[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endocrine-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endocrine-diseases":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100268136","evaluation-of-children-with-endocrine-and-metabolic-related-conditions-100268136",false,"NCT02769975","Evaluation of Children With Endocrine and Metabolic-Related Conditions","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Participants with known or suspected endocrine disorder age 3 months-18 years are eligible for this protocol.\n* Relatives ages 3 months-100 years may be enrolled if clinically indicated for the diagnosis of a proband.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Lack of suspected endocrine disorders.\n* Any medical, physical, psychiatric, or social conditions, which, in the opinion of the investigators, would make participation in this protocol not in the best interest of the patient, will exclude participation. Patients who are critically ill, unstable, or with severe organ failure that may affect\u002Flimit the endocrine evaluation and place unsustainable demands on Clinical Center or NICHD resources will be excluded.","ALL","3 Months","100 Years",{"count":19,"type":20},15000,"ESTIMATED","OBSERVATIONAL","Background:\n\nEndocrine glands give off hormones. Researchers want to learn more about the disorders that affect these glands in children. These disorders might be caused by changes in genes. Genes contain DNA, which is the blueprint of how a cell works. Researchers want to identify the genes involved in endocrine and metabolic disorders. This might help develop new ways to diagnose and treat the disorders.\n\nObjective:\n\nTo study the inheritance of endocrine or metabolism disorders.\n\nEligibility:\n\nChildren ages 3month-18 with known or suspected endocrine or metabolism disorders.\n\nFamily members ages 3months-100. They may participate in the DNA part of the study.\n\nDesign:\n\nParticipants will be screened with a review of their medical records. Their parents or guardians will allow the records to be released.\n\nParticipants will have a clinic visit. This may include a physical exam and medical history.\n\nParents or guardians will give their consent for the study. Participants may have tests, surgery, or other procedures to help diagnose or treat their condition. These could include:\n\nBlood, urine, and saliva tests\n\nGrowth hormone test\n\nPituitary and adrenal function tests\n\nPicture of chromosomes\n\nImaging tests. These may include X-ray, ultrasound, scans, or a skeletal survey.\n\nGenetic tests\n\nSleep study\n\nMedical photographs\n\nIf surgery is done, a tissue sample will be taken.\n\nParticipants may have follow-up visits for diagnosis and treatment.\n\nParticipating relatives will have one visit. This will include medical history and blood and saliva tests. The blood and saliva will be used for DNA testing.",[24,25,26,27,28],"Adrenal Insufficiency","Growth Disorder","Endocrine Diseases","Metabolic Disease","Bone Diseases, Metabolic",[30,31,32,25,33],"Endocrinology","Obesity","Pediatric","Pubertal Development","RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-25","ACTUAL",{"date":40,"type":38},"2016-07-12",{"date":42,"type":20},"2030-12-31",{"name":44,"class":45},"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","NIH",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":46},"100057209","phase-1-diagnosis-of-pheochromocytoma-100057209","NCT00004847","Diagnosis of Pheochromocytoma","Diagnosis, Pathophysiology, and Molecular Biology of Pheochromocytoma and Paraganglioma","* INCLUSION CRITERIA:\n\nPatients are eligible for inclusion in this study if they are adults or children of age 3 years old and up with known, sporadic or familial PHEO\u002FPGL, on the basis of one or more of the following:\n\n1. High levels of blood or urinary catecholamines, metanephrines, methoxytyramine or chromogranin A.\n2. Highly suspected presence of PHEO\u002FPGL based on imaging studies, even with normal biochemistry.\n3. Personal or family history of PHEO\u002FPGL or genetic pathogenic variants known to predispose individuals to develop PHEO\u002FPGL.\n\nSigned informed consent is required. The informed consent may be signed by the patient, parent\u002Fguardian in pediatric patients or legally authorized representative (LAR) in adults who lack-decision making capacity to consent to research participation.