[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electrical-impedance-tomography\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electrical-impedance-tomography":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,77,109,134],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100615169","peep-titration-guided-by-electrical-impedance-tomography-in-laparoscopic-surgery-the-pearl-study-100615169",false,"NCT07289113","PEEP Titration Guided by Electrical Impedance Tomography in Laparoscopic Surgery The PEaRL Study","Personalized PEEP Titration Guided by Electrical Impedance Tomography in Patients Undergoing Laparoscopic Surgery: A Randomized Controlled Trial - The PEaRL Study","PEaRL","Inclusion Criteria:\n\n* scheduled for laparoscopic abdominal surgery\n* informed consent signed\n\nExclusion Criteria:\n\n* COPD\n* Acute respiratory failure\n* Hemodynamic instability\n* Pregnancy\n* Contraindications for EIT device","ALL","18 Years",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background:\n\nLaparoscopic surgery has gained widespread adoption due to its minimally invasive nature, offering advantages such as reduced postoperative pain, shorter hospitalization, and faster functional recovery compared with traditional open surgery. Nevertheless, postoperative respiratory complications remain a major source of morbidity. Factors such as general anesthesia, the Trendelenburg position, and CO₂ pneumoperitoneum can impair respiratory mechanics, reduce total lung capacity, and promote atelectasis, leading to compromised gas exchange.\n\nRationale:\n\nPositive end-expiratory pressure (PEEP) is routinely applied to prevent alveolar collapse and improve oxygenation during mechanical ventilation. However, the use of standardized, non-individualized PEEP levels may be suboptimal, as inappropriate settings can cause alveolar overdistension or persistent collapse. Personalized PEEP titration, tailored to patient-specific lung mechanics, has recently emerged as a promising strategy to minimize ventilator-induced lung injury (VILI).\n\nMethods and Tools:\n\nElectrical Impedance Tomography (EIT) is a non-invasive, bedside monitoring technique that enables real-time assessment of regional lung ventilation. By evaluating ventilated and non-ventilated lung areas, EIT can guide PEEP optimization and support individualized ventilatory management. Recent studies suggest that EIT-guided PEEP titration improves respiratory parameters and reduces atelectasis in patients undergoing major surgery.\n\nObjective:\n\nThe present study aims to evaluate the efficacy of EIT-guided PEEP personalization in patients undergoing laparoscopic and robotic surgery. Primary endpoints include improvements in regional ventilation, respiratory system compliance, and intraoperative gas exchange, as well as postoperative pulmonary function.",[27],"Electrical Impedance Tomography",[29,27,30],"PEEP","Laparoscopy","RECRUITING","2026-06-03",{"date":34,"type":35},"2026-06-04","ACTUAL",{"date":37,"type":35},"2026-01-12",{"date":39,"type":21},"2026-11",{"name":41,"class":42},"ASST Fatebenefratelli Sacco","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100616312","effects-of-inspiratory-vs-expiratory-breath-hold-on-lung-perfusion-measured-by-eit-saline-indicator-method-a-self-controlled-study-100616312","NCT07303972","Effects of Inspiratory vs Expiratory Breath-Hold on Lung Perfusion Measured by EIT Saline Indicator Method: A Self-Controlled Study","Electrical Impedance Tomography Saline Indicator Technique for Assessing Differences in Lung Perfusion Between Inspiratory and Expiratory Breath-Hold Phases: A Prospective Self-Controlled Study","Inclusion Criteria:\n\n* Age 18 to 65 years\n* Able to provide written informed consent\n* Able to perform standardized inspiratory and expiratory breath-hold maneuvers for at least 8 seconds\n* No known acute cardiopulmonary disease\n* Suitable for noninvasive electrical impedance tomography monitoring and intravenous saline administration\n\nExclusion Criteria:\n\n* Known severe cardiopulmonary disease (e.g., advanced chronic obstructive pulmonary disease, severe pulmonary hypertension, or heart failure)\n* Hemodynamic instability or clinically significant cardiac arrhythmia\n* Contraindication to intravenous saline administration