[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emergencies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emergencies":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,25,0,[8,52,80,108,138,163,188,213,245,272,296,328,354,378,411,434,461,499,519,545,574,634,662,686,707],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100550030","simulation-trial-of-telemedical-support-for-paramedics-100550030",false,"NCT06441760","Simulation Trial of Telemedical Support for Paramedics","Efficacy of Teleconsultation to Improve Prehospital Patient Safety for Critically Ill Infants and Children - A Multicenter, Simulation-based Randomized Control Trial","R01","Inclusion Criteria:\n\n* Certified Emergency Medical Technicians (EMTs), Advanced EMTs (AEMTs), and Paramedics (EMT-Ps) who provide direct scene response.\n* Board-certified Pediatric Emergency Medicine (PEM) and Emergency Medicine (EM) physicians whose practice includes online medical support for EMS are eligible.\n* The control arm will include physicians who provide radio\u002Ftelephone support in usual care at each site. In the intervention arm, experts will be PEM with\u002Fwithout EMS board-certification as they have relevant pediatric training and experience.\n\nExclusion Criteria:\n\n* EMS personnel providing interfacility transport and\u002For pediatric specialty transport\n* Resident physicians-in-training\n* Non-physician providers","ALL","21 Years",{"count":20,"type":21},420,"ESTIMATED","INTERVENTIONAL",[24],"NA","In the United States, the current standard of prehospital (i.e. outside of hospitals) emergency care for children with life-threatening illnesses in the community includes remote physician support for paramedics providing life-saving therapy while transporting the child to the hospital. Most prehospital emergency medical services (EMS) agencies use radio-based (audio only) communication between paramedics and physicians to augment this care. However, this communication strategy is inherently limited as the remote physician cannot visualize the patient for accurate assessment and to direct treatment.\n\nThe purpose of this pilot randomized controlled trial (RCT) is to evaluate whether use of a 2-way audiovisual connection with a pediatric emergency medicine expert (intervention = \"telemedical support\") will improve the quality of care provided by paramedics to infant simulator mannequins with life threatening illness (respiratory failure). Paramedics receiving real-time telemedical support by a pediatric expert may provide better care due to decreased cognitive burden, critical action checking, protocol verification, and error correction. Because real pediatric life-threatening illnesses are rare, high stakes events and involve a vulnerable population (children), this RCT will test the effect of the intervention on paramedic performance in simulated cases of pediatric medical emergencies.\n\nThe two specific aims for this research are:\n\n* Aim 1: To test the intervention efficacy by determining if there is a measurable difference in the frequency of serious safety events between study groups\n* Aim 2: To compare two safety event detection methods, medical record review, and video review",[27,28,29,30],"Emergencies","Cardiopulmonary Arrest","Acute Respiratory Failure","Status Epilepticus",[32,33,34,35,36,37,38],"Prehospital emergency care","Emergency medical services (EMS)","Paramedics","Infant simulator mannequins","Telemedical support","Critically ill infants and children","Pediatric emergencies","RECRUITING","2026-06-29",{"date":42,"type":43},"2026-06-30","ACTUAL",{"date":45,"type":43},"2025-07-10",{"date":47,"type":21},"2028-12",{"name":49,"class":50},"Boston Medical Center","OTHER",9,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100498953","phase-4-evaluation-of-the-effects-of-ketorolac-dose-on-duration-of-analgesia-in-emergency-department-ed-renal-colic-patients-100498953","NCT05776953","Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Renal Colic Patients","Evaluation of the Effects of Ketorolac 15mg IV Versus 30mg IV on Duration of Analgesia in Patients Who Present to the Emergency Department With Renal Colic","Inclusion Criteria:\n\nPatients will be included if they present to the Emergency Department with (all of the following):\n\n* Adult emergency department patients \\\u003C 65 years old\n* One or more of the following common ED chief complaints associated with the suspected diagnosis of renal colic. These chief complaints include but are not limited to: flank pain, back pain, abdominal pain, left and\u002For right lower quadrant pain, and\u002For pelvic pain\n* Pain score of 4 or greater on the 0-10 NRS\n* Determination of treatment with IV ketorolac\n\nExclusion Criteria:\n\nPatients will be excluded if any of the following apply:\n\n* Allergy to ketorolac\n* Pregnant patients\n* Previously received analgesic medications within 4 hours prior to administration of ketorolac in our ED\n* Known or stated history of renal insufficiency\n* Body weight \\\u003C 50 kg\n* Age greater than 65 years\n* Patients that do no read\u002Fwrite Spanish or English","18 Years","65 Years",{"count":62,"type":21},86,[64],"PHASE4","This is a prospective interventional study examining the effect of ketorolac at doses of 15mg versus 30 mg for duration of analgesia in emergency department patients with suspected renal colic.",[67,68,27,69],"Renal Colic","Flank Pain","Analgesia","2026-05-20",{"date":72,"type":43},"2026-05-22",{"date":74,"type":43},"2023-12-21",{"date":76,"type":21},"2026-09-01",{"name":78,"class":50},"Hackensack Meridian Health",1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100640270","ed-medicaid-support-100640270","NCT07594782","ED Medicaid Support","Maintaining Continuous Medicaid Coverage for Eligible Children in New Jersey","Inclusion Criteria:\n\n* Parent\u002Fguardian\u002F legal authorized representative (age 18 years or older) with children aged: 1 month to 17 years of age who obtain care in the pediatric emergency department\n* Child Uninsured (ie, Charity Care, HUMC Charity Care, Pending Medicaid, Self-Pay)\n* Interested in applying or receiving assistance with NJfamilycare\n* Not pending private insurance coverage\n* Primary language of the parent or guardian is identified as English\n* Pediatric patient lives in New Jersey\n\nExclusion Criteria:\n\n* Parent\u002Fguardian\u002Flegal authorized representative with children aged: less than 1 month and greater than 17 years old Insured pediatric patient Parent\u002F Guardian\u002FLegal Authorized Representative not present Parent\u002F Guardian\u002FLegal Authorized Representative age 17 years or younger Primary language not identified as English Patients visiting the Emergency Department related to Motor Vehicle Accidents Already participated in this study",true,{"count":89,"type":21},180,[24],"The study introduces a bedside intervention assisting families with the enrollment or re-enrollment process through patient direct contact with NJFamily Care and financial departments, using an emergency department (ED)-based navigator tool. The primary objective is to identify the barriers contributing to the lack of insurance coverage through NJ Family Care coverage using a brief survey with the parents of children who are treated in the ED and identified as uninsured, and to study the effect of a bedside intervention designed to assist families with the enrollment or re-enrollment process.",[93,27],"Pediatric Uninsured Emergency Visits",[95,96,97,98],"Pediatric uninsured emergency visits","lack of insurance","linkage to resources","Medicaid","NOT_YET_RECRUITING","2026-05-11",{"date":102,"type":43},"2026-05-19",{"date":104,"type":21},"2026-05-15",{"date":106,"type":21},"2028-05-15",{"name":78,"class":50},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":87,"sex":17,"minAge":59,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":22,"phases":119,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":79},"100537755","phase-1-nebulized-fentanyl-in-healthy-volunteers-100537755","NCT06281951","Nebulized Fentanyl in Healthy Volunteers","Nebulized Fentanyl in Healthy Volunteers : Comparison of Facial Versus Intranasal Aerosol Administration by Pharmacometric Modeling","AEROfen","Inclusion Criteria:\n\n* Age ≥ 18 years and \\\u003C 68 years\n* BMI between 19 and 29 kg\u002Fm²\n* Affiliation to a social security scheme\n* Adult who has read and understood the information letter and signed the consent form\n* Woman capable of procreating (a woman is considered capable of procreating, i.e. fertile, after menarche and until she becomes menopausal, unless she is definitely sterile ) having very effective contraception (combined hormonal contraception (containing estrogens and progestins) associated with inhibition of ovulation, progestin-only hormonal contraception associated with inhibition of ovulation, intrauterine device, hormone-releasing intrauterine system (IUS), bilateral tubal occlusion, vasectomized partner, sexual abstinence) for 1 year and a negative urine pregnancy test at inclusion and during the duration of the study.