[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electric-stimulation-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electric-stimulation-therapy":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100113251","phase-2-effects-of-brain-stimulation-on-food-intake-and-behavioral-weight-loss-treatment-100113251",false,"NCT00739362","Effects of Brain Stimulation on Food Intake and Behavioral Weight Loss Treatment","The Effects of Transcranial Direct Current Stimulation (TDCS) on Food Intake and Weight Loss","* INCLUSION CRITERIA:\n* BMI \\>= 25 kg\u002Fm\\^2\n* Age 18-60 years. Women who are post-menopausal will be excluded from the study due to changes in their metabolism that could affect weight loss. We will set the cutoff at age 60 so that the age difference between the men and women is not too great for analysis purposes. Minors under the age of 18 will be excluded because the time requirements of the study are such that they would interfere with school schedules.\n* Right-handedness (because the treatment will be given to the left dorsolateral prefrontal cortex and the evidence accumulated in this region was only in right-handed individuals).\n* Weight stable (+\u002F- 5 percent) for last 3 months as determined by volunteer report.\n\nEXCLUSION CRITERIA:\n\n* Weight \\> 300 lbs (136 kg), as this is the general size limit of the fMRI machine. Participants \\>300 pounds may be included if their body habitus will allow them to fit within the diameter of the MRI machine. This will be determined on a case-by-case basis after consultation with staff at Banner Health Neuroimaging Center.\n* Use of medication affecting metabolism and appetite in the last three months\n* Current pregnancy, pregnancy within the past 6 months or currently lactating\n* History or clinical manifestations of acute or chronic disorders or conditions that may affect appetite or energy expenditure (such as, but not limited to type 1 or type 2 diabetes, Cushing s disease, thyroid disorders, coccidiomycoses)\n* Gastrointestinal disease, including inflammatory bowel diseases (e.g. Chron s disease and ulcerative colitis), malabsorption syndromes (e.g. celiac disease), gastric ulcer (active) which may alter metabolism\n* Current, unstable medical conditions such as hepatitis, renal insufficiency, cancer requiring treatment in the last 5 years, or central nervous system disorders etc. as assessed by history and physical exam\n* Evidence of alcohol abuse as defined by \\>= 8 point score on the Alcohol consumption screening AUDIT questionnaire in adults\n* Evidence of drug use such as amphetamines, cocaine, heroin, or marijuana\n* Current use of tobacco products that exceed \"Very Low Dependence\" on the Fagerstr(SqrRoot)(Delta)m Test for Nicotine Dependence Tool (score greater than 2)\n* Postmenopausal women or symptoms of perimenopause (e.g. hot flashes, onset of irregular periods following age 40, elevation of FSH \\>20 IU following age 40 years)\n* Any conditions contraindicated for MRI (e.g., pacemaker, metal in the cranial cavity, significant claustrophobia, holes in the skull made by trauma or surgery)\n* Any condition not specifically mentioned above that, in the opinion of the investigator, may interfere with the study or prove unsafe for participation.",true,"ALL","18 Years","60 Years",{"count":21,"type":22},148,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This study will determine whether electrical stimulation of an area of the brain called the dorsolateral prefrontal cortex, which is important in determining the feeling of fullness after eating, affects how much food a person eats and weight loss over 4 weeks. It will also compare weight changes in people who attend weight loss counseling sessions and those who do not over this period of time.\n\nObese, non-diabetic people between 18 and 60 years of age who are in good health and who live in the Phoenix, AZ, metropolitan area are eligible for this study. Candidates must have a body mass index of 35 kg\u002Fm(2) or more and weigh less than 350 pounds.\n\nParticipants are admitted to the NIH inpatient unit in Phoenix for the first 9 days of the study for tests, which include meal tests to determine eating behaviors and caloric intake, blood and urine tests, glucose tolerance test, weight measurement, psychological assessments and DEXA scan to measure body fat. For 3 of the days, they will be asked to eat all of their food from automated vending machines. Some subjects receive transcranial direct current stimulation (TDCS). For this procedure, electrodes that conduct electricity are placed on the head and arm and the current is turned on for 40 minutes. Some tingling may be felt under the electrodes. Other subjects receive sham TDCS, with the current turned on only very briefly.