[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emergence-from-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emergence-from-anesthesia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100627017","phase-3-comparison-between-total-intravenous-anesthesia-with-magnesium-sulphate-versus-total-intravenous-anesthesia-with-dexmedetomidine-in-patients-undergoing-lumbar-spine-surgeries-100627017",false,"NCT07443163","Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries","Comparison Between Total Intravenous Anesthesia With Magnesium Sulphate Versus Total Intravenous Anesthesia With Dexmedetomidine in Patients Undergoing Lumbar Spine Surgeries on Extubation Time: A Randomized Double-Blinded Comparative Study","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status I, II.\n* Scheduled for elective spine surgery up to two levels under general anesthesia\n\nExclusion Criteria:\n\n* History of preoperative neuromuscular disease, hepatic impairment \\[defined as a known diagnosis of liver cirrhosis, hepatitis with elevated liver enzymes (\\>2 times upper standard limit), or Child-Pugh score B or C\\], renal impairment \\[defined as chronic kidney disease with an estimated glomerular filtration rate (eGFR) \\\u003C60 mL\u002Fmin\u002F1.73 m² or history of dialysis\\], endocrinal disorders \\[including uncontrolled diabetes mellitus (HbA1c \\>8.5%), thyroid dysfunction (untreated hypo\u002Fhyperthyroidism), or adrenal insufficiency\\], hematological disorder \\[such as anemia (Hb \\\u003C10 g\u002FdL), coagulopathies (INR \\>1.5, platelet count \\\u003C100,000\u002Fmm³), or bleeding diathesis\\] or cardiovascular dysfunction \\[defined as history of ischemic heart disease, arrhythmias requiring treatment, heart failure (NYHA class II or higher), or uncontrolled hypertension (SBP \\>160 mmHg or DBP \\>100 mmHg)\\].\n* Any degree of heart block.\n* Known allergy to the study drugs.\n* Scoliosis surgery.\n* Cervical spine surgeries.\n* Surgeries with an anticipated duration of more than 4 hours.\n* Receiving magnesium supplementation.\n* Any Preoperative Disturbed consciousness level or cognitive dysfunction.\n* Drugs known to have a significant interaction with NMDAs.\n* Chronic use of opioids and current treatment with a β-blocker or calcium channel blocker.","ALL","18 Years","65 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"PHASE3","Although total intravenous anesthesia (TIVA) provides advantages such as accelerated recuperation and diminished postoperative nausea, it also has constraints, such as the potential for hemodynamic instability and inadequate analgesia. TIVA is less suitable for major surgeries, particularly those involving the spine, when used alone, due to these limitations, as they necessitate substantial muscle relaxation and pain management.\n\nA non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, magnesium sulfate (MgSO4), exhibits antinociceptive properties. The infusion of Magnesium during general anesthesia has been shown to decrease the need for anesthesia and the consumption of postoperative analgesics in numerous clinical studies. MgSO4, when utilized as an adjunct to TIVA, has been demonstrated to decrease the duration of extubation, facilitate earlier emergence from anesthesia, and facilitate intraoperative neurophysiological monitoring (IOM) during spine surgery.\n\nDexmedetomidine is a selective α2-adrenoreceptor agonist whose sedative effects are predominantly mediated by its action on α-2 adrenergic receptors in the brain and spinal cord. It delivers efficient sedation without the pronounced respiratory depression that is frequently observed with other sedatives. Dexmedetomidine induces a profound sense of tranquility and alleviates anxiety by selectively targeting specific receptors in the central nervous system, in addition to offering analgesic advantages. Dexmedetomidine has been employed in the surgical intensive care unit to expedite the extubation process. Dexmedetomidine is now being utilized more frequently as an adjuvant for propofol-based TIVA in procedures that necessitateintraoperative neurophysiological monitoring.