[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emotional-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emotional-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,50,85,111,132,162,185,211,244],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100645295","effectiveness-of-the-group-unified-protocol-for-emotional-disorders-in-adults-in-a-public-mental-health-setting-100645295",false,"NCT07682064","Effectiveness of the Group Unified Protocol for Emotional Disorders in Adults in a Public Mental Health Setting","Effectiveness of the Group Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al. 2011, 2019a, 2019b) in Adults in a Public Mental Health Setting","PSIGTE","Inclusion Criteria:\n\n* Aged 18 to 65 years.\n* Ability and willingness to provide written informed consent.\n* Sufficient proficiency in Spanish to participate in the intervention and complete study assessments.\n* Sufficient cognitive capacity to understand the intervention content.\n* A primary diagnosis of an emotional disorder with mild, moderate, or severe symptom severity, including Depressive Disorders, Anxiety Disorders, Obsessive-Compulsive and Related Disorders, Trauma and Stressor-Related Disorders, Dissociative Disorders and Somatic Symptom and Related Disorders.\n* Presence of emotional symptoms (e.g., anxiety, depressive, or phobic symptoms), somatic symptoms, obsessive symptoms, and\u002For avoidance behaviors associated with clinically significant impairment, as indicated by moderate or higher scores on the GAD-7, PHQ-9, and\u002For PHQ-15.\n\nExclusion Criteria:\n\n* Refusal to provide informed consent or withdrawal of consent during the study.\n* Current severe substance use disorder or behavioral addiction.\n* Current high suicide risk.\n* Current psychotic symptoms or psychotic disorder.\n* Neurological disorders or severe medical conditions that could interfere with participation in or adherence to the intervention.\n* Intellectual disability, significant language difficulties, or any other condition that may impair the participant's ability to understand the intervention content.","ALL","18 Years","65 Years",{"count":21,"type":22},106,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study has three primary objectives:\n\n1. To adapt the Spanish version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP; Barlow et al., 2011, 2019a, 2019b) for delivery in a group format within the Spanish Public Mental Health System for adults diagnosed with emotional disorders.\n2. To evaluate the effectiveness of the intervention.\n3. To assess its clinical feasibility and acceptability in routine clinical practice.\n\nOutcomes will include anxiety, depression, somatic symptoms, transdiagnostic variables, functional impairment, quality of life, and participant satisfaction. These outcomes will be assessed at baseline, post-treatment, and 3-month follow-up.\n\nThe intervention is expected to improve emotional symptoms, functional impairment, and quality of life. In addition, the study will explore whether this group-based transdiagnostic approach may help lower demand on public mental health services.",[28,29,30,31],"Emotional Disorders","ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)","Depressive Disorder","Somatic Disorders",[33,34,35,36],"Unified Protocol","emotional disorder","UP","treatment","RECRUITING","2026-06-30",{"date":40,"type":41},"2026-07-02","ACTUAL",{"date":43,"type":41},"2024-04-27",{"date":45,"type":22},"2026-12",{"name":47,"class":48},"Patricia Fernández Couto","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":4},"100596874","efficacy-of-a-personalized-response-based-transdiagnostic-intervention-for-emotional-disorders-delivered-via-the-internet-a-protocol-for-an-adaptive-randomized-controlled-trial-100596874","NCT07051148","Efficacy of a Personalized, Response-based Transdiagnostic Intervention for Emotional Disorders Delivered Via the Internet: A Protocol for an Adaptive Randomized Controlled Trial","Inclusion Criteria:\n\n* Spanish speakers\n* OASIS score +\u002F= 8\n* ODSIS score +\u002F= 7\n* Access to Internet\n* Email\n\nExclusion Criteria:\n\n* Severe mental disorder: schizophrenia\u002Fbipolar disorder\n* Active substance abuse\n* High suicide risk\n* Ongoing psychological\u002Fpharmacological treatment\n* Interfering physical illness","70 Years",{"count":58,"type":22},366,[25],"This adaptive randomized controlled trial evaluates the efficacy of a transdiagnostic, internet-delivered psychological intervention for emotional disorders, tailored to patient´s early clinical response. 