[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"empyema-pleural\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:empyema-pleural":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,78,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100600274","phase-4-once-daily-intrapleural-enzyme-therapy-in-complicated-parapneumonic-effusion-or-empyema-100600274",false,"NCT07095361","Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema","Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema (ONLY ONCE)","ONLY ONCE","Inclusion Criteria:\n\n* Written informed consent obtained from patient or patient's legally authorized representative (LAR) to participate in the study and HIPAA authorization for release of personal health information.\n* Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.\n* Age ≥ 18 years at the time of consent.\n* Patient is admitted to the hospital and with a pleural effusion that is drained with a small-bore chest tube or one that allows for administration of IET\n* Pleural fluid that is one of the following:\n\n  (i) Macroscopically purulent or pleural fluid gram stain or culture positive for bacteria (ii) potential of hydrogen (pH) \\\u003C 7.2 (iii) Pleural fluid glucose \\\u003C 60mg\u002FdL (iv) Pleural fluid Lactate Dehydrogenase (LDH) \\> 1,000 IU\u002FL\n* Patient is deemed a candidate to receive intrapleural enzyme therapy as defined by having a residual collection or persistent sepsis 24 hours after initial chest tube placement\n\nExclusion Criteria:\n\n* Known pregnancy or lactating females\n* Prisoners\n* Age \\\u003C18 years at time of consent\n* Previous treatment with intra-pleural fibrinolytic agents, DNase, or both during the same hospital admission\n* Known sensitivity or allergic reaction to DNAse or tPA\n* Coincidental stroke, major hemorrhage (requiring blood transfusions within the last 5 days), major trauma, or major surgery within the last 5 days\n* Previous pneumonectomy or active bronchopleural fistula on the affected side\n* Therapeutic systemic anticoagulation or antiplatelet agents that cannot held for more than 48 hours prior to IET administration\n* Expected survival of less than 3 months due to a pathologic condition other than that causing the pleural infection","ALL","18 Years",{"count":20,"type":21},270,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections). These medications-tissue plasminogen activator (tPA) and deoxyribonuclease (DNase)-are placed through a chest tube into the space between the lung and the chest wall to help clear out the infection.\n\nThe investigators are trying to learn:\n\n* Does using the medicine once a day work just as well as using it twice a day?\n* Are there any differences in outcomes between patients who get the medicine once a day versus twice a day?\n* Does more or less fluid remain in the chest (seen on a chest x-ray) depending on how often the medicine is given?\n\nParticipants will:\n\n* Have an infection around their lung and will already be getting normal hospital care, including a chest tube to drain the infected fluid around their lung.\n* Be asked to give permission to join the study.\n* Be randomly chosen (like flipping a coin) to get the medications either once a day or twice a day through the chest tube.",[27,28,29,30,31,32,33,34],"Pleural Infection Bacterial","Pleural Infections","Pleural Infections and Inflammations","Empyema, Pleural","Empyema","Complicated Pleural Effusion\u002F Empyema","Pleural Effusion Associated With Pulmonary Infection","Pleural Effusion",[36,37,38,39],"Lytics","Intrapleural enzyme therapy","Once daily","lytic therapy","RECRUITING","2026-05-14",{"date":43,"type":44},"2026-05-19","ACTUAL",{"date":46,"type":44},"2025-09-11",{"date":48,"type":21},"2028-09-30",{"name":50,"class":51},"University of North Carolina, Chapel Hill","OTHER",6,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100637813","phase-4-flush-lyse-operate-100637813","NCT07592520","Flush, Lyse, Operate","Flush, Lyse, Operate: A Pilot Trial of Step-Wise Escalation for Pleural Infection: FLO Trial","FLO","Inclusion Criteria:\n\n* Age 18+\n* Complicated Parapneumonic Effusion or Empyema Requiring Thoracostomy\n* Are able to personally or have a designated medical decision maker provide consent\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Have received any intrapleural medications prior to enrolment via current chest tube\n* Have a contraindication to tPA\u002FDNase:\n\n  * Anticoagulation\n  * Active hemorrhage\n  * Allergy to tPA\u002FDNase\n  * Pregnancy\n* Are unable to personally or do not have a designated medical decision maker provide consent",{"count":62,"type":21},30,[24],"The goal of this observational study is to learn if saline results in improvement for patients with infection of their plerual space. The main question it aims to answer is:\n\nWhat is the time to chest tube removal? Do these patients after need to escalate to fibrinolytics? Do these patients after need to escalate to surgery?