\n\nThere is a paucity of literature comparing TIVA with magnesium sulphate and TIVA with dexmedetomidine in spine surgeries.",[27],"Emergence From Anesthesia","NOT_YET_RECRUITING","2026-02-27",{"date":31,"type":32},"2026-03-02","ACTUAL",{"date":34,"type":21},"2026-03",{"date":36,"type":21},"2026-10",{"name":38,"class":39},"Cairo University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":16,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":54,"conditions":55,"keywords":61,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100626441","efficacy-of-ultrasound-guided-greater-auricular-nerve-block-in-preventing-postoperative-emergence-agitation-in-pediatric-patients-undergoing-microscopic-middle-ear-surgery-100626441","NCT07435675","Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery.","Efficacy of Ultrasound-guided Greater Auricular Nerve Block in Preventing Postoperative Emergence Agitation in Pediatric Patients Undergoing Microscopic Middle Ear Surgery: A PROSPECTIVE RANDOMIZED DOUBLE- BLINDED CLINICAL TRIAL","Inclusion Criteria:\n\n* Age between 5 and 14 years (preschool to early school age group at highest risk for EA).\n* ASA physical status I or II.\n* Scheduled for elective microscopic middle ear surgery under general anesthesia (e.g., tympanoplasty, myringoplasty).\n* Ability to comply with FLACC and PAED scoring during postoperative period.\n* Informed consent obtained from a parent or legal guardian.\n\nExclusion Criteria:\n\n* Known neurological, developmental, or psychiatric disorders (e.g., autism, ADHD, seizure disorder).\n* Known hypersensitivity to amide local anesthetics (e.g., lidocaine, bupivacaine).\n* Skin infection, hematoma, or trauma at or near the proposed block site.\n* Non-elective (emergency) or combined surgeries.\n* Inability to assess pain or agitation due to hearing loss, or communication impairment.\n* Parental or legal guardian refusal to participate.",true,"5 Years","14 Years",{"count":51,"type":21},74,[53],"NA","This study is designed to evaluate the effectiveness of ultrasound-guided greater auricular nerve block (GAN) on the reduction of emergence agitation (EA) occurrence and EA severity in children who are receiving general anesthesia for a microscopic middle ear operation.",[56,57,27,58,59,60],"Emergence Agitation","Emergence Delirium, Anesthesia","Emergence Delirium","Emergence Delirium in Pediatric Anesthesia","Emergence Agitation, Post Operative Behavioral Changes",[62,63,64],"emergence agitation","emergence delirium","EA","RECRUITING","2026-02-23",{"date":29,"type":32},{"date":69,"type":32},"2025-08-01",{"date":71,"type":21},"2026-04-01",{"name":73,"class":39},"Fayoum University",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":86,"studyType":87,"phases":4,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":4},"100612545","an-observational-prospective-study-of-anesthetic-sensitivity-assessed-by-alpha-band-power-and-its-association-with-emergence-time-from-sevoflurane-general-anesthesia-in-young-adults-100612545","NCT07254975","An Observational Prospective Study of Anesthetic Sensitivity Assessed by Alpha Band Power and Its Association With Emergence Time From Sevoflurane General Anesthesia in Young Adults.","ALPHA-SET","Inclusion Criteria\n\n* Elective surgery under general anesthesia\n* Age 35-50 years\n* ASA physical status I-II\n\nExclusion Criteria\n\n* Neurological or psychiatric disorders\n* Use of psychotropic drugs or opioids\n* Altered consciousness\n* BMI \\> 35 kg\u002Fm²\n* Renal, cardiac, or hepatic dysfunction\n* Emergency surgery\n* Pregnancy\n* Regional anesthesia","35 Years","50 Years",{"count":85,"type":21},70,"1 Day","OBSERVATIONAL","The goal of this observational study is to determine the relationship between brain activity patterns and recovery time in adult patients (ages 35-50, ASA I-II) undergoing elective general anesthesia.\n\nThe main question it aims to answer is:\n\n\\- Does a lower magnitude of intraoperative alpha wave power correlate with a longer time for patients to emerge from general anesthesia?\n\nParticipants will:\n\n* Undergo a standardized general anesthesia (GA) protocol for elective surgery.\n* Have their EEG activity recorded using a standard clinical BIS™ anesthetic depth monitor during the procedure.\n* Have their time to awakening precisely measured after the cessation of anesthetic gases.",[27,90],"EEG Power Spectra",[92,93,94,95],"emergence from anesthesia","general anesthesia","sevoflurane","alpha power","2025-11-19",{"date":98,"type":32},"2025-11-28",{"date":100,"type":21},"2025-11-24",{"date":102,"type":21},"2026-08-31",{"name":104,"class":39},"University of Chile"]