[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endocarditis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endocarditis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,39,63,86,107,131,155,177,201],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100481331","clinical-and-diagnostic-features-of-endocarditis-100481331",false,"NCT05547607","Clinical and Diagnostic Features of Endocarditis","Observational Prospective Multicenter Study to Characterize the cLinical ANd DiagnoStiC feAtures of Endocarditis in the contemPorary Era","ENDO-LANDSCAPE","Inclusion Criteria:\n\n* Patients above the age of 18 years.\n* all consecutive patients referred for echocardiography (transthoracic or transesophageal approach) to exclude endocarditis.\n* patients with a diagnosis of endocarditis on echocardiography independently by the request for the exam.\n\nExclusion Criteria:\n\n* patient's refusal.","ALL","18 Years",{"count":20,"type":21},500,"ESTIMATED","OBSERVATIONAL","The burden of endocarditis has changed in the last years due to an increase in percutaneous valve procedures offered to a more fragile, and old population. Therefore an update in epidemiology data is necessary. The Observational prospective multicenter study to characterize the cLinical ANd DiagnoStiC feAtures of endocarditis in the contemPorary Era, (ENDO-LANDSCAPE study) is an observational, multicenter and international study. The study has two arms: retrospective and prospective.\n\nThe retrospective arm will involve collecting data from patients discharged with a diagnosis of endocarditis between 2016 and 2022. The data obtained in the retrospective arm of the study will be utilized in a power calculation to determine the sample size for the prospective arm of the study. In the prospective phase in every participating center, all patients referred for echocardiography to assess for endocarditis and those with established endocarditis independent of the screened request will be eligible. Patients will then be stratified according to the presence or abscence of endocarditis. Those with an established diagnosis of endocarditis will be prospectively followed for outcomes.",[25],"Endocarditis","RECRUITING","2026-04-27",{"date":29,"type":30},"2026-05-01","ACTUAL",{"date":32,"type":30},"2022-09-09",{"date":34,"type":21},"2028-06-30",{"name":36,"class":37},"University Hospital of Ferrara","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":38},"100450491","interest-of-parametric-positron-emission-imaging-in-the-diagnosis-of-infections-on-cardiac-valve-prosthesis-100450491","NCT05146180","Interest of Parametric Positron Emission Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis","Interest of Parametric Positron Emission Computed Tomography Imaging in the Diagnosis of Infections on Cardiac Valve Prosthesis : PARAVA Study","PARAVA","Inclusion Criteria:\n\n* Age superior to18 years,\n* Effective contraception for women of childbearing age or negative pregnancy test on the day of the exam\n* Good general condition. WHO ≤ 1\n* Suspicion of endocarditis on a prosthetic heart valve implanted more than 3 months ago\n* Labeled polynuclear scintigraphy performed within a maximum of 15 days before positron emission computed tomography\n* Standard positron emission computed tomography planned as part of the extension assessment\n* Informed and signed consent before any specific study procedure.\n* Patient affiliated to the social security system\n\nExclusion Criteria:\n\n* Presence of an active cancer in the previous three years\n* Pregnancy or breastfeeding\n* Poorly controlled diabetic patients\n* Protected adults (under guardians or curators)\n* Impossible decubitus (orthopnea, ...),\n* Hypersensitivity to FDG or to one of the excipients of the radiopharmaceutical.",{"count":48,"type":21},30,"INTERVENTIONAL",[51],"NA","The objective of this study is to determine if early parametric positron emission computed tomography is useful to diagnose cardiac prosthetic valve infections.",[25],"2025-12-29",{"date":56,"type":30},"2026-01-02",{"date":58,"type":30},"2022-02-24",{"date":60,"type":21},"2027-03-01",{"name":62,"class":37},"Centre Henri Becquerel",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":73,"conditions":74,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":38},"100547120","impact-of-preoperative-dental-screening-in-reducing-infective-endocarditis-risk-in-surgical-valve-replacement-patients-100547120","NCT06403839","Impact of Preoperative Dental Screening in Reducing Infective Endocarditis Risk in Surgical Valve Replacement Patients","Impact of Targeted Preoperative Dental Screening on Post-procedural Risk of Infective Endocarditis in Patients Undergoing Surgical Valve Replacement: a Prospective Observational Study","DENSVAR","Inclusion Criteria:\n\n* Patients undergoing surgical valve replacement\n\nExclusion Criteria:\n\n* None",{"count":72,"type":21},1000,"In Odense University Hospital preoperative dental screening (PDS) protocol for patients treated with surgical valve replacement was changed from mandatory to targeted PDS to from march 2024.