\n* Woman definitely surgically sterile (hysterectomy, bilateral salpingectomy and bilateral oophorectomy). Postmenopausal woman: The postmenopausal state is defined by the absence of periods for 12 months without any other medical cause.\n\nExclusion Criteria:\n\n* Weight \\\u003C 50 kg\n* Taking long-term painkillers or narcotics\n* Sharp pain\n* Stable chronic pain (\\>3 months, with or without long-term treatment)\n* Known chronic pathology stabilized or decompensated (hypertension, renal, cardiac, hepatic insufficiency, etc.)\n* Stable or decompensated chronic respiratory pathology\n* Chronic neuropsychiatric pathology likely to modify the pain threshold\n* Long-term treatment with an action on the nervous system such as respiratory depression: benzodiazepines, neuroleptics, agonist\u002Fantagonist of the opioid system\n* Treatment or toxicant whose association is not recommended with fentanyl (alcohol, cannabis, etc.)\n* Central nervous system modulator treatment\n* Pathologies blocking the pupillary response: Claude-Bernard-Horner syndrome, Adie syndrome, Argyll-Robertson pupil, senile miosis, dysautonomic neuropathy (advanced diabetes, systemic amyloidosis), cataract\n* Treatment responsible for fluctuation in PUAL measurements: parasympathetic modulators (clonidine, dexmedetomidine, droperidol, metoclopramide)\n* No-indication to FENTANYL PIRAMAL 100µg\u002F2mL, solution for injection in ampoule\n* No-indication to PROAMP SODIUM CHLORIDE 0.9%, solution for injection\n* Ongoing treatment with nasal vasoconstrictors\n* Peripheral oxygen saturation less than 93%\n* Alteration of cognitive state: comprehension disorder, language disorder, memory disorder, confusion\n* Deaf or mute patient\n* Usual heart rate such as HR\\\u003C 40 bpm and\u002For hypotension with systolic blood pressure SBP\\\u003C 100 mm Hg\n* Atrioventricular block on ECG\n* History of cataract surgery\n* Confirmed or suspected covid 19 \u002F active flu infection less than 15 days old\n* Allergy to plastic\n* Pregnant or parturient or breastfeeding woman or proven absence of contraception\n* Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection\u002Funder guardianship or curatorship\n* Person participating in research participating in another trial \u002F having participated in another trial within 2 weeks\n* History of illness or psychological or sensory abnormality likely to prevent the subject from fully understanding the conditions required for participation in the protocol or preventing them from giving informed consent","68 Years",{"count":118,"type":21},20,[120],"PHASE1","Pain constitutes the predominant motive prompting individuals to seek emergency medical attention, accounting for 80% of admissions to emergency departments. Presently, it is imperative to employ expeditious and efficacious analgesia-sedation methodologies, obviating the necessity for intravenous administration, while ensuring the secure delivery of pharmaceutical agents. The objective of this study is to assess the feasibility and comfort of nebulized intranasal or facial aerosol administration of Fentanyl through the implementation of a pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) study",[69,27],[124,125,126,127,128,129],"Severe acute pain","Pharmacometry","Fentanyl","Emergency medicine","Pupillometry (PUAL)","Non-invasive analgesia (Intranasal, Facial aerosol)","2026-05-06",{"date":100,"type":43},{"date":133,"type":43},"2024-04-26",{"date":135,"type":21},"2027-06-01",{"name":137,"class":50},"University Hospital, Rouen",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":144,"targetDuration":146,"studyType":147,"phases":4,"briefSummary":148,"conditions":149,"keywords":150,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":79},"100579026","nomogram-for-predicting-difficult-laparoscopic-appendectomy-100579026","NCT06818942","Nomogram for Predicting Difficult Laparoscopic Appendectomy","Inclusion Criteria:\n\n* Clinical diagnosis of acute appendicitis\n* Participants who underwent laparoscopic appendectomy\n\nExclusion Criteria:\n\n* Participants refused or could not tolerate laparoscopic appendectomy\n* Incomplete preoperative examination or missed information",{"count":145,"type":21},500,"3 Months","OBSERVATIONAL","No prior studies have stratified the difficulty of laparoscopic appendectomy (LA). The investigators aimed to investigate preoperative factors as indicators of difficult LAs based on the experience of surgical trainees and to develop a predictive model accordingly.",[27],[151,152,153],"Laparoscopic appendectomy","Surgical difficulty","Training program","2026-05-02",{"date":156,"type":43},"2026-05-07",{"date":158,"type":43},"2025-01-26",{"date":160,"type":21},"2027-12-31",{"name":162,"class":50},"Shanghai 6th People's Hospital",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":79},"100552198","phase-2-evolution-of-the-initial-distribution-volume-of-glucose-in-the-severe-burned-adults-100552198","NCT06469970","Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA: Evolution of the Initial Distribution Volume of Glucose in the Severe Burned Adults","INDICIA","Inclusion Criteria:\n\n* Patients over 18 years of age\n* Patients hospitalized with burns of at least 30% of body surface area\n\n  * By a thermal mechanism\n  * At the CHR Metz-Thionville burn center\n  * managed within the 8 hours post-burn\n* Patient affiliated to a social security scheme\n* Written consent obtained from the patient (or from the trusted person, family or relatives if the patient is unable to sign\u002Fexpress consent) or emergency inclusion if the patient is unable to express consent and neither the trusted support person nor any member of the family or relatives is present at the time of inclusion.\n\nExclusion Criteria:\n\n* Diabetic patients on insulin\n* Patient with a CONTRAINDICATION to GLUCOSE 30% PROAMP, solution for injection\n* Patients with pre-hospital cardiac arrest\n* extra corporeal circulation patient: Extra Corporeal Membranous Oxygenation (ECMO) or Extra Corporeal Life Support (ECLS) or CRRT (Continuous Renal Replacement Therapy)\n* patient without a central venous line or arterial catheter\n* Patient moribund or immediately subject to therapeutic limitation\n* Impossibility of trans-pulmonary thermodilution monitoring (vascular access difficulties)\n* Pregnant, parturient or breast-feeding women\n* Patient under guardianship, curatorship or safeguard of justice\n* Cognitive impairment or language barrier",{"count":172,"type":21},15,[174],"PHASE2","This is a prospective, observational, monocentric, phase II (exploratory) cohort study aiming to describe the evolutionary profile of the initial volume of glucose distribution (IDVG) during the first four days of management of severely burned patient.",[177,178,27],"Burns","Intensive Care","2026-03-10",{"date":181,"type":43},"2026-03-12",{"date":183,"type":43},"2024-11-28",{"date":185,"type":21},"2027-03-28",{"name":187,"class":50},"Centre Hospitalier Régional Metz-Thionville",{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":79},"100349424","lumbar-brace-deployment-in-the-emergency-department-for-benign-low-back-pain-100349424","NCT03829631","Lumbar Brace Deployment in the Emergency Department for Benign Low Back Pain","Lumbar Brace Deployment in The Emergency Department for Benign Low Back Pain: Effectiveness and Impact on Pain, Spine Function, Analgesic Use and Community Resources","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Ambulatory\n* Able to read and understand English\n* Living in Edmonton\n* Presenting to an emergency department\n\nExclusion Criteria:\n\n* Back pain due to systemic or specific disease such as known cancer, spinal infection, fracture, or ankylosing spondylitis\n* Pregnancy\n* Significant compression of the spinal cord\u002Fnerves\n* Previous back surgery\n* On-going workers' compensation or litigation cases",{"count":196,"type":21},152,[24],"Low back pain accounts