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":566,"targetDuration":567,"studyType":24,"phases":4,"briefSummary":568,"conditions":569,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":45},"100590075","assessing-the-performance-of-gpt-4o-in-evaluating-the-safety-of-home-environment-for-older-adults-100590075","NCT06962696","Assessing the Performance of GPT-4o in Evaluating the Safety of Home Environment for Older Adults","Inclusion Criteria:\n\n1. Age ≥65 years old\n2. Staying in the place of residence for a long time\n3. Having normal listening, speaking, and comprehension skills\n\nExclusion Criteria:\n\nDoes not live regularly in the place of residence",{"count":138,"type":23},"1 Day","This study is an investigative study, taking the elderly in Beijing community as an example, and taking photos of different areas in the home environment of the elderly who agree to participate in the study (a total of seven aspects, including pathways\u002Fentrance to home, hallways, stairs\u002Fsteps, living room, kitchen, restroom, bedroom). Subsequently, the multi-modal large model GPT-4o and a professional occupational therapist will use the \"Home Environment Assessment\" scale to evaluate the home environment shown in the photos and give corresponding suggestions for modification. A professional occupational therapist (non-evaluator) will analyze and compare the evaluation results and guidance recommendations of GPT-4o and the evaluator, and compare whether there are any significant differences between the two analysis results.",[27,570],"Home Environment Related Disease","2025-06-17",{"date":573,"type":37},"2025-06-22",{"date":575,"type":37},"2025-03-01",{"date":577,"type":23},"2025-10-31",{"name":579,"class":44},"Peking University Third Hospital",{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":586,"enrollmentInfo":587,"targetDuration":4,"studyType":55,"phases":588,"briefSummary":589,"conditions":590,"keywords":594,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":597,"startDateStruct":599,"completionDateStruct":601,"leadSponsor":603,"locationsCount":45},"100594495","efficacy-of-inpatient-pulmonary-rehabilitation-program-in-elderly-patients-with-acute-exacerbation-of-copd-100594495","NCT07020182","Efficacy Of Inpatient Pulmonary Rehabilitation Program In Elderly Patients With Acute Exacerbation Of COPD","Inclusion Criteria:\n\n* Patients with acute exacerbation of COPD in both gender\n* Patient older than 65 years\n* Patient with clear consciousness\n* Patients had been diagnosed with shortness of breath or dyspnea that was not caused by heart disease, pneumothorax, or pulmonary edema\n\nExclusion Criteria:\n\n* Patient with systolic blood pressure lower than 90 mmHg\n* Patient with an unstable psychological status, hemoptysis, pneumothorax, pulmonary edema","78 Years",{"count":85,"type":23},[57],"The study aimed to identify the effect of early pulmonary rehabilitation in elderly patients with Acute exacerbation (AE) of COPD (AECOPD) in exercise tolerance, dyspnea, sleep quality, fatigue, and time to discharge from hospital.",[591,27,592,593],"COPD Received PR","COPD","COPD Acute Exacerbation",[595],"Elderly patients with acute exacerbation of COPD","2025-06-05",{"date":598,"type":37},"2025-06-13",{"date":600,"type":23},"2025-06-10",{"date":602,"type":23},"2025-09-15",{"name":604,"class":44},"Al-Azhar University",{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":610,"acronym":4,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":612,"targetDuration":4,"studyType":55,"phases":614,"briefSummary":615,"conditions":616,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":596,"lastUpdatePostDateStruct":619,"startDateStruct":621,"completionDateStruct":623,"leadSponsor":625,"locationsCount":45},"100593730","phase-2-dose-attenuated-ist-and-hetrombopag-in-elderly-65-years-patients-with-severe-aplastic-anemia-100593730","NCT07010237","Dose-attenuated IST and Hetrombopag in Elderly (≥65 Years) Patients With Severe Aplastic Anemia","Dose-attenuated IST and Hetrombopag in the Treatment of Elderly (≥65 Years) Patients With Very Severe\u002FSevere Aplastic Anemia: A Single-Center, Single-Arm, Phase IIB Clinical Study on Efficacy and Safety","Inclusion Criteria:\n\n* Clinical diagnosis of VSAA\u002FSAA.\n* Age ≥65 years.\n* Completion of all screening assessments.\n* Must be able to swallow tablets.\n* Signed informed consent (by patient or legal guardian if patient is incapacitated).\n\nExclusion Criteria:\n\n* Clonal cytogenetic abnormalities (excluding isolated -Y or +8).\n* Prior treatment with ATG\u002Fhigh-dose cyclophosphamide.\n* Prior cyclosporine\u002Ftacrolimus use \\>12 months.\n* Prior TPO-RA therapy \\>3 months.\n* Uncontrolled malignancies or conditions contraindicating ATG.\n* Severe organ dysfunction (e.g., creatinine ≥177 μmol\u002FL).