[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emotion-dysregulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emotion-dysregulation":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100636395","preved-mr-improving-emotion-dysregulation-through-mixed-reality-based-dialectical-behavioral-therapy-in-adolescents-and-young-adults-at-risk-of-developing-eating-disorders-100636395",false,"NCT07565129","PrevED MR. Improving Emotion Dysregulation Through Mixed Reality Based Dialectical Behavioral Therapy in Adolescents and Young Adults at Risk of Developing Eating Disorders.","PrevED MR","Inclusion Criteria:\n\n* Adolescents and young adults aged 13 to 35 years.\n* Spanish-speaking participants who are able to understand the study procedures and complete the assessment instruments.\n* Students recruited from participating schools, universities, or related recruitment settings.\n* Participants at mid-to-high risk of developing eating disorders, as assessed by the Eating Attitudes Test-26 (EAT-26) and selected subscales of the Eating Disorder Inventory-3 (EDI-3).\n* Participants who provide informed consent. For minors, informed consent from a parent or legal guardian will also be required, together with the minor's assent when applicable.\n\nExclusion Criteria:\n\n* Current or past self-reported diagnosis of an eating disorder.\n* Current severe psychiatric symptoms or diagnosis that could interfere with participation, including suicidal, manic, or psychotic symptoms.\n* Severe neurodevelopmental disorder, intellectual disability, or other cognitive impairment that could interfere with understanding or completing the study procedures.\n* Physical, motor, or sensory impairment that could interfere with the assessment procedures or the use of the mixed\u002Fvirtual reality intervention.\n* Current psychological or pharmacological treatment for a mental health disorder delivered on a weekly or biweekly basis.\n* Inability to understand Spanish.\n* Failure to provide informed consent. For minors, lack of parent or legal guardian consent will also be an exclusion criterion.",true,"ALL","13 Years","35 Years",{"count":21,"type":22},72,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of this study is to evaluate the feasibility and preliminary effects of PrevED MR, a group-based preventive intervention for adolescents and young adults at risk of developing eating disorders. PrevED MR is based on dialectical behavior therapy skills and uses mixed reality and virtual reality activities to support emotion regulation, mindfulness, distress tolerance, and body-related acceptance.\n\nParticipants will be randomly assigned to either the PrevED MR intervention group or a waiting-list control group. The intervention will be delivered over 6 weeks, with two sessions per week, for a total of 12 sessions. Assessments will be conducted at baseline and after the intervention to examine changes in eating disorder symptoms, body image acceptance, emotion regulation strategies, rumination, usability, sense of presence, cybersickness, satisfaction, and adherence.",[28,29],"Eating Disorders","Emotion Dysregulation",[31,32,33,34,35,36,37,38],"Eating disorders","Eating disorder prevention","Emotion regulation","Dialectical behavior therapy","Mixed reality","Adolescents","Young adults","Body image","RECRUITING","2026-06-22",{"date":42,"type":43},"2026-06-25","ACTUAL",{"date":45,"type":43},"2026-04-28",{"date":47,"type":22},"2027-09",{"name":49,"class":50},"Universitat Internacional de Catalunya","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":51},"100590160","dbt-p-treatment-study-100590160","NCT06963801","DBT-P Treatment Study","Developing Pregnancy-specific Dialectical Behavior Therapy Skills to Promote Multigenerational Mental Health","REACH","Inclusion Criteria:\n\n* Emotion dysregulation score of 88 or above\n* At least 12 weeks pregnant\n* Singleton Pregnancy\n* Fluent in English\n\nExclusion Criteria:\n\n* Active psychosis\n* Drug or alcohol use disorder during pregnancy\n* High risk of an imminent suicide attempt\n* Significant health complications (e.g., cancer)\n* Illiterate and\u002For unable to independently complete and comprehend written measures","FEMALE","18 Years","45 Years",{"count":64,"type":22},100,[25],"The goal of this study is to find out if improving emotion regulation skills use during pregnancy reduces maternal stress and improves heart rate.\n\nThe main questions it aims to answer are:\n\n* Does improving emotion regulation skills during pregnancy reduce stress and improve the ability to cope?\n* How is a participant's heart rate affected by their ability to control their emotions during pregnancy?\n\nResearchers will test the hypothesis that dialectical behavior therapy skills groups (DBT-P) will improve emotion regulation skills use as well as heart rate.\n\nParticipants will:\n\n* Visit the clinic for 3 sessions at the beginning, middle and end of their pregnancy.\n* Compete surveys and interviews asking about their thoughts, feelings and how they cope with emotions.\n* Have their heart rate taken.\n* If assigned to the investigational group, they will complete weekly remote emotion regulation skills groups for 10 weeks and complete daily diary cards that ask about mood and any thoughts of self-harm.