for billions of dollars in health care expenditures. Most cases of back pain do not have a clear cause. Thus, low back pain management methods usually rely on targeting people' pain and discomfort. Painkillers, including opioids, are usually prescribed in the emergency departments for people with low back pain. But, like all medications, painkillers can have side effects, and some of those can be serious. There are also serious concerns about the overuse of painkillers. Thus, newer pain management methods are needed to reduce the use of painkillers in people with low back pain. Lumbar braces are one of the underutilized low back pain management methods in the emergency departments. Like crutches for leg and ankle injuries, they can minimise movements of the spine. This may decrease people pain and improve their function. This may also reduce the use of painkillers. In support of this approach, two recent studies conducted in a primary-care setting observed a reduction in the use of painkillers in people with low back pain who wore lumbar braces. The investigators are conducting this study to determine if wearing a lumbar brace for 4 weeks following emergency department presentation will reduce people's pain and discomfort and increase spine function. This may decrease the use of painkiller and future use of healthcare resources. This research study may also assist emergency-department staff with offering new recommendations to improve the quality of clinical decisions.",[200,201,27,202,203],"Low Back Pain","Brace","Pain","Health Care Resources","2026-01-29",{"date":206,"type":43},"2026-02-02",{"date":208,"type":43},"2019-06-12",{"date":210,"type":21},"2026-12-31",{"name":212,"class":50},"University of Alberta",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":87,"sex":17,"minAge":221,"maxAge":222,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":225,"briefSummary":226,"conditions":227,"keywords":231,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":244},"100595081","feasibility-and-efficacy-of-ambulance-based-m-health-for-pediatric-emergencies-feamer-trial-100595081","NCT07027813","Feasibility and Efficacy of Ambulance-Based m-Health for Pediatric Emergencies (FEAMER) Trial","Feasibility and Efficacy of Ambulance-Based m-Health for Pediatric Emergencies in Low Resource Settings (FEAMER) Trial","FEAMER","CHILDREN\n\nInclusion criteria:\n\n* Age 0-14 years\n* Children transported by an SIEHS ambulance with a transport time of ≥20 minutes\n* Children presenting to the ChildLife Emergency Department with a parent\u002F guardian present in the ambulance to consent\n* Children classified as \"Charlie, Delta, Echo\" on the Medical Priority Dispatch System\n\nExclusion Criteria:\n\n• Children transported without an adult parent or guardian\n\nEMERGENCY MEDICAL TECHNICIANS (EMTs)\n\nInclusion Criteria:\n\n• EMTs currently employed by the SIEHS EMS service.\n\nExclusion Criteria:\n\n• EMTs who refuse to participate or consent to the study.\n\nTELEMEDICINE PHYSICIANS (TMPs)\n\nInclusion Criteria:\n\n• TMPs currently employed by the CLF Telemedicine services.\n\nExclusion Criteria:\n\n• TMPs who refuse to participate or consent to the study.","1 Minute","14 Years",{"count":224,"type":21},900,[24],"Investigators hypothesize that in a low-resource setting, linking ambulances that transport acutely ill children to a remote pediatric emergency physician using a simple audio-video device will improve the quality of these children's medical decisions and health outcomes. For this purpose, the investigators will conduct a study in Karachi, Pakistan, where they will collect medical data for ill children at the time of ambulance pickup, hospital drop-off, and during hospital triage. During transport, one group will receive a telemedicine call from a trained physician, while the other group will receive basic paramedic treatment. The investigators will then compare both groups.",[27,228,229,230],"mHealth","Child Health","Critical Illness",[232,233,234],"Emergency Medical Services","Ambulance","Telemedicine","2026-01-05",{"date":237,"type":43},"2026-01-07",{"date":239,"type":43},"2025-06-04",{"date":241,"type":21},"2026-09-30",{"name":243,"class":50},"Weill Medical College of Cornell University",3,{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":251,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":271},"100338520","platelet-inhibitor-treated-patients-with-head-injury-trauma-meeting-nice-criteria--is-the-ct-scan-mandatory--100338520","NCT03687528","Platelet Inhibitor Treated Patients With Head Injury Trauma Meeting NICE Criteria : is the CT-scan Mandatory ?","Platelet Inhibitor Treated Patients With Head Injury Trauma Without Any Clinical Symptoms of Cerebral Haemorrhage (NICE Criteria) : is the CT-scan Mandatory ?","TCAP","Inclusion Criteria:\n\n* At least 18 years old\n* Patient with a head injury trauma, described by the patient or seen at the clinical exam\n* Glasgow score between 13 and 15 at the clinical exam\n* Current treatment with antiplatelet inhibitors\n* Informed non opposition form signed\n\nExclusion Criteria :\n\n* Absence of CT-scanner\n* Patients with double anti-platelet aggregation\n* Patients on anticoagulants",{"count":254,"type":21},3200,"At the emergencies rooms, patients with head trauma meeting one of the NICE criteria, which include antiplatelet inhibitors treatment, are considered as patients with a risk of cerebral haemorrage and are taken systematically for a CT-scanner.\n\nHowever, there are more and more antiplatelet inhibitor's patient with minor head injury traumas seen at the emergencies room and the efficiency of this NICE criteria is controversial on litterature.\n\nThis study aims to determine that the absence of no other NICE criteria than antiplatelet inhibitors is a sufficient condition to eliminate a cerebral haemorrhage for patients with head injury traumas, and conversely, that antiplatelet inhibitors treatment would not be by itself an indication for a CT-scanner.",[257,27],"Head Injury Trauma",[259,260,261,262],"emergencies","platelet inhibitors","minor head injury trauma","CT-scan","2025-12-31",{"date":235,"type":43},{"date":266,"type":43},"2020-06-15",{"date":268,"type":21},"2026-12",{"name":270,"class":50},"Rennes University Hospital",12,{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":11,"sex":17,"minAge":280,"maxAge":281,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":284,"briefSummary":285,"conditions":286,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":79},"100559535","remote-oximeter-monitoring-post-discharge-to-reduce-emergency-room-visits-and-rehospitalization-100559535","NCT06565390","Remote Oximeter Monitoring Post-discharge to Reduce Emergency Room Visits and Rehospitalization","Remote Oximeter Monitoring Post-discharge to Reduce Emergency Room Visits and Rehospitalization (ROMPER): A Randomized Clinical Trial","ROMPER","Inclusion Criteria:\n\n* Infants being discharged from the NICU\n* Off all respiratory support (oxygen, CPAP, ventilator) before discharge home\n* Gestational age ≥ 22 0\u002F7 weeks' gestation at birth\n* Parents\u002Flegal guardians have provided consent for enrollment\n\nExclusion Criteria:\n\n* a major malformation, a neuromuscular condition that affects respiration or causes apnea, complex congenital heart disease and hemodynamically significant shunts, or terminal illness or decision to withhold or limit support.\n* Infants being discharged from the neonatal intensive care unit (NICU) with a cardiorespiratory monitor or respiratory support are not eligible for inclusion.","22 Weeks","6 Months",{"count":283,"type":21},700,[24],"This randomized clinical trial will determine the efficacy of remote patient monitoring using an Owlet OSS 3.0 pulse oximeter for the reduction of emergency room visits and high-acuity rehospitalizations among high-risk infants after NICU discharge.",[27],"2025-09-24",{"date":289,"type":43},"2025-09-30",{"date":291,"type":43},"2025-09-11",{"date":293,"type":21},"2030-12-31",{"name":295,"class":50},"University of Alabama at Birmingham",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":302,"eligibilityCriteria":303,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":304,"targetDuration":4,"studyType":22,"phases":306,"briefSummary":307,"conditions":308,"keywords":311,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":327},"100480700","optimisation-strategy-for-emergency-tracheal-intubation-100480700","NCT05539391","Optimisation Strategy for Emergency Tracheal Intubation","Effectiveness of an Optimisation Strategy for Emergency Tracheal Intubation on Postintubation Morbidity: A Cluster Randomized Controlled Trial","OSETIM","Inclusion Criteria:\n\n* Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.