[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endocrinology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endocrinology":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100633957","long-term-follow-up-of-pituitary-and-hypothalamic-dysfunction-in-children-who-have-suffered-moderate-to-severe-head-trauma-included-in-the-endoc-tc-cohort-100633957",false,"NCT07533435","Long-term Follow-up of Pituitary and Hypothalamic Dysfunction in Children Who Have Suffered Moderate to Severe Head Trauma Included in the ENDOC TC Cohort","ENDOC TC 2","Inclusion Criteria:\n\n* Consent of the child if under 18 years of age and no objection from both parents, or no objection from the adult patient\n* Patients included in the Princeps Endoc TC study in Lyon\n\n  * Patients who have suffered a traumatic brain injury\n  * Children aged 2 months to 16 years inclusive\n  * Admitted to pediatric intensive care\n  * Initial Glasgow Coma Scale score between 3 and 12, regardless of the mechanism of head injury\n  * Informed consent signed by parents\n\nExclusion Criteria:\n\n* Patient deceased since the end of Endoc TC study","ALL",{"count":18,"type":19},90,"ESTIMATED","OBSERVATIONAL","The annual incidence of traumatic brain injury (TBI), all causes combined, varies between 180 and 300 per 100,000. TBI increases the risk of death or serious sequelae by a factor of 8.\n\nStudies conducted in adults have shown an anterior pituitary deficit in 28% to 68% of patients with TBI. The variability of these studies does not currently allow for standardization of the management of these children in either the acute or late phases.\n\nSeveral studies, including a Lyon-based study called Endoc TC (Ref. Clinical Trials: NCT01250132), have aimed to investigate the association between anterior pituitary deficits in the acute phase and those identified a few months after the trauma.\n\nSince then, few studies have been conducted more than five years after the trauma to study its pituitary consequences.\n\nTo date, the investigators have sought to study the long-term prevalence of pituitary and hypothalamic dysfunction in patients who suffered moderate to severe head trauma during childhood, specifically patients included in the initial Endoc TC study in Lyon.\n\nTo this end, the main objective is to determine the current height of these patients and whether there are any associated growth delays or other clinical signs that may suggest the presence of a pituitary or hypothalamic hormone deficiency.\n\nThis study consists of a telephone questionnaire lasting approximately 15 minutes, with participants from Lyon who took part in ENDOC TC study, designed to determine the growth of these patients and the presence or absence of symptoms that may be related to post-traumatic damage to the hypothalamic-pituitary system linked to head trauma.",[23,24,25,26],"Craniocerebral Trauma","Hypothalamic-pituitary Disorders","Pediatric","Endocrinology",[28,29,30,31,32],"Traumatic brain injury","Anterior pituitary deficits","Growth delaus","Pituitary or hypothalamic hormone deficiency","Initial Endoc TC study (Ref. Clinical Trials : NCT01250132)","NOT_YET_RECRUITING","2026-05-20",{"date":36,"type":37},"2026-05-22","ACTUAL",{"date":39,"type":19},"2026-04-22",{"date":41,"type":19},"2026-09-30",{"name":43,"class":44},"Hospices Civils de Lyon","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":65,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":76,"locationsCount":78},"100581945","behavioral-and-adherence-model-for-improving-quality-health-outcomes-and-cost-effectiveness-of-healthcare-100581945","NCT06856902","BEhavioral and Adherence Model for Improving Quality, Health Outcomes and Cost-Effectiveness of healthcaRe","BEAMER","Inclusion Criteria:\n\n* Having the diagnosis of the pilot sites target groups described above as per clinical assessment or validated diagnosis criteria\n* Having the age of the pilot sites target groups described above\n* Having accepted to participate in the study and provided written informed consent\n* Having the availability to participate on all study activities\n\nExclusion Criteria:\n\n* Individuals that do not fulfil ALL the inclusion criteria will be excluded to participate.",{"count":54,"type":19},3100,"INTERVENTIONAL",[57],"NA","Lack of adherence to treatment is a widespread issue worldwide, which leads to higher healthcare utilisation rates and even premature death. While the level of adherence may differ based on the specific condition and treatment, studies estimate that approximately 50% of medications are not taken according to the prescribed instructions. In addition, adherence rates tend to decrease even further when the treatment requires a behavioural change. Literature reviews about factors that affect people's adherence show that it is challenging to predict whom can be considered to have adherent