[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endarterectomy-carotid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endarterectomy-carotid":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100637073","carotid-endatorectomy-and-general-anesthesia-assessment-and-evaluation-of-cerebral-ischemic-damage-with-clinical-laboratory-and-imaging-parameters-100637073",false,"NCT07602400","CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters","CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters: a Single-center, Prospective, Randomized, Comparative Clinical Study","Inclusion Criteria:\n\n* Age ≥ 18 years\n* ASA 1-4\n* For planned carotid endarterectomy\n* Absence of major established neurological deficits that would not allow neurological evaluation and performance of the MoCA test\n* Patient consent to participate in the study\n\nExclusion Criteria:\n\n* Age ≤ 18 years\n* Presence of major neurological deficits that will not allow neurological evaluation and performance of the MoCA test\n* Claustrophobia and inability to enter the MRI scanner\n* Cochlear implants\n* Intracranial vascular clips\n* Neurostimulation systems\n* Pacemaker incompatible for MRI\n* Small cell and non-small cell lung cancer\n* Neuroendocrine tumors\n* Melanoma\n* Seminoma\n* Teratoma\n* Malignant pheochromocytoma\n* CNS or NM diseases\n* Schizophrenia\n* Allergy or contraindication to any anesthetic factor\n* Patient refusal to participate in the study","ALL","18 Years",{"count":19,"type":20},160,"ESTIMATED","3 Days","OBSERVATIONAL","This study is aiming to provide us with information about the neuroprotective effect of two commonly used anesthetic drugs, during carotid endarterectomy. A day before sugery, a brain MRI will be performed as well as a cognitive function assessment test. The day of the surgery each patient will receive anesthesia either by using intravenous anesthetic drug or an inhalation agent and during the intraoperative period, the Anesthesiologist will draw a small amount of blood in three different times in order to measure brain biomarkers. A day after the surgery, a second brain MRI will be performed as well as a second cognitive function assessment test and their results will be compared to the preoperative ones. The study will focus on whether there is a higher incidence of microischemic brain lesions shown in imaging tests or whether cognitive function is impaired postoperative or whether brain biomarkers indicating brain damage are elevayed with any of these drugs and thus conclude which one shows or not a neuroprotective effect, with the condition that no change in the regular anesthesia management was made and no danger was imposed on the patient.",[25,26,27],"Carotid Artery Stenosis","Endarterectomy, Carotid","Ischemic Cerebrovascular Accident",[29,30,31,32,33,34],"carotid endarterectomy","MRI brain","general anesthesia","neuroprotection","propofol","sevoflurane","NOT_YET_RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-22","ACTUAL",{"date":41,"type":20},"2026-05-30",{"date":43,"type":20},"2027-12",{"name":45,"class":46},"University Hospital of Patras","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":5},"100575082","urgent-carotid-endarterectomy-cea-versus-delayed-cea-in-symptomatic-carotid-stenosis-spread-staci-ii-100575082","NCT06767657","Urgent Carotid Endarterectomy (CEA) Versus Delayed CEA in Symptomatic Carotid Stenosis (SPREAD-STACI II)","Multicenter, Open-label Randomized Study Comparing Urgent Carotid Endarterectomy (CEA) (Within 72 Hours) Versus Delayed CEA (After 72 Hours) in Patients With Symptomatic Carotid Stenosis (SPREAD-STACI II)","Time_to_sCEA","Eligibility Criteria\n\nInclusion Criteria:\n\nPatients presenting with the following characteristics:\n\nDe novo stenosis of the carotid bifurcation and\u002For internal carotid artery origin, equal to or greater than 50% (NASCET method), diagnosed by color Doppler ultrasound, MR angiography (MRA), CT angiography (CTA), or catheter angiography.\n\nTIA or minor ischemic stroke (NIHSS ≤ 5) ipsilateral to the carotid stenosis, occurring within the previous 24 hours.\n\nPreserved consciousness and neurologically stable symptoms. No evidence of ongoing cerebral ischemia, or evidence of cerebral ischemia with a diameter \\\u003C25 mm.\n\nAge between 45 and 90 years. ASA score \\\u003C 4. Ability to comply with follow-up requirements as specified. Willingness to provide informed consent for participation in the study.\n\nA patient with an NIHSS ≤ 5 who is aphasic may be unable to provide consent. In these cases:\n\nThe attending physician assesses the feasibility of including the patient. Family members are informed but, under Italian law, cannot provide consent. A third-party physician certifies that the patient meets the inclusion criteria.\n\nThe attending physician signs the appropriate form, and randomization proceeds. If and when the patient regains the ability to provide or refuse consent, the informed consent form will be presented to them. Should they decline, their data will be removed from the study database.\n\nAdditionally, the study includes patients who underwent thrombolysis and\u002For mechanical thrombectomy after the onset of the index symptom, followed by a brain CT\u002FMRI without secondary cerebral hemorrhage (PH1, PH2, or PHr).\n\nExclusion Criteria:\n\nStenosis \\\u003C 50% (NASCET method) at the bifurcation and\u002For internal carotid artery origin, diagnosed by ECD, CTA, or MRA.\n\nCarotid thrombosis or dissection. NIHSS \\> 5. Cerebral hemorrhage. Impaired consciousness or neurologically unstable condition. Cancer, any condition with a poor prognosis, major cardiopathy, or any severe neurological disorder.\n\nCT or MRI evidence of cerebral ischemia \\> 25 mm in diameter. CT or MRI evidence of cerebral lesions of uncertain origin. Recurrent TIA or stroke-in-evolution. Age \\\u003C 45 years or \\> 90 years. ASA risk score = 4. Lack of informed consent. Inability to undergo CEA within 72 hours of the initial ischemic symptom. Inability to participate in a 90-day follow-up after the initial ischemic symptom.\n\nPrevious CEA or stenting of the examined carotid artery.","45 Years","90 Years",{"count":58,"type":20},456,"INTERVENTIONAL",[61],"NA","In patients with internal carotid artery (ICA) stenosis of 50% or greater (measured according to the criteria of the North American Symptomatic Carotid Endarterectomy Trial (NASCET)) who have experienced a transient ischemic attack (TIA) or minor ipsilateral stroke, carotid endarterectomy (CEA) offers maximum benefit if performed within 15 days of the initial ischemic symptom. National and international guidelines recommend surgical treatment (CEA) within this timeframe; however, no studies have specifically evaluated the optimal timing for CEA after a TIA or minor stroke.\n\nIt is well established that the risk of a major stroke is highest in the first few days following a transient ischemic attack or minor stroke and then decreases over the subsequent days and weeks.\n\nThis raises the hypothesis that performing an urgent carotid endarterectomy (within 3 days) may provide greater benefit compared to a delayed procedure (between 4 and 15 days).",[64,65,26,66],"Stroke, Ischemic","Transient Ischemic Accident","Stroke Prevention",[68,69,70,71],"stroke","endarterectomy","transient ischemic accident","stroke prevention","RECRUITING","2026-03-02",{"date":75,"type":39},"2026-03-04",{"date":77,"type":39},"2025-07-03",{"date":79,"type":20},"2028-01-01",{"name":81,"class":46},"Italian Society of Vascular and Endovascular Surgery"]