or fluid bolus\n* Pregnancy or breastfeeding\n* Skin conditions or chest wall abnormalities preventing proper placement of EIT electrodes",true,"65 Years",{"count":54,"type":21},100,[24],"This study aims to compare lung perfusion distribution between inspiratory breath-hold and expiratory breath-hold phases using the saline indicator method combined with electrical impedance tomography (EIT). A self-controlled crossover design will be used in which each participant undergoes both breath-hold conditions with standardized rapid intravenous saline injections. The primary objective is to evaluate changes in global and regional pulmonary perfusion under different lung volume states. The findings may improve understanding of perfusion redistribution with lung inflation and support optimized ventilatory strategies in clinical practice.",[58,59,27,60],"Lung Perfusion","Respiratory Physiology","Ventilation-Perfusion Mismatch",[27,58,62,63,64,65,66],"Saline Indicator","Breath-Hold","Inspiratory \u002F Expiratory Phases","Regional Perfusion","Ventilation-Perfusion Matching","NOT_YET_RECRUITING","2025-12-23",{"date":70,"type":35},"2025-12-26",{"date":72,"type":21},"2026-01-01",{"date":74,"type":21},"2028-01-01",{"name":76,"class":42},"Shanghai Zhongshan Hospital",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":43},"100617055","eit-guided-peep-optimization-in-trauma-and-postoperative-ards-100617055","NCT07313644","EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS","Electrical Impedance Tomography-Guided Positive End-Expiratory Pressure Optimization in Patients With Trauma-Related and Postoperative Acute Respiratory Distress Syndrome","EIT-PEEP-SURG","Inclusion Criteria:\n\n* Mechanically ventilated surgical intensive care patients with trauma- or postoperative-associated moderate to severe ARDS, as defined by the 2023 Global Definition of ARDS.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>90 years.\n* Severe acute brain injury or acute stroke with Glasgow Coma Scale \\\u003C8.\n* Thoracic trauma with pneumothorax or pneumomediastinum.\n* End-stage diseases under palliative care (e.g., metastatic cancer, cirrhosis, end-stage renal disease).\n* Severe multiorgan failure with expected survival \\\u003C7 days.\n* Conditions requiring prolonged mechanical ventilation (e.g., Guillain-Barré syndrome, cervical spinal cord injury).\n* Contraindications to hypercapnia (e.g., elevated intracranial pressure, acute coronary syndrome).\n* Prior use of advanced respiratory therapies (e.g., ECMO, inhaled nitric oxide, prone positioning, high-frequency ventilation).\n* Pregnancy, breastfeeding, or skin lesions at electrode placement sites.\n* Implanted electrical devices interfering with EIT (e.g., pacemaker, ICD).\n* Known allergy to electrode materials.\n* Refusal to participate or concurrent enrollment in another study","90 Years",{"count":87,"type":21},80,[24],"Acute respiratory distress syndrome (ARDS) remains a serious and often fatal complication in patients following severe trauma or major surgery. Mechanical ventilation is essential for supportive care in this population, but may aggravate lung injury when suboptimal ventilatory settings are applied. Positive end-expiratory pressure (PEEP) is crucial for maintaining alveolar recruitment; however, optimal PEEP selection in trauma- or postoperative-associated ARDS remains uncertain. Electrical impedance tomography (EIT) enables bedside, real-time assessment of regional ventilation and may support optimal PEEP titration by balancing alveolar overdistension and collapse. This study compares EIT-guided PEEP optimization with the conventional low FiO₂-PEEP strategy in terms of oxygenation and respiratory mechanics in patients with moderate to severe ARDS following trauma or surgery.",[91,92,27,93],"Acute Respiratory Syndrome Distress","Positive End-Expiratory Pressure","Trauma and Postoperative Pulmonary Insufficiency",[95,92,96,97,98,99],"Acute respiratory syndrome distress","electrical impedance tomography","Trauma and Postoperative","blood oxygenation","pulmonary mechanics","2025-12-17",{"date":102,"type":35},"2026-01-02",{"date":104,"type":35},"2025-03-15",{"date":106,"type":21},"2026-12-15",{"name":108,"class":42},"Nguyen Dang