[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endodontic-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endodontic-disease":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,48,79,110,140,165,187,213,236,268,291,316,341,368],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100588957","exploration-of-the-utility-of-dental-dedicated-mri-for-dentistry-100588957",false,"NCT06948162","Exploration of the Utility of Dental-dedicated MRI for Dentistry","Inclusion Criteria:\n\n1. Patient Age: 18 years old or older\n2. Receiving imaging for routine dental care\n3. Does not have a serious medical condition\n4. Is not pregnant or is not potentially pregnant\n5. Is willing and able to give consent in English\n6. Has the ability to manage their own calendar and schedule appointments\n7. Willing to have a separate 2-hour appointment to have an MRI\n\nExclusion Criteria:\n\n1. Unable to consent to participant in English\n2. Serious health condition, which includes but not limited to renal failure\u002Fon dialysis, unstable heart disease (uncontrolled arrhythmia, cardiomyopathy and\u002For unable to lay flat, within 1 month of cardiac catheterization or myocardial infarction), unstable cerebral vascular disease (within 1 month of stroke and\u002For stent placement), diabetes (type I or II) not controlled by medication or diet, uncontrolled seizures, uncontrolled hyperthyroidism, non-allergic bronchospasm (chronic obstructive pulmonary disease and emphysema), uncontrolled movement disorder, and liver failure\n3. Pregnant and\u002For intending to become pregnant,\n4. Prisoner and\u002For not able to manage their own scheduling\n5. Screen positive on MR safety questionnaire, specifically including people that have worked with or otherwise been exposure to metal particles and have the potential for such particles to be embed within them.",true,"ALL","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This description observational research is comparative in design, that is comparing existing standard clinical dental images, not obtained in this study, to test (i.e., ddMRI) images. The standard clinical dental images consist of radiographs, such as bitewings, periapical, panoramic, cone-beam CT, and medical CT, as well medical MRIs of the temporomandibular joints (TMJ).The conceptualization of research questions, study designing, and interpretation of imaging data has and will involve content expertise in all ddMRI research.",[24,25,26,27,28,29,30,31],"Dental Crowding","Dental Occlusion, Traumatic","Dental Pain","TMD\u002FOrofacial Pain","TMD","Orthodontics","Endodontic Disease","Orthodontic Treatment",[33,34],"Diagnosis","Magnetic resounance imaging","RECRUITING","2026-05-18",{"date":38,"type":39},"2026-05-20","ACTUAL",{"date":41,"type":39},"2025-03-14",{"date":43,"type":20},"2027-12-31",{"name":45,"class":46},"University of Minnesota","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":47},"100632839","phase-4-nanozymes-in-endodontics-100632839","NCT07518901","Nanozymes in Endodontics","Ferumoxytol Nanozymes for Biofilm Disruption: A Clinical Study","Inclusion Criteria:\n\n1. Patients willing to participate in the study.\n2. Patients are 18 years or above.\n3. Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II).\n4. Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and\n\n   1. responding to thermal sensitivity testing negatively (Difluordichlormethane at 50 °C, Endo-Ice,\n   2. Coltène\u002FWhaledent Inc., Cuyahoga Falls, Ohio) or a negative response to EPT testing.\n5. Tooth with adequate remaining tooth structure for proper isolation with rubber dam.\n6. No history of previous endodontic treatment on the tooth.\n7. Teeth with single roots or multirooted teeth.\n\nExclusion Criteria:\n\n1. Self-reported pregnancy.\n2. Patients requiring antibiotic premedication prior to dental treatment.\n3. Patients with multiple drug allergies.\n4. Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products.\n5. Patients who are scheduled for MRI for the head region within three months after Ferumoxytol nanoparticles application.\n6. Periodontal changes (pockets 3 mm, mobility Grade I, or gingival edema).\n7. Patients who cannot return for a subsequent appointment or follow-ups.\n8. Radiographic presence of resorptive processes.