[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"elective-surgical-procedures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:elective-surgical-procedures":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,56,94,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100431190","phase-4-opioid-free-anesthesia-analgesia-strategy-and-surgical-stress-in-elective-open-abdominal-aortic-aneurysm-repair-100431190",false,"NCT04894864","Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair","Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study","Inclusion Criteria:\n\n1. Patient Consent\n2. Age between 40 and 85 years old\n3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair\n\nExclusion Criteria:\n\n1. Immunocompromised patients\n2. Patients with active infection\n3. Reoperation on the aorta\n4. Inflammatory bowel Disease\n5. Malignancy\n6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis)\n7. Chronic corticosteroid or immunosuppressive drug use\n8. Intraoperative transfusion with \\>2 units of packed Red Blood Cells","ALL","40 Years","85 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Open Abdominal Aortic Aneurysm (AAA) repair is a high-risk surgical procedure accompanied by intense endocrine and metabolic responses to surgical stress, with subsequent activation of the inflammatory cascade, cytokine and acute-phase protein release, and bone marrow activation. There is a proven correlation of surgical stress, which patients undergoing open AAA repair are subjected to, with patient outcome, morbidity\u002Fmortality, intensive care unit stay and overall length of stay. Modern general anesthetic techniques have been revised and rely on perioperative multimodal anesthetic and analgesic strategies for improved overall patient outcome. Based on this context of a multimodal anesthetic technique and having taken into consideration the international \"opioid-crisis\" epidemic, an Opioid Free Anesthesia-Analgesia (OFA-A) strategy started to emerge. It is based on the administration of a variety of anesthetic\u002Fanalgesic agents with different mechanisms of action, including immunomodulating and anti-inflammatory effects.\n\nOur basic hypothesis is that the implementation of a perioperative multimodal OFA-A strategy, involving the administration of pregabalin, ketamine, dexmedetomidine, lidocaine, dexamethasone, dexketoprofen, paracetamol and magnesium sulphate, will lead to attenuation of surgical stress response compared to a conventional Opioid-Based Anesthesia-Analgesia (OBA-A) strategy. Furthermore, the anticipated attenuation of the inflammatory response, is pressumed to be associated with equal or improved analgesia, compared to a perioperative OBA-A technique.",[27,28,29,30,31,32,33,34],"Elective Surgical Procedures","Postoperative Pain","Anesthesia","Opioid Use","Abdominal Aortic Aneurysm Without Rupture","Vascular Surgical Procedure","Interleukin 6","Immunomodulators",[36,37,38,39,40,41,42],"Opioid-free Anesthesia-Analgesia","Cytokines","Opioid-based Anesthesia-Analgesia","Haemodynamic Stability","Open Abdominal Aortic Aneurysm Repair","Immunomodulation","Inflammatory Markers","RECRUITING","2026-06-13",{"date":46,"type":47},"2026-06-16","ACTUAL",{"date":49,"type":47},"2020-10-08",{"date":51,"type":21},"2027-09-01",{"name":53,"class":54},"University of Crete","OTHER",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":67,"briefSummary":69,"conditions":70,"keywords":75,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":93},"100638709","prehabilitation-before-major-surgery-100638709","NCT07590141","Prehabilitation Before Major Surgery","PRehabilitation In Advance of Major Elective Surgery: A Pilot Randomized Controlled Trial (PRIME Pilot)","PRIME","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Undergoing major elective intra-thoracic, intra-abdominal or orthopedic surgery. Major surgery is defined as any operation performed under general and\u002For spinal anesthesia requiring a skin incision extending beyond the subcutaneous tissue\n* More than 3 weeks from the date of scheduled operation\n\nExclusion Criteria:\n\n* Emergency Surgery\n* Operation in less than 3 weeks from time of initial research contact\n* Patients who are pregnant\n* Unable\u002Funwilling to sign written informed consent\n* Physical, cognitive or psychological impairment\n* Unable to understand\u002Fcommunication in English.","18 Years",{"count":66,"type":21},120,[68],"NA","The goal of this clinical trial is to learn if a virtually monitored, home-based prehabilitation program is feasible and acceptable for adults undergoing major elective surgery. The main questions it aims to answer are:\n\n1. Can researchers successfully recruit and retain participants across multiple sites?