[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"electrolyte-changes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:electrolyte-changes":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100613511","heart-lung-machine-impact-of-the-priming-solution-on-acid-base-balance-electrolytes-and-outcome-on-patients-undergoing-cardiac-surgery-100613511",false,"NCT07267546","Heart-Lung Machine: Impact of the Priming Solution on Acid-Base Balance, Electrolytes and Outcome on Patients Undergoing Cardiac Surgery","Heart-Lung Machine: Impact of the Priming Solution on the Body's Acid-Base Balance, Electrolyte Composition and Clinical Outcome (PRIMEII)","PRIMEII","Inclusion Criteria:\n\n* Patients 18 years and above\n* Undergoing coronary artery bypass graft (CABG) surgery as single surgery\n* Undergoing aortic valve replacement (AVR) as single surgery (AtriClip is allowed)\n* Given consent to participate, both verbal and written\n\nExclusion Criteria:\n\n* Subnormal heart function (defined as an ejection fraction \\\u003C45%), and no signs of heart failure (edema).\n* Body weight \\\u003C60 kg or \\>120 kg\n* Preoperative hemoglobin \\\u003C120 g\u002FL,\n* Subnormal kidney function (defined as GFR \\\u003C30 ml\u002Fmin),\n* Blood sodium outside normal range (135-145 mmol\u002Fl),\n* Need of acute surgery\n* AVR due to aortic valve insufficiency\n* Changes in operating method or addition of intraoperative procedures.","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Most cardiac surgery procedures requires the use of heart-lung machine. The heart-lung machine circuit needs to be filled with a fluid before connecting it to the patients circulation. This is called priming and is accomplished by filling the circuit with a solution used for fluid replacement. The circuit in our institution requires 1100 mL to be filled.\n\nThe body has several mechanisms with the purpose to maintain its state of balance. When a large amount of clear solution suddenly enters the blood stream this balance can be altered. The goal of this clinical trial is to investigate different priming solutions in the heart-lung machine circuit. The main questions it aims to answer are:\n\nHow do different priming solutions alter the acid-base balance, osmolality and electrolytes which reflects the body's water balance for patients undergoing cardiac surgery with the use of heart-lung machine?\n\nThere will be 4 different groups:\n\n1. Ringer-Acetate, 1100 mL \u002F no addition\n2. Ringer-Acetate, 1100 mL + 80 mmol sodium chloride (NaCl)\n3. Ringer-Acetate, 1100 mL + 160 mmol NaCl\n4. Plasmalyte, 1100 mL \u002F no addition Blood samples will be taken before, during and after surgery, post operative day 1 and 4 to analyze acid-base balance, electrolytes, and plasma osmolality. Urine output and hydration status will also be collected until post operative day 1. After 3 months, a blood sample will be taken for analysis of electrolytes and kidney function.",[27,28,29,30,31],"Acid Base Imbalance","Osmolality Disturbance","Crystalloid Solutions","Electrolyte Changes","Cardiopulmonary Bypass",[33,34,35,36,37],"cardiopulmonary bypass","priming solution","acid base balance","electrolytes","plasma osmolality","RECRUITING","2025-12-04",{"date":41,"type":42},"2025-12-05","ACTUAL",{"date":44,"type":42},"2025-09-01",{"date":46,"type":21},"2026-11-01",{"name":48,"class":49},"Region Skane","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":50},"100501814","trial-of-variable-dialysate-bicarbonate-100501814","NCT05814146","Trial of Variable Dialysate Bicarbonate","Randomized, Controlled, Double-blind Trial of Lower Versus Higher Dialysate Bicarbonate in Hospitalized Maintenance Hemodialysis Patients","Inclusion Criteria:\n\n* prevalent end-stage renal disease, on maintenance HD \\> 90 days\n* age ≥ 18 years old\n* thrice weekly HD\n\nExclusion Criteria:\n\n* hemoglobin \\\u003C 8.0 g\u002FdL\n* pregnancy\n* any physical, mental or medical condition which limited the ability to provide written informed consent","120 Years",{"count":60,"type":21},141,[24],"QTc prolongation and premature ventricular contractions (PVCs) are common in hemodialysis (HD) patients and are associated with sudden cardiac death.\n\nIt is known that higher dialysate bicarbonate is associated with more QTc prolongation during HD sessions.\n\nThis study aims to assess the effects of lower (30 mEq\u002FL) versus higher (35 mEq\u002FL) dialysate bicarbonate in adult maintenance HD patients admitted to the hospital.\n\nThe investigators will randomly assign subjects to lower versus higher dialysate bicarbonate concentrations during their hospital stay for up to a maximum of six HD sessions or until their hospital discharge.",[64,65,30,66,67],"Peri-dialytic Cardiac Rhythms","Intradialytic Hypotension","pH Changes","Adverse Symptoms","2025-11-19",{"date":70,"type":42},"2025-11-24",{"date":72,"type":42},"2023-08-24",{"date":74,"type":21},"2026-10-01",{"name":76,"class":49},"Brigham and Women's Hospital"]