[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"end-of-life-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:end-of-life-care":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,91,138,168,192,225,248],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100633346","die-logue-program-for-community-dwelling-adults-a-randomized-controlled-trial-100633346",false,"NCT07525492","Die-logue Program for Community Dwelling Adults: A Randomized Controlled Trial","Effects of a Die-logue Program in Enhancing Community Dwelling Adults's Death Attitudes, Coping With Death and Readiness for Advance Care Planning: A Two-phase Study","Inclusion Criteria:\n\n* Between the ages of 40 to 60 years\n* Able to comprehend the English language\n* Have not completed any form of advance directives\n* Able and willing to participate in the Die-logue programme and surveys\n\nExclusion Criteria:\n\n* Individuals diagnosed with any life limiting diseases\n* Individuals with self-reported history of mental health disorders or neurological disorders",true,"ALL","40 Years","60 Years",{"count":21,"type":22},148,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to evaluate whether the Die-logue program can improve attitudes toward death, coping with death, and readiness for advance care planning (ACP) among community-dwelling middle-aged adults aged 40-60 years who have not completed any advance directives and not diagnosed with any life limiting diseases.\n\nThis study aims to address the following research questions:\n\n* Does the Die-logue program improve community-dwelling middle-aged adults' attitudes towards death, ability to cope with death, readiness and uptake for Advanced Care Planning (ACP).\n* What are community-dwelling middle-aged adults' perceptions of advance care planning, death and dying, and their experiences of participation in the Die-logue program.\n\nResearchers will compare participants who receive the Die-logue program (death conversation and online ACP education) with participants who receive only the online ACP education to see if informal death conversations improve attitudes toward death, coping with death, and readiness for ACP.\n\nParticipants will:\n\n* Complete online questionnaires measuring attitudes toward death, coping with death, and readiness for advance care planning.\n* Participate in a facilitator-led group discussion session about perceptions of death, coping with death, and readiness for ACP (intervention group only).\n* Complete an asynchronous online ACP education session consisting of short recorded videos and an online discussion forum (both intervention and control group).\n* Complete follow-up surveys, including a 6-month follow-up assessing whether they have undertaken advance care planning.",[28,29,30,31],"Death Attitude (Implicit\u002FExplicit)","Death Anxiety","End of Life Care","Advanced Care Planning (ACP)",[33,29,34,35],"Death Conversation","Advance Care Planning","Death Attitude","NOT_YET_RECRUITING","2026-04-06",{"date":39,"type":40},"2026-04-13","ACTUAL",{"date":42,"type":22},"2026-04-01",{"date":44,"type":22},"2027-12-31",{"name":46,"class":47},"National University of Singapore","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":16,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":77,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100619558","communityrx-dementia--peer-navigation-crxdpeer-100619558","NCT07346183","CommunityRx-Dementia + Peer Navigation (CRxDpeer)","CommunityRx-Dementia + Peer Navigation (CRxDpeer): A Real-World Implementation and Effectiveness Study of an IT-Based Social Care Intervention","CRxDpeer","Inclusion Criteria:\n\n* Self-identifies as a caregiver of a home-dwelling person with Alzheimer's disease or related dementias (ADRD)\n* Resides in the target geographic region of the study\n* Has access to a cell phone and agrees to receive text messages from the study\n* Has an email address that they can receive emails from\n* Individuals under the age of 18 who are emancipated minors in the state of Illinois and a caregiver of a person with dementia\n\nExclusion Criteria:\n\n* Minors who are not emancipated in the state of Illinois.\n* Previously participated in the intervention arm of the CommunityRx-Dementia clinical trial","18 Years",{"count":59,"type":22},330,[25],"The CRxDpeer intervention, delivered by a trained peer navigator, in practice called a \"peer mentor\", includes three evidence-based components: (a) focused education about common social (e.g., food and housing insecurity) and caregiving (e.g., respite and end of life care) needs, (b) activation of personalized community resource information for social and caregiving needs through delivery of a resource list (HealtheRx) at the baseline encounter and coaching on how to communicate with service providers, coordinate services and manage social support (e.g., connect with their peer navigator, reach out to friends or relatives for support, identify support groups, etc.) and (c) ongoing navigation-focused support meant to boost the baseline intervention, including a series of proactive text messages over 12 months. During this time, the subject can respond to and communicate with the peer navigator for ongoing support.",[63,64,65,66,67,68,69,30,70,71,72,73,74,75,76,34],"Alzheimer