[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elective-surgical-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elective-surgical-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100570273","phase-1-gabapentin-and-pressor-response-to-intubation-100570273",false,"NCT06705101","Gabapentin and Pressor Response to Intubation","GABAPENTIN ATTENUATES THE PRESSOR RESPONSE TO DIRECT LARYNGOSCOPY AND TRACHEAL INTUBATION","Inclusion Criteria:\n\n* ASA I or II patients (American Society of Anesthesiologists Physical Status Classification).\n* Age between 18 and 59 years.\n* Scheduled for elective surgery under general anesthesia with endotracheal intubation.\n\nExclusion Criteria:\n\n* Anticipated difficult intubation.\n* ASA III or greater.\n* Patients with hiatus hernia or gastro-esophageal reflux disease (GERD).\n* Body weight more than 20% of ideal body weight.\n* Patients on antihypertensive drugs, sedatives, hypnotics, or antidepressants.","ALL","18 Years","59 Years",{"count":20,"type":21},144,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This study evaluates the effectiveness of oral gabapentin in reducing the pressor response (increased MAP, HR, and BP) during laryngoscopic intubation. It is a prospective, double-blind randomized controlled trial involving 144 patients undergoing elective surgery. Gabapentin 300 mg or placebo will be administered preoperatively, with hemodynamic parameters monitored before and after intubation. The study aims to determine if gabapentin attenuates the sympathetic stress response compared to placebo.",[28,29],"Elective Surgical Patients","Blood Pressure",[31,32,33,34],"Gabapentin","Laryngoscopy","Hemodynamic Stability","Pressor Response","NOT_YET_RECRUITING","2024-11-22",{"date":38,"type":39},"2024-11-26","ACTUAL",{"date":41,"type":21},"2024-12-15",{"date":43,"type":21},"2025-07-16",{"name":45,"class":46},"Liaquat National Hospital & Medical College","OTHER"]