\n* Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.\n\nExclusion Criteria:\n\n* Patient presenting of a contraindication to succinylcholine, and\u002For rocuronium, and\u002For sugammadex (rocunorium antagonist).\n* Patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis).\n* Patient that are not members of a medical aid scheme (beneficiary or main member).\n* Patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship\u002Fcuratorship.",{"count":305,"type":21},1500,[24],"This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. This strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and Gum Elastic Bougie (GEB) use.",[27,309,310],"Out-of-hospital Setting","Tracheal Intubation",[312,313,314,315,316,317,318],"Out-of-hospital","Intubation","Complications","Vital distress","Rapid sequence intubation","Rocuronium","Gum Elastic Bougie","2025-09-23",{"date":287,"type":43},{"date":322,"type":43},"2023-01-14",{"date":324,"type":21},"2026-09",{"name":326,"class":50},"University Hospital, Bordeaux",22,{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":334,"eligibilityCriteria":335,"healthyVolunteers":11,"sex":17,"minAge":336,"maxAge":4,"enrollmentInfo":337,"targetDuration":4,"studyType":22,"phases":338,"briefSummary":339,"conditions":340,"keywords":343,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":346,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":79},"100596914","the-rightcall-implementing-a-sepsis-diagnostic-toolkit-to-improve-pediatric-diagnosis-in-ed-transfer-calls-100596914","NCT07051668","The RightCall: Implementing a Sepsis Diagnostic Toolkit to Improve Pediatric Diagnosis in ED Transfer Calls","The Right Call: Implementing a Sepsis Diagnostic Safety Toolkit in a Pediatric Transfer Call Center to Improve Diagnosis of Children in General Emergency Settings","RightCall","Inclusion Criteria:\n\n* Patients transferred to Children's Hospital Colorado (CHCO) for emergency or inpatient care, as identified in the extant CHCO transfer center database AND in the extant CHCO quality improvement sepsis database AND one of the following:\n* Patients who met Phoenix sepsis criteria 1) in the referring ED, 2) during transport, 3) in the first 6 hours after arrival at the pediatric hospital, or 4) patients who developed Phoenix sepsis within 24 hours of arrival at the Children's Hospital underwent independent physician review by three emergency physicians. Patients in whom all three physicians agreed sepsis was most likely present, using the structured SaferDx tool were included\n\nExclusion Criteria:\n\n* Patients less than one month of age\n* Patients whose transfer call recording was not available in the database","1 Month",{"count":145,"type":21},[24],"Sepsis is a leading cause of death in children, and an early diagnosis that improves outcomes is less likely in children who are treated in general Emergency Departments (EDs), that treat adults and children, compared to pediatric Emergency Departments. The study team, in collaboration with invested clinicians and expert partners, has developed a pediatric sepsis diagnostic safety toolkit that we will implement in a pediatric health system's transfer call center. Preparation for launch of the toolkit will include education throughout Children's Hospital Colorado (CHCO), with a focus on transfer center nurses and accepting CHCO physicians who will be partnering in delivering the toolkit. Usual avenues for clinical education will be used, including meetings, endorsement from clinical leaders, emails, and physical materials such as badge and pocket cards. Referring Emergency Department (ED) providers outside of CHCO will not receive education about the toolkit by design, since they are the recipients of the toolkit which is designed to disseminate sepsis diagnostic knowledge in real time to general EDs within existing transfer workflows. This research will test whether the toolkit improves early pediatric sepsis diagnosis in general EDs where most children receive their first critical hours of care.",[341,342,27],"Sepsis","Diagnosis",[344],"Pediatric, Diagnosis","2025-08-12",{"date":347,"type":43},"2025-08-15",{"date":349,"type":43},"2025-07-08",{"date":351,"type":21},"2027-07-31",{"name":353,"class":50},"University of Colorado, Denver",{"id":355,"slug":356,"hasResults":11,"nctId":357,"briefTitle":358,"officialTitle":359,"acronym":360,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":364,"conditions":365,"keywords":367,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":345,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":376,"locationsCount":79},"100568404","pro-active-monitoring-of-vital-signs-in-oncology-patients-using-a-smartwatch-100568404","NCT06680778","Pro-active Monitoring of Vital Signs in Oncology Patients Using a Smartwatch","The Use of Proa-active Monitoring by Measuring Vital Signs Using a Fitbit for a 3-month Period Before, During, and After Chemotherapy in Patients With Cancer","PROGRESS","Inclusion Criteria:\n\n* Age ≥18 years;\n* Diagnosis of stomach or esophageal cancer with an indication of starting chemotherapy\n* Knowledge how to handle a Fitbit\n* Mastery of Dutch language\n* Able and willing to give written informed consent\n\nExclusion Criteria:\n\n* Cognitive disorders or severe emotional instability\n* Already participating in an exercise trial",{"count":363,"type":21},175,"The goal of this single center prospective observational study is to determine the effect of chemotherapy on (the change in) vital parameters. The main question it aims to answer are: Can changes in vital parameters be measured by using a Fitbit in patients with cancer while undergoing chemotherapy. Participants will be asked to wear a Fitbit for the first two cycles of chemotherapy to evaluate the changes in vital parameters.",[366,27],"Cancer",[368,369,370],"cancer","monitoring","Fitbit",{"date":372,"type":43},"2025-08-13",{"date":374,"type":43},"2025-07-01",{"date":263,"type":21},{"name":377,"class":50},"Erasmus Medical Center",{"id":379,"slug":380,"hasResults":11,"nctId":381,"briefTitle":382,"officialTitle":383,"acronym":384,"eligibilityCriteria":385,"healthyVolunteers":87,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":386,"targetDuration":4,"studyType":22,"phases":388,"briefSummary":389,"conditions":390,"keywords":396,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":79},"100593588","high-sensitivity-troponin-i-in-addition-to-guideline-based-care-in-ems-100593588","NCT07008391","High-Sensitivity Troponin I in Addition to Guideline-Based Care in EMS","High-Sensitivity Troponin I in Addition to Guideline-Based Care in Emergency Medical Service - an Open Randomized Controlled Trial","TIGER","Inclusion Criteria:\n\n* Chestpain \u002F discomfort and\u002For\n* Clinical suspicion of myocardial infarction by the prehospital personeel\n\nExclusion Criteria:\n\n* Patients suffering from a trauma and conveyed to the trauma level 1 hospital.\n* Missing valid social security number\n* Not beeing able to give informed consent\n* Not a primary assignment",{"count":387,"type":21},1419,[24],"The TIGER study is a study investigating the utlility of a point-of-care blood analyse of Troponin I to help identify patients with heart attacks in the prehospital emergency care. The study is conducted within the ambulance services of Region Stockholm and compares standard medical care with and without the addition of this quick test.\n\nChest pain is one of the most common reasons for ambulance dispatch, but currently only about one-third of heart attacks are detected before arriving at the hospital-mainly through ECG. The remaining two-thirds are not identified until after further testing at the emergency department. The TIGER study aims to improve early diagnosis by using a high-sensitivity, point-of-care Troponin I test already in the prehospital phase.\n\nThe study is a randomized controlled trial, where participants are randomly assigned to one of two groups. One group receives standard emergency care along with the rapid Troponin I test in the ambulance. The other group receives standard care without the test. The goal is to evaluate whether the use of Troponin I testing leads to faster and more accurate identification of heart attacks, ultimately improving patient outcomes.