\n* Optional Element: Complete a 20-30min infant neurobehavior exam (NNNS exam) after delivery.",[29],[69,70,71,72,73,74,75,76],"Emotion dysregulation","Pregnancy","Maternal health","RSA","Coping","Stress","DBT-P","Moms2B","2026-04-06",{"date":79,"type":43},"2026-04-08",{"date":81,"type":43},"2025-06-06",{"date":83,"type":22},"2026-10-19",{"name":85,"class":50},"Duke University",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":112,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":51},"100493968","neurostimulation-versus-therapy-for-problems-with-emotions-100493968","NCT05712057","Neurostimulation Versus Therapy for Problems With Emotions","Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis","Inclusion Criteria:\n\n* age 18 to 55\n* elevated overall score on Difficulties with Emotion Regulation Scale (DERS total score \\>=90)\n* has been in the same type of psychotherapy (including none) for the last 4 weeks\u002F1mo (\\*except for current CBT) and is willing to stay on the same regimen throughout the study.\n* low self-reported use of cognitive restructuring (ERQ restructuring subscale average score \\\u003C 4.7)\n* meets criteria for at least one mood (including Bipolar II w\u002Fo current hypomania), anxiety, stressor, OCD, Impulse Control, ADHD, or eating DSM-5 disorder (except exclusionary diagnoses such as severe anorexia). Note: Both current or partial remission of the disorder will be ok for inclusion into the study.\n* verbal agreement to maintain dose of prescribed psychotropic medication (if any) constant throughout the study, provided they are stable on it for the past 4 weeks (except exclusion medication and except if there is a medical emergency requiring changes in medication).\n* Naïve to rTMS\n\nExclusion Criteria:\n\n* current hypomania (Note: Bipolar II w\u002Fo current hypomanic episode is ok for inclusion)\n* meets diagnostic criteria for current or history of psychotic disorder, or psychotic features,\n* meets diagnostic criteria for Bipolar I disorder\n* meets diagnostic criteria on SCID5 for current alcohol or substance use disorder (moderate and high severity) or meets past history of severe alcohol use disorder\n* unable to read, blind, or deaf, or unwilling to give consent\n* non-English speaker,\n* verbal IQ \\\u003C 90 on the North American Adult Reading Test (NART).\n* current uncontrolled anorexia or other condition requiring hospitalization\n* high risk for suicide defined as either having attempted suicide in past 6 months or reporting current suicidal ideation that includes a method, plan, or intent to die\n* current serious medical illness, including current severe migraine headaches\n* started\u002Fchanged psychotropic medications in the prior 4 weeks, or plans to change medication during the study\n* history of seizure except those therapeutically induced by ECT (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesions that are contraindications for TMS, devices that may be affected by TMS (pacemaker, medication pump, cochlear implant, implanted brain stimulator), have left elbow\u002Fhand\u002Fwrist tendonitis\n* conditions associated with increased intracranial pressure, space occupying brain lesion (considered significant and unsafe for TMS by the study MD), transient ischemic attack, cerebral aneurysm, dementia, Parkinson's or Huntington's disease, multiple sclerosis\n* Wellbutrin \\>300mg per day or on daily stimulant\u002FADHD medications above the recommended FDA daily recommendations\n* use of investigational drug or devices within 4 weeks of screening\n* cochlear implants\n* Pregnancy\n* metal in body that would exclude them from the MRI scan; severe claustrophobia\n* is a prisoner or in police custody at time of screening, or has pending court case jeopardizing the participation in the study\n* has had TMS in their lifetime\n* has had CBT in the past 4 weeks or plans to start therapy during the study\n* weighs over 300 pounds (could not fit in MRI scanner)","55 Years",{"count":95,"type":22},240,[25],"The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for response to emotion regulation training.\n\nParticipants will undergo brain imaging while engaging in an emotional regulation task. Participants will be randomly assigned to learn one of two emotion regulation skills. Participants will be reminded of recent stressors and will undergo different types of neurostimulation, targeted using fMRI (functional MRI) results. Participants who may practice their emotion regulation skills during neurostimulation in a one-time session. Following this training, participants will undergo another fMRI and an exit interview to assess for immediate neural and behavioral changes. Measures of emotion regulation will be assessed at a one week and a one month follow up visit.",[99,100,101,102,103,104,28,105,106,107,108,109,110,29,111],"Emotion Regulation","Mood Disorders","Stress Disorder","Anxiety Disorders","OCD","Impulse Control Disorder","Emotional Dysfunction","Emotional Instability","Emotional Distress","Emotional Maladjustment","Emotional Impulsivity","Obsessive-Compulsive Disorder","Borderline Personality Disorder",[29,113,114,115,116,117,118,119,33],"Distress Intolerance","Neuromodulation","Neurostimulation","TMS","cognitive restructuring","regulation skills","neuroimaging","2026-03-02",{"date":122,"type":43},"2026-03-04",{"date":124,"type":43},"2023-05-15",{"date":126,"type":22},"2027-12-01",{"name":85,"class":50}]