\n\nPatients must have an outside general practitioner or endocrinologist. Patients with metastatic disease must also have an outside oncologist.\n\nFamily Members of Patients Arm (Linkage Analysis)\n\nParticipants are eligible for inclusion in this study arm if they are:\n\n* Adult family members of patients enrolled in this study;\n* The index family member in this study has a suspected hereditary PHEO\u002FPGL based on previous genetic testing and other suspicious hereditory patterns such as family history of multiple individuals with PHEO\u002FPGL; early age of disease onset; multiplicity of primary tumors; recurrence, etc. and\n* Signed informed consent form is required\n\nEXCLUSION CRITERIA:\n\nPotential patients will be excluded on the basis of one or more of the following:\n\n1. Pregnant or breastfeeding women\n2. Severe cardiac dysfunction\n3. Currently on dialysis\n\nA pregnancy test is performed in women of childbearing age (up to age 55) as a screening after consenting. If a patient is found to have a positive pregnancy test, her participation in this protocol will be terminated. The patient can enroll or re-enroll in the protocol when she is no longer pregnant or breastfeeding.\n\nIn-person participating patients who are not willing to return to the NIH (e.g., after surgery or an initial evaluation) for more than 2 years may be removed from the protocol.\n\nSPECIFIC INCLUSION\u002FEXCLUSION CRITERIA FOR IMAGING STUDIES WITHIN OUR PROTOCOL:\n\nIn adult patients (Excludes Linkage Analysis Arm)\n\nImaging studies are not done in patients that have the following exclusion criteria:\n\n* Inability to lie still for the entire imaging time (e.g., cough, severe arthritis, etc.).\n* Inability to complete the needed investigational and standard-of-care imaging examinations due to other reasons (e.g., severe claustrophobia, radiation phobia, etc.)\n* Any additional medical conditions, serious illness, or other extenuating circumstance that, in the opinion of the Principal Investigator, may significantly interfere with study compliance.\n\nIn pediatric patients:\n\nInclusion criteria for research PET imaging in children:\n\n* Children over 10 years old with very high suspicion of sporadic or familial PHEO\u002FPGL based on at least one of the following:\n\n  * The presence of new onset of symptoms typical of PHEO\u002FPGL such as hypertension or hypertensive episodes, sweating, headaches, pallor, palpitations, drug resistant hypertension, etc.\n  * Family history of PHEO\u002FPGL or genetic pathogenic variants known to predispose individuals to develop these tumors.\n  * The presence of a tumor on conventional imaging including ultrasound, CT and\u002For MRI or \\[123I\\]-MIBG or PET imaging not limited to \\[18F\\]-FDG.\n* Children must give informed assent and be willing to return to the NIH for follow-up.\n\nExclusion criteria for research PET imaging in children:\n\n* Children of less than 10 years of age.\n* Children with impaired mental capacity that precludes informed assent.\n* Inability to lie still for the entire imaging time (e.g., cough, turbulent children, severe claustrophobia, etc.).","3 Years","120 Years",{"count":57,"type":20},3000,"INTERVENTIONAL",[60],"PHASE1","The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas. These tumors, which usually arise from the adrenal glands, are often difficult to detect with current methods. Pheochromocytomas release chemicals called catecholamines, causing high blood pressure. Undetected, the tumors can lead to severe medical consequences, including stroke, heart attack and sudden death, in situations that would normally pose little or no risk, such as surgery, general anesthesia or childbirth.\n\nPatients with pheochromocytoma may be eligible for this study. Candidates will be screened with a medical history and physical examination, electrocardiogram, and blood and urine tests. Study participants will undergo blood, urine, and imaging tests, described below, to detect pheochromocytoma. If a tumor is found, the patient will be offered surgery. If surgery is not feasible (for example, if there are multiple tumors that cannot be removed), evaluations will continue in follow-up visits. If the tumor cannot be found, the patient will be offered medical treatment and efforts to detect the tumor will continue. Main diagnostic and research tests may include the following:\n\n1. Blood tests - mainly measurements of plasma or urine catecholamines and metanephrines as well as methoxytyramine. If necessary the clonidine suppression test can be carried out.