[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"end-of-life\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:end-of-life":265},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,46,85,138,162,187,212,238],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100625872","resilience-building-for-advance-care-planning-100625872",false,"NCT07428278","Resilience-Building for Advance Care Planning","Facilitating Advance Care Planning Discussions Between Patients With Advanced Cancer and Their Family Caregivers Using a Resilience-Building Intervention: A Randomized Controlled Trial.","ROCKS","Inclusion Criteria:\n\n* Eligible patients will (1) be ≥ 18 years of age; (2) be diagnosed with stage 3 or 4 cancer; and (3) have a family caregiver who is willing to participate.\n* Eligible family caregivers will be ≥ 18 years of age. All participants must be able to read, write, and speak English with minimal assistance from others and have access to the internet on a smartphone, laptop, or computer.\n\nExclusion Criteria:\n\n* Patient participants will be ineligible if they have (1) a Short Portable Mental Status Questionnaire (SPMSQ) score \\\u003C 8; or (2) have completed any form of advance directive.","ALL","18 Years","80 Years",{"count":21,"type":22},152,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aims of this study are to (1) assess the feasibility, acceptability, and usability of the ROCKS intervention among patients with advanced cancer and their family caregivers through a randomized controlled trial in a cancer center setting; (2) evaluate the preliminary efficacy of ROCKS, as compared to usual care, on changes in completion of advance directives; and (3) explore the dyadic effects of resilience on self-efficacy, optimism, dyadic communication and coping, anxiety, and depression using an actor-partner interdependence model.",[28,29],"Advanced Cancer","End of Life",[31,32],"Resilience","Advance Care Planning","RECRUITING","2026-06-05",{"date":36,"type":37},"2026-06-09","ACTUAL",{"date":39,"type":37},"2026-05-28",{"date":41,"type":22},"2028-07-31",{"name":43,"class":44},"University of Illinois at Chicago","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":66,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":84},"100571599","palliative-care-education-in-assisted-living-for-dementia-care-providers-pceal-dcp-100571599","NCT06722352","Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)","Preparing Assisted Living Staff to Provider Palliative Care to Residents With Dementia: Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)","PCEAL-DCP","Inclusion Criteria:\n\nThe AL community eligibility criteria include a minimum of 40+ beds and provide memory care services to at least 35% of their residents, and access to hospice services from Lifepath or Suncoast Hospice. The AL size of 40+ beds is selected so we will be able to recruit a minimum of 14 residents per site, based on the power analysis for the sample size of 450 for the primary study outcome of documentation of ACP discussions.\n\nResidents are eligible if 1) they have a dementia diagnosis confirmed by the resident's physician (physician's signature required by University of South Florida (USF) Institutional Reiew Board (IRB) in prior clinical trial) regardless of dementia severity (mild, moderate, or severe), 2) if they have been admitted to the AL in the last month, and 3) if they have a legally responsible representative who understands English.\n\nStaff are eligible if they are currently employed with the participating study AL as a registered\u002Flicensed practical nurse, administrator, or dementia care coordinator of a memory care unit and English speaking and 21 years of age or older.\n\nFamily members are eligible if 1) they are listed as the legally responsible party in the chart records for the resident with ADRD, 2) they understand English, and 3) are at least 21 years of age or older. This could include someone related to the person, a close friend or a legal guardian who oversees the person's care and is responsible for decisions about their care.\n\nExclusion Criteria:\n\nAL sites will be ineligible if 1) the are not a licensed Florida assisted living facility; 2) they have previously participated in a PCEAL-DCP clinical trial (2018-2021) to avoid possible experimental contamination effects, and 3) if no staff employed at the AL are willing to participate in the study.\n\nResidents are ineligible if they: 1) are currently receiving hospice services because residents who receive hospice are already engaged in ACP discussions upon admission; 2) if they are discharged from assisted living to another setting (nursing home or hospital) or are admitted to hospice or have died before baseline data is collected.\n\nStaff will be ineligible if they are not licensed nurses, administrators or dementia care coordinators of a dementia care unit or terminated\u002Fresign before baseline data is collected.\n\nFamily are ineligible if: 1) they are under 21 years of age and do not understand spoken or written English and if there is already a legal authorized representative for a resident participating in the study (one family member per resident).