[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emotional-dysfunction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emotional-dysfunction":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,64,90,115,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":42,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":63},"100493968","neurostimulation-versus-therapy-for-problems-with-emotions-100493968",false,"NCT05712057","Neurostimulation Versus Therapy for Problems With Emotions","Neurostimulation Enhanced Cognitive Restructuring for Transdiagnostic Emotional Dysregulation: A Component Analysis","Inclusion Criteria:\n\n* age 18 to 55\n* elevated overall score on Difficulties with Emotion Regulation Scale (DERS total score \\>=90)\n* has been in the same type of psychotherapy (including none) for the last 4 weeks\u002F1mo (\\*except for current CBT) and is willing to stay on the same regimen throughout the study.\n* low self-reported use of cognitive restructuring (ERQ restructuring subscale average score \\\u003C 4.7)\n* meets criteria for at least one mood (including Bipolar II w\u002Fo current hypomania), anxiety, stressor, OCD, Impulse Control, ADHD, or eating DSM-5 disorder (except exclusionary diagnoses such as severe anorexia). Note: Both current or partial remission of the disorder will be ok for inclusion into the study.\n* verbal agreement to maintain dose of prescribed psychotropic medication (if any) constant throughout the study, provided they are stable on it for the past 4 weeks (except exclusion medication and except if there is a medical emergency requiring changes in medication).\n* Naïve to rTMS\n\nExclusion Criteria:\n\n* current hypomania (Note: Bipolar II w\u002Fo current hypomanic episode is ok for inclusion)\n* meets diagnostic criteria for current or history of psychotic disorder, or psychotic features,\n* meets diagnostic criteria for Bipolar I disorder\n* meets diagnostic criteria on SCID5 for current alcohol or substance use disorder (moderate and high severity) or meets past history of severe alcohol use disorder\n* unable to read, blind, or deaf, or unwilling to give consent\n* non-English speaker,\n* verbal IQ \\\u003C 90 on the North American Adult Reading Test (NART).\n* current uncontrolled anorexia or other condition requiring hospitalization\n* high risk for suicide defined as either having attempted suicide in past 6 months or reporting current suicidal ideation that includes a method, plan, or intent to die\n* current serious medical illness, including current severe migraine headaches\n* started\u002Fchanged psychotropic medications in the prior 4 weeks, or plans to change medication during the study\n* history of seizure except those therapeutically induced by ECT (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives, stroke, brain surgery, head injury, cranial metal implants, known structural brain lesions that are contraindications for TMS, devices that may be affected by TMS (pacemaker, medication pump, cochlear implant, implanted brain stimulator), have left elbow\u002Fhand\u002Fwrist tendonitis\n* conditions associated with increased intracranial pressure, space occupying brain lesion (considered significant and unsafe for TMS by the study MD), transient ischemic attack, cerebral aneurysm, dementia, Parkinson's or Huntington's disease, multiple sclerosis\n* Wellbutrin \\>300mg per day or on daily stimulant\u002FADHD medications above the recommended FDA daily recommendations\n* use of investigational drug or devices within 4 weeks of screening\n* cochlear implants\n* Pregnancy\n* metal in body that would exclude them from the MRI scan; severe claustrophobia\n* is a prisoner or in police custody at time of screening, or has pending court case jeopardizing the participation in the study\n* has had TMS in their lifetime\n* has had CBT in the past 4 weeks or plans to start therapy during the study\n* weighs over 300 pounds (could not fit in MRI scanner)","ALL","18 Years","55 Years",{"count":20,"type":21},240,"ESTIMATED","INTERVENTIONAL",[24],"NA","The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC). The secondary aim is to identify key changes in the emotion regulation neural network following the combined intervention versus each of the components alone. The third aim is to explore personalized biomarkers for response to emotion regulation training.