s Disease","Dementia","Caregiver","Loneliness","Health-Related Social Needs","Social Care","Healthcare Utilization","Caregiver Burden","Anxiety","Stress","Depression","Self-Efficacy","Peer Support","Implementation Science",[78,79,80,81,82],"resource navigation","peer navigator","peer mentor","social care","dementia caregiver",{"date":84,"type":40},"2026-04-07",{"date":86,"type":22},"2026-06-01",{"date":88,"type":22},"2029-02-28",{"name":90,"class":47},"University of Chicago",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":102,"conditions":103,"keywords":117,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100629619","non-invasive-detection-and-preservation-of-neurocognitive-signals-in-the-peri-death-period-using-brain-computer-interface-and-artificial-intelligence-100629619","NCT07477028","Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence","Feasibility of Non-Invasive Detection and Preservation of Neurocognitive Signals in the Peri-Death Period Using Brain-Computer Interface and Artificial Intelligence: A Prospective Observational Study (NeuroCogPresv)","NeuroCogPresv","Inclusion Criteria:\n\n1. Adults ≥18 years with terminal illness or severe acute trauma\n2. Do-not-resuscitate (DNR\u002FDNI) order in place\n3. Surrogate decision-maker available and willing to provide informed consent\n4. Expected survival ≤7 days (physician estimate)\n\nExclusion Criteria:\n\n1. Brain death already declared \\> 24 hours prior to enrollment\n2. Contraindication to EEG\u002FBCI headset placement (e.g., severe scalp injury)\n3. Patient lacks a legally authorized representative",{"count":100,"type":22},20,"OBSERVATIONAL","Background: Recent electroencephalography (EEG) data indicate that the transition from clinical death to cellular death is marked by highly organized neurophysiological events, including significant surges in gamma-band power, cross-frequency coupling, and distinct spreading depolarization waves. This prospective, observational feasibility study utilizes rapid-deployment, high-density, noninvasive BCI hardware paired with proprietary AI analytics to detect, classify, and securely archive these terminal neurocognitive signals.\n\nObjectives: (1) Quantify transient gamma-band activity and cross-frequency connectivity post-clinical death; (2) Validate the efficacy of machine learning models for real-time signal classification in high-noise clinical environments; (3) Establish a highly secure, encrypted bio-informational archive of peri-life EEG data.\n\nDesign: Prospective, open-label, multicenter, observational cohort (n\\>20).",[104,105,106,107,29,108,109,110,111,112,113,114,115,116],"Terminal Illness","End-of-Life Care","Death","Brain Death","Consciousness","Electroencephalography","Gamma Oscillations","Near-Death Phenomena","Cognitive","Cognition","Memory","EEG","Severe Acute Trauma",[118,119,120,106,110,113,108,121,122,123,114,124,125,126,127],"AI","BCI","Brain Computer Interface","Pefi-death","Brain death","Reservation","Life","Life experience","Transfer","Convergence","2026-03-12",{"date":130,"type":40},"2026-03-17",{"date":132,"type":22},"2026-09-01",{"date":134,"type":22},"2035-09-30",{"name":136,"class":137},"Noah Tech, Corp.","INDUSTRY",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100624979","death-dying-violence-and-aggression-as-shown-on-medical-television-series-100624979","NCT07416669","Death, Dying, Violence and Aggression as Shown on Medical Television Series.","End of Life, Violence and Aggression on TV.","Inclusion Criteria:\n\n* Any are clearly visible and\u002For audible, intentional acts of violence occurring as self-contained scenes within an episode, set in a hospital environment, and taking place between two or more individuals in a medical or professional treatment setting.\n* All patients dying within the hospital setting. The death scene must be explicitly shown or named (e.g., flatline, burial, covering of the body). The death must be visibly depicted on screen (the viewer must see the death happen).\n\nExclusion Criteria:\n\n* Violence: Violence outside the hospital. Self-harming behaviour or acts of violence that originate from a purely private context and do not arise within a professional medical setting.\n* Death: Death outside the hospital. Stories or mentions of death without visual depiction do not count. Implied or off-screen deaths without explicit confirmation or depiction are excluded. Implied or off-screen deaths without explicit confirmation or depiction are excluded.",{"count":146,"type":22},500,"Medical TV dramas have become very popular in recent years. These shows are mainly created for entertainment and often do not reflect what really happens in hospitals. However, television plays an important role in sharing information, shaping how people think, and teaching the public about medicine.\n\nDeath and dying in hospitals, especially in Intensive Care Units (ICUs), are highly emotional experiences. In real life, these situations often turn out very differently from what patients and families expect. Because of this, it is important to understand how medical TV shows portray major hospital events such as end-of-life care, death, and the delivery of bad news. When what is shown on TV does not match the reality of ICU care, it can lead to unrealistic expectations, false hope, and greater distress for patients and their families at the end of life.