Thu",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":43},"100581479","recruitment-maneuvers-and-peep-guided-electrical-impedance-tomography-for-abdominal-laparoscopic-surgery-patients-100581479","NCT06850844","Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients","Impact of Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography on Regional Ventilation, Gas Exchange, and Pulmonary Mechanics in in Abdominal Laparoscopic Surgery Patients","PEEP-EIT","Inclusion Criteria:\n\n* Age \\> 18 years\n* Scheduled for abdominal laparoscopy surgery\n* At increased (i.e., intermediate or high) risk of postoperative pulmonary complications according to the \"Assess Respiratory Risk in Surgical Patients in Catalonia\" (ARISCAT) score (≥ 26 points)\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Major previous lung surgery (e.g., lung resection)\n* Severe chronic obstructive pulmonary disease and\u002For severe emphysema\n* Increased intracranial pressure\n* Contraindications for EIT (pacemakers, automatic external defibrillators, cases of chest trauma or recent chest surgery limiting EIT belt application)\n* Presence of pneumothorax that is either undrained or newly occurred.\n* Unstable hemodynamics with a mean arterial pressure \\\u003C 60 mmHg and unresponsive to resuscitation measures, and\u002For heart rate \\\u003C 60 bpm.\n* Pregnancy.\n* Severe neuromuscular disease.",{"count":118,"type":21},70,[24],"Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays. However, the use of intraoperative pneumoperitoneum and general anesthesia with mechanical ventilation may lead to postoperative pulmonary complications, such as atelectasis. This condition can result in diminished respiratory mechanics and impaired gas exchange.\n\nIn recent years, intraoperative lung-protective mechanical ventilation techniques, including recruitment maneuvers (RMs) and positive end-expiratory pressure (PEEP) strategies, have gained popularity. These approaches aim to prevent the repeated collapse and reopening of alveoli, thereby reducing the risk of atelectasis. Nonetheless, determining the optimal PEEP level for individual patients remains a complicated and unresolved issue.\n\nElectrical impedance tomography (EIT) is a bedside imaging technique that assesses regional ventilation distribution, providing a method for personalizing PEEP settings in mechanically ventilated patients. By addressing the competing risks of alveolar overdistension and collapse, EIT enhances the precision of PEEP titration.\n\nThis study aims to compare the effects of recruitment maneuvers and EIT-guided PEEP selection against conventional ventilation on regional ventilation, gas exchange, and pulmonary mechanics in patients undergoing abdominal laparoscopic surgery.",[122,92,27],"Laparoscopic Surgery",[122,92,124,96,98,125,99],"Recruitment Maneuver","regional ventilation","2025-02-23",{"date":128,"type":35},"2025-02-27",{"date":130,"type":35},"2024-08-01",{"date":132,"type":21},"2025-12-30",{"name":108,"class":42},{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":141,"phases":4,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":43},"100579660","by-assessing-the-continuous-respiratory-physiological-changes-through-prone-position-determine-the-optimal-duration-for-prone-position-100579660","NCT06827184","By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position","Inclusion Criteria:\n\n1. Acute respiratory distress syndrome\n2. Age \\> 18\n3. Serial arterial blood gas data：PaO2\u002FFiO2 \\\u003C150. The mechanical ventilator setting：FiO2\\>0.6, PEEP\\>5 cmH2O\n\nExclusion Criteria:\n\n1. Implantable electronic devices (e.g., pacemakers)\n2. Body mass index \\> 30\n3. Major thoracic and abdominal surgery\n4. Patients with unstable spine and pelvis conditions\n5. Pregnant women in the second and third trimesters\n6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure\n7. Hemodynamically unstable patients unsuitable for prone ventilation therapy\n8. Patients with active seizures",{"count":54,"type":21},"OBSERVATIONAL","The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.",[144,145,27],"Acute Respiratory Distress Syndrome","Prone Position","2025-02-16",{"date":148,"type":35},"2025-02-19",{"date":150,"type":35},"2024-09-20",{"date":152,"type":21},"2030-12-31",{"name":154,"class":42},"National Taiwan University Hospital"]