\n\nParticipants will undergo brain imaging while engaging in an emotional regulation task. Participants will be randomly assigned to learn one of two emotion regulation skills. Participants will be reminded of recent stressors and will undergo different types of neurostimulation, targeted using fMRI (functional MRI) results. Participants who may practice their emotion regulation skills during neurostimulation in a one-time session. Following this training, participants will undergo another fMRI and an exit interview to assess for immediate neural and behavioral changes. Measures of emotion regulation will be assessed at a one week and a one month follow up visit.",[27,28,29,30,31,32,33,34,35,36,37,38,39,40,41],"Emotion Regulation","Mood Disorders","Stress Disorder","Anxiety Disorders","OCD","Impulse Control Disorder","Eating Disorders","Emotional Dysfunction","Emotional Instability","Emotional Distress","Emotional Maladjustment","Emotional Impulsivity","Obsessive-Compulsive Disorder","Emotion Dysregulation","Borderline Personality Disorder",[40,43,44,45,46,47,48,49,50],"Distress Intolerance","Neuromodulation","Neurostimulation","TMS","cognitive restructuring","regulation skills","neuroimaging","Emotion regulation","RECRUITING","2026-03-02",{"date":54,"type":55},"2026-03-04","ACTUAL",{"date":57,"type":55},"2023-05-15",{"date":59,"type":21},"2027-12-01",{"name":61,"class":62},"Duke University","OTHER",1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":16,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":4},"100604489","shared-decision-making-for-families-in-critical-dialysis-initiation-100604489","NCT07150182","Shared Decision-Making for Families in Critical Dialysis Initiation","The Integrated Shared Decision-making Program of Critical Hemodialysis Initiation - the Effects on Decision Conflict, Decision Regret, Anxiety and Depression Among Family Members","Inclusion Criteria:\n\n(A)Patients: (1)Age ≥ 20 years. (2)Admitted to the ICU. (3)Diagnosed with acute kidney injury (AKI) requiring urgent hemodialysis. (4)No medical disputes occurred during the current hospitalization. (B) Family members:\n\n1. Age ≥ 20 years.\n2. Mentally alert and able to communicate in Mandarin or Taiwanese.\n3. Key person for the patient's admission (primary contact between patient, family, and medical team).\n4. Willing to participate in the clinical trial.\n\nExclusion Criteria:\n\n(A) Patients:\n\n1. Age \\\u003C 20 years.\n2. End-stage kidney disease already receiving renal replacement therapy (including hemodialysis, peritoneal dialysis, or kidney transplantation). (B) Family members:\n\n(1)Unable to comply with study procedures. (2)Rarely visiting the patient (less than once every three days). (3)History of alcohol or substance abuse, mental disorders, or cognitive impairment affecting participation.","20 Years","99 Years",{"count":74,"type":21},100,[24],"Background:Acute kidney injury (AKI) is a frequent and serious complication in critically ill patients, often necessitating difficult decisions about starting hemodialysis. While shared decision-making (SDM) is known to improve communication, the effectiveness of structured SDM programs specifically designed for family members in this critical context is not well-established.\n\nAims: The primary purpose of this study is to evaluate the effectiveness of a structured shared decision-making (SDM) program for family members of patients requiring critical hemodialysis initiation. We will assess the program's impact on the quality of the decision-making process (e.g., decision conflict, regret) and the psychological well-being (e.g., anxiety, depression) of the family members.\n\nMethods: This study is a parallel-group, randomized controlled trial. Eligible participants (family members of patients with AKI initiating hemodialysis) will be randomly assigned to either an intervention group or a control group. The intervention group will receive a structured SDM support program, while the control group will receive standard care. Primary outcomes, including decision conflict, decision regret, anxiety, and depression, will be measured at baseline and follow-up. Data will be analyzed using the generalized estimating equation (GEE) model to compare the effectiveness between the two groups.",[78,79,34],"Acute Kidney Injury","Decision Making ,Shared","NOT_YET_RECRUITING","2025-08-29",{"date":83,"type":55},"2025-09-02",{"date":85,"type":21},"2025-10-01",{"date":87,"type":21},"2026-12-31",{"name":89,"class":62},"Taipei Medical University WanFang Hospital",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":16,"minAge":17,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":63},"100510780","focus-groups-in-ethnically-and-racially-diverse-families-100510780","NCT05930886","Focus Groups in Ethnically and Racially Diverse Families","Focus Groups to Optimize Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children With ADHD and Emotional Dysregulation","Inclusion Criteria:\n\n* Adult parents\u002Fcaregivers self-identified as Black or Hispanic\u002FLatino\n* With a family member 6-18 years old with suspected ADHD and\u002For emotional dysregulation, or provide care for, or teach someone who meets these criteria\n* Who have sought or are interested in treatment\n* Willing to discuss child's mental health care needs and provide feedback regarding feasibility study\n* Able to attend focus groups in person\n* Able to communicate in English or Spanish\n* Agree