\n\nThe investigators will therefore compare the risk of IE before vs after march 2024.",[75,76,25],"Surgical Valve Replacement","Dental","2025-08-12",{"date":79,"type":30},"2025-08-15",{"date":81,"type":30},"2020-01-01",{"date":83,"type":21},"2028-03-01",{"name":85,"class":37},"Odense University Hospital",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":17,"minAge":92,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":38},"100549437","barts-endocarditis-research-registry-100549437","NCT06434012","Barts Endocarditis Research Registry","Inclusion Criteria:\n\n* • Patients aged 16 and over (Patients under 16 years of age are not admitted to Barts Heart Centre)\n\n  * Patients admitted to Barts Heart Centre with confirmed Endocarditis (see above)\n  * Patients attending outpatients with confirmed\u002Fsuspected Endocarditis\n  * Patients with possible IE who complete treatment for endocarditis\n  * Patients with cardiac device related Endocarditis\n  * Patients with the ability to provide informed consent\n\nExclusion Criteria:\n\n* • Patients with pacemaker pocket infection with no evidence of pacemaker lead or valve infection\n\n  * Patients who refuse consent to be included in the research database\n  * Patients with \"rejected\" endocarditis","16 Years",{"count":72,"type":21},"The Barts Endocarditis Research Registry is being set up to give a unique opportunity to assess the characteristics of Infective Endocarditis (IE) in our population cohort, the current use of imaging techniques, as well as the implementation of the ESC guidelines and its consequence in terms of prognosis. All this will help improve the diagnosis and management of IE. The registry will also form the core of all our subsequent work, including interventional studies. The endocarditis research registry is to record the epidemiological, demographic, microbiological, surgical and outcome data in our cohort of endocarditis patients. This work will underpin all future work in endocarditis by clearly defining our patient cohort and the outcomes from treatment. We have a series of studies planned that we believe will influence the management of endocarditis (we are working up proposals for genomic and therapeutic trials that will subsequently be presented for ethical and hospital approval). The registry will be generic to all our planned studies, and will allow us to capture data to assess treatment effectiveness",[96,25,97],"Infective Endocarditis","Endocarditis, Bacterial","2025-07-10",{"date":100,"type":30},"2025-07-15",{"date":102,"type":30},"2019-04-24",{"date":104,"type":21},"2029-04-30",{"name":106,"class":37},"Queen Mary University of London",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":49,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":38},"100354228","cytokine-removal-in-critically-ill-patients-requiring-surgical-therapy-for-infective-endocarditis-recreate-100354228","NCT03892174","Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE)","Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE) - an Investigator-initiated Prospective Randomized Controlled Clinical Trial Comparing Two Established Clinical Protocols","RECREATE","Inclusion Criteria:\n\n* Subjects scheduled for routine cardiac surgery for infectious endocarditis (diagnosed according to the predefined \"DUKE\" criteria) with antibiotic therapy for ≤ 14 days.\n* Presence of informed consent\n* Age ≥18 yrs.