[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elective-major-abdominal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elective-major-abdominal-surgery":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100616303","effectiveness-of-goal-directed-fluid-therapy-guided-by-cardiac-index-versus-central-venous-pressure-in-major-abdominal-surgery-patients-in-the-icu-100616303",false,"NCT07303855","Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal Surgery Patients in the ICU.","Inclusion Criteria:\n\n* Adult patients aged 18 to 65 years.\n* Patients with a Body Mass Index (BMI) between 18 and 30 kg\u002Fm².\n* Patients undergoing elective major abdominal surgery with a planned postoperative admission to the ICU.\n* Patients with an American Society of Anesthesiologists (ASA) physical status classification of I to III.\n\nExclusion Criteria:\n\n* Patients with pre-operative cardiovascular disorders (Coronary Artery Disease, or heart failure NYHA Class III and IV).\n* Patients with severe renal impairment (Chronic Kidney Disease Stage V) with or without hemodialysis and fluid restrictions.\n* Non-sinus cardiac rhythm.\n* Pregnancy.\n* Patients with right heart failure (patients with signs of congestion and symptoms of right heart failure accompanied by evidence of reduced right ventricular function, indicated by TAPSE \\\u003C 17 mm).\n* Patients with pulmonary hypertension (patients with echocardiographic suspicion of tricuspid regurgitation, tricuspid regurgitation velocity \\> 3.4 m\u002Fs, or mean pulmonary artery pressure \\> 20 mmHg from right heart catheterization).\n* Patients with Acute Respiratory Distress Syndrome (ARDS) or patients requiring specialized ventilation modes.\n* Patients who refuse to participate in the study.","ALL","18 Years","65 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare two different methods for guiding intravenous (IV) fluid therapy in patients during their first 6 hours in the ICU after major abdominal surgery. The goal is to determine which method leads to a more optimal and precise amount of fluid administration. The objective is to compare the total fluid volumes administered when guided by Cardiac Index versus Central Venous Pressure, as well as mortality, length of stay, relaparotomy and reintubation in order to identify the more precise fluid management strategy for postoperative ICU patients.",[26],"Elective Major Abdominal Surgery",[28,29,30,31,32,33],"cardiac index","central venous pressure","goal-directed fluid therapy","elective major abdominal surgery","postoperative fluid management","intensive care","RECRUITING","2025-12-24",{"date":37,"type":38},"2025-12-29","ACTUAL",{"date":40,"type":38},"2025-12-01",{"date":42,"type":20},"2026-02-28",{"name":44,"class":45},"Indonesia University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":15,"minAge":17,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100530087","postoperative-neurocognitive-dysfunction-after-major-abdominal-surgery-pandaman-100530087","NCT06182215","PostoperAtive Neurocognitive Dysfunction After Major AbdomiNal Surgery (PANDAMAN)","Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery: A Prospective Observational Cohort Study","PANDAMAN","Inclusion Criteria:\n\n1. 65 to 90 years old to receive elective major abdominal surgery (expected operation time over 2 hours); ,\n2. American society of Aneshesiologists（ASA）physical status I-III;\n\nExclusion Criteria:\n\n1. Mini-Mental State Examination (MMES) score \\\u003C 15;\n2. Renal failure (requiring dialysis) or liver failure (Child-Pugh score \\> 5);\n3. Severe impairment due to structural or hypoxic brain injury, more than 2 days in ICU one month before surgery;\n4. Underwent major heart, lung or abdominal surgery within 1 year;\n5. Positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or symptomatic (e.g. fever, cough, loss of taste\u002Fsmell);\n6. The cognitive assessment cannot be completed because the subject is blind, deaf, or unable to communicate in the local language;\n7. Long-term follow-up unavailable (homelessness, active psychosis or substance abuse).","90 Years",{"count":57,"type":20},500,"3 Months","OBSERVATIONAL","Predisposing and precipitating factors for perioperative delirium for the elderly remain elusive. This research will be conducted to determine risk factors of postoperative delirium.",[26],"2024-06-13",{"date":64,"type":38},"2024-06-17",{"date":66,"type":38},"2023-12-11",{"date":68,"type":20},"2026-12-31",{"name":70,"class":45},"Sixth Affiliated Hospital, Sun Yat-sen University"]