to focus group session audio recording\n\nExclusion Criteria:\n\n* Unwilling to be recorded",true,"80 Years",{"count":100,"type":21},30,"OBSERVATIONAL","Focus groups to identify treatment needs and barriers to participation in the planned multinutrient study among racially and ethnically diverse (Black and Hispanic) communities.",[104,34,105],"Attention Deficit\u002FHyperactivity Disorder","Irritable Mood","2025-04-01",{"date":108,"type":55},"2025-04-04",{"date":110,"type":55},"2023-04-15",{"date":112,"type":21},"2025-10-04",{"name":114,"class":62},"Oregon Health and Science University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":123,"maxAge":124,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":63},"100526322","optimizing-research-with-diverse-families---feasibility-and-acceptability-study-fast-100526322","NCT06133231","Optimizing Research With Diverse Families - Feasibility and Acceptability Study (FAST)","A Feasibility and Acceptability Study (FAST) to Optimize Research Methodology in a Multinutrient Study of Racially and Ethnically Diverse Children With ADHD and Emotional Dysregulation","FAST","Inclusion Criteria:\n\n* Children, ages 6-17 years at enrollment, with suspected or definite ADHD based on parent report in a majority of families that identify as Black or Hispanic or multicultural\n* Meet criteria on Child and Adolescent Symptom Inventory-5 (CASI-5) ADHD scale (6+ symptoms ≥ 2), occurring in \\>1 setting, plus one impairing irritability symptom (≥2) from Oppositional Defiant Disorder (ODD) or Disruptive Mood Dysregulation Disorder (DMDD) subscale\n* Able and willing to swallow up to 8 pills per day\n* Medication free for 2 weeks prior to baseline\n* Willing to use Tasso® OnDemand SST+ to collect blood at home and filter cards to provide urine samples\n* Able to communicate in English\n* Parent\u002Fcare giver identifies child as Black\u002FAfrican American or Hispanic\u002FLatina\u002Fo or more than one race (target 70-100%)\n\nExclusion Criteria:\n\n* Neurological disorders\n* Medical conditions (e.g. cancer, kidney or liver disease, diabetes, hyperthyroidism)\n* Psychiatric conditions requiring hospitalization\n* Allergy to any supplement ingredient\n* In people with a uterus: sexually active, pregnancy or suspected pregnancy\n* Abnormality of mineral metabolism","6 Years","17 Years",{"count":100,"type":21},[24],"Evaluate feasibility and acceptability of recruiting Black and Hispanic families for an open label clinical trial of multinutrients while collecting real-time parent-reported child behavior data and collecting at-home biospecimens to explore their potential as biomarkers, in a study of pediatric ADHD.",[104,34,105],"2025-01-14",{"date":131,"type":55},"2025-01-16",{"date":133,"type":55},"2024-01-06",{"date":135,"type":21},"2026-01",{"name":114,"class":62},{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":153,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":63},"100499169","brief-interventions-for-coping-with-distress-100499169","NCT05779761","Brief Interventions for Coping with Distress","A Randomized Controlled Trial of Brief Interventions for Coping with Distress","Inclusion Criteria:\n\n* Between the ages of 18 and 65\n* Fluent in English (and therefore able to provide consent)\n* Currently living in New York City\n* Access to a smartphone and the internet\n* High self-reported worry, rumination, and\u002For self-criticism\n* Meet Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) criteria for at least one, current psychological disorder\n\nExclusion Criteria:\n\n* Active suicidal ideation or intent\n* Substance dependence disorder, schizophrenia, bipolar-I disorder, or a primary DSM-5 diagnosis of borderline or narcissistic personality disorder\n* Individuals currently receiving therapy or psychosocial treatment who do not plan to continue with the same treatment throughout the study period\n* Individuals taking psychotropic mediation that has not been stabilized for a period of at least 3 months\n* Current students at Teachers College, Columbia University\n* Individuals with cardiac conditions, diagnosed hyperhidrosis, and traumatic brain injuries or other neurological conditions (e.g., dementia, Parkinson's, epilepsy)","65 Years",{"count":146,"type":21},180,[24],"This study is being done to compare the effectiveness of three different skills trainings to cope with distress. These three trainings are: 1) an attention skills training, 2) an attention and reflective thought skills training, and 3) a health and wellness education training.",[150,34,151,152],"Distress, Emotional","Anxiety","Depression",[27,154,151,152,155,156,157,158],"Distress Disorders","Worry","Rumination","Self-Criticism","Skills Training","2024-11-18",{"date":161,"type":55},"2024-11-21",{"date":163,"type":55},"2023-05-12",{"date":165,"type":21},"2025-12",{"name":167,"class":62},"Teachers College, Columbia University"]