\n9. Cracked and fractured teeth.",{"count":56,"type":20},72,"INTERVENTIONAL",[59],"PHASE4","The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment. Building on prior protocols that demonstrated ferumoxytol nanozymes antimicrobial activity as a root canal irrigant, ferumoxytol solution will be applied topically, assessment of clinical and radiographical findings will determine its potential as a novel disinfection and its long-term outcome.",[62,30,63],"Apical Periodontitis","Root Canal Infection",[65,66,67,68],"Nanozymes","Root canal irrigants","Nanotechnology","iron oxide nanoparticles","NOT_YET_RECRUITING","2026-04-01",{"date":72,"type":39},"2026-04-09",{"date":74,"type":20},"2026-06",{"date":76,"type":20},"2028-06",{"name":78,"class":46},"University of Pennsylvania",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":86,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":57,"phases":90,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":47},"100611355","a-randomized-controlled-trial-evaluating-whether-pre-operative-trinase-reduces-post-operative-pain-in-patients-with-symptomatic-irreversible-pulpitis-compared-to-placebo-using-vas-scores-and-analgesic-intake-over-48-hours-100611355","NCT07239505","A Randomized Controlled Trial Evaluating Whether Pre-operative Trinase Reduces Post-operative Pain in Patients With Symptomatic Irreversible Pulpitis Compared to Placebo, Using VAS Scores and Analgesic Intake Over 48 Hours.","The Role Of Trinase In Reducing Post-Operative Pain For Patients With Symptomatic Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Systemically healthy male patients (ASA I or II)\n* Aged 18 to 50 years\n* Presenting with symptomatic irreversible pulpitis in a restorable mandibular molar\n* Preoperative moderate to severe pain (VAS ≥45 mm)\n* Normal periapical tissue (no radiolucency, pocket depth ≤5 mm, mobility ≤ Grade I)\n\nExclusion Criteria:\n\nMedically compromised patients (ASA III or higher)\n\n* History of allergy or intolerance to Trinase or any of its components (trypsin, bromelain, rutin)\n* Vertical root fracture\n* External or internal root resorption\n* Periodontal pocket depth \\>5 mm\n* Tooth mobility Grade II or III\n* Presence of periapical lesion (radiolucency)\n* Female patients (to standardize pain perception and hormonal factors)","MALE","50 Years",{"count":89,"type":20},182,[91],"NA","This study aims to determine whether Trinase, an enzyme-based anti-inflammatory medication, can reduce pain after root canal treatment in patients with symptomatic irreversible pulpitis. A total of 182 male patients aged 18 to 50 years who present with moderate to severe tooth pain will be randomly assigned to receive either a Trinase tablet or a placebo 30 minutes before treatment. All root canal procedures will be performed in a single visit using standard endodontic techniques.\n\nPain levels will be measured on a Visual Analogue Scale (VAS) before treatment and at 6, 12, 24, and 48 hours after treatment. Patients will also record the number of pain-relief tablets they take during the first 48 hours. The goal of the study is to see whether Trinase can lower post-operative pain and reduce the need for analgesic medication compared with placebo. This information may help improve pain management for patients undergoing root canal therapy.",[94,95,30,26],"Symptomatic Irreversible Pulpitis (SIP)","Postoperative Pain After Endodontic Treatment",[97,98,99,100],"Visual Analogue Scale (VAS)","Randomized Controlled Trial","Trinase","Postoperative Pain","2025-11-27",{"date":103,"type":39},"2025-12-01",{"date":105,"type":39},"2025-08-01",{"date":107,"type":20},"2025-12-15",{"name":109,"class":46},"Fayoum University",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":117,"targetDuration":4,"studyType":57,"phases":119,"briefSummary":122,"conditions":123,"keywords":126,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":47},"100532011","phase-2-the-antimicrobial-potential-of-diclofenac-sodium-as-an-intracanal-medicament-100532011","NCT06207253","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with teeth diagnosed with apical periodontitis\n* Periapical Index (PAI) ≥ 2\n* The teeth are restorable\n\nExclusion Criteria:\n\n* Teeth with immature roots\n* Non restorable teeth\n* Medically compromised patients with systemic complication that would alter the treatment.