\n\nExclusion Criteria:\n\n* Previous treatment (last 6 months) with immunologically-active biologicals or specific immunomodulatory drugs (e.g. Rituximab)\n* high-dose chronic (i.e. before onset of infectious endocarditis) steroid medication with prednisone equivalent of \\>30 mg\u002Fd\n* Patients on Extracorporeal membrane oxygenation (ECMO), or any other (pre-operative) cardiac assist device\n* Moribund patient (life expectancy \\\u003C14 days)",{"count":116,"type":21},54,[51],"Infectious endocarditis (IE) and other severe infections are well-known to induce significant changes in the immune response including immune functionality in a considerable number of affected patients. In fact, numerous patients with IE develop a persistent functional immunological phenotype that can best be characterized by a profound anti-inflammation and\u002For functional anergy. This was previously referred to as \"injury-associated immunosuppression (IAI)\" by Pfortmüller et al., published in Intensive Care Medicine Experimental 2017. IAI can be assessed by measurement of cellular (functional) markers. Persistence of IAI is associated with prolonged ICU length of stay, increased secondary infection rates, and death. Immunomodulation to reverse IAI was shown beneficial in immunostimulatory (randomized controlled) clinical trials. CytoSorb® treatment is currently used as standard of care in some institutions in surgically treated IE patients. The investigators aim to investigate two accepted treatment protocols and aim to explore whether adsorption with a cytokine adsorption filter can increase immune competence in treated individuals.",[25,120,121],"Sepsis","Septic Shock","2024-11-07",{"date":124,"type":30},"2024-11-12",{"date":126,"type":30},"2019-11-14",{"date":128,"type":21},"2024-12-31",{"name":130,"class":37},"Insel Gruppe AG, University Hospital Bern",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":49,"phases":140,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":145,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":38},"100548532","phase-4-an-oral-doxycycline-regimen-to-prevent-bacteremia-following-dental-procedures-100548532","NCT06422221","An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures","Inclusion Criteria:\n\n* Subjects must have at least 10 teeth.\n* Subjects must have the need for a dental extraction under general anesthesia (for behavioral reasons).\n* Subjects will be recruited regardless of the extent and severity of their dental and\u002For periodontal disease.\n\nExclusion Criteria:\n\n* Age under 18 years\n* Body weight under 40 kg\n* Receipt of antibiotics in the previous 3 months\n* Routine use of oral antiseptics\n* A history of allergy or intolerance to doxycycline\n* A history of allergy or intolerance to cindamycin\n* Any type of congenital or acquired immunodeficiency\n* Any known risk factor for bacterial endocarditis\n* Any known risk factor for prolonged bleeding","65 Years",{"count":139,"type":21},150,[141],"PHASE4","Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. The last American Heart Association (AHA) and European Society of Cardiology (ESC) guidelines include several important changes, highlighting that clindamycin (CLI) is no longer recommended as an alternative to amoxicillin in those allergic to penicillin. This new project aims to evaluate the effectiveness of oral doxycycline in preventing post-dental extraction bloodstream infection.",[144,25],"Bacteremia","NOT_YET_RECRUITING","2024-06-13",{"date":148,"type":30},"2024-06-17",{"date":150,"type":21},"2024-07-15",{"date":152,"type":21},"2025-06-30",{"name":154,"class":37},"University of Santiago de Compostela",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":162,"targetDuration":4,"studyType":49,"phases":164,"briefSummary":165,"conditions":166,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":167,"lastUpdatePostDateStruct":168,"startDateStruct":170,"completionDateStruct":172,"leadSponsor":174,"locationsCount":176},"100450354","phase-4-accelerated-treatment-of-endocarditis-100450354","NCT05144399","Accelerated Treatment of Endocarditis","POET II","Inclusion Criteria:\n\n* Admitted with left-sided infectious endocarditis (duke criteria)\n* \\\u003C 14 days of relevant antibiotic treatment for endocarditis\n* One of the following bacteria: Streptococci, enterococcus faecalis, staphylococcus aureus\n* \\> 18 years old\n\nExclusion Criteria:\n\n* Known immune incompetency,\n* Relapse endocarditis with 6 months,\n* Unable to give informed concent",{"count":163,"type":21},475,[141],"Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks one or more types of intravenously administered antibiotics. The long hospitalization increases several risks for the patient, including mental strain and increased loss of function. Furthermore, it poses a significant financial burden on the health systems. Current guidelines fail to use available clinical and paraclinical, data collected from patients (echo, temperature, CRP, leukocytes, procalcitonin etc.) to determine duration of treatment. A strategy including these data in treatment algorithms ensures an individualized treatment, targeting the individual patient's course and response to treatment. Thus, the purpose of this open-label, prospective, non-inferiority, RCT study is to investigate the safety and effectiveness of shortening treatment of endocarditis based on the individual patient's initial treatment response, sampling 475 patients, approx. 