[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"end-stage-chronic-renal-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:end-stage-chronic-renal-failure":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,80,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100642745","microvasculature-ultrasound-super-resolution-in-transplant-delayed-graft-function-100642745",false,"NCT07645599","Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function","MUST-D","Inclusion Criteria:\n\nFor stage 1 of the study:\n\n1. We will enroll patients ≥18 years of age\n2. Patients who received a kidney transplant 2a. Patients requiring dialysis in the first 14 days after transplant 2b. Patients with working allografts not requiring dialysis (control group)\n\nFor stage 2 of the study\n\n1. We will enroll patients at least 18 years of age or older\n2. Patients who received a kidney transplant 2a. Patients who received kidney transplants from low KDPI kidneys (KDPI \\\u003C 35) 2b. Patients who received kidney transplants from high KDPI kidneys (KDPI \\> 75)\n\nExclusion Criteria:\n\n1. BMI \\> 40\n2. Inability to provide informed consent\n3. Pregnant woman\n4. Breastfeeding women\n5. Hypersensitivity to perfluten lipid microsphere and components including polyethylene glycol (PEG)\n6. Unstable cardiopulmonary condition (acute myocardial infarction, acute coronary artery symptoms, worsening or unstable congestive heart failure, serious ventricular arrhythmias).\n7. Known history of cardiac shunts\n8. Patients who have known sickle cell disease or trait","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","3 Years","OBSERVATIONAL","This pilot study is testing a new ultrasound imaging method called Super-Resolution Ultrasound (SRU) to look at blood flow and tiny blood vessels in transplanted kidneys in very detailed images after kidney transplant surgery. The goal is to see whether changes in the kidney's small blood vessels can help predict how well the transplanted kidney will work early after transplant, including whether delayed graft function may occur.\n\nInvestigators hope this technique can become a safe, noninvasive way to evaluate transplanted kidneys without needing as many invasive biopsies. It may also help doctors better assess donor kidneys at higher-risk of suboptimal functioning.",[25,26,27,28],"End Stage Chronic Renal Failure","Renal Transplant","Microvascular Changes","Microvascular Circulation",[30,31,32,33,34,35,36,37,38,39],"renal allograft","kidney allograft","kidney transplant","super-resolution ultrasound","lipid microspheres","renal microvasculature","kidney microvasculature","delayed graft function","Kidney Donor Profile Index","deceased donor kidney transplant","NOT_YET_RECRUITING","2026-06-08",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":20},"2026-06-01",{"date":48,"type":20},"2028-06-30",{"name":50,"class":51},"Roderick Tan","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100634102","study-of-patient-preferences-in-dialysis-treatment-choice-a-discrete-choice-experiment-100634102","NCT07535320","Study of Patient Preferences in Dialysis Treatment Choice: a Discrete Choice Experiment","PREFDOM","Inclusion Criteria:\n\n* Adult patient\n* Patient with advanced chronic kidney disease receiving pre-surgery information (presentation of methods)\n* Patient enrolled in a social security program\n* Patient able to read and understand French\n* Patient able to complete the questionnaire (cognitive and sensory)\n\nExclusion Criteria:\n\n* Minor patients\n* Patients transitioning from one method of extrarenal purification to another\n* Patients requiring urgent dialysis\n* Patients who cannot read or understand French\n* Patients under legal protection (guardianship, curatorship, judicial protection)",{"count":61,"type":20},500,"Background Compared to in-center dialysis, home dialysis is associated with better quality of life and lower healthcare system costs. However, barriers remain to its wider adoption. Chronic disease, particularly at an advanced stage, is a major driver of socioeconomic vulnerability. Among dialysis patients, the proportion of individuals covered by France's Universal Health Protection scheme (PUMA) is higher than in the general population. Similarly, those from the most disadvantaged social classes are overrepresented among dialysis patients compared to the overall French population. Dialysis can also lead to job loss. Financial compensation schemes may influence the choice of home dialysis. In France, patients who perform dialysis at home-either independently or with help from a trained family caregiver-are eligible for a \"third-person compensatory allowance\" (DTP). For some socioeconomically vulnerable patients, eligibility for DTP may influence their decision to opt for home treatment. The DTP is specific to the French healthcare system but could be considered in other countries, particularly within the European Union. Indeed, in most countries with income levels comparable to France, the additional cost of home dialysis is borne by the patient. This study aims to determine whether receiving financial compensation plays a role in choosing a dialysis modality (home-based versus in-center or assisted home dialysis).\n\nObjectives To investigate factors associated with patient preferences regarding renal replacement therapy.