\n\n\\-",true,"21 Years",{"count":57,"type":22},792,[25],"The palliative care education in assisted living for dementia care providers (PCEAL-DCP) is a 4-week intervention (once a week for 1.5 hours, a total of 6 hours) for licensed nurses, administrators and dementia care coordinators to improve quality of dementia care outcomes",[61,29,62,63,64,65],"Alzheimer Disease","Caregiver Burden","Caregiver Burnout","Patient Participation","Self Efficacy",[67,68,69,70,71,72,73,74],"end of life","palliative care","education","staff training","assisted living","dementia","dementia care","Alzheimer's","2026-04-27",{"date":77,"type":37},"2026-04-29",{"date":79,"type":37},"2025-01-28",{"date":81,"type":22},"2029-08-01",{"name":83,"class":44},"University of South Florida",2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":137},"100462136","comparative-effectiveness-trial-of-two-supportive-cancer-care-delivery-models-for-adults-with-cancer-100462136","NCT05297734","Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer","Inclusion Criteria:\n\n1. Newly diagnosed patients with solid tumor cancer diagnosis or recurrence of the disease.\n2. Patients must have the ability to understand and willingness to provide verbal consent.\n3. Participants must speak English, Spanish, Chinese, or Vietnamese.\n\nExclusion Criteria:\n\n1. Inability to consent to the study\n2. Plans to change oncologist within 12 months\n3. Employed by the practice site\n4. Patients who anticipate moving from the area within 12 months",{"count":92,"type":22},2996,[25],"This cluster-randomized comparative effectiveness trial compares a technology-based supportive cancer care (SCC) approach with a redesigned team-based supportive cancer care (SCC) approach.",[29,96],"Cancer",[98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127],"Carcinoma","Lung Neoplasms","Carcinoma, Non-Small-Cell Lung","Melanoma","Pancreatic Neoplasms","Sarcoma","Ovarian Neoplasms","Carcinoma, Ovarian Epithelial","Stomach Neoplasms","Glioblastoma","Rectal Neoplasms","Colonic Neoplasms","Esophageal Neoplasms","Breast Neoplasms","Carcinoma, Renal Cell","Skin Neoplasms","Small Cell Lung Carcinoma","Osteosarcoma","Myelodysplastic Syndromes","Disease Progression","Neoplasms, Glandular and Epithelial","Neoplasms by Histologic Type","Neoplasms","Respiratory Tract Neoplasms","Thoracic Neoplasms","Neoplasms by Site","Lung Diseases","Respiratory Tract Diseases","Urogenital Neoplasms","Carcinoma, Bronchogenic","2026-04-24",{"date":130,"type":37},"2026-04-30",{"date":132,"type":37},"2022-06-24",{"date":134,"type":22},"2028-02-28",{"name":136,"class":44},"Stanford University",17,{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":45},"100516253","eliciting-informed-goals-of-care-in-elderly-patients-100516253","NCT06002113","Eliciting Informed Goals of Care in Elderly Patients","Assessment of Shared Decision-making Tool for Eliciting Informed Goals of Care in the Hospitalized Elderly (ASKMEGOC): A Randomized Clinical Trial","ASKMEGOC","Inclusion Criteria:\n\n* Hospitalized patients ≥ 80 years old with an acute medical or surgical condition admitted to any hospital ward\n* Previously or currently documented CODE STATUS preferences include any life sustaining therapies\n* Duration of admission ≥ 24 hours\n* English speaking, or translator present\n* Competent patient or substitute decision maker\n\nExclusion Criteria:\n\n* Treating physician, patient, or substitute decision maker declines\n* Documented resuscitation preferences for comfort or supportive care\n* New diagnosis of life-limiting illness on this hospital admission, for example, new diagnosis of metastatic cancer\n* Clinically unstable, admitted to an intensive care unit, or currently receiving acute life support treatment (mechanical ventilation, acute dialysis, or inotropic\u002Fvasopressor support)\n* Readmission after index hospitalization\n* Pre-existing need for chronic mechanical ventilation (invasive mechanical ventilation via tracheostomy \\> 90 days) or maintenance dialysis (peritoneal or hemodialysis \\> 90 days)",{"count":147,"type":22},1200,[25],"Patient-centered medical care considers a patient's values and goals for their health and well-being. Healthcare providers use this information to formulate a medical care plan that is aligned with these expectations. This shared-decision making process should occur with every medical decision, but it is especially important whenever decisions about end-of-life care are being considered. Eliciting patient preferences about resuscitation and life-support treatments in the event of life-threatening illnesses are considered to be a standard of excellent and appropriate medical care. Unfortunately, these discussions don't happen consistently and even when they do occur, are rarely ideal. The consequences can be devastating, often resulting in the delivery of unwanted medical care that can be associated with significant physical and mental suffering among patients and their families. In response to this problem, the investigators developed a novel tool to help guide these difficult conversations between healthcare providers and patients. The investigators previously tested this tool in a small group of hospitalized patients who found it acceptable and helpful. In this larger study, the investigators will compare how effective this tool is compared to usual care in ensuring hospitalized patients have their treatment preferences identified, documented and result in end-of-life care that is consistent with their preferences.",[151,152,29],"Goals of Care","Patient Preference","2025-11-18",{"date":155,"type":37},"2025-11-21",{"date":157,"type":37},"2023-10-03",{"date":159,"type":22},"2027-06-01",{"name":161,"class":44},"Royal Victoria Hospital, Canada",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":172,"phases":4,"briefSummary":173,"conditions":174,"keywords":175,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":45},"100607640","identification-of-obstacles-and-levers-to-the-outpatient-care-of-patients-in-terminal-palliative-situations-100607640","NCT07191184","Identification