125 patients with each type of bacteria (Streptococci; Enterococcus faecalis; Staphylococcus aureus).",[25],"2024-01-17",{"date":169,"type":30},"2024-01-18",{"date":171,"type":30},"2019-04-01",{"date":173,"type":21},"2026-12-31",{"name":175,"class":37},"Herlev Hospital",2,{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":185,"targetDuration":187,"studyType":22,"phases":4,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":38},"100449984","the-endocarditis-aumc-data-collection-100449984","NCT05139589","The ENDOCARDITIS AUMC Data Collection","The ENDOCARDITIS AUMC Data Collection : a Matched Cohort Study on Perioperative Coagulation in Conservatively and Surgically Treated Patients With Valvular Dysfunction, With and Without Infective Endocarditis","ENDO_AUMC","Inclusion Criteria:\n\n* Patients \\> 18 years\n* Dutch or English speaking\n* All patients with infective endocarditis admitted to Amsterdam UMC in the study period\n* All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period\n\nExclusion Criteria:\n\n* Previous history of coagulation disorders",{"count":186,"type":21},3000,"10 Years","The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.",[25,190,191],"Coagulation Disorder","Valve Disease, Heart","2023-07-24",{"date":194,"type":30},"2023-07-25",{"date":196,"type":21},"2023-08-06",{"date":198,"type":21},"2030-12-31",{"name":200,"class":37},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":207,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":49,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":145,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":4},"100486427","effectiveness-of-antibiotic-prophylaxis-of-infective-endocarditis-for-invasive-dental-procedures-in-patients-with-prosthetic-heart-valves-andor-history-of-infective-endocarditis-100486427","NCT05613933","Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis for Invasive Dental Procedures in Patients With Prosthetic Heart Valves and\u002For History of Infective Endocarditis","Effectiveness of Antibiotic Prophylaxis of Infective Endocarditis Before Invasive Dental Procedures in Patients With Prosthetic Heart Valves and\u002For History of Infective Endocarditis: a Prospective, Registry-based, Cluster-randomized Trial in Primary Care","PROPHETS","Inclusion Criteria:\n\n* All French Health Territories (Territoires de santé, TDS) will be included and each TDS will contribute as a cluster for randomization.\n* All dentists working in each TDS will be included.\n* Among individuals receiving an invasive dental procedure, all patients aged 18 years or more identified with prosthetic heart valves or recorded with prior infective endocarditis will be included.\n\nExclusion Criteria:\n\n* No exclusion criteria for health territories, dentists and patient.\n* However, dental procedures that had been performed less than 6 months after the date of first implantation of prosthetic heart valve won't be included.",{"count":210,"type":21},250000,[51],"Infective endocarditis (IE) continues to cause serious morbidity and mortality. To reduce its incidence, antibiotic prophylaxis has been recommended before invasive dental procedures in patients with at risk predispositions. Several studies have examined the effect of antibiotic prophylaxis on the incidence of IE and have brought conflicting results. The investigators aim to evaluate the effectiveness of antibiotic prophylaxis before invasive dental procedures to prevent oral streptococcal infective endocarditis in patients with prosthetic heart valves and\u002For history of IE, using a registry-based, cluster-randomized, controlled trial. In secondary objectives, the investigators aim to analyze changes in dentists' practices.",[97,25,214],"Endocarditis Acute and Subacute",[216,217,218,219,220],"Registry based randomized controlled trial","antibiotic prophylaxy","dentist","invasive dental procedure","infective endocarditis","2023-01-31",{"date":223,"type":30},"2023-02-02",{"date":225,"type":21},"2023-02-01",{"date":227,"type":21},"2027-12-31",{"name":229,"class":37},"University Hospital, Bordeaux"]