\n\nIn total, about 1,419 adult patients with chest pain or suspected heart attack will participate. The primary outcome being measured is the time from first medical contact to PCI (balloon angioplasty). Secondary outcomes include time spent in different parts of care, hospital length of stay, the occurrence of serious events (such as heart attack, stroke, or death), and the diagnostic accuracy of the test.\n\nThe study has been approved by the Swedish Ethical Review Authority and includes safety monitoring through an interim analysis after the first 150 patients. Test results from the Troponin I analysis are clearly marked as part of the research study and should be interpreted by the responsible physician alongside other clinical findings.",[232,391,392,393,394,395,27,233],"Nursing Care","Cardiology","Myocardial Infarction","Myocardial Infarction or Chest Pain","Myocardial Infarction, Acute",[233,397,398,399,400,401],"Prehospital emergency nurse","Sweden","Point-of-care","troponin","high sensitive troponin","2025-06-27",{"date":404,"type":43},"2025-07-02",{"date":406,"type":43},"2025-06-25",{"date":408,"type":21},"2026-12-30",{"name":410,"class":50},"Karolinska Institutet",{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":416,"acronym":4,"eligibilityCriteria":417,"healthyVolunteers":87,"sex":17,"minAge":418,"maxAge":4,"enrollmentInfo":419,"targetDuration":4,"studyType":22,"phases":421,"briefSummary":422,"conditions":423,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":79},"100544577","comparison-of-three-pre-oxygenation-strategies-100544577","NCT06370689","Comparison of Three Pre-oxygenation Strategies","Comparison of Three Pre-oxygenation Strategies for Prehospital Anaesthesia Induction in Children, Normal Weight Adults and Obese Adults","Inclusion Criteria:\n\n* Normal-weight adults (BMI 18.5-24.9 kg\u002Fm2) with an \"American Society of Anesthesiologists Physical Status Classification System (ASA) \" score of I or II\n* Adults with a BMI 25-39.9 kg\u002Fm2 with and ASA score \\\u003C3\n* Healthy (ASA I) children aged 6-12 years\n\nExclusion Criteria:\n\n* ASA 3\n* Age \\\u003C 6 and age 12-18\n* pregnant women\n* missing informed consent\n* signs and symptoms of an acute respiratory illness on the study day","6 Years",{"count":420,"type":21},45,[24],"Study objective: Comparing the efficacy of three different preoxygenation strategies, i.e. non-rebreather face mask (NRM), bag-valve-mask (BVM) with and BVM without additional positive end-expiratory pressure (PEEP) in three subgroups of spontaneously breathing volunteers.\n\nStudy endpoints\n\nPrimary Endpoint:\n\nDifference in expiratory oxygen concentration (FeO2) at the end of the 3 min preoxygenation sessions.\n\nSecondary endpoints:\n\n* Difference in Oxygen Reserve Index (ORi) at the end of the 3 min preoxygenation sessions.\n* Changes in regional ventilation from baseline to 1.5 min and 3 min into the preoxygenation sessions, assessed using electrical impedance tomography (EIT)\n* Time to reaching an Oxygen Reserve Index (ORi) ≥ 0.5\n* Time to reaching an Oxygen Reserve Index (ORi) =1\n* Time to Oxygen Reserve Index (ORi) back to baseline after the 3 min preoxygenation sessions.\n\nNumber of participants 15 participants per subgroup, i.e. 45 participants in total.\n\nInclusion criteria\n\n* Normal-weight adults (body mass index, BMI 18.5-24.9 kg\u002Fm2) with an \"American Society of Anesthesiologists Physical Status Classification System (ASA) \" score of I or II\n* Adults with a BMI 25-39.9 kg\u002Fm2 with and ASA score \\\u003C3\n* Healthy (ASA I) children aged 6-12 years Exclusion criteria ASA 3, Age \\\u003C 6 and age 12-18, pregnant women, missing informed consent, signs and symptoms of an acute respiratory illness on the study day.\n\nAfter informed consent and a medical check-up, baseline measurements will be done for 10 minutes (peripheral oxygen saturation SpO2, ORI, regional ventilation). Then the participants will undergo 3 different preoxygenation sessions with the 3 interfaces (i.e. non-rebreather facemask with reservoir and a bag-valve-mask with and without PEEP) in a randomized order and a 20 min washout between the sessions. Each preoxygenation session is conducted in a supine position and will be proceeded until the measured FeO2 (end expiratory O2 fraction) reaches 90% or up to a maximum time of 3 min. Afterwards 10 min of SpO2, ORI and regional ventilation measurements will follow.",[27,424],"Anesthesia","2025-03-25",{"date":427,"type":43},"2025-03-28",{"date":429,"type":43},"2024-05-23",{"date":431,"type":21},"2025-07-30",{"name":433,"class":50},"Institute of Mountain Emergency Medicine",{"id":435,"slug":436,"hasResults":11,"nctId":437,"briefTitle":438,"officialTitle":438,"acronym":439,"eligibilityCriteria":440,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":443,"conditions":444,"keywords":447,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":452,"lastUpdatePostDateStruct":453,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":79},"100484871","gender-differences-and-age-related-differences-in-emergency-department-admission-100484871","NCT05593692","Gender Differences and Age Related Differences in Emergency Department Admission","SADE","Inclusion Criteria:\n\n* Age over 18 y\n* Admitted to emergency department\n\nExclusion Criteria:\n\n* Age under 18 y",{"count":442,"type":21},15000,"The goal of this observational study is to learn about difference related to age and gender in patients admitted to emergency department.",[27,445,446],"Gender","Age Problem",[448,449,450,451],"sex","gender","age","emergency department","2025-03-03",{"date":454,"type":43},"2025-03-05",{"date":456,"type":43},"2022-10-18",{"date":458,"type":21},"2025-10-28",{"name":460,"class":50},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":462,"slug":463,"hasResults":11,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":467,"eligibilityCriteria":468,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":469,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":470,"conditions":471,"keywords":479,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":79},"100572802","national-emergency-bariatric-surgery-audit-100572802","NCT06738004","National Emergency Bariatric Surgery Audit","A National Multi-centre Prospective Audit of Unplanned Surgical and Endoscopic Interventions in Patients Who Have Undergone Bariatric Surgery in the UK or Abroad","NEBSA","Inclusion Criteria:\n\n* Admissions from i) the emergency department, clinic, urgent care or primary care to the bariatric surgical team as an emergency; ii) from an inpatient team as an urgent referral; iii) a return to theatre following an elective bariatric procedure; iv) another hospital via patient transfer to a specialised unit.\n* Participants undergoing any intervention or procedure to treat or diagnose bariatric complications, (e.g., OGDs, interventional radiology, surgery, supplemental enteral or parenteral nutrition).\n\nExclusion Criteria:\n\n* age \\\u003C18 years old\n* have a length of stay \\\u003C24 hrs.\n* initial diagnosis of BSE is changed or if their readmission is found to be unrelated to previous bariatric surgery.",{"count":145,"type":21},"The goal of this observational study is to investigate the incidence, management, and outcomes of complications following bariatric surgery in patients in the United Kingdom. The main questions it aims to answer are:\n\n* What is the prevalence of unplanned interventions due to complications following bariatric surgery in the UK?\n* What are the current practices for managing these complications, and how do they impact patient outcomes?\n\nParticipants will:\n\nBe identified from hospitals treating patients presenting with complications following bariatric surgery.\n\nHave their data collected regarding demographics, surgical history, complications, treatments, and outcomes.