of Obstacles and Levers to the Outpatient Care of Patients in Terminal Palliative Situations","Identification of Obstacles and Levers to the Outpatient Care of Patients in Terminal Palliative Situations: Exploratory Study Among General Practitioners in Bas-Rhin","PTPS","Inclusion Criteria:\n\n* General physician based in Bas-Rhin\n* Agreeing to participate in the research\n\nExclusion Criteria:\n\n* Refusing to participate in the research\n* Replacement physician, specialist physician, based outside Bas-Rhin",{"count":171,"type":22},12,"OBSERVATIONAL","80% of patients wish to die at home. The number of deaths will increase in the coming years due to the aging population. The general practitioner (GP) is at the center of this care. Despite national plans for the development of palliative care, dying at home remains complicated. The difficulties described and known are organizational (workload) and linked to the doctor's experience with the suffering of the patient and their family. Many studies have been conducted in hospital settings, and the solutions developed are often not very accessible to GP. Conducting a study on this subject will allow us to take stock of this outpatient care provided by general practitioners following numerous changes that have occurred in recent years, both in terms of palliative care teaching and in terms of modifications to the care offered.",[29],[176,177],"Palliative care","Terminal palliative situations","2025-09-22",{"date":180,"type":37},"2025-09-24",{"date":182,"type":37},"2024-09-16",{"date":184,"type":22},"2025-12-16",{"name":186,"class":44},"University Hospital, Strasbourg, France",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":54,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":172,"phases":4,"briefSummary":195,"conditions":196,"keywords":198,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":205,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":45},"100473133","evaluation-of-the-acceptability-appropriateness-and-feasibilityusability-of-a-metastatic-breast-cancer-specific-prognostic-calculator-among-clinicians-100473133","NCT05440929","Evaluation of the Acceptability, Appropriateness, and Feasibility\u002FUsability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians","Inclusion Criteria:\n\n1. Verbal informed consent obtained to participate in the study.\n2. Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.\n3. Physician, nurse practitioner, physician assistant, or nurse navigator\n4. At least 6 months of experience in the clinical care of patients with metastatic breast cancer in the United States.\n\nExclusion Criteria:\n\n* Non-English Speaking",{"count":194,"type":22},15,"I this qualitative study, Investigators will conduct semi-structured interviews with clinicians that are involved in the care of patients with breast cancer to evaluate the acceptability, appropriateness, and feasibility\u002Fusability of a metastatic breast cancer-specific prognostic tool. These interviews will be conducted by the UNC CHAI Core and will continue until thematic saturation (estimated 10 participants). The investigators will code the qualitative data using emerging themes, guided by a well-established implementation science theory, the Consolidated Framework for Implementation Research (CFIR). The information gained from these studies will inform an implementation approach to increase the usability and acceptability of a novel prognostic tool to assist oncologists in the prognosis of patients with metastatic breast cancer.",[197,29],"Metastatic Breast Cancer",[197,199,200,201,202,203,204],"Prognostic Tool","End of life","Clinicians","Prognosis","Qualitative Interview","Caregivers",{"date":180,"type":37},{"date":207,"type":37},"2022-07-07",{"date":209,"type":22},"2027-08-10",{"name":211,"class":44},"UNC Lineberger Comprehensive Cancer Center",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":220,"targetDuration":4,"studyType":23,"phases":222,"briefSummary":223,"conditions":224,"keywords":225,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":237},"100521552","impact-of-a-protocol-for-announcing-decision-of-withholding-and-withdrawing-life-sustaining-treatments-on-the-stress-of-the-relatives-in-the-emergency-departments-100521552","NCT06071078","Impact of a Protocol for Announcing Decision of Withholding and Withdrawing Life-sustaining Treatments on the Stress of the Relatives in the Emergency Departments","Impact of a Protocol for Announcing the Limitation and Discontinuation of Therapies in the Emergency Departments on the Stress of Families","DISCUSS","Inclusion Criteria:\n\nFor relatives, will be included in the study:\n\n* Trusted persons, families or relatives present in the emergency departments and to whom the 1st announcement of a decision to limit or stop therapies is made by a physician participating in the study. Several persons can be included for the same patient (maximum 3) in the following order: trusted person \\> family \\> close relative.\n* Age of trusted person, family or close friends over 18 years old.\n* Informed consent given and voice rights signed for families accepting the semi-directed interview.\n\nFor caregivers, also included in the study will be:\n\n* Caregivers on participating wards.\n* Informed consent given and voice rights signed for families accepting the semi-directed interview.\n\nFor partner families, will be included in the study:\n\n* Trusted persons, families or relatives present in the emergency department and to whom the 1st announcement of a decision to limit or stop therapy by a physician in a participating emergency department is made.