\n\nAfter the evaluations, subjects are discharged home from the NIH unit and instructed to eat 25 percent fewer calories than they consumed while on a weight maintenance diet the first 3 days of their inpatient stay. They maintain the lower calorie diet at home for 4 weeks. During this period they come to the NIH unit 3 days a week to receive either real or sham TDCS.\n\n...",[28,29,30,31],"Electric Stimulation Therapy","Obesity","Weight Loss","Eating",[33,29,34,30,35],"Behavioral Weight Loss Treatment","Appetite Control","Transcranial Direct Current Stimulation (TDCS)","RECRUITING","2026-06-27",{"date":39,"type":40},"2026-06-30","ACTUAL",{"date":42,"type":40},"2009-01-19",{"date":44,"type":22},"2027-01-31",{"name":46,"class":47},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":78,"locationsCount":48},"100556048","evaluating-safety-and-feasibility-of-transcutaneous-spinal-cord-stimulation-following-traumatic-and-non-traumatic-spinal-cord-injury-a-pilot-study-100556048","NCT06520020","Evaluating Safety and Feasibility of Transcutaneous Spinal Cord Stimulation Following Traumatic and Non-Traumatic Spinal Cord Injury: A Pilot Study","STIM","Inclusion Criteria:\n\n* Age: = 18 years and = 80 years.\n* Written informed consent by patient and\u002For legal authorized representative (LAR).\n* No other life-threatening condition.\n* No evidence of sepsis.\n* No evidence of superficial skin infection at site of surgery and intervention.\n* An established diagnosis of either:\n\n  * cervical myelopathy with modified Japanese Orthopaedic Association score of 8-14, or\n  * acute cervical \u002F thoracic SCI with ASIA Impairment Scale grade A-D (as assessed within 72 hours of injury) with neurologic level of injury (NLI) from C2 to T12.\n* The ability to undergo, or have had, surgical intervention. -. The ability to undergo transcutaneous intervention including study procedures in the posterior cervical or thoracic midline at or after 14 days from surgery.\n\nExclusion Criteria:\n\n* Any concomitant impairment of the upper and lower limb at baseline that could potentially confound the neurologic assessments; including but not limited to traumatic or disease conditions like brachial plexus injury, peripheral neuropathy, spinal hematoma, transverse myelitis, non-compressive myelopathy, dementia, and Parkinson's disease.\n* mJOA of \\>= 15 and \\\u003C= 7, or AIS grade E tSCI at baseline assessment.\n* Currently involved in another non-observational ntSCI or tSCI study, or receiving another interventional drug, that could interfere with recordings and confound adverse events.\n* Other illness (including mental disorder) that could preclude accurate medical and neurological evaluation, at discretion of the treating surgeon and\u002For principal investigator.\n* Unable to commit to the follow-up schedule.\n* Recent history of regular substance abuse (illicit drugs, alcohol), which in the opinion of the investigator would interfere with the subject's participation in the study.\n* Any condition likely to result in the patient's death within the next 12 months.\n* Prisoner.\n* Pregnancy.\n* Cardiac pacemaker dependent, unable to undergo electrical stimulation.\n* Brain implant, skull prosthesis, plate and screws limiting transcranial stimulation.\n* Tattoo at site of skin electrode that causes heat\u002Fpain during stimulation.\n* Subjects who in the opinion of the investigator are not suitable for inclusion in the study, with reason documented.","80 Years",{"count":58,"type":22},30,[60],"NA","The study will be a non-randomized, non-blinded pilot study to analyze the safety and feasibility of a non-significant risk device, transcutaneous spinal cord stimulation. The aim is to include 30 total patients, 10 patients in each of 3 groups:\n\n1. Non-traumatic spinal cord injury (ntSCI) with diagnosis of degenerative cervical myelopathy and offered surgical intervention.\n2. Early tSCI screened during the hospital admission when cervical\u002Fthoracic spinal injury was diagnosed.\n3. Delayed tSCI (control) screened 6-24 months after acute cervical\u002Fthoracic spinal injury.",[63,28,64,65],"Spinal Cord Stimulation","Traumatic Spinal Cord Injury","Cervical Myelopathy",[67,68,69,70,71],"Stimulation","Transcutaneous","MagStim","Transcranial","Magnetic","2025-06-05",{"date":74,"type":40},"2025-06-06",{"date":76,"type":40},"2024-10-23",{"date":39,"type":22},{"name":79,"class":80},"Francis Farhadi","OTHER"]