[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electroencephalogram-eeg\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electroencephalogram-eeg":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100643016","phase-4-the-effects-of-different-anesthetics-on-the-brains-neural-networks-100643016",false,"NCT07644663","The Effects of Different Anesthetics on the Brain's Neural Networks","Propofol, Dexmedetomidine, and Esketamine-Induced Unresponsive States: Alterations in Information Integration and Brain Networks","Inclusion Criteria:\n\n* Patients scheduled for elective non-cardiac surgery;\n* American Society of Anesthesiologists (ASA) physical status classification I-II;\n* Aged 18 to 65 years, regardless of gender;\n* Body mass index (BMI) greater than 18 kg\u002Fm² and no more than 31 kg\u002Fm²;\n* Written informed consent voluntarily signed by the patient or legal authorized representative for participation in this study.\n\nExclusion Criteria:\n\nSubjects meeting any one of the following items will be excluded from this study:\n\n* Presence of severe cardiovascular diseases or hepatic and renal insufficiency;\n* Hearing impairment;\n* History of psychiatric disorders or communication disorders;\n* Anticipated difficult airway;\n* Pregnant or lactating women;\n* History of allergic reaction or contraindication to any of the three anesthetic drugs used in this trial;\n* Participation in other clinical trials within the past 3 months.","ALL","18 Years","65 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","This study aims to analyze the electroencephalographic power spectrum and connectivity during unresponsive states induced by propofol, esketamine and dexmedetomidine, respectively. It intends to explore the macro neural mechanisms underlying anesthetic unresponsiveness, so as to further elucidate the mechanisms by which anesthetics induce loss and recovery of consciousness. In addition, this study will identify neural biomarkers under general anesthesia for monitoring patients' actual intraoperative consciousness status. The findings will facilitate the development of monitoring indicators and devices reflecting intraoperative consciousness during general anesthesia, enabling more accurate assessment of patients' intraoperative consciousness status.",[27,28],"Electroencephalogram (EEG)","Anesthesia",[30,31,32],"EEG","anesthesia","loss of responsiveness","NOT_YET_RECRUITING","2026-06-08",{"date":36,"type":37},"2026-06-12","ACTUAL",{"date":39,"type":21},"2026-06-09",{"date":41,"type":21},"2026-09-10",{"name":43,"class":44},"Fudan University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":53,"targetDuration":55,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":45},"100558945","exploring-the-characteristics-of-epileptogenic-foci-in-drug-resistant-epilepsy-based-on-multimodal-imaging-technology-100558945","NCT06557720","Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Based on Multimodal Imaging Technology","Exploring the Characteristics of Epileptogenic Foci in Drug-Resistant Epilepsy Using Multimodal Imaging Techniques: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n1. Aged ≥18 years old;\n2. Meet the 2010 International League Against Epilepsy (ILAE) diagnostic criteria for drug-resistant epilepsy;\n3. Duration of epilepsy ≥2 years, with an average seizure frequency of ≥2 times per month in the 3 months prior to enrollment;\n4. Adequate intake of two or more anti-epileptic drugs, with no intervention in the treatment plan during the trial period;\n5. Capable of cooperating to complete treatment and related examination items; The patient and family fully understand and voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n1. In a state of continuous epileptic seizures;\n2. Complicated with severe infections, cerebrovascular diseases, malignant tumors, and other diseases, accompanied by severe dysfunction of the heart, liver, kidney, or other organs, or with mental disorders, or with uncorrectable hyperglycemia, or 3.patients on long-term use of corticosteroid medications;\n\n4.Pregnant or lactating women; 5.Contraindications for PET, MR, EEG examinations; 6.Patients with examinations (with ferromagnetic metal implants in the body; high fever); 7.Participating in other clinical trials at the same time; 8.The patient or family withdraws the informed consent form.",{"count":54,"type":21},50,"2 Months","OBSERVATIONAL","Using multimodal imaging technology, this study aims to explore the characteristics of epileptogenic foci in patients with drug-resistant epilepsy and identify key network nodes (such as central nodes) to provide more assistance for the diagnosis of drug-resistant epilepsy.",[59,60,27],"Drug Resistant Epilepsy","Magnetic Resonance Imaging","RECRUITING","2025-06-23",{"date":64,"type":37},"2025-06-25",{"date":66,"type":37},"2024-06-11",{"date":68,"type":21},"2027-08-01",{"name":70,"class":44},"Xijing Hospital"]