\n2. Will participants adhere to the prehabilitation program at a high enough rate to justify a larger trial?\n\nResearchers will compare the prehabilitation program to standard preoperative care to see if the intervention is feasible to implement and whether it may help reduce postoperative complications.\n\nParticipants will:\n\n* Be randomly assigned to receive either the prehabilitation program or usual care\n* Complete questionnaires and physical assessments before and after the intervention\n* (For those in the intervention group) Receive exercise, nutrition, and mindfulness guidance, protein supplements, and use the CloudDX virtual care platform to support their activities",[71,72,27,73,74],"Prehabilitation","Preoperative Care","Postoperative Complications","Surgical Procedures, Operative",[76,77,78,79,80,81,82],"Home-based Care","Virtual Care","Remote Health Monitoring","Exercise Therapy","Nutritional Support","Psychological Support","Postoperative Outcomes","NOT_YET_RECRUITING","2026-05-10",{"date":86,"type":47},"2026-05-15",{"date":88,"type":21},"2026-06-01",{"date":90,"type":21},"2028-01-31",{"name":92,"class":54},"Queen's University",3,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":100,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":16,"minAge":64,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":105,"conditions":106,"keywords":110,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":55},"100598181","telenursing-in-the-immediate-preoperative-period-of-elective-surgeries-100598181","NCT07068152","TELENURSING IN THE IMMEDIATE PREOPERATIVE PERIOD OF ELECTIVE SURGERIES","COST-EFFECTIVENESS ANALYSIS OF \"PIGGYBACK\" TELENURSING IN THE IMMEDIATE PREOPERATIVE PERIOD OF ELECTIVE SURGERIES: RANDOMIZED CLINICAL TRIAL PROTOCOL","TIPPES","Inclusion Criteria:\n\n* Patient recruitment will be conducted using the hospital's general surgical center surgical map. The participating population will consist of:\n* All patients 18 years of age or older, of both sexes, in the immediate preoperative period;\n* Admitted on the day of elective surgery;\n* Coming from their home.\n\nExclusion Criteria:\n\n* Inpatients;\n* Ophthalmology, obstetrics, and pediatrics specialties;\n* Exams performed in the surgical center, such as endoscopy, colonoscopy, video hysteroscopy, and others.",{"count":103,"type":21},352,[68],"Introduction: Telenursing encompasses Nursing Consultation, Interconsultation, Consulting, Monitoring, Health Education and Reception of Spontaneous Demand mediated by Information and Communication Technology. Objective: To perform a cost-effectiveness analysis of telenursing in the immediate preoperative period of adult patients undergoing elective surgeries in a university hospital of the SUS. Materials and method: Cost-effectiveness analysis nested in a clinical trial or empirical economic analysis of the piggyback evaluation type. Divided into 2 phases: a) Experimental research - randomized clinical trial to be carried out in a university hospital located in Rio de Janeiro and part of the SUS, with two parallel groups - intervention and control - with 1:1 allocation. The inclusion criteria will be adult patients, of both sexes, in the immediate preoperative period who are admitted on the day of elective surgery from their home. Patients who are hospitalized, patients in ophthalmology and obstetrics specialties, and those who will undergo examinations in the surgical center will be excluded. The sample size calculation was performed with a 95% confidence level and a sample loss of 5%, totaling 352 patients. The sampling will be random. Randomization and allocation concealment will be performed by the independent researcher. Patients in the GI will receive telenursing on the day before surgery with an anamnesis script for telenursing by the main researcher. On the day of surgery, all patients on the surgical map who came from their residence will be directed to the nursing assessment room where the auxiliary researcher will apply the in-person anamnesis script. The