[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"emotional-memory\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:emotional-memory":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100448529","intracranial-neurophysiological-signatures-of-fear-and-anxiety-in-humans-100448529",false,"NCT05120635","Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans","Inclusion Criteria:\n\n* 18 years of age or older\n* Has undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement\n* Willing to provide informed consent and participate in the study\n* Ability to read and write English fluently\n\nExclusion Criteria:\n\n* Unwilling to provide informed consent\n* Has not undergone acute depth or chronic responsive neurostimulation (RNS) electrode placement\n* Pregnant women\n* Participants with active psychosis\n* Participants with suicidal ideation\n* Participants with substance abuse issues",true,"ALL","18 Years","70 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.\n\nThe purpose of this study is to understand the brain mechanisms that produce fear and anxiety in humans. To accomplish this goal, we will measure the brain activity along with the heart rate and skin perspiration of patients while they are completing tasks on a computer. Some of the tasks will also use a virtual reality headset and transport the patient in a video game-like environment. These tasks will expose the participants to various levels of fear-provoking images. Participants with responsive neurostimulation (RNS) implants will be enrolled under Pro00117931 at Duke, but their results for fear and anxiety tasks will be reported under NCT05120635.",[27,28,29,30],"Fear","GAD","Emotional Memory","PTSD","RECRUITING","2025-12-11",{"date":34,"type":35},"2025-12-16","ACTUAL",{"date":37,"type":35},"2021-10-01",{"date":39,"type":21},"2026-06-30",{"name":41,"class":42},"Duke University","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100607647","study-on-the-effect-of-transcranial-magnetic-stimulation-on-the-perception-of-emotional-images-100607647","NCT07191275","Study on the Effect of Transcranial Magnetic Stimulation on the Perception of Emotional Images","The Effect of TMS on Emotional Valence Evaluation of Aversive Pictures","SAME-M","Inclusion Criteria:\n\n* Generally healthy\n* Normotensive (BP 90\u002F60mmHg - 140\u002F90mmHg)\n* BMI: 18 - 30 kg\u002Fm2\n* Fluent in speaking German\n\nExclusion Criteria:\n\n* Metal in the head area (e.g., splinters, fragments, clips, etc.)\n* Implanted neurostimulator (e.g., DBS, epidural\u002Fsubdural, VNS)\n* Cardiac pacemaker or intracardiac lines\n* Medication infusion device\n* Non removable metal piercings in the head area, pivot teeth (retainers are no exclusion criterion)\n* Tattoos (head area) less than 3 months old or older than 20 years\n* Condition after neurosurgery\n* Hearing problems or tinnitus\n* Not able to sit still due to tremor, tics, itching\n* History of repeated syncope\n* Head trauma diagnosed as concussion or associated with loss of consciousness\n* diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his\u002Fher close family (parents and siblings)\n* TMS in the past showing problems\n* Spinal or ventricular derivations\n* Positive pregnancy test\n* Alcohol intake 12 hours before TMS visits\n* Regular intake of any medication (excluding oral contraceptives)\n* CNS-active medication or illegal drugs 48h before TMS visits\n* Individual's rMT above the limits of rTMS device\n* Suicidal tendency as measured by Montgomery-Åsberg Depression Rating Scale (MADRS), item 10 \\> 0","30 Years",{"count":53,"type":21},33,[24],"The goal of the current clinical trial is to investigate whether transcranial magnetic stimulation (TMS) over specific brain areas can influence the perception of emotional images and emotional memory. TMS is a non-invasive superficial brain stimulation generated by a magnetic field. The results of the study aim to provide valuable insights for the use of TMS in the investigation of mental processes.",[29],[58,59,60,61,62],"memory","emotional memory","transcranial magnetic stimulation","emotional valence","emotional arousal","2025-11-17",{"date":65,"type":35},"2025-11-21",{"date":67,"type":35},"2025-11-01",{"date":69,"type":21},"2026-10-01",{"name":71,"class":42},"Prof. Dominique de Quervain, MD",1]