\n* Teeth with internal\u002Fexternal root resorption\n* Patient with an allergy to diclofenac sodium",{"count":118,"type":20},48,[120,121],"PHASE2","PHASE3","The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis.\n\nThe main question\\[s\\] it aims to answer are:\n\n• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.",[30,124,125],"Pulp Disease, Dental","Intracanal Medication",[127,128,129,130],"Sodium diclofenac","Intracanal medication","Calcium hydroxide","Apical periodontitis","2025-05-26",{"date":133,"type":39},"2025-05-30",{"date":135,"type":20},"2025-11",{"date":137,"type":20},"2025-12",{"name":139,"class":46},"British University In Egypt",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":57,"phases":150,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":163,"locationsCount":47},"100511120","effect-of-photobiomodulation-to-reduce-post-operative-pain-after-endodontic-surgery-100511120","NCT05935306","Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery","Effect of Photobiomodulation to Reduce Post-operative Pain After Endodontic Surgery: a Randomized Controlled Clinical Trial","Inclusion Criteria\n\n:• Patients with periapical lesions who have already undergone endodontic treatment (lesions smaller than 10mm in their greatest diameter - Metin et al., 2018, single and chronic lesions)\n\n* Patients with not comorbidities,\n* Age from 18 to 70 years,\n* Both genders,\n* Healthy permanent teeth with good hygiene.\n\nExclusion Criteria:\n\n* Who are taking drugs that affect bone metabolism and the inflammatory process (for example: corticosteroids, bisphosphonates),\n* Smokers, pregnant or lactating women,\n* Who used anti-inflammatory drugs in the last 3 months before surgery.\n* Who for any reason interrupted the evolution of the treatment for not attending joint appointments.\n* Patients who do not follow the guidelines or have an injury in the acute phase (pain, edema, exudate)","70 Years",{"count":149,"type":20},34,[91],"The objective of this study will be to evaluate if photobiomodulation (FBM) can reduce postoperative pain in patients who will undergo endodontic surgery. For this randomized, controlled and double-blind clinical study, 34 patients without comorbidities who need endodontic surgery in the upper jaw (15 to 25 teeth) will be recruited. They will be randomly divided into an experimental group (n = 17) photobiomodulation (808nm, 100 mW, and 4J\u002Fcm2 with 5 points per vestibular). Applications will be made in the immediate postoperative period and 24 hours after surgery. Control group (n = 17) a FBM simulation will be performed in the same way as in the experimental group. In this group, the required analgesia will be administered within the standard with ibuprofen. Both groups will perform the necessary conventional procedures considered the gold standard in the literature. Both the patient and the evaluator will be blinded to the intervention performed. The primary outcome variable of the study will be postoperative pain, which will be assessed using the visual analog scale at all postoperative control visits (baseline, 24 hours and 7 days). As for the secondary outcome variables, the amount of systemic medication received according to the patient's need (will be provided by the investigator).. Radiographic images will be obtained after 1 and 2 months for evaluation of the repair (dimensions of the lesion, radiopacity). These radiographs will be taken digitally with the positioners implemented. Edema, ecchymosis, and evaluation of soft tissues in the anterior portion of the intra and extra-oral maxilla will also be evaluated. In addition, a digital thermometer. These parameters will be evaluated 24 hours and 7 days after the intervention. The X-rays will be taken in the 1st and 3rd month respectively.",[153,30,154,155,156],"Photobiomodulation","Pain","Inflammation","Surgery","2025-05-03",{"date":159,"type":39},"2025-05-07",{"date":161,"type":39},"2024-06-30",{"date":103,"type":20},{"name":164,"class":46},"University of Nove de Julho",{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":16,"minAge":171,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":57,"phases":175,"briefSummary":176,"conditions":177,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":4},"100586307","phase-2-postoperative-pain-and-incidence-of-extrusion-following-the-use-of-two-intra-canal-medications-in-retreatment-of-single-rooted-teeth-100586307","NCT06913673","Postoperative Pain and Incidence of Extrusion Following the Use of Two Intra-canal Medications in Retreatment of Single Rooted Teeth","Inclusion Criteria:\n\n* Patients with failed endodontic treatment in single root teeth\n* Systemic free\n\nExclusion Criteria:\n\n* Muktirooted teeth","16 Years","40 Years",{"count":174,"type":20},30,[120],"This study aims to compare the postoperative pain and incidence of extrusion of two intracanal medications in the retreatment of single-rooted teeth.