366 adults with clinically significant symptoms of depression and\u002For anxiety will begin a 12 module self-applied program. Based on sympton reduction after the first three modules, participants will be classified as early or late responders and randomized into different experimental arms. The main hypothesis is that a hybrid format (self-applied modules plus synchronous sessions with a therapist) will yield better outcomes for late responders. Outcomes include symptom reduction, emotional regulation and internet based therapheutic alliance.",[28,62,63],"Anxiety","Depression, Unipolar",[65,66,67,68,28,69,70,71,72,73,74],"transdiagnostic","internet based therapy","anxiety","depression","adaptive intervention","blended treatment","digital interventions","personalization","personalized treatment","adaptive trial","NOT_YET_RECRUITING","2026-05-21",{"date":78,"type":41},"2026-05-27",{"date":80,"type":22},"2027-05-01",{"date":82,"type":22},"2030-07",{"name":84,"class":48},"Universitat Jaume I",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":92,"maxAge":18,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100559600","cultural-adaptation-and-implementation-of-dbt-for-adolescents-with-emotional-disorders-100559600","NCT06566235","Cultural Adaptation and Implementation of DBT for Adolescents With Emotional Disorders","Cultural Adaptation and Implementation of Dialectical Behavior Therapy Skills Training Group for Adolescents With Emotional Disorders: a Feasibility Study and a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age 12-18 years.\n2. Informed consent provided by the youth and one parent.\n3. Sufficient Mandarin Chinese proficiency to complete study questionnaires.\n4. Total score of PHQ-9 ≥ 8 or GAD-7 ≥ 8, or SDQ total score ≥ 10, or SDQ hyperactivity subscale score ≥ 3.\n5. Primary diagnosis of depressive, anxiety disorder, or ADHD based on K-SADS-\n\n   E interview, including:\n\n   Depression (F32-33) Persistent mood disorder (F34) Phobic anxiety disorder (F40) Other anxiety disorder (F41) Adjustment disorders (F43.2) ADHD (F90)\n6. Stable medication use for at least four weeks and willingness to maintain stable dosage during the study.\n7. Individuals with comorbid emotional disorders are included; comorbidities are not stratified to avoid increasing study design complexity.\n\nExclusion Criteria:\n\n1. Educational level of elementary school or university.\n2. Comorbid intellectual disability or psychotic disorder.\n3. Acute suicidality.\n4. Insufficient Chinese language skills.\n5. Unwillingness to discontinue current psychotherapy.\n6. Unwillingness to accept video recording during group therapy.\n7. Medication changes during the trial are not exclusionary if judged necessary or clinically important by the treating clinician, to maintain a naturalistic setting.","12 Years",{"count":94,"type":22},160,[25],"The goal of this study is to learn if Dialectical behavior therapy Skills\n\nTraining for Adolescents (DBT-A-ST) works on emotional disorders in adolescents. The main questions it aims to answer are:\n\nDoes DBT-A-ST produce faster improvements (i.e., steeper slopes), compared to ASG, on primary and secondary outcome measures during treatment and 3-month follow-up?\n\nDoes DBT-A-ST produce greater improvements, compared to SBG, on primary and secondary outcome measures?\n\nParticipants is:\n\nRandomly assigned to (a) a culturally adapted DBT-A-ST or (b) Satir-based group (SBG).\n\nReceived five assessments before the start of the trial (T1), after 4, 8 sessions (T2, T3), at post-intervention (T4), and 3-month follow-up (T5).",[28],[99,100,28],"Dialectical Behavior Therapy Skills Training Group","Adolescents","2026-05-07",{"date":103,"type":41},"2026-05-12",{"date":105,"type":41},"2024-10-24",{"date":107,"type":22},"2028-07-31",{"name":109,"class":48},"Mackay Memorial Hospital",2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":49},"100614506","weekly-dynamics-of-psychopathological-and-symptom-networks-during-mindfulness-based-interventions-for-emotional-distress-100614506","NCT07280481","Weekly Dynamics of Psychopathological and Symptom Networks During Mindfulness-Based Interventions for Emotional Distress","Inclusion Criteria:\n\n* experiencing emotional distress such as depression or anxiety (Kessler-10 score \\> 21)\n\nExclusion Criteria:\n\n* prior experience with mindfulness meditation\n* current self-harm or suicidal risk\n* bipolar disorder or schizophrenia\n* history of substance abuse\n* severe personal trauma history",{"count":118,"type":22},500,[25],"The goal of this clinical study is to learn how Mindfulness Intervention for Emotional Distress (MIED) helps people with emotional distress and how their symptoms and psychological patterns change over time.\n\nThe main questions it aims to answer are:\n\n* How do the relationships between emotions, thoughts, and behaviors change week by week during mindfulness training?\n* Which psychological skills, such as distress tolerance or cognitive flexibility, improve first and lead to later emotional relief? Two groups will be compared - one that takes part in an online mindfulness intervention and one that waits to join - to see how the intervention changes emotional and psychological networks over time.\n\nParticipants will:\n\n* Complete a 7-week online self-guided Mindfulness Intervention for Emotional Distress（iMIED） designed for people experiencing high emotional distress.\n* Fill out short weekly questionnaires about their emotions, thoughts, and behaviors before, during, and after the course (9 times in total).