[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electroconvulsive-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electroconvulsive-therapy":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,58,88,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":36,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100640612","flumazenil-for-benzodiazepine-reversal-in-electroconvulsive-therapy-100640612",false,"NCT07619092","Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy","Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy (FLEET): A Randomized Controlled Trial","FLEET","Inclusion criteria:\n\n* Current depressive episode (unipolar or bipolar), corresponding to ICD-10 codes F31.3-5, F32 or F33.\n* Admitted at a study affiliated department in the Mental Health Services of the Capital Region of Denmark\n* Referred to ECT by the regular psychiatrist and has given consent to ECT\n* Currently receiving treatment with a benzodiazepine and\u002For zopiclone, at a minimum daily dose equivalent to 0.5 mg lorazepam.\n\nExclusion criteria:\n\n* Involuntary treatment with ECT\n* Known gross abnormalities in brain structure deemed likely to influence cognitive functioning\n* Pregnancy or breast-feeding\n* Inability to read or understand Danish\n* Acute organic brain disease (e.g., delirium) influencing the ability to give informed consent\n* Any pre-existing condition associated with an increased risk of prolonged or uncontrollable seizures, including but not limited to epilepsy or alcohol- or benzodiazepine withdrawal states\n* Conditions associated with reduced metabolism of flumazenil (e.g., liver failure)","ALL","18 Years",{"count":20,"type":21},145,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this study is to investigate whether administering flumazenil to reverse the effects of benzodiazepines and\u002For zopiclone during electroconvulsive therapy (ECT) can help reduce cognitive side effects without diminishing treatment effectiveness in hospitalized patients with depression.\n\nThe investigators hypothesize that blockade of the GABA receptor with flumazenil will reduce cognitive side effects through improved seizures and a reduced need for electrical charge escalation during the ECT series. Cognitive side effects will be measured by the total score on the Screening for Cognitive Impairment in Psychiatry (SCIP) (primary outcome) at follow-up after completion of the ECT series. Furthermore, it is expected that the flumazenil strategy will reduce pre-treatment anxiety and improve patient satisfaction (secondary outcomes). In addition, flumazenil strategy is hypothesized to have beneficial effects on subjective cognitive complaints, autobiographical memory, and executive functioning (secondary outcomes). Finally, the flumazenil strategy is expected to be associated with more favorable structural and functional changes in executive functioning and memory-related brain networks after completion of the ECT series, which may, in turn, be linked to better overall cognition and autobiographical memory (secondary outcome measures). For exploratory purposes, the study will also examine longitudinal changes in depressive symptoms and cognitive outcomes from baseline to follow-up (tertiary outcomes).\n\nInvestigators will compare two different pre-ECT benzodiazepine management strategies:\n\n1. Flumazenil strategy (experimental): continued benzodiazepine and\u002For zopiclone use up until the time of the ECT session, followed by administration of flumazenil immediately prior to ECT\n2. Benzodiazepine withholding strategy (treatment as usual):\n\ndiscontinuation of benzodiazepines and\u002For zopiclone prior to the ECT in accordance with standard clinical practice",[27,28,29,30,31,32,33,34,35],"Depression - Major Depressive Disorder","Bipolar Disorder (BD)","Functional Magnetic Resonance Imaging (fMRI)","Cognition","Autobiographical Memory","Electroconvulsive Therapy","ECT","Treatment Outcome","Inpatients",[37,38,39,40,41,42,35,43,44,34,30],"flumazenil","benzodiazepine reversal","electroconvulsive therapy","randomized controlled trial","functional magnetic resonance imaging","Autobiographical Memory Test (AMT)","Major Depressive Disorder","Bipolar Disorder","RECRUITING","2026-05-27",{"date":48,"type":49},"2026-06-01","ACTUAL",{"date":51,"type":49},"2026-01-15",{"date":53,"type":21},"2028-08",{"name":55,"class":56},"Anders Jørgensen","OTHER",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":22,"phases":69,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":57},"100629359","multimodal-clinical-study-of-electroconvulsive-therapy-and-magnetic-seizure-therapy-100629359","NCT07473648","Multimodal Clinical Study of Electroconvulsive Therapy and Magnetic Seizure Therapy","Patients Inclusion Criteria:\n\nAged 12-80 years; Diagnosis confirmed by two psychiatrists per DSM-5; Stable medication regimen pre-enrollment; Indicated for neuromodulation OR with visual field defects.\n\nPatients Exclusion Criteria:\n\nMajor systemic diseases; Prior neuromodulation within 3 months; Pregnancy or potential pregnancy; Metal implants or claustrophobia.\n\nHealthy Control Inclusion Criteria:\n\nAged 12-80 years; No history of neuropsychiatric disorders; No significant systemic diseases; Normal or corrected vision.