\n\nThe main question it aims to answer is:\n\nDoes the injection of intra-canal medication into the shaped root canal after complete removal of the old obturating material lead to post-operative pain and paste extrusion to periapical tissues or not?",[30],"2025-04-03",{"date":180,"type":39},"2025-04-06",{"date":182,"type":20},"2025-04-01",{"date":184,"type":20},"2025-05-01",{"name":186,"class":46},"Minia University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":15,"sex":16,"minAge":171,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":57,"phases":195,"briefSummary":196,"conditions":197,"keywords":199,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":47},"100565552","role-of-gtr-on-healing-outcome--quality-of-life-in-combined-endo-perio-lesions-with-communication-100565552","NCT06643663","Role of GTR on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication","\"Role of Guided Tissue Regeneration on Healing Outcome & Quality of Life in Combined Endo Perio Lesions With Communication: A Randomized Controlled Trial\"","Inclusion Criteria:\n\n1. Patients of age 16yrs and above.\n2. Patients with apico-marginal defects and deep pocket upto apex of tooth.\n3. Failed primary root canal treatment.\n4. Presence of interproximal bone loss.\n5. Negative response to vitality test.\n6. ASA-1 or ASA- 2 according to the classification of the American Society of Anesthesiologists)\n\nExclusion criteria:\n\n1. Presence of vertical root fracture\n2. Presence of root perforations\n3. ASA-3 or ASA-4 according to the classification of the American Society of Anesthesiologists)\n4. Presence of root resorption\n5. Combined endodontic-periodontic lesions.\n6. Pregnancy",{"count":174,"type":20},[91],"The recovery of periapical defects linked to periodontal communication frequently yields less satisfactory results. Numerous studies and case reports have highlighted the notable success achieved through the application of guided tissue regeneration techniques. More recently, autologous platelet concentrate plug \\& placental membrane have emerged as a treatment option for addressing such lesions. Nevertheless, there has been no study using PRF-Medium with ACM membrane on the healing of aforesaid lesion \\& quality of life assessment.",[198,30],"Periapical Diseases",[200,201,202,203],"Guided tissue regeneration","healing","endo-perio lesions","endodontic surgery","2025-01-06",{"date":206,"type":39},"2025-01-08",{"date":208,"type":39},"2024-05-23",{"date":210,"type":20},"2025-12-23",{"name":212,"class":46},"Postgraduate Institute of Dental Sciences Rohtak",{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":172,"enrollmentInfo":220,"targetDuration":4,"studyType":57,"phases":221,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":234,"locationsCount":47},"100566870","irrigation-activating-techniques-on-irrigant-penetration-depth-and-microbial-reduction-100566870","NCT06660797","Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction","Effect of Different Irrigation Activating Techniques on Irrigant Penetration Depth and Microbial Reduction in Root Canals (Clinical Study)","Inclusion Criteria:\n\n* • Asymptomatic vital\u002Fnon vital teeth requiring root canal treatment.\n\n  * Teeth with sound periodontal apparatus.\n  * Teeth without pus or inflammatory exudates draining through the canal.\n  * Teeth without anatomic variations.\n  * Teeth with sinus tract.\n\nExclusion Criteria:\n\n* • Patients with any systemic diseases.\n\n  * Pregnant or lactating patients.\n  * Immunocompromised patients.\n  * Apparently thin roots in which apical preparation with #40 or #50 file would be overzealous.\n  * Patient allergic to anything used in this procedure especially rubber dam material and Iohexol (radiographic contrast media).