data will be processed by two independent researchers in an electronic spreadsheet and will be analyzed using descriptive and inferential statistics. The research will respect all legal and ethical frameworks necessary for its implementation; b) Prospective analysis of complete economic evaluation - in the piggyback evaluation modality - of the cost-effectiveness type. The effectiveness of telenursing will be verified by the outcome of surgical cancellation. A decision tree model will be used with a view to analyzing the SUS user at the local level (microcosting). The time horizon will be two days. The cost-effectiveness threshold will be 1 GDP per capita and the data analysis will include deterministic and probabilistic sensitivity. Expected results: It is expected to prove that telenursing can be a safe and efficient method for guiding patients before surgery, generating greater patient satisfaction, increasing access to information about health care for users through remote communication with nurses, reducing the waiting list by reducing surgical cancellations and possible incorporation of telenursing as a consolidated practice in the university hospital studied.",[72,107,108,27,109],"Telenursing","Patient Safety","Hospitals",[27,111,112,72,109],"telenursing","patient safety","2025-07-16",{"date":115,"type":47},"2025-07-20",{"date":117,"type":21},"2025-08-01",{"date":119,"type":21},"2027-02",{"name":121,"class":54},"Rio de Janeiro State University",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":129,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":132,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":55},"100503930","impact-of-ces1-genotype-on-remimazolam-100503930","NCT05841667","Impact of CES1 Genotype on Remimazolam","A Clinical Study to Explore the Effect of Carboxylesterase 1 (CES1) Genotype on Pharmacokinetics, Safety, and Efficacy of Remimazolam","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status 1 or 2\n* Age 19-70 years\n* Elective surgery\n\nExclusion Criteria:\n\n* Concomitant regional anesthesia\n* Uncontrolled hypertension (systolic blood pressure \\>180 mmHg)\n* Uncontrolled diabetes mellitus (HbA1c \\>9.0%)\n* Aspartate transaminase (AST), Alanine transferase (ALT), Total bilirubin \\> more than 2 times the normal upper limit\n* Estimated glomerular filtration rate \\\u003C60 ml\u002Fmin\u002F1.73m2\n* Moderate to severe chronic pulmonary obstructive disease or respiratory failure\n* Emergency\n* Hepatectomy, Liver transplantation\n* Cardiopulmonary bypass use\n* Craniotomy due to head trauma, unstable intracranial pressure, or brain disease\n* Use of benzodiazepine medications (if tolerance is present)\n* Anxiety, alcohol\u002Fdrug dependence, or addiction to tricyclic antidepressants\n* Reported hypersensitivity and adverse reactions to benzodiazepines, flumazenil, and other agents used during anesthesia\n* Lactose-related genetic disorders\n* Myasthenia gravis or myasthenia gravis syndrome\n* Newly diagnosed myocardial infarction\u002Fclinically significant coronary artery disease, cerebral ischemic attack\u002Fstroke within 6 months, or significant untreated coronary artery disease\n* Implanted rate-responsive cardiac pacemaker with a bioelectrical impedance sensor.\n* Intrinsic brain disorders or other conditions that make it difficult to determine the depth of anesthesia through EEG measurements (e.g., epilepsy)\n* History of severe allergies\n* Cognitive impairment that prevents comprehension of the instructions and consent form of this study, in case of sedation\n* Expected intraoperative blood loss of 1000 ml or more\n* Judged by the investigator to be unsuitable for participation in this study due to other reasons","19 Years","70 Years",{"count":66,"type":21},"OBSERVATIONAL","Remimazolam is primarily metabolized via CES1, and other drugs that are commonly metabolized by CES1 are known to have their pharmacokinetics and clinical effects affected by genetic polymorphisms in CES1.\n\nThe goal of this observational study is to investigate the impact of the CES1 genotype on the pharmacokinetics, safety, and efficacy of remimazolam in patients undergoing elective surgery.",[135,136,27],"Adult","Middle Aged","2024-10-09",{"date":139,"type":47},"2024-10-15",{"date":141,"type":47},"2023-09-06",{"date":143,"type":21},"2025-12-31",{"name":145,"class":54},"Korea University Guro Hospital"]