\n* Receive access to the mindfulness program after the study if they are in the wait-list group.\n\nThis study includes about 500 adults aged 18 and older who feel anxious, depressed, or emotionally distressed but have no major psychiatric disorders. By tracking weekly changes, the research aims to identify how mindfulness intervention leads to emotional improvement and which skills play the most important roles in that process.",[122,28],"Depression, Anxiety","2026-04-24",{"date":125,"type":41},"2026-04-27",{"date":127,"type":41},"2025-11-16",{"date":129,"type":22},"2026-05-22",{"name":131,"class":48},"Peking University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":139,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":148,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":49},"100628166","the-step-mied-trial-digital-stepped-care-for-emotional-disorders-100628166","NCT07458100","The STEP-MIED Trial: Digital Stepped-Care for Emotional Disorders","Effectiveness and Cost-effectiveness of a Digital Stepped-care Mindfulness Intervention for Recovery From Emotional Disorders: a Multicentre Pragmatic Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age: 18-65 years.\n2. Diagnosed with an emotional disorder by a outpatient psychiatrist, including depressive disorders, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, agoraphobia, social anxiety disorder), obsessive-compulsive disorder, post-traumatic stress disorder, and eating disorders (e.g., anorexia nervosa, bulimia nervosa).\n3. Symptom severity meeting the threshold: PHQ-9 score ≥10 or GAD-7 score ≥8.\n\nExclusion Criteria:\n\n1. Current diagnosis of psychotic disorders or bipolar disorder.\n2. Current organic mental disorders, pervasive developmental disorders, severe cognitive impairment, or substance use disorders.\n3. Current suicide risk (PHQ-9 item 9 score \\>2).\n4. Antisocial personality disorder.\n5. Severe medical illnesses that may affect intervention participation or require recent hospitalization.\n6. Previous participation in a systematic 8-week mindfulness course.\n7. Inability to access the internet.",{"count":140,"type":22},464,[25],"The goal of this clinical trial is to evaluate the effectiveness and cost-effectiveness of a digital mindfulness-based intervention in adults (aged 18-65) diagnosed with emotional disorders like depression or anxiety. The main questions it aims to answer are:\n\n* Does adding a digital mindfulness intervention to usual care help people recover from emotional disorders faster and more sustainably over two years?\n* Is this combined approach more cost-effective than usual care alone? Researchers will compare the group receiving the digital mindfulness intervention plus their usual treatment to the group receiving only their usual treatment to see if the intervention leads to better long-term recovery and represents good value for money.\n\nParticipants in the intervention group will:\n\n* Attend eight weekly 2-hour online group mindfulness sessions.\n* Use a WeChat mini-program for 49 days of guided mindfulness exercises and daily tasks.\n* Patients who have not achieved reliable recovery after group retraining voluntarily participate in individual UP\\&MIED counseling.\n* Complete regular questionnaires and interviews over two years to track their progress.\n\nAll participants will continue to receive their usual medical care from their doctors throughout the study.",[28,30,144,145,146,147],"Anxiety Disorders","Obsessive-Compulsive Disorder","Post-Traumatic Stress Disorder, PTSD","Eating Disorders",[149,150,151,152,153,28],"Cost-effectiveness","Mindfulness","Recovery","randomized controlled trial","stepped-care","2026-04-18",{"date":156,"type":41},"2026-04-21",{"date":158,"type":41},"2026-03-23",{"date":160,"type":22},"2028-05",{"name":131,"class":48},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":49},"100619476","cost-effectiveness-and-implementation-of-a-transdiagnostic-internet-based-intervention-for-emotional-disorders-in-community-care-100619476","NCT07345117","Cost-effectiveness and Implementation of a Transdiagnostic Internet-based Intervention for Emotional Disorders in Community Care.","From Research to Clinical Practice: Implementation of an Internet-based Transdiagnostic Treatment Program for Emotional Disorders in Primary Care (TREAT-ED)","TREAT-ED","Patient Inclusion Criteria:\n\n* Over 18 years of age.\n* Meet the diagnostic criteria for an anxiety or depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).\n* Understand and read Spanish or Catalan.\n* Have access to the Internet and an email address\n* Give informed consent.\n\nPatient Exclusion Criteria:\n\n* Diagnosis of schizophrenia, bipolar disorder, or alcohol or substance dependence.\n* High risk of suicide.\n* Presence of a medical condition that prevents psychological treatment.\n* Receiving other psychological treatment (other than TAU or the online program) during the study.\n* For participants in the online treatment condition with pharmacological treatment, this must be stabilized (doses cannot be changed or increased during the study, only reduced).