\n2. Standard imaging tests - Non-investigational imaging tests include computed tomography (CT), magnetic resonance imaging (MRI), sonography, and 123I-MIBG scintigraphy and FDG (positron emission tomography) PET\u002FCT. These scans may be done before and\u002For after surgical removal of pheochromocytoma.\n3. Research PET scanning is done using an injection of radioactive compounds. Patients may undergo 18F-FDOPA, 18F-DA, as well as 68Ga-DOTATATE PET\u002FCT . Each scan takes up to about 2 hours.\n4. Genetic testing - A small blood sample is collected for DNA analysis and other analyses.",[63,64,26],"Pheochromocytoma","Endocrine Disease",[66,67,68,69],"Genetics","Metanephrines","PET","Catecholamines","2026-06-17",{"date":72,"type":38},"2026-06-18",{"date":74,"type":38},"2000-03-22",{"date":76,"type":20},"2048-11-30",{"name":44,"class":45},{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":15,"minAge":86,"maxAge":17,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":46},"100272756","evaluation-of-adults-with-endocrine-and-metabolic-related-conditions-100272756","NCT02830308","Evaluation of Adults With Endocrine and Metabolic-Related Conditions","Evaluation of Adults With Endocrine-Related Conditions","* INCLUSION CRITERIA:\n* Participants with known or suspected endocrine disorder age 18 years and older are eligible for this protocol. Protocol investigators will make the actual selection of subjects most appropriate for clinical evaluation.\n* Relatives ages 18 years and older may be enrolled if clinically indicated for the diagnosis of a proband.\n\nEXCLUSION CRITERIA:\n\n* Anyone under the age of 18 years old\n* Any medical, physical, psychiatric, or social conditions, which, in the opinion of the investigators, would make participation in this protocol not in the best interest of the subject. Subjects who are critically ill, unstable, or with severe organ failure that may affect\u002Flimit the endocrine evaluation and place unsustainable demands on Clinical Center or NIDDK resources.",true,"18 Years",{"count":88,"type":20},1250,"Background:\n\nThere are many endocrine and metabolic-related conditions. Two well-known disorders include diabetes and thyroid disease. Some of these diseases are caused by a change in genes. Researchers want to identify the genes involved in these disorders. They hope this will help them learn more about these diseases.\n\nObjectives:\n\nTo learn more about conditions that affect the hormone-secreting glands (endocrine glands) in adults. To train doctors to diagnose and treat people with endocrine or metabolic conditions.\n\nEligibility:\n\nAdults age 18 years and older with a known or suspected endocrine disorder.\n\nRelatives ages 18 years and older.\n\nDoctors will review all requests and available medical records to determine final eligibility for the protocol.\n\nDesign:\n\nParticipants will have a medical history and physical exam.\n\nMost participants will have 1 visit, and may have follow up visits if necessary. They may have tests, surgery, or other procedures to help diagnose or treat their condition. These could include:\n\n* Blood, urine, and saliva tests\n* Imaging tests. These may include X-ray, ultrasound, or scans.\n* Sleep study\n* Medical photographs\n* Visits with other specialists at NIH\n\nParticipants will provide blood, urine, saliva, or tissue samples. Some of these samples may be stored in the freezer for future studies.\n\nParticipants may be asked to participate in genetic testing. They will give a blood or saliva sample for this.",[26],[92,93,94,95,96,97],"Hormones","Endocrine","Hypercortisolism","Bone","Hypothalamic-Pituitary Dysfunction","Natural History","2026-05-09",{"date":100,"type":38},"2026-05-12",{"date":102,"type":38},"2016-07-09",{"date":104,"type":20},"2029-12-31",{"name":106,"class":45},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)"]