[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electric-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electric-stimulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100590486","effectiveness-of-personalized-alternating-current-stimulation-for-treating-cognitive-impairment-in-cns-demyelination-patients-100590486",false,"NCT06968039","Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients","This Study is Designed to Evaluate the Efficacy of Personalized Alternating Current Stimulation in the Treatment of Working Memory in Patients With Inflammatory Demyelination of the Central Nervous System","Inclusion Criteria:\n\n* Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria;\n* Patients with SDMT scores \\\u003C55 or subjective cognitive decline;\n* Age between 18 and 65 years, gender unrestricted;\n* No relapse or medication changes in the past month;\n* EDSS (Expanded Disability Status Scale) score ≤6;\n* Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions; -Willing to participate and have signed informed consent.-\n\nExclusion Criteria:\n\n* Relapse record within the past month;\n* Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques;\n* Participating in any other clinical research within 1 month prior to enrollment or currently;\n* Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices;\n* Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives;\n* History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;\n* Pregnant or lactating women, or those planning pregnancy in the near future;\n* Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness;\n* Concurrent severe or unstable organic diseases;\n* Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance;\n* Other situations deemed inappropriate for study participation by the researchers.","ALL","18 Years","65 Years",{"count":20,"type":21},85,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.\n\nObjective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders.\n\nMethods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized a one-time tES intervention, measuring changes in cognitive domains including working memory, attention, executive function, and processing speed.\n\nAnticipated Results: We hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases.\n\nSignificance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.",[27,28],"Multiple Sclerosis","Electric Stimulation","RECRUITING","2025-05-05",{"date":32,"type":33},"2025-05-13","ACTUAL",{"date":35,"type":33},"2024-12-31",{"date":37,"type":21},"2027-10-01",{"name":39,"class":40},"Xuanwu Hospital, Beijing","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":41},"100569623","electrical-muscle-stimulation-effect-versus-myofascial-release-on-quality-of-life-in-female-fibromyalgia-100569623","NCT06696651","Electrical Muscle Stimulation Effect Versus Myofascial Release on Quality of Life in Female Fibromyalgia","Electrical Muscle Stimulation Effect Compared With Myofascial Release on Quality of Life in Female Fibromyalgia","Inclusion Criteria:\n\n1. Sixty females have diagnosed suffering from fibromyalgia syndrome.\n2. Their ages will be ranged from 45 to 55 years old.\n3. Their body mass index will be ranged from 25 to 34 ( overweight and obese type 1)\n4. They have willingness to participate in this study.\n\nExclusion Criteria:\n\n1. Peripheral vascular diseases.\n2. Drug abuse.\n3. Smokers.\n4. Chest disease. ( either obstructive or restrictive ).\n5. Clinical signs of sever cardiac events ( eg. Congestive heart disease).","FEMALE","45 Years","55 Years",{"count":53,"type":21},60,[24],"the study was done to investigate the effect of Electrical Muscle Stimulation as muscle strengthening versus the effect of myofascial releasing on quality of life in female fibromyalgia patients while following Mediterranean diet.",[28,57,58],"Myofascial Release","Fibromyalgia","NOT_YET_RECRUITING","2024-11-18",{"date":62,"type":33},"2024-11-20",{"date":64,"type":21},"2024-12-15",{"date":66,"type":21},"2025-03-15",{"name":68,"class":40},"Cairo University"]