\n\nHealthy Control Exclusion Criteria:\n\nMetal implants or claustrophobia; Ocular diseases or surgery history.",true,"12 Years","80 Years",{"count":68,"type":21},200,[24],"To compare the efficacy and tolerability of Electroconvulsive Therapy (ECT) and Magnetic Seizure Therapy (MST) in patients with major depressive disorder (MDD).",[32,43,72],"Magnetic Seizure Therapy",[74,75,76,77,78],"Electroconvulsive Therapy (ECT)","Magnetic Seizure Therapy(MST)","Major Depressive Disorder(MDD)","Electroencephalography(EEG)","Resting-state Functional MRI (fMRI)","2026-03-10",{"date":81,"type":49},"2026-03-16",{"date":83,"type":49},"2025-09-01",{"date":85,"type":21},"2028-01",{"name":87,"class":56},"The Second Hospital of Anhui Medical University",{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":64,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":22,"phases":97,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":57},"100619873","comparing-virtual-reality-simulation-to-high-fidelity-simulation-as-an-educational-modality-for-electroconvulsive-therapy-training-a-non-inferiority-study-100619873","NCT07350278","Comparing Virtual Reality Simulation to High Fidelity Simulation as an Educational Modality for Electroconvulsive Therapy Training: A Non-Inferiority Study","ECT-SIM","Inclusion Criteria:\n\n* Is a medical student at the University of Toronto\n* Has not received formal ECT training before\n\nExclusion Criteria:\n\n* Visual or hearing impairment that does not allow the participant to use VR.\n* History of significant motion sickness.",{"count":96,"type":21},78,[24],"The goal of this prospective, open-label non-inferiority randomized controlled trial is to investigate if Virtual Reality (VR) based simulation are an effective training tool for novice medical trainees. The main questions it aims to answer are:\n\n* Is the VR-based electroconvulsive therapy (ECT) training program non-inferior to traditional, mannequin-based ECT training programs in fostering ECT skill acquisition?\n* What are the changes in confidence in administering ECT, as well as number of training repetitions completed in the VR and mannequin training groups?\n* What is the ease of use of the VR-based ECT training program? Researchers will compare the VR-based ECT training program to a mannequin-based ECT training program to see if the VR-based ECT training program is comparable to traditional methods at training for ECT.\n\nParticipants will:\n\n* Complete an ECT skills assessment at the beginning and end of the study session.\n* Watch a 30-minute didactic ECT lecture video.\n* Be randomized to either the VR ECT simulation group or the mannequin ECT simulation group and be given 30 minutes to practice ECT administration with their assigned education tool.",[100,32,101],"Education, Medical, Undergraduate","Virtual Reality Simulation",[103,104,105,39],"virtual reality","mannequin","education","NOT_YET_RECRUITING","2026-01-13",{"date":109,"type":49},"2026-01-20",{"date":111,"type":21},"2026-01-05",{"date":113,"type":21},"2027-06-01",{"name":115,"class":56},"Sunnybrook Health Sciences Centre",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":64,"sex":17,"minAge":18,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":131,"overallStatus":106,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":4},"100591469","development-of-virtual-reality-for-nursing-students-electroconvulsive-therapy-100591469","NCT06980831","Development of Virtual Reality for Nursing Students: Electroconvulsive Therapy","Developmental of Virtual Reality for Nursing Students: Electroconvulsive Therapy","Experimental","Inclusion Criteria:\n\n* the researchers will include Thai-nursing students who 1) are between 18 and 24 years of age; 2) are proficient in Thai; 3) volunteer\n\nExclusion Criteria:\n\n* the researchers will exclude Thai nursing students who 1) current presence of physical or mental conditions such as learning disorders and psychiatric disorders, all of which make full participation in all aspects of this study questionable; 2) had already studied in ECT or had experienced for taking care patients with ECT.","24 Years",{"count":126,"type":21},140,[24],"Project: \"Development of virtual reality for nursing students: ECT\"\n\nFor this project the researchers will adapte 'health belief model' as a core concept for developing knowledge, attitude and skills of nursing students to take care of psychiatric patients with ECT. For their practice, the participants will be taught to take care of patients with ECT into 3 phases: before, during, and after ECT.\n\nThe researchers believe that this VR technology will help Thai-nursing students better understand and know how to take care of patients with ECT.\n\nThis project will consist of two phase. phase I: developing VR- ECT technology for nursing students. we will pilot test VR-ECT in Nursing students by randomizing nursing students volunteers into two groups: an experimental group and waitlist control group (N = 140). Knowledge, attitude and satisfaction and self-confidence will be measured at baseline (day 1), week 8 after intervention complete",[32,130],"Knowledge, Attitudes, Practice",[132,133,134,135,39],"knowledge","attitude","satisfaction","self-confidence","2025-05-12",{"date":138,"type":49},"2025-05-20",{"date":140,"type":21},"2025-06-01",{"date":142,"type":21},"2026-12-31",{"name":144,"class":56},"Mae Fah Luang University"]