\n\nRetreatment cases. Teeth with calcified canals.",{"count":174,"type":20},[91],"This in-vivo study aim to evaluate effect of different irrigation activating techniques on Irrigant Penetration Depth and Microbial Reduction in root Canals",[224,30],"Irrigation Activation",[226,227],"Different Irrigation Activating Techniques","primary Endodontic Infection cases","2024-10-25",{"date":230,"type":39},"2024-10-28",{"date":232,"type":39},"2024-06-01",{"date":182,"type":20},{"name":235,"class":46},"Tanta University",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":57,"phases":245,"briefSummary":246,"conditions":247,"keywords":253,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":47},"100560208","effect-of-photobiomodulation-on-pain-and-healing-of-the-vertical-releasing-incision-after-endodontic-microsurgery-100560208","NCT06574152","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I or II.\n* At least one tooth will receive EMS.\n* Flap design that includes at least one VRI (triangular, rectangular, papilla base or submarginal rectangular).\n\nExclusion Criteria:\n\n* ASA III or IV.\n* Current heavy smokers (\\>10 cigarettes\u002Fday)\n* Uncontrolled diabetes (HbA1c ≥ 7%) or other uncontrolled systemic diseases that may comprise healing, such as vitamin C deficiency, neutrophil deficiencies, immunodeficiency syndromes, or leukemia.\n* Surgical access on the palatal surface.\n* Acute swelling or abscess present on the day of the surgery.\n* Any event or condition that would make continued participation in the study not in the best interest of the subject, as determined by the investigator.\n* Pregnancy.\n* Development of any medical condition that might affect the treatment and clinical outcomes, as determined by the investigator.\n* Initiation of any treatment or exposure that might affect therapy's healing, as determined by the investigator.",{"count":244,"type":20},40,[91],"The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of Dentistry Graduate Endodontic Clinic and to assess the soft tissue healing of the vertical releasing incision (VRI) after PBM",[62,248,30,249,250,251,252],"Endodontically Treated Teeth","Apical Cyst","Apical Granuloma","Periradicular Disease","Previous Endodontic Treatment",[254,255,256,257,258],"vertical incision","photobiomodulation","apicoectomy","endodontic microsurgery","laser therapy","2024-08-27",{"date":261,"type":39},"2024-08-29",{"date":263,"type":39},"2024-08-20",{"date":265,"type":20},"2025-07-31",{"name":267,"class":46},"The University of Texas Health Science Center, Houston",{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":15,"sex":16,"minAge":275,"maxAge":276,"enrollmentInfo":277,"targetDuration":4,"studyType":57,"phases":279,"briefSummary":280,"conditions":281,"keywords":282,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":284,"lastUpdatePostDateStruct":285,"startDateStruct":287,"completionDateStruct":289,"leadSponsor":290,"locationsCount":47},"100531186","phase-2-anti-bacterial-potential-of-nano-calcium-hydroxide-as-an-intracanal-medication-100531186","NCT06196515","Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication","Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial","Inclusion Criteria:\n\n* healthy males and females.\n* age range between 21-49.\n* patients with no physical disability or psychological problems.\n* patients presenting with single permanent molar with signs and\u002For symptoms of apical periodontitis, and having Periapican index ≥ 2.\n\nExclusion Criteria:\n\n* pregnant women.\n* patients with immune-compromised disease.\n* patients with complicated systemic diseases.\n* patients who took antibiotics within a period of 1 month.\n* patients with known sensitivity to the medicaments or pharmaceuticals used in this study.\n* Non-restorable teeth including root fractures, and\u002For advanced periodontal involvement.","21 Years","49 Years",{"count":278,"type":20},54,[120,121],"The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.",[30,124],[283],"intracanal medication","2024-08-16",{"date":286,"type":39},"2024-08-19",{"date":288,"type":20},"2024-08",{"date":137,"type":20},{"name":139,"class":46},{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":15,"sex":16,"minAge":298,"maxAge":299,"enrollmentInfo":300,"targetDuration":4,"studyType":57,"phases":301,"briefSummary":302,"conditions":303,"keywords":305,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":47},"100557061","antimicrobial-efficacy-of-nano-based-icm-on-ef-100557061","NCT06533215","Antimicrobial Efficacy of Nano-Based ICM on E.F","Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis","Inclusion Criteria:\n\n* Single rooted, single canal premolar teeth.