\n\nResearchers will compare different management strategies and their impact on patient outcomes, with the aim of identifying best practices to improve emergency bariatric care and factors leading to patients attending as an emergency.",[472,473,27,474,475,476,477,478],"Bariatric Surgery","Postoperative Complications","Surgical Procedures, Operative","Outcome Assessment (Health Care)","Quality Improvement","Morbidity","Mortality",[480,481,482,483,484,485,486,487,488,489],"Bariatric surgery","Emergency complications","National audit","Surgical outcomes","Management strategies","United Kingdom","Patient safety","Quality improvement","Morbidity and mortality","Postoperative complications","2024-12-12",{"date":492,"type":43},"2024-12-17",{"date":494,"type":43},"2023-11-09",{"date":496,"type":21},"2025-12-09",{"name":498,"class":50},"Bedfordshire Hospitals NHS Foundation Trust",{"id":500,"slug":501,"hasResults":11,"nctId":502,"briefTitle":503,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":87,"sex":17,"minAge":59,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":508,"conditions":509,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":79},"100568253","how-can-volunteers-in-the-nhs-be-best-supported-100568253","NCT06678815","How Can Volunteers in the NHS Be Best Supported?","Inclusion Criteria:\n\n* working as\u002Fwith or treated by CFR\n\nExclusion Criteria:\n\n* not working as\u002Fwith or treated by CFR","100 Years",{"count":507,"type":21},30,"This study aims to investigate the impact of volunteers in the English National Health Service (NHS) and increase the evidence base for supporting and developing volunteering to best help patients and services. The research will focus on one relatively established role: Community First Responders (CFR) supporting the ambulance service in English NHS Ambulance Trusts. We will take a mixed methods approach, combining qualitative and quantitative methods to learn more about the effectiveness and wider perceived value of the CFR role from the perspectives of CFRs themselves, other NHS staff and NHS patients who may interact with them.\n\nOur primary Research Question is: How can we maximise the impact of the Community First Responder role? Secondary Research Questions focus on what we can learn from the Community First Responders to support volunteer roles more widely. In particular: How can policy makers improve the deployment of volunteers? How do staff perceive the support they receive from volunteers (including impact on their workload and morale)? How do patients perceive the support they receive from volunteers? How are volunteers impacting services? What opportunities are there for further developing the volunteer role? We will work with (up to five) Ambulance Trusts already involved in the National Ambulance Volunteering Dashboard to extract quantitative data from existing management systems. These data will focus on (1) number and demographic characteristics of CFRs; (2) aggregate CFR activity (incidents attended, first on scene, responses times, response outcomes) and (3) CFR incident data (including location, time, category and CFR attendance). From these Trusts we will select 2 for qualitative data collection consisting of documentary analysis and semi-structured interviews with CFRs, NHS staff and patients. This research aims to generate evidence to inform decisions on where policymakers can most efficiently focus future volunteer interventions and how the NHS can best support volunteers in the system.",[27],"2024-11-06",{"date":512,"type":43},"2024-11-07",{"date":514,"type":21},"2025-01",{"date":516,"type":21},"2025-07",{"name":518,"class":50},"King's College London",{"id":520,"slug":521,"hasResults":11,"nctId":522,"briefTitle":523,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":527,"conditions":528,"keywords":532,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":539,"leadSponsor":541,"locationsCount":544},"100420916","prehospital-management-of-hypotensive-trauma-in-hems-100420916","NCT04760977","Prehospital Management of Hypotensive Trauma in HEMS","SPITFIRE","Inclusion Criteria:\n\n* Age \\> 18 years\n* Witnessed traumatic event managed by HEMS\n* Shock at first evaluation (Systolic blood pressure \\\u003C 90 mmHg)\n* Suspect or obvious ongoing haemorrage\n\nExclusion Criteria:\n\n* Patients in cardiac arrest at HEMS arrival in which resuscitation is not started or interrupted by HEMS crew",{"count":145,"type":21},"Up to today, inadequate evidences and knowledge exist about the best prehospital management of hypotensive trauma patients and its clinical consequence on the in-hospital recovery and mortality.\n\nAlso new emerging therapies such as prehospital blood transfusion and REBOA (resuscitative endovascular balloon occlusion of the aorta) are lacking strong evidences in, eventually, reducing hospital mortality and improving outcomes.\n\nMoreover, prehospital emergency medicine is throughout Italy an heterogeneous system that has no unique standard operating procedures and, even among HEMS (helicopter emergency medical service), management and therapies on complex trauma patients may vary upon local policies.\n\nWith this study we aim to enroll hypotensive trauma patients and study factors of prehospital rescue that can be associated with in-hospital mortality and recovery, eventually even with hospital outcome. For each patients data as demographic, kind of trauma (mechanism, injury scores), therapies and maneuvers will be recorded and then analyzed in comparison with in-hospital data such as need for transfusion, ABG parameters, length of stay (in-ward and ICU), need of therapies like invasive ventilation and renal replacement therapy, recovery and outcome",[529,530,27,531],"Hypotension and Shock","Wounds and Injuries","Critical Care",[533,530,27,531],"Transportation of Patients","2024-08-10",{"date":536,"type":43},"2024-08-13",{"date":538,"type":43},"2021-05-01",{"date":540,"type":21},"2026-05-01",{"name":542,"class":543},"Azienda Usl di Bologna","OTHER_GOV",16,{"id":546,"slug":547,"hasResults":11,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":551,"eligibilityCriteria":552,"healthyVolunteers":11,"sex":17,"minAge":418,"maxAge":553,"enrollmentInfo":554,"targetDuration":4,"studyType":22,"phases":556,"briefSummary":558,"conditions":559,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":565,"lastUpdatePostDateStruct":566,"startDateStruct":568,"completionDateStruct":570,"leadSponsor":572,"locationsCount":79},"100528438","phase-3-intravenous-ketorolac-vs-morphine-in-children-with-acute-abdominal-pain-100528438","NCT06160778","Intravenous Ketorolac Vs. Morphine In Children With Acute Abdominal Pain","Intravenous Ketorolac Vs. Morphine In Children Presenting With Acute Abdominal Pain And\u002For Suspected Appendicitis: A Multi-centre Non-Inferiority Randomized Controlled Trial","KETOAPP","Inclusion Criteria:\n\n1. Age 6 to 17 years\n2. Abdominal pain ≤5 days duration\n3. Acute abdominal pain that is being investigated (suspected) by the clinical team for appendicitis\n4. Patient with IV cannula in situ or ordered\n5. Currently experiencing moderate to severe abdominal pain at rest or with movement: self-reported pain score ≥5 using the verbal Numerical Rating Scale\n\nExclusion Criteria:\n\n1. Previous enrollment in the trial\n2. NSAID use within 3 hours and\u002For opioid use within 1 to 2 hours (1 hour post-IV or intra-nasal fentanyl and 2 hours post IV morphine).\n3. Children who need immediate resuscitation, are hemodynamically unstable as deemed by the clinical team or have a Canadian Triage Assessment Score of 1\n4. Significant caregiver and\u002For child cognitive impairment precluding the ability to complete study questions.\n5. Chronic pain requiring daily analgesic use: confounding as response to analgesics maybe altered.\n6. History of severe undiagnosed gastrointestinal bleeding requiring medical intervention, peptic or duodenal ulcer disease or inflammatory bowel disease, coagulation disorders, prior cerebrovascular bleeding, known arterio-vascular malformations. History of minor gastrointestinal bleeding from conditions such as resolved fissures, polyps or allergic colitis will not exclude patients from participating.\n7. History of chronic and active interstitial kidney disease\n8. History of chronic and active hepatocellular disease: ketorolac is metabolized by the liver.\n9. Known or suspected pregnancy at the time of enrollment or breastfeeding females\n10. Known hypersensitivity to NSAIDs or opioids.\n11. Absence of a parent\u002Fguardian for children who are \\\u003C16 years of age if they are not a mature minor.