\n\nInclusion Criteria for mental health Professionals:\n\n* They work at centers participating in the study.\n* They agree to participate in the study.\n* They sign an informed consent form.",{"count":171,"type":22},200,[25],"Emotional disorders (ED) are one of the leading causes of disability. They are highly prevalent and have an impact on quality of life. Addressing them places an overload on the National Health System (NHS), generating waiting lists and limiting appropriate care. The need for cost-effective solutions has led to the consideration of the transdiagnostic approach and the use of digital solutions. Both perspectives have demonstrated efficacy in a large number of randomized clinical trials. As a result, investment in digital health interventions is on the rise to improve access to care in overburdened healthcare systems. However, their integration and implementation in health systems remains limited. Implementation Science emerges to facilitate the integration of interventions into clinical practice through specific strategies that overcome barriers and optimize their sustainability. The objective of this project is to examine the effectiveness, economic costs and feasibility of implementing an online psychological treatment program for emotional disorders in mental health services. The Mutua and UJI teams have already carried out the transfer of the online program. In order to facilitate the adoption and sustainability of this program and that it can be used by mental health professionals in daily practice, a hybrid design 1 study will be carried out in which not only the efficacy but also the possibility of adoption and the analysis of economic costs in comparison with the usual treatment will be evaluated.",[28,175,176,144],"Depression Anxiety Disorder","Depression Disorders","2026-03-17",{"date":179,"type":41},"2026-03-18",{"date":181,"type":22},"2026-04-01",{"date":183,"type":22},"2029-01-01",{"name":84,"class":48},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":192,"targetDuration":4,"studyType":23,"phases":194,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":49},"100626228","blended-unified-protocol-for-emotional-disorders-in-primary-care-100626228","NCT07432906","Blended Unified Protocol for Emotional Disorders in Primary Care","Feasibility and Preliminary Efficacy of the Unified Protocol in a Blended Format for Emotional Disorders in Primary Care: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged between 18 and 65 years.\n* Scoring 8 or higher on the Overall Anxiety Severity and Impairment Scale (OASIS) OR the Overall Depression Severity and Impairment Scale (ODSIS), indicating clinical severity.\n* Ownership of a smartphone (Android or iOS) and ability to use mobile applications.\n* Literacy in Turkish.\n* Willingness to participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* Diagnosis of bipolar disorder, psychotic disorder, or antisocial personality disorder (assessed via MINI 5.0.0).\n* High risk of suicide (assessed via MINI 5.0.0).\n* Cognitive impairment (Score \\\u003C 21 on the Montreal Cognitive Assessment - MoCA).\n* Current substance alcohol or drug dependence.\n* Currently receiving another psychological treatment (psychotherapy).\n* Changes in psychopharmacological treatment (medication dosage or type) within the last 3 months (participants must be on a stable dose).",{"count":193,"type":22},45,[25],"The goal of this clinical trial is to learn if a \"blended\" therapy format (combining face-to-face therapy sessions with a smartphone app) works to treat emotional disorders, such as depression and anxiety, in adults. It will also see if this blended format is feasible and acceptable for patients in primary care settings.\n\nThe main questions it aims to answer are:\n\nDoes the blended therapy format reduce symptoms of depression and anxiety?\n\nIs the blended format as effective as standard face-to-face therapy?\n\nDo participants find the smartphone app easy and helpful to use?\n\nResearchers will compare the blended therapy group to a standard face-to-face therapy group and a wait-list control group to see if the blended approach works well.\n\nParticipants will:\n\nAttend therapy sessions based on the Unified Protocol (a type of cognitive-behavioral therapy) for about 10 weeks.\n\nUse a smartphone app to complete exercises and track their emotions (if assigned to the blended group).\n\nAnswer questionnaires about their symptoms and quality of life at the beginning, at the end of treatment, and 3 months later.",[28,62,197],"Depression",[33,199,200,201],"Blended care","Primary care","Transdiagnostic","2026-02-19",{"date":204,"type":41},"2026-02-25",{"date":206,"type":22},"2026-02",{"date":208,"type":22},"2026-10",{"name":210,"class":48},"Aydin Adnan Menderes University",{"id":212,"slug":213,"hasResults":11,"nctId":214,"briefTitle":215,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":219,"targetDuration":4,"studyType":23,"phases":221,"briefSummary":222,"conditions":223,"keywords":230,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":240,"leadSponsor":242,"locationsCount":110},"100585999","ultra-brief-psychological-treatments-for-emotional-symptoms-and-disorders-100585999","NCT06909669","Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders","Ultra-brief Psychological Treatments for Emocional Symptoms and Disorders: An Efficacy and Efficiency Analysis","UltraPsyBrief","Inclusion Criteria:\n\n\\- Patients presenting negative emotional symptomatology (anxiety, depression or somatizations), mild or moderate. Specifically, they will be included in the study if they present a score ≥ 5 on the PHQ-9, the GAD-7 or the PHQ-15.