\n\nParticipants will:\n\n* Receive receive saline into their pleural space through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will receive fibrynolytics through an existing chest tube\n* If they fail to improve, which will be determined by fluid size after treatment or signs of persistent infection, they will be referred to surgery.",[66,30],"Complicated Parapneumonic Effusion","NOT_YET_RECRUITING","2026-05-11",{"date":70,"type":44},"2026-05-18",{"date":72,"type":21},"2026-04",{"date":74,"type":21},"2027-04",{"name":76,"class":51},"Dartmouth-Hitchcock Medical Center",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100548941","chest-drain-regular-flushing-in-complicated-parapneumonic-effusions-and-empyemas-100548941","NCT06427538","Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas","RELIEF","Inclusion Criteria:\n\n* Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy\n* Age \\> 18 years old.\n\nExclusion Criteria:\n\n* Patients who have surgical tubes that can't accommodate a three-way stopcock.\n* Study subject has any disease or condition that interferes with the safe completion of the study.\n* Inability to provide informed consent.\n* Inability to undergo a chest X-ray.\n* If the managing clinician believes the chest tube will be placed for less than 24 hours.\n* Patients with an indwelling pleural catheter (IPC)",{"count":86,"type":21},96,[88],"NA","Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.",[30,91],"Pleural Infection",[93,94,95,96],"empyema","pleural infection","chest tube","saline flush","2026-02-18",{"date":99,"type":44},"2026-02-20",{"date":101,"type":44},"2024-06-21",{"date":103,"type":21},"2026-12-30",{"name":105,"class":51},"Vanderbilt University Medical Center",5,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":115,"maxAge":18,"enrollmentInfo":116,"targetDuration":4,"studyType":118,"phases":4,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":77},"100566647","complicated-pneumonia-cp-in-children-in-south-east-europe-100566647","NCT06657898","Complicated Pneumonia (CP) in Children in South-East Europe","Increasing Incidence of Complicated Pneumonia in Children in South-East Europe: a Retrospective Multi-center Analysis of Incidence, Characteristics and Outcomes","CP","Inclusion Criteria\n\n* Children aged 1 month to 18 years of age\n* Children diagnosed with complicated community acquired pneumonia (pneumonia with parapneumonic effusion, necrotizing pneumonia and lung abscess)\n* Children who were hospitalized from January 1st 2014 to April 30th 2024 and required at least 24 hours of hospital stay\n\nExclusion Criteria\n\n* Children with increased risk for severe lung infections (cystic fibrosis, primary ciliary dyskinesia, immunodeficiencies, congenital lung abnormalities, neurological conditions, chemotherapy)\n* Children with hospital-acquired pneumonia","1 Month",{"count":117,"type":21},300,"OBSERVATIONAL","This retrospective observational study aims to evaluate clinical course of complicated community acquired pneumonia in children, particularly focusing on necrotizing pneumonia cases, as well as determination of etiological agents (viruses and bacteria) and its association to severity and outcomes of the disease. Furthermore, therapeutic approach, complications, short-term and long-term outcomes and the prevention of the disease are to be assessed. The study will encompass data from pediatric centers in the South-East Europe willing to participate in the study, encompassing ten-year period of time.",[121,122,30],"Pneumonia, Necrotizing","Lung Abscess",[124,125,93,126],"pneumonia in children","necrotizing pneumonia","lung abscess","2024-10-23",{"date":129,"type":44},"2024-10-26",{"date":131,"type":44},"2024-05-27",{"date":133,"type":21},"2025-10-01",{"name":135,"class":51},"Aleksandar Sovtic"]