\n12. Inability to obtain consent due to a language barrier and the absence of language translator in person or by a phone translation service available in the ED.","17 Years",{"count":555,"type":21},495,[557],"PHASE3","Appendicitis is a common condition in children 6-17 years of age, and the top reason for emergency surgery in Canada. Children with appendicitis can have very bad pain in their belly. Children often need pain medications given to them through a needle in their arm called an intravenous (IV). The most common IV pain medication is a type of opioid called morphine. We know that opioids work well to improve pain, but there are risks and side effects when taking them. There are non-opioid medications that doctors can give to patients, like ketorolac. Ketorolac helps decrease inflammation and pain and has fewer side effects when a patient takes it for a short period of time. Our past and present overuse of opioids, driven by an unproven assumption that opioids work best for pain, resulted in an Opioid Crisis and doctors are now looking for alternatives. To do this, we need to prove that there are other options to treat children's pain that are just as good as opioids, with less side effects.\n\nThe goal of our study is to discover if school aged children who arrive at the emergency department with belly pain, improve just as much with ketorolac as they do with morphine. To answer this question, we will need a very large number of patients in a study that includes several hospitals across Canada. With a flip of a coin, each participant will either get a single dose of morphine or a single dose of ketorolac. To make sure that our pain assessment is impartial, no one will know which medicine the child received except the pharmacist who prepared the medicine.",[560,561,562,563,27,564],"Acute Pain","Abdomen, Acute","Abdominal Pain","Appendicitis","Child, Only","2024-06-21",{"date":567,"type":43},"2024-06-24",{"date":569,"type":43},"2024-05-27",{"date":571,"type":21},"2029-12",{"name":573,"class":50},"University of Calgary",{"id":575,"slug":576,"hasResults":11,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":580,"eligibilityCriteria":581,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":582,"targetDuration":584,"studyType":147,"phases":4,"briefSummary":585,"conditions":586,"keywords":604,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":625,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":79},"100409713","acutelines-a-large-data-biobank-of-acute-and-emergency-medicine-100409713","NCT04615065","Acutelines: a Large Data-\u002FBiobank of Acute and Emergency Medicine","Acutelines: a Large Biobank Aiming to Improve Early Recognition of Acute Diseases, Contribute to the Development of Personalized Medicine and Optimize Short- and Long-term Outcome","Acutelines","Inclusion Criteria, at least one of the following:\n\n* Triaged as one of highest two triage categories (red or orange) according to the Manchester triage system;\n* Triaged as the third highest triage category (yellow) and arrival by EMS of Helicopter Emergency Medical Service (HEMS;\n* Shock\n* Suspicion of sepsis (based on either physicians' suspicion, Sepsis-2 or Sepsis-3 criteria)\n* Acute kidney injury (AKI)\n* Anaphylactic reaction\n* Syncope\n* Intoxication\n* Thrombosis\n* Pulmonary embolism\n* Bleeding while using anti-coagulant drugs\n* Gastro-intestinal bleeding\n* Electrolyte disturbance\n\nExclusion Criteria:\n\n* Referred for organ transplantation as recipient\n* Transfer from other hospital\n* Accidental contact patient material (i.e. internal work-related accident)\n\nWhile data- and imaging will be collected from all these patients, biomaterials will only be collected from patients fulfilling the first criterion (i.e. triaged as one of highest two triage categories \\[red or orange\\] according to the Manchester triage system) and from patients with shock or a suspicion of sepsis.",{"count":583,"type":21},35000,"5 Years","Research in acute care faces many challenges, including enrollment challenges, legal limitations in data sharing, limited funding, and lack of singular ownership of the domain of acute care. To overcome some of these challenges, the Center of Acute Care of the University Medical Center Groningen in the Netherlands, has established a de novo data-, image- and biobank named \"Acutelines\". Acutelines is initiated to improve recognition and treatment of acute diseases and obtain insight in the consequences of acute diseases, including factors predicting its outcome. Thereby, Acutelines contributes to development of personalized treatment and improves prediction of patient outcomes after an acute admission.",[587,341,588,589,590,591,592,593,594,595,596,597,598,27,599,600,601,602,603],"Acute Disease","Pneumonia","Frailty","Complication of Treatment","Pulmonary Embolism","Thrombosis","Acute Kidney Injury","Electrolyte Disturbance","Hemorrhage","Shock","Polypharmacy","Intoxication by Drug","Urinary Tract Infections","Skin Infection","Syncope","Anaphylaxis","Dyspnea",[605,341,606,607,608,609,127,610,611,612,613,614,478,615,616,617,618,619,620,621,622,623,624],"Acute disease","Emergency Medical Service (EMS)","Outcome","Precision medicine","Personalized medicine","Multidisciplinary","General practitionar","Pharmacy","Hospitalization","Health insurance","Quality of life (QoL)","Overcrowding","Patient logistics","Point-of-care ultrasound (POCUS)","Helicopter Emergency Medical Service (HEMS)","Biobank","Databank","Electrophysiological waveforms","Electrocardiogram (ECG)","Plethysmogram","2024-06-12",{"date":627,"type":43},"2024-06-13",{"date":629,"type":43},"2020-09-01",{"date":631,"type":21},"2030-09-01",{"name":633,"class":50},"University Medical Center Groningen",{"id":635,"slug":636,"hasResults":11,"nctId":637,"briefTitle":638,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":640,"targetDuration":4,"studyType":22,"phases":642,"briefSummary":643,"conditions":644,"keywords":648,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":660,"locationsCount":79},"100551367","position-intervention-to-reduce-hypoxemia-in-sedation-patients-100551367","NCT06459167","Position Intervention to Reduce Hypoxemia in Sedation Patients","Inclusion Criteria:\n\n1. Patients with 18 years or older\n2. Without obvious cardiovascular or pulmonary dysfunction\n3. Scheduled to undergo procedure or surgery with sedation\n4. Signed the informed consent form\n\nExclusion Criteria:\n\n1. Preexisting bradycardia (heart rate \\\u003C50 beats\u002Fmin), hypotension (systolic blood pressure \\\u003C 80mmHg), or hypoxemia (SpO2 \\\u003C 90%);\n2. Requiring supplemental chronic or intermittent oxygen therapy because of preexisting diseases\n3. Preexisting diseases which unable to tolerate reduced SpO2 or Partial pressure of carbon dioxide in artery (PaCO2) diseases, such as severe cardiovascular and cerebrovascular diseases, intracranial hypertension or severe lung diseases;\n4. Coagulation disorders or a tendency of nose bleeding;\n5. Patients whose body position cannot be altered;\n6. Participated in other intervention clinical studies in the past 3 months;\n7. Other conditions deemed unsuitable for inclusion by the researcher;\n8. Patients and guardians refused to participate in this trial.",{"count":641,"type":21},1752,[24],"Hypoxemia was defined as an SpO2 of \\\u003C 90% for any duration. Failure to treat promptly can lead to hypoxemia, which may increase the risks of arrhythmia, nausea and vomiting, and cognitive dysfunction. Studies have shown that body position has a direct impact on respiratory function. In special environments, including outside the operating room where emergency airway management for critically ill and injured patients is needed, or in areas with limited medical resources like remote areas, adopting simple interventions by changing position to maintain patients' respiratory function can be more economical, convenient and safe.",[645,646,27,647],"Hypoxemia","Sedation Complication","Airway Remodeling",[649,650,651,652,653],"position","hypoxemia","sedation","emergency","upper airway","2024-06-10",{"date":656,"type":43},"2024-06-14",{"date":658,"type":21},"2024-06-20",{"date":42,"type":21},{"name":661,"class":50},"First Affiliated Hospital of Zhejiang University",{"id":663,"slug":664,"hasResults":11,"nctId":665,"briefTitle":666,"officialTitle":666,"acronym":4,"eligibilityCriteria":667,"healthyVolunteers":87,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":668,"targetDuration":4,"studyType":147,"phases":4,"briefSummary":670,"conditions":671,"keywords":675,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":684,"locationsCount":79},"100543949","incidence-of-episodes-of-disconnected-consciousness-among-emergency-patients-admitted-in-the-resuscitation-room-100543949","NCT06362525","Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room","Inclusion Criteria:\n\n* patients admitted in the resuscitation room of our university hospital\n* French speaking\n\nExclusion Criteria:\n\n* Refusal\n* Chronic disorder of consciousness\n* Deafness\n* Blindness\n* Dementia\n* Hemineglect\n* Aphasia",{"count":669,"type":21},100,"This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who survived a critical condition and who meet at least one of these criteria during their stay in the resuscitation room: (1) deep sedation, (2) intubation, (3) cardiopulmonary resuscitation, or (4) (non-drug-induced) Glasgow Coma Scale score = 3. We also investigate the potential (neuro)physiological markers and biomarkers. In order to help determine the potential risk factors of such episodes, cognitive factors such as dissociative propensity are also investigated. Unexpected visual and auditory stimuli will be displayed. In addition, we assess the evolution of memory, as well as short- and long-term consequences on quality of life, anxiety, and attitudes towards care.