\n* Investigator judgment of unsuitability.",{"count":613,"type":23},65,[467],"This is a prospetive,Single-Center, Single-Arm, Phase IIB Clinical Study.This study aims to evaluate the efficacy and safety of dose-attenuated IST combined with Hetrombopag in elderly patients (≥65 years) with VSAA\u002FSAA.",[617,27,618],"Sever Aplastic Anaemia","Immunosuppressive Treatment",{"date":620,"type":37},"2025-06-08",{"date":622,"type":37},"2025-02-01",{"date":624,"type":23},"2029-07-01",{"name":626,"class":44},"Institute of Hematology & Blood Diseases Hospital, China",{"id":628,"slug":629,"hasResults":12,"nctId":630,"briefTitle":631,"officialTitle":631,"acronym":4,"eligibilityCriteria":632,"healthyVolunteers":18,"sex":633,"minAge":20,"maxAge":391,"enrollmentInfo":634,"targetDuration":4,"studyType":55,"phases":635,"briefSummary":636,"conditions":637,"keywords":638,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":642,"startDateStruct":644,"completionDateStruct":646,"leadSponsor":648,"locationsCount":45},"100594178","acute-effects-of-motor-imagery-and-action-observation-in-the-elderly-single-blind-randomized-controlled-trial-100594178","NCT07016061","Acute Effects of Motor Imagery and Action Observation in the Elderly: Single-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Being aged 65 years or older, Female gender, Literate in Turkish, Scoring 21 or above on the Montreal Cognitive Assessment (MoCA) Version 7.1, No health conditions that would prevent participation in exercise\n\nExclusion Criteria:\n\n* Presence of serious health problems that would prevent participation in the study (e.g., trauma, cancer, surgery, severe cardiac or musculoskeletal disorders)\n\nParticipation in other intervention trials or observational studies during the intervention period, or initiation of a physical exercise program within 2 weeks following the intervention period\n\nAny medical condition or chronic medication use that may jeopardize safety or affect cognitive functions (e.g., neuroleptics)","FEMALE",{"count":465,"type":23},[57],"The aim of this study is to investigate the effects of acute action observation, motor imagery, exercise, and combined exercise training on parameters such as balance, reaction time, flexibility, fear of falling, cognitive status, attention, and memory in older adults.",[27],[639,640,447],"imagery","Mirror Neurons","2025-06-03",{"date":643,"type":37},"2025-06-11",{"date":645,"type":23},"2025-06-15",{"date":647,"type":23},"2025-08-20",{"name":649,"class":44},"Dokuz Eylul University",{"id":651,"slug":652,"hasResults":12,"nctId":653,"briefTitle":654,"officialTitle":655,"acronym":656,"eligibilityCriteria":657,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":658,"targetDuration":4,"studyType":55,"phases":660,"briefSummary":661,"conditions":662,"keywords":665,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":668,"lastUpdatePostDateStruct":669,"startDateStruct":671,"completionDateStruct":673,"leadSponsor":675,"locationsCount":45},"100585929","risk-of-falling-and-cardiac-rehabilitation-100585929","NCT06908759","Risk of Falling and Cardiac Rehabilitation","Risk of Falling Assessment in a Population of Patients With Cardiovascular Diseases Undergoing Cardiac Rehabilitation","CARDIO-BALANCE","Inclusion Criteria:\n\n\\- Age \\> 65 years\n\nRecent acute cardiac event, including:\n\n1. Cardiac surgery (CABG, aortic and\u002For mitral valve replacement, mitral valvuloplasty, or combined CABG + valve surgery)\n2. Recent myocardial infarction treated with percutaneous revascularization\n3. Episode of acute heart failure\n\nExclusion Criteria:\n\nPersistent clinical instability, defined as:\n\n* Marked hypotension (BP ≤ 95\u002F60 mmHg) or hypertension (BP ≥ 160\u002F100 mmHg)\n* Bradycardia (HR \\\u003C 50 bpm) or tachycardia (HR \\> 115 bpm)\n* Resting dyspnea\n* Signs and symptoms of infection",{"count":659,"type":23},150,[57],"Background and Rationale Cardiac rehabilitation (CR) is a key intervention for patients with chronic heart disease or recent acute cardiovascular events. In elderly and frail patients, CR aims not only to improve functional capacity but also to maintain or recover independence in daily activities. Hospitalization following an acute event often leads to bed rest, which-even after just 2-3 days-can cause hypokinetic syndrome, characterized by loss of muscle tone, orthostatic hypotension, decreased mobility, and psychological decline, including depression. Moreover, immobility increases thrombotic risk and vascular complications.\n\nTo mitigate these effects, CR is initiated promptly after clinical stabilization and includes three phases:\n\n1. Phase I - In-hospital rehabilitation\n2. Phase II - Early outpatient rehabilitation\n3. Phase III - Long-term maintenance Elderly patients are particularly vulnerable to falls due to the combined effects of reduced muscle strength, orthostatic hypotension, cognitive decline, and pre-existing sarcopenia-often exacerbated by acute events and immobility. Approximately 60% of cardiac patients hospitalized for acute events present with moderate-to-high fall risk. Fall risk in this population is multifactorial, involving cardiovascular issues (e.g., arrhythmias, orthostatic hypotension), medication effects, and non-cardiac factors such as vision loss, balance impairment, neuromuscular conditions, and cognitive deficits.",[663,27,664],"Risk of Falling","Cardiovascular Diseases",[666,667],"risk of fall","cardiac rehabilitation","2025-04-02",{"date":670,"type":37},"2025-04-03",{"date":672,"type":37},"2024-05-31",{"date":674,"type":23},"2025-06-30",{"name":676,"class":44},"IRCCS San Raffaele Roma"]