\n* Age of trusted person, family or close friends over 18 years old.\n* Signed consent for the right to voice recording.\n\nExclusion Criteria:\n\nFor relatives:\n\n* Trusted person, family or close friend whose announcement would have been made entirely by telephone.\n* Trusted person, family or close friend unable to understand or write in French.\n* Pregnant women, women in labor or nursing mothers.\n* Persons deprived of liberty by a judicial or administrative decision.\n* Persons under psychiatric care.\n* Persons admitted to a health or social institution for purposes other than research.\n* Persons of full age who are subjects to a legal protection measure (guardians, curators).\n* Persons not affiliated to a social security system or beneficiaries of a similar system.\n\nFor caregivers:\n\n\\- Persons not affiliated to a social security system or beneficiaries of a similar system.",{"count":221,"type":22},538,[25],"Death is a daily reality in the emergency department. Deaths represent 0.3 to 0.5% of emergency admissions, i.e. approximately 26,000 per year for the whole of France. For 80% of these deceased patients, a decision of withholding and withdrawing life-sustaining treatments was made in the emergency departments. The announcement of death and decision of withholding and withdrawing life-sustaining treatments in this context is complex because of the lack of time and the inappropriate places for the announcement. In addition, the short delay in the occurrence of these events may increase the stress and anxiety of families who are unprepared for the announcement. However, there is little data in the literature on the impact on families in terms of their experience of announcements in the emergency context.\n\nIt has been established that symptoms of anxiety and depression are correlated with the onset of posttraumatic stress disorder and that the latter is more important in the families of deceased patients and after a decision to undergo decision of withholding and withdrawing life-sustaining treatments in the intensive care unit. In order to identify it, several tools have been developed, including the Impact Event Scale (IES), which has been widely used to detect symptoms related to PTSD.\n\nIt has also been shown that training nursing staff in communication skills or the use of written support in dealing with the families of patients who have died in intensive care reduces the appearance of post-traumatic stress symptoms.\n\nHuman simulation is a pedagogical technique for learning interpersonal skills through role playing. It is used, among other things, in announcement situations in medicine. Nevertheless, its impact in emergency medicine has not been evaluated.\n\nMoreover, it has been shown that the involvement of the patient-partner in the care process must be improved and encouraged and that its impact has yet to be evaluated. Therefore, the objective is to evaluate the impact of a model protocol for announcing decision of withholding and withdrawing life-sustaining treatments, with human simulation and the intervention of partner families in a simulation center and in situ, on the reduction of family stress following the announcement of a decision of withholding and withdrawing life-sustaining treatments in the emergency departments.\n\nHypothesis is that training all emergency department caregivers in the use of a model announcement protocol with the support of human simulation, combining training of pairs in a simulation center and in situ training, and the participation of partner families, would allow for a better understanding of announce of withholding and withdrawing life-sustaining treatments decision in the emergency department and reduce their impact on families in terms of the occurrence of acute stress and post-traumatic stress symptoms.",[29],[226,227,200],"Limitation and cessation of treatment","Stress","2025-08-21",{"date":230,"type":37},"2025-08-28",{"date":232,"type":37},"2024-01-19",{"date":234,"type":22},"2026-01-19",{"name":236,"class":44},"Hospices Civils de Lyon",9,{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":23,"phases":247,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":45},"100560248","embedded-palliative-care-in-the-micu-100560248","NCT06574672","Embedded Palliative Care in the MICU","Impact of an Embedded Palliative Care and Hospice Practitioner in the Medical ICU","Inclusion Criteria:\n\n* Patients admitted to the medical intensive care units at a tertiary referral center\n* Patients must be at least 18 years of age\n\nExclusion Criteria:\n\n* None",{"count":246,"type":22},2600,[25],"The goal of this study is to investigate whether embedding a hospice and palliative care practitioner within a medical intensive care unit will improve patient outcomes and healthcare usage. The practitioner will work solely within the medical intensive care units and offer timely as well as proactive consultations based on clinical criteria and estimated mortality risk. The study team will compare patients seen by the practitioner to patients in an adjacent ICU and historical patients to determine whether patient care is improved by this intervention.",[250,29,251],"Critical Illness","Quality of Life",[253,254,255],"Palliative Care","Hospice","Medical ICU","2025-07-14",{"date":258,"type":37},"2025-07-16",{"date":260,"type":37},"2024-07-29",{"date":262,"type":22},"2027-06",{"name":264,"class":44},"Washington University School of Medicine","End-of-Life"]