and non-adherent behaviours. In addition, the studies highlight that it is challenging to support a person to be adherent. Based on this knowledge the BEAMER project was established (Behavioural and Adherence Model for improving quality, health outcomes and cost-Effectiveness of healthcaRe). The overall goal of the project is to improve the quality of life of individuals, enhance healthcare accessibility and sustainability, thereby transforming the way healthcare stakeholders engage with patients to understand their condition and adherence levels throughout their healthcare journey. To address the overall goal, the BEAMER project has developed a disease agnostic model named \"B-COMPASS: BEAMER-COmputational Model for Patient Adherence and Support Solutions\". The aim of the B-COMPASS is to identify patients' needs and preferences which enables the creation of patient-specific supports, with the intention of improving their adherence to treatment within the heterogeneity of the different disease-areas and healthcare contexts. Based on the validated BEAMER questionnaire, the B-COMPASS predicts relative adherence and offers an elicitation process of patient needs and preferences to enable targeted supports to improve patient adherence. This results in an allocation of patients to different groups based on their needs and preferences. Overall, the B-COMPASS provides patient insights that will enable more effective design of patient support, most likely resulting in better patient experience, improved adherence and lower healthcare and societal costs.\n\nSo far, several activities from a technical and user perspective have already been conducted in the project to refine the B-COMPASS. This has been done by applying an iterative mixed method approach were both stakeholders (regulator, pharma, academic\u002Fresearch and small and medium-sized enterprises) and end users (patients, health providers and health systems) have been involved. Despite the finetuning of the B-COMPASS, the effectiveness of the B-COMPASS hinges on empirical investigations into the structural elements that impact patient behaviour and the identification of predictive factors that can assist healthcare providers' (HCP) and Research Leads in designing more effective treatment plans (the term HCPs\u002FResearch Lead include both the individuals and the institutions where care is delivered). Therefore, validation studies will be conducted to assess the B-COMPASS's performance in six therapeutic areas (cardiovascular, endocrinology, immunology, neurology, oncology and rare diseases) with patients recruited in at least Italy (FISM), Portugal (APDP and MEDIDA) Norway (AHUS), Spain (FHUNJ and FIIBAP), The Netherlands (WDO), and Germany (UDUS). The collected data will be used to evaluate the B-COMPASS's capacity to attend to a variety of needs and challenges for adherence.",[60,26,61,62,63,64],"Cardiovascular Diseases","Inmunology","Neurology","Oncology","Rare Diseases",[66,67,68],"Digital health","adherence to treatment","healthcare","RECRUITING","2026-03-26",{"date":72,"type":37},"2026-04-01",{"date":74,"type":37},"2025-03-01",{"date":41,"type":19},{"name":77,"class":44},"Technical University of Madrid",10,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":45},"100605539","retrospective-study-of-the-cohort-of-transgender-patients-who-began-medical-support-before-the-age-of-18-100605539","NCT07163832","Retrospective Study of the Cohort of Transgender Patients Who Began Medical Support Before the Age of 18","Retrospective Single-center Study of the Cohort of Transgender Patients Who Began Medical Support Before the Age of 18 at the Strasbourg University Hospital","TRANS","Inclusion Criteria:\n\n* Minor patient (≥18 years old)\n* First-time patient for transgender issues at the Strasbourg University Hospital in child psychiatry and\u002For pediatric endocrinology (in at least one of the two departments)\n* Patient (and\u002For their legal representative) who has not expressed opposition to the reuse of their data for scientific research purposes.\n\nExclusion Criteria:\n\n* Patient (and\u002For their representative) who has expressed opposition to the reuse of their data for scientific research purposes.\n* Patient aged over 18 at the first consultation\n* Patient with insufficient data","8 Years","17 Years",{"count":90,"type":19},115,"Gender incongruence is characterized by a marked and persistent incongruity between the gender with which a person identifies and their assigned sex. Behaviors and preferences that vary by sex do not, in and of themselves, justify the assignment of diagnoses in this group.",[26],[94,95],"Pediatric endocrinology","Child Psychiatry","2025-09-01",{"date":98,"type":37},"2025-09-09",{"date":100,"type":37},"2025-05-15",{"date":102,"type":19},"2026-05-15",{"name":104,"class":44},"University Hospital, Strasbourg, France"]