\n\nMemory of patients who did not meet the above-mentioned criteria are also investigated. A group of 15 healthy participants will be invited to test the stimuli display.\n\nFinally, (neuro)physiological parameters of a subsample of dying patients are also investigated.",[230,672,673,674,27],"Near-Death Experience","Consciousness, Loss of","Quality of Life",[676],"Dream","2024-04-08",{"date":679,"type":43},"2024-04-12",{"date":681,"type":43},"2023-10-09",{"date":683,"type":21},"2027-09-30",{"name":685,"class":50},"University of Liege",{"id":687,"slug":688,"hasResults":11,"nctId":689,"briefTitle":690,"officialTitle":691,"acronym":4,"eligibilityCriteria":692,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":693,"targetDuration":584,"studyType":147,"phases":4,"briefSummary":695,"conditions":696,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":699,"lastUpdatePostDateStruct":700,"startDateStruct":702,"completionDateStruct":703,"leadSponsor":705,"locationsCount":4},"100479840","safety-and-efficacy-of-emergent-tavi-in-patients-with-severe-as-100479840","NCT05528211","Safety and Efficacy of Emergent TAVI in Patients With Severe AS","Safety and Efficacy of Emergent Transcatheter Aortic Valve Implantation (TAVI) in Patients With Severe Aortic Valve Stenosis (AS): a Single-center, Prospective, Observational Cohort Study.","Inclusion Criteria:\n\n1. Every patient that diagnosed with severe aortic valve stenosis (evaluated by echocardiography: peak transaortic valve blood flow rate ≥4.0m\u002Fs, or mean transaortic valve pressure gradient ≥40mmHg (≥5.32kPa), or aortic Valve area \\\u003C0.8cm2, or AVA\\\u003C0.5cm2\u002Fm2);\n2. Every patient that 1) required cardiopulmonary resuscitation due to cardiac arrest, or requiring external chest compressions during surgery (Salvage), 2) or has ongoing, refractory (difficult, complicated, and\u002For unmanageable) unrelenting cardiac compromise, with or without hemodynamic instability, and not responsive to any form of therapy except cardiac surgery (STS\u002FACC TVT defined \"Urgent Status\"), 3) or required urgent procedure during same hospitalization in order to minimize chance of further clinical deterioration (examples include, but are not limited to, worsening, sudden chest pain, heart failure, acute myocardial infarction, anatomy, intra-aortic balloon pump, unstable angina with intravenous nitroglycerin or rest angina) (STS\u002FACC TVT defined \"Urgent Status\");\n3. Every patient that has been informed of the objectives of the study, agreed to participate, has signed the approved consent form, and was willing to accept all relevant examinations and clinical follow-up.\n\nExclusion Criteria:\n\n1. Anatomically, the approach or aortic root is not suitable for transcatheter aortic valve implantation (TAVI).\n2. Anatomical morphology or vascular diseases affecting the device approach.\n3. Left ventricular outflow tract obstruction.\n4. Primary dilated cardiomyopathy.\n5. The echocardiogram indicates the presence of left ventricular thrombus.\n6. Cannot tolerate anticoagulation and antiplatelet therapy.\n7. Are allergic or resistant to nickel titanium alloys.\n8. Active infective endocarditis, or other active infections affecting the effect of TAVI.\n9. Severe disabling Alzheimer's disease.\n10. Life expectancy\\\u003C 6 months.\n11. Other conditions (examples include poor compliance of patients and families) considered by the investigator to be inappropriate for participation in this clinical trial.",{"count":694,"type":21},10,"This is a single-centre, prospective, observational cohort study focusing on of patients suffering severe aortic valve stenosis (AS) undergoing emergent transcatheter aortic valve implantation (TAVI). AS patients undergoing emergent TAVI always have complicated clinical situations. Therefore, the aims of the study are to collect the incidence and outcomes of emergent TAVI in patients with severe symptomatic AS, to assess the safety and effectiveness of emergency TAVI system for severe AS, and to describe a more practical evidence of emergency TAVI system in severe AS patients.",[697,698,27],"Aortic Valve Stenosis","Transcatheter Aortic Valve Implantation","2022-09-01",{"date":701,"type":43},"2022-09-06",{"date":699,"type":21},{"date":704,"type":21},"2028-11-01",{"name":706,"class":50},"Qilu Hospital of Shandong University",{"id":708,"slug":709,"hasResults":11,"nctId":710,"briefTitle":711,"officialTitle":712,"acronym":713,"eligibilityCriteria":714,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":715,"targetDuration":717,"studyType":147,"phases":4,"briefSummary":718,"conditions":719,"keywords":4,"overallStatus":99,"whyStopped":4,"lastUpdateSubmitDate":722,"lastUpdatePostDateStruct":723,"startDateStruct":725,"completionDateStruct":727,"leadSponsor":729,"locationsCount":4},"100396820","assertive-community-treatment-for-alcohol-misuse-disorder-patients-who-are-high-utilizers-of-emergency-department-services-100396820","NCT04447079","Assertive Community Treatment for Alcohol Misuse Disorder Patients Who Are High Utilizers of Emergency Department Services","Assertive Community Treatment for Alcohol Misuse Disorder Patients Who Are High Utilizers of Emergency Department Services: - A Prospective, Multi-centre, Before-and-After Cohort Study","ARFA","Inclusion Criteria:\n\n* • Patients who are not on active follow-up at the National Addictions Management Service at the Institute of Mental Health (IMH).\n\n  * Patients who speak English or Mandarin.\n  * Patients who are 21 years of age or older.\n  * ≧2 SNOMED alcohol-related ED visits in last 12 months AND ≧5 Emergency Department visits (All-cause)\n  * Patients who are cognitively intact and able to understand and appreciate the contents of the consent.\n\nExclusion Criteria:\n\n* • Patients who are on active follow-up at the NAMS at the Institute of Mental Health (IMH).\n\n  * Patients who are uncontactable by phone AND through opportunistic recruitment.\n  * Patients who do not give consent.\n  * Patients who do not speak English or Mandarin.\n  * Patients who are under 21 years of age.",{"count":716,"type":21},300,"2 Years","Background Frequent attenders (FAs) at emergency department (ED) in Singapore hospitals have been increasing over the years. More than half of the FAs are reported to be alcohol-related frequent attenders (ARFA) and they were found to be using EDs unnecessarily. We aim to assess if there will be a difference in patient outcomes in terms of ED usage and cost-effectiveness by implementing an assertive community treatment (ACT) program to manage AFRAs.\n\nMethods This is a prospective, multi-centre, before-and-after, superiority and cohort study to assess the impact of ACT from 4 study sites. 200-300 patients will be recruited and followed up for 12 months. The primary objective of the study is to investigate whether there will be a reduction in AFRA ED attendances. The secondary objective is to estimate the change in total cost utilization.\n\nConclusion\u002FSignificance All patients who are on ACT programme will be enrolled in this study. The study intervention will be used as a new mode of care at participating hospitals. We expect to see reduced alcohol addiction level, reduced isolation level, improved motivation and better overall health. With reduced alcohol-related hospital visits, we would also expect to see improved healthcare utilization by ARFAs which will lead to increased cost savings to the healthcare systems and decreased social costs.",[720,721,27],"Alcoholism and Alcohol Abuse","Alcohol Use Disorder","2020-08-03",{"date":724,"type":43},"2020-08-05",{"date":726,"type":21},"2020-08",{"date":728,"type":21},"2027-08",{"name":730,"class":50},"Khoo Teck Puat Hospital"]