\n\nExclusion Criteria:\n\n* Bipolar disorder, personality disorder, psychosis or substance abuse, indicated by SCID-5-CV\n* Recent suicide attempt.\n* Severe emotional symptoms (PHQ-15 or GAD-7 ≥ 15; or PHQ-9 ≥ 20).",{"count":220,"type":22},184,[25],"The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms and disorders, as well as to find out which variables of cognition and of the intervention process itself are involved in the therapeutic improvement.\n\nThe investigators will compare the interventions of four groups: brief group treatment (1), ultra-brief group treatment (2), ultra-brief individual treatment (3) with the ultra-brief relaxation (control) group.\n\nThe main questions the study aims to answer are:\n\n* Will the brief and ultra-brief treatment formats works better than the relaxation-based control group?\n* Will results obtained between the brief group therapy group and the ultra-brief group therapy group be similar?\n* Will the individual ultra brief therapy be more effective than the two group therapies because of common factors, such as the therapeutic alliance?\n* Will group therapies be more beneficial for cost and in terms of capability to reduce emocional symptoms than individual therapy? Participants will be randomly assigned to each of the groups and will receive the corresponding treatment, with different number of sessions. They will answer a series of questionnaires at the beginning and at the end of the intervention, as well as 3 months and 6 months after the end of the treatment.",[224,225,226,62,227,228,229,28],"Depression - Major Depressive Disorder","Generalized Anxiety Disorder","Generalized Anxiety","Somatoform Disorders","Somatic Symptom Disorder (DSM-5)","Somatization",[231,232,233,234,235],"ultra-brief therapy","brief therapy","transdiagnostic therapy","cognitive-behavioral therapy","randomized controled trial","2025-12-15",{"date":238,"type":41},"2025-12-22",{"date":206,"type":22},{"date":241,"type":22},"2028-09",{"name":243,"class":48},"Universidad de Córdoba",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":251,"sex":17,"minAge":18,"maxAge":252,"enrollmentInfo":253,"targetDuration":4,"studyType":23,"phases":255,"briefSummary":256,"conditions":257,"keywords":258,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":49},"100602932","unified-protocol-group-treatment-in-a-university-outpatient-clinic-100602932","NCT07129941","Unified Protocol Group Treatment in a University Outpatient Clinic","Transdiagnostic Group Treatment of Emotional Disorders: A Cross-sectional and Naturalistic Study of Outcome, Change Processes, and Clinical Training","Inclusion Criteria:\n\n* Age 18-40\n* Fulfilling diagnostic criteria for an anxiety disorder and\u002For unipolar depression (ICD F.3x - 4x)\n* Motivated for short-term treatment in group format\n\nExclusion Criteria:\n\n* Suicidality\n* Self-harm\n* Severe psychiatric disorder (bipolar disorder, psychosis)\n* Substance use disorders\n* Use of anxiolytic medication (i.e., benzodiazepines)\n* Unstable antidepressant medication (i.e., stable dosage \\\u003C6 months)\n* Other ongoing psychological treatment",true,"40 Years",{"count":254,"type":22},140,[25],"This clinical trial aims to evaluate the effectiveness and underlying processes of change of the Unified Protocol (UP) for treating emotional disorders in a university outpatient clinic. The study will involve 140 patients receiving UP treatment in a group format, delivered either by experienced or novice therapists, along with a non-clinical control group of 45 participants. Participants will self-refer on the basis of advertisement about the study through flyers, posters, project website, social media or local news media. Outcomes will be assessed through self-report measures of well-being, symptoms, emotion regulation, and the non-specific factors of treatment credibility and therapeutic alliance. Additionally, psychophysiological measures of heart rate variability and interoception will be used to explore processes influencing treatment response. Qualitative interviews will complement the quantitative data by capturing participants' perspectives on the treatment and experiences of what contributed to change.",[28,62,224],[33,259,260,62,197,261],"Transdiagnostic treatment","Emotional disorders","Group therapy","2025-08-11",{"date":264,"type":41},"2025-08-19",{"date":266,"type":41},"2025-05-08",{"date":268,"type":22},"2034-12",{"name":270,"class":48},"University of Bergen"]