\n* Teeth indicated for non-surgical root canal retreatment.\n* Teeth have signs and\u002For symptoms of post-treatment disease manifested by recurrent acute and\u002For chronic periapical abscess.\n* Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.\n* Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.\n* Symptomatic or asymptomatic teeth with short root canal filling indicated for prosthetic restoration\n\nExclusion Criteria:\n\n* Patients with any systemic diseases.\n* Pregnant or lactating patients.\n* Immunocompromised patients.\n* Non-restorable tooth.\n* Calcified root canal.\n* Teeth with root fracture.\n* Teeth with periodontal pocket deeper than 4mm.\n* Teeth have procedural error like ledge, broken instrument, or perforation","19 Years","60 Years",{"count":174,"type":20},[91],"This in-vivo study aims to evaluate the antimicrobial effect of nano based intracanal medications (Triple antibiotic-loaded chitosan nanoparticles and chlorohexidine loaded by silver nanoparticles) on Enterococcus faecalis count reduction in secondary endodontic infection cases.",[304,248,30],"Enterococcus Faecalis Infection",[283,306,307],"Enterococcus Faecalis","secondary endodontic infection cases.","2024-07-30",{"date":310,"type":39},"2024-08-01",{"date":312,"type":39},"2024-01-02",{"date":314,"type":20},"2025-03-02",{"name":235,"class":46},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":57,"phases":326,"briefSummary":327,"conditions":328,"keywords":330,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":47},"100491640","endo-perio-disease---treatment-outcomes-using-conventional-and-hydraulic-calcium-silicate-sealer-with-or-without-lprf-100491640","NCT05681754","Endo-perio Disease - Treatment Outcomes Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF","Endodontic-periodontal Disease - Comparison of Treatment Outcome Using Conventional and Hydraulic Calcium Silicate Sealer With or Without LPRF and Characterisation of Host-microbiome Interaction","Inclusion Criteria:\n\n* • Diagnosis of Endodontic-periodontal disease without root damage in periodontitis patients, Grades I, II, III according to Herrera 2017 classification.\n\n  * Presence of ≥ 1 intrabony defect: interproximal probing pocket depth ≥ 5 mm and ≥ 3mm radiographic intrabony defect, adjacent to single rooted and multi-rooted teeth associated with endodontic-periodontal disease\n  * Age: 18-80\n  * Non-smokers (zero cigarettes within last 5 years)\n\nExclusion Criteria:\n\n* Endodontic considerations: severely sclerosed canals, external cervical resorption and internal root resorption, perforations, root fracture or cracking, re- RCT, apical surgery and unrestorable teeth\n* Teeth with defects not amenable to regeneration or molar teeth planned for root resection\n\n  \\- Periodontal treatment carried out previously to the study site within the last 12 months (excluding not-extensive subgingival debridement as judged by the examining clinician),\n* presence of drug induced gingival overgrowth.\n* Smoking (current or in past 5 years) including e-cigarettes\u002F vaping\n* History of alcohol or drug abuse,\n* Systemic antibiotic therapy during the 3 months preceding the baseline exam,\n* History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures,\n* Anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam,\n* Medical history of diabetes or transmittable diseases,\n* Chronic inflammatory conditions: chronic peptic ulcer, tuberculosis, rheumatoid arthritis, ulcerative colitis, crohn's disease, active hepatitis, inflammatory bowel diseases, irritable bowel syndrome, autoimmune diseases, liver diseases, renal diseases or cancer\n* Medications which alter bone metabolism: hormone replacement therapy, immunosuppressive drugs, corticosteroids, selective serotonin reuptake inhibitors, tumour necrosis factor blockers, IV bisphosphonates, and\u002For antiresorptive drugs,\n* Self-reported pregnancy or lactation\n* Surgical procedures in the last 6months (