[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elective-surgical-patient\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elective-surgical-patient":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":5},"100570818","phase-1-effect-of-dexmedetomidine-on-hemodynamic-response-to-endotracheal-intubation-in-hypertensive-patients-100570818",false,"NCT06712186","Effect of Dexmedetomidine on Hemodynamic Response to Endotracheal Intubation in Hypertensive Patients","Title: the Effects of Dexmedetomidine on Hemodynamic Responses to Endotracheal Intubation in Hypertensive Patients Undergoing Surgery","Inclusion Criteria:\n\n* ASA Grade II\n* Age \\> 60 years\n* Elective surgical procedures under GA.\n* All patients with a diagnosis of hypertension for 6 months or more and undergoing treatment with antihypertensive medications.\n\nExclusion Criteria:\n\n* Patient refusal\n* ASA Grade III and IV\n* Severely Hypovolemic state\n* Emergency surgeries\n* Body weight more than 20% of ideal body weight.\n* Patients with known or unanticipated difficult intubation and those requiring more than 15 sec or two attempts at laryngoscopy\n* Allergic to dexmedetomidine\n* Non complaint hypertensive patients\n* Patients with uncontrolled hypertension.","ALL","60 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","Dexmedetomidine, an alpha-2 adrenergic agonist, has been shown to provide several benefits during endotracheal intubation:\n\n1. \\_Reduced anxiety and stress\\_: Dexmedetomidine's anxiolytic and sedative effects help reduce anxiety and stress associated with endotracheal intubation.\n2. \\_Improved intubating conditions\\_: Dexmedetomidine can improve intubating conditions by reducing the incidence of coughing, bucking, and laryngospasm.\n3. \\_Decreased hemodynamic responses\\_: Dexmedetomidine can attenuate the hemodynamic responses to intubation, including tachycardia, hypertension, and increased cardiac output.\n4. \\_Increased ease of intubation\\_: Dexmedetomidine can facilitate smoother and easier intubation by reducing the need for additional anesthetics or muscle relaxants.\n\nThe physiological responses to dexmedetomidine during intubation include:\n\n1. \\_Decreased heart rate\\_: Dexmedetomidine can cause a decrease in heart rate due to its effects on the sympathetic nervous system.\n2. \\_Decreased blood pressure\\_: Dexmedetomidine can also cause a decrease in blood pressure due to its vasodilatory effects.\n3. \\_Increased sedation\\_: Dexmedetomidine's sedative effects can help reduce anxiety and stress during intubation.\n4. \\_Reduced respiratory rate\\_: Dexmedetomidine can cause a decrease in respiratory rate due to its effects on the respiratory centers in the brain.\n\nThe clinical benefits of dexmedetomidine during intubation include:\n\n1. \\_Improved patient comfort\\_: Dexmedetomidine's sedative and anxiolytic effects can improve patient comfort during intubation.\n2. \\_Reduced need for additional anesthetics\\_: Dexmedetomidine can reduce the need for additional anesthetics or muscle relaxants during intubation.\n3. \\_Decreased risk of complications\\_: Dexmedetomidine's effects on hemodynamic responses and respiratory rate can decrease the risk of complications during intubation.",[27,28,29,30,31],"Elective Surgical Patient","Hypertensive Patients","Blood Pressure","Hypertensive Elderly Patients","Anxiolytic",[33,34,35,36,37,38,39,40,41,42,31],"Laryngoscopy","Dexmedetomidine","Hemodynamic Response","Endotracheal intubation","Pressor response","Hypertension","Intubation","General anesthesia","a 2 agonist","Sedative","RECRUITING","2024-12-06",{"date":46,"type":47},"2024-12-11","ACTUAL",{"date":49,"type":47},"2024-06-22",{"date":51,"type":20},"2024-12-01",{"name":53,"class":54},"Liaquat National Hospital & Medical College","OTHER"]