\n\nMethods A discrete choice experiment (DCE) was conducted comparing two options: home dialysis (PD and HHD, with DTP) versus in-center hemodialysis (no DTP).\n\nPerspectives If financial compensation influences patients' choices toward home dialysis, the DTP model could be used to address barriers to home-based treatment.",[25],[65,66,67,68],"Nephrology","Home Dialysis","Chronic Kidney Disease","Discrete Choice Experiment","RECRUITING","2026-04-09",{"date":72,"type":44},"2026-04-17",{"date":74,"type":44},"2025-12-16",{"date":76,"type":20},"2027-12-31",{"name":78,"class":51},"University Hospital, Caen",2,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":52},"100622594","deceased-donor-kidney-storage-at-10-celsius-versus-conventional-storage-100622594","NCT07385651","Deceased Donor Kidney Storage at 10 Celsius Versus Conventional Storage","Participant inclusion criteria\n\n1\\. All adult single organ kidney transplant candidates on the waiting list at Vanderbilt University Medical Center (VUMC) will be eligible for enrollment.\n\nParticipant exclusion criteria\n\n1. Kidney transplant candidates less than 18 years old\n2. Kidney transplant candidates that decline consent\n3. Transplant candidates listed for multi-organ transplant\n\nDeceased donor organ inclusion criteria:\n\n1. Donation after brain death or donation after circulatory death kidney donors, whose health care proxy has consented for donation and the possibility of research\n2. Deceased donor kidneys that have been allocated to VUMC as a primary match offer prior to organ procurement will be eligible\n\nDeceased donor organ exclusion criteria:\n\n1. Donors whose health care proxy has declined consent for the possibility of research\n2. Deceased donor kidneys that have been allocated to VUMC as a backup offer\n3. Deceased donor kidneys that have been allocated to VUMC as a post procurement offer\n4. Deceased donor kidneys that have already been placed on ice",{"count":87,"type":20},30,"INTERVENTIONAL",[90],"NA","The goal of this clinical trial is to test how storage temperature of deceased donor kidneys affects kidney function after transplant in adult patients receiving a kidney transplant.\n\nThe main question it aims to answer is:\n\n• Do patients that receive a kidney transplant stored at 10 °C have improved post-transplant kidney function? Researchers will compare patients who receive kidneys stored at 10 °C versus kidneys stored at 4°C (on ice, i.e. conventional storage) to see if kidneys stored at 10 °C have improved function.\n\nParticipants will:\n\n* Be made aware of and consent to receive a kidney transplant that had been stored at 10 °C\n* Have their urine collected 24 hours after surgery to be analyzed for research",[25,93,94],"Chronic Kidney Disease (Stages 4 and 5)","Kidney Transplantation Recipients",[96,37,97,98],"kidney transplant recipients","ischemia reperfusion injury","10 Celsius kidney storage","2026-04-03",{"date":101,"type":44},"2026-04-06",{"date":103,"type":44},"2024-11-18",{"date":105,"type":20},"2027-12",{"name":107,"class":51},"Vanderbilt University Medical Center",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":88,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":52},"100630697","impact-of-sglt2-inhibitors-on-chronic-peritoneal-dialysis-patients-100630697","NCT07491042","Impact of SGLT2 Inhibitors on Chronic Peritoneal Dialysis Patients.","Impact of SGLT2 Inhibitors on Chronic Peritoneal Dialysis Patients: A Six-month Prospective .Study","Inclusion Criteria:\n\n* o age equal to or more than13 years.\n\n  * All genders.\n  * All patients undergoing chronic Peritoneal Dialysis.\n  * Urine output equal or more than 150 ml\u002F24 hours.\n\nExclusion Criteria:\n\n* o Age less than 13 years\n\n  * Patients with type I diabetes mellitus.\n  * Patients with recurrent urinary tract infection (UTI) or peripheral vascular diseases (P.V.D).\n  * Patients with urine output less than 150 ml\u002F24hours.\n  * Patients with recurrent hypoglycemic episodes\n  * Patients with acute or chronic liver disease,\n  * Patients who refuse to participate in the study.\n  * peritoneal Dialysis catheter (PDC) related peritonitis in last 3 months","13 Years",{"count":117,"type":20},38,[90],"This project aims to examine the effects of six-month treatment with selective SGLT2 inhibitor dapagliflozin in patients with end-stage kidney disease on chronic peritoneal dialysis.\n\nMethods: A prospective, open label, single-arm interventional clinical trial, will conduct at Nizwa Hospital from March 1st, 2026, to August 31th , 2026, and includes thirty (30) end-stage kidney disease diabetic and non-diabetic patients on chronic peritoneal dialysis, will receive selective SGLT2i Dapagliflozin 10 mg once daily (OD). Clinical and laboratory parameters will be assessed at baseline, then three and six months after drug initiation.\n\nThe primary outcomes are:1- change in ultrafiltration volume, 2- change in Kt\u002FV (dialysis adequacy), 3. Change in the mean 24-hour urine volume.",[25],[122,123,124],"SGLT-2 inhibitor","Peritoneal Dialysis","urine volume","2026-03-19",{"date":127,"type":44},"2026-03-24",{"date":129,"type":20},"2026-04-01",{"date":131,"type":20},"2027-01-31",{"name":133,"class":134},"Oman Ministry of Health","OTHER_GOV"]