[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emotion\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emotion":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100617547","evaluation-of-emotion-related-salivary-molecular-biomarkers-100617547",false,"NCT07320040","Evaluation of Emotion-related Salivary Molecular Biomarkers","Evaluation of Emotion-related Salivary Molecular Biomarkers Following Olfactory Stimuli","EMJOY","Inclusion Criteria:\n\n* Subject willing to follow study procedures\n* Subject able to understand the purpose, nature and methodology of the study\n* Subject has signed informed consent form\n* Subjects between 18 and 60 years of age.\n\nExclusion Criteria:\n\n* Subjects deprived of liberty, protected adults, vulnerable persons or minors\n* Subjects with a proven or suspected chronic infectious disease that could entail a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)\n* Rejection to sign the consent form.\n\nNon specific inclusion criteria:\n\n* Pregnant or breastfeeding women\n* Subjects presenting anosmia during the last 15 days\n* Subjects presenting symptoms and signs of active oral inflammation, advanced periodontitis or severe gingivitis.",true,"ALL","18 Years","60 Years",{"count":22,"type":23},240,"ESTIMATED","OBSERVATIONAL","Recent studies show that emotional states can be discriminated by physiological responses. This physiological regulation results from the action of enzymes and hormones that represent the activity of the autonomic nervous system. The measurement of specific biomarkers, using non-invasive biological tests in saliva, would therefore provide physiological data on an individual's emotional state in response to stimuli, particularly olfactory stimuli.",[27],"Emotion",[29,30,31],"Biomarkers","Stimuli","Related","RECRUITING","2026-01-27",{"date":35,"type":36},"2026-01-29","ACTUAL",{"date":38,"type":36},"2022-11-14",{"date":40,"type":23},"2027-06-14",{"name":42,"class":43},"Sys2Diag","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":44},"100621487","effects-of-virtual-reality-with-multisensory-stimulation-on-emotional-and-behavioral-disorders-in-individuals-with-acquired-brain-injury-and-disability-requiring-institutional-care-a-single-case-experimental-design-sced-study-100621487","NCT07371260","Effects of Virtual Reality With Multisensory Stimulation on Emotional and Behavioral Disorders in Individuals With Acquired Brain Injury and Disability Requiring Institutional Care: a Single Case Experimental Design (SCED) Study.","Rév In MAS","Inclusion Criteria:\n\n* Resident aged over 18\n* Diagnosis of stroke, traumatic brain injury, tumor, or cerebral anoxia for more than 3 years.\n* Living in a nursing home for at least 6 months\n* Presence of one or more emotional and behavioral disorders during initial assessments (NPI-ES) for at least 3 months.\n* Sufficient cognitive abilities to understand instructions and answer questions using a Likert scale.\n* Normal or corrected visual acuity\n* Resident affiliated with the social security system\n\nExclusion Criteria:\n\n* Motor or sensory disorders incompatible with the use of VR\n* Unstabilized photosensitive epilepsy or presence of a seizure in the past year\n* Change in the prescription of neuroleptic treatments, antidepressants, benzodiazepines, sedatives, anxiolytics, mood stabilizers, antiepileptics, or betablockers within the last 3 months.\n* Unstabilized major psychiatric disorders.\n* Craniectomy\n* Limited range of cervical movement due to orthopedic disorders\n* Moderate or severe hearing loss not compensated by a hearing aid\n* Anosmia\n* Asthma\n* Pregnant women or women suspected of being pregnant\n* Breastfeeding women\n* Neurocognitive disorders preventing understanding of instructions during assessments\n* The resident is included in another research protocol",{"count":5,"type":23},"INTERVENTIONAL",[55],"NA","Acquired brain injuries (ABIs) frequently cause emotional and behavioral disorders that impair independence and quality of life, particularly in institutions. Virtual reality (VR), already used in various mental and neurological disorders, offers therapeutic potential that remains largely unexplored in this context.\n\nMultisensory devices offer enhanced immersion that can potentially increase the relaxation and calming effect. Their use in specialized care home (SCH) could provide additional support for care.\n\nThe main objective of the study is to measure the effect of an 8-week multisensory VR relaxation program on the most significant emotional and behavioral disorders in adults with acquired brain injury living in SCH. The SCED method with multiple baselines across subjects (ABA) is used with three adult residents with ABCI and behavioral disorders living in SCH. The study consists of three phases (baseline, intervention, follow-up), during which the three main emotional and behavioral disorders of each resident are assessed weekly based on observations made throughout the week. Additional measures include the assessment of the socio-emotional profile by the care team (ECCSEG) and the emotional distress experienced by residents (QOLIBRI), collected twice per phase. The intervention consists of eight weeks of VR relaxation (VirtySens®), with two 15-minute sessions per week.\n\nAll measurements taken during the experiment will be anonymized and used only by the investigators, who are fully aware of the European GDPR (General Data Protection Regulation) concerning the protection of personal data.",[58,59,60,27,61],"Brain Injury","Virtual Reality","Behavior","Well-being",[63,60,27,61,59,64,65],"Acquired Brain Injury","Multisensory","Specialized Care Home","NOT_YET_RECRUITING","2026-01-19",{"date":33,"type":36},{"date":70,"type":23},"2026-02-15",{"date":72,"type":23},"2027-02-01",{"name":74,"class":75},"Hopital La Musse","OTHER",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":53,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":44},"100620362","cardiovascular-effects-of-grieving-100620362","NCT07356635","Cardiovascular Effects of Grieving","Investigating Cardiovascular Reactivity and Recovery of Young Adults During Grief-Recall, With Self-Affirmation as Potential Intervention","SAGE","Inclusion Criteria:\n\n* Individuals aged 18 and older who have experienced the death of family member and\u002For friend within the last 2 to 18 months.\n* Participants must also be fluent in English as all procedures will be conducted in English.\n\nExclusion Criteria:\n\n\\- Individuals with a history of cardiovascular disease or disorders, those who report being pregnant, or are taking medication which may alter\u002Faffect cardiovascular and\u002For cognitive processes.",{"count":85,"type":23},140,[55],"Self-affirmation (SA) theory proposes that people are motivated to maintain a positive self-image of being worthy, stable, and capable. Self-affirmation (SA) manipulations have been shown to effectively increase self-worth as well as reduce cardiovascular reactivity while enhancing cardiovascular recovery in response to stress. While SA is discussed as a way to alleviate grief, its effect on cardiovascular reactivity (CVR) and recovery to grief recall has yet to be studied within laboratory settings. This study proposes an experimental design to examine how an in-lab manipulation promoting self-affirmation can improve patients' cardiovascular responses during and after a grief recall procedure. The investigators hypothesized that grief severity (a continuous variable) interacts with condition (a categorical variable with two levels, i.e., SA intervention vs. control) to predict CV reactivity and recovery as outcomes.\n\nPrimary Objective 1: To investigate effects of self-affirmation intervention on cardiovascular responses among grieving participants during and after grief recall.\n\nSecondary Objective 1: To investigate the relationship of grief severity with psychological stress.",[89,90,27],"Grief","Cardiovascular Health",[92,93,94,95,96,97,98,99,100],"grief","cardiovascular reactivity","cardiovascular health","heart rate variability","psychophysiology","self-affirmation","value-affirmation","stress","mourning","2026-01-14",{"date":103,"type":36},"2026-01-21",{"date":105,"type":36},"2025-10-16",{"date":107,"type":23},"2027-03",{"name":109,"class":75},"University of South Florida"]