\n\nAt the same time, violence and aggression towards healthcare providers have increased in recent years. This can include verbal abuse as well as physical attacks. Looking at how healthcare workers are treated in medical TV shows may help us understand whether these programmes influence what behaviour is seen as acceptable. Since violence against healthcare staff has become especially concerning since the COVID-19 pandemic, the possible role of media should not be ignored, even though many factors are involved.\n\nThis study aims to describe how death and dying are shown in popular medical TV series and to explore how violence or aggression towards healthcare providers is portrayed in these settings.",[30,149,150,151],"Violent Aggressive Behavior","Television Viewing","Media Use",[153,154,155,156,157],"violence","aggression","death","dying","medical tv shows","2026-02-10",{"date":160,"type":40},"2026-02-18",{"date":162,"type":22},"2026-05-10",{"date":164,"type":22},"2027-12",{"name":166,"class":47},"King's College Hospital NHS Trust",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":178,"conditions":179,"keywords":182,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":190,"locationsCount":4},"100623806","life-sustaining-treatments-in-critically-ill-children-100623806","NCT07401420","Life Sustaining Treatments in Critically Ill Children","Project Plan Physicians' Experiences of the Decision-making Process Regarding Decisions to Withhold\u002FDiscontinue Life-sustaining Treatment in Children Cared for in Intensive Care Units in Sweden. A Qualitative Study.","LST-Ped-Int","Inclusion Criteria:\n\n* Specialist physicians in critical care with experience from end of life care in critically ill children.\n\nExclusion Criteria:\n\nNone\n\n\\-",{"count":177,"type":22},30,"Summary of the Research on Withdrawing and Withholding Life-Sustaining Treatment for Critically Ill Children Background Medical treatments require regular evaluation to ensure they align with the patient's best interests, particularly in intensive care where quality of life is often compromised. In the context of critically ill children, the challenge increases as patients may not be fully conscious or capable of expressing their needs and preferences. While intensive care can extend life, end-of-life situations necessitate careful consideration to avoid providing futile treatments that do not benefit the patient.\n\nDecision-Making Complexity Identifying when further treatment is beneficial poses significant challenges, influenced by various factors including the wishes of the patient and guardians. Previous studies indicate variability among healthcare providers in treatment decisions, often stemming from personal experiences and emotional responses. However, comparable research focusing on critically ill children in Nordic contexts remains scarce. Medical decisions often require balancing potential benefits against the risks of extended suffering or loss of valuable time at the end of life.\n\nA previous survey on end-of-life care in Europe indicated similar attitudes across regions but highlighted the need for cultural considerations. Sweden's distinct social and cultural values, characterized by individualism and secularism, may influence practices surrounding life-sustaining treatment.\n\nResearch Aims This research aims to investigate the factors affecting decision-making regarding the withdrawal and withholding of life-sustaining treatments for critically ill children in Swedish and Nordic intensive care units (ICUs). It will examine practitioners' experiences, attitudes, and the relative impact of children's autonomy in these decisions, excluding neonatal care.\n\nKey scientific questions focus on Physicians' attitudes and challenges regarding treatment withdrawal.\n\nMethodology\n\nSemi-structured interviews in multiple ICUs to explore ethical dilemmas faced by physicians.",[180,181,30],"Critical Illness","Ethics",[183,181,184],"Critical illness","End of life care","2026-02-06",{"date":158,"type":40},{"date":188,"type":22},"2026-02-01",{"date":44,"type":22},{"name":191,"class":47},"Göteborg University",{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":202,"conditions":203,"keywords":206,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":48},"100611627","code-status-discussions-in-muslim-icu-patients-insights-into-physician-family-communication-100611627","NCT07243041","Code Status Discussions in Muslim ICU Patients: Insights Into Physician-Family Communication","A Prospective Study Exploring Factors Affecting ICU Transitions and Handling of Code Status - Insights Into Physician and Family Communication in a Muslim Patient Population","FAITH-ICU","Inclusion Criteria:\n\n* ICU physicians (residents, fellows, assistant consultants, or consultants) involved in direct patient care\n* ICU physicians who conduct code status or Do Not Attempt Resuscitation (DNAR) discussions with patients' families during ICU admission\n* Willingness of ICU physicians to participate voluntarily by completing a post-goals-of-care discussion questionnaire\n* Adult patients (≥18 years) admitted to the ICU during the study period for whom a code status discussion occurred\n\nExclusion Criteria:\n\n* ICU physicians who decline participation\n* Code status discussions involving patients younger than 18 years of age\n* Discussions in which the physician was not directly involved",{"count":201,"type":22},320,"This observational study aims to explore the real-time experiences, perceptions, and challenges faced by intensive care unit (ICU) physicians during goals-of-care discussions-specifically Do Not Attempt Resuscitation (DNAR) and end-of-life decision-making conversations-with families of critically ill patients in a Muslim-majority healthcare setting.\n\nThe study seeks to identify factors that influence whether a DNAR decision is reached after physician-family discussions, and how physician experience, family dynamics, religious perspectives, and institutional support affect communication outcomes and care transitions.\n\nParticipants will include ICU physicians (residents, fellows, and consultants) who routinely conduct DNAR discussions as part of clinical care. After each discussion, physicians will complete a brief structured questionnaire about their perceptions of the interaction, family emotions, and decision outcomes. These responses will be anonymously linked to limited, de-identified patient-level data (e.g., diagnosis, ICU course, and outcome) extracted retrospectively from the electronic medical record.\n\nNo patients or family members will be contacted directly. Data collection will occur prospectively over two years at King Faisal Specialist Hospital \\& Research Centre-Jeddah.\n\nFindings from this study are expected to provide culturally grounded insights that inform physician training, enhance family-centered communication, and guide policy development for DNAR and end-of-life discussions in Muslim-majority intensive care units.",[30,204,205],"Muslim","Decision Making ,Shared",[207,208,209,210,211,212,213,214],"goals of care","do not attempt resuscitation","ICU","Shared Decision-Making","Family Communication","Muslim Healthcare Context","Cultural Factors","palliative care","RECRUITING","2025-12-14",{"date":218,"type":40},"2025-12-19",{"date":220,"type":40},"2025-11-01",{"date":222,"type":22},"2027-10-31",{"name":224,"class":47},"King Faisal Specialist Hospital & Research Center",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":17,"minAge":231,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":234,"conditions":235,"keywords":237,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":48},"100518107","practice-analysis-of-care-paraclinical-exams-and-treatments-received-by-geriatric-patients-both-during-the-last-week-and-the-last-24-hours-of-their-lives-100518107","NCT06026241","Practice Analysis of Care, Paraclinical Exams and Treatments Received by Geriatric Patients Both During the Last Week and the Last 24 Hours of Their Lives.","Inclusion Criteria:\n\n* All patients over 75 years old who died in a geriatric short-stay department at Saint-Etienne University Hospital.\n\nExclusion Criteria:\n\n\\- Patients under 75 years old","75 Years",{"count":233,"type":22},100,"End-of-life care is a core topic for geriatricians. One of the key aspects of end-of-life management is deciding when to discontinue active care measures (for example blood pressure monitoring, blood tests and X-rays) in favor of exclusive comfort care. In this retrospective observational study, the investigators looked at the care measures, treatments and paraclinical exams received by geriatric patients both one week and 24 hours before their death.",[236],"End-of-life Care",[184,238,106],"Geriatric","2025-03-17",{"date":241,"type":40},"2025-03-18",{"date":243,"type":40},"2024-03-01",{"date":245,"type":22},"2025-12-31",{"name":247,"class":47},"Centre Hospitalier Universitaire de Saint Etienne",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":101,"phases":4,"briefSummary":258,"conditions":259,"keywords":266,"overallStatus":215,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":48},"100369752","burden-mortality-and-supply-costs-in-intensive-care-unit-patients-100369752","NCT04094428","Burden, Mortality and Supply Costs in Intensive Care Unit Patients","Burden, Mortality and Supply Costs in Intensive Care Unit Patients. Health Services Research.","PLV_Ulm","Inclusion Criteria:\n\n* All patients dying on the ICU and all patients staying for at least 72 hours on the ICU\n\nExclusion Criteria:\n\n* No",{"count":257,"type":22},700,"This study systematically observes in a pragmatic trail under real world conditions the association between strategies of therapy (maximal therapy, withhold, withdraw) and treatment success in three endpoint related initial risk groups (high, intermediate, low risk) regarding three endpoints (burden, mortality and supply costs).",[260,261,236,262,263,264,265],"Burden, Dependency","Mortality","Intensive Care Unit","Critically Ill Patient","Frailty","Multiple Organ Failure",[267,268,269,270,271,272,265],"burden","mortality","end-of-life care","intensive care unit","critically ill patient","frailty","2024-01-16",{"date":275,"type":40},"2024-01-17",{"date":277,"type":40},"2019-10-21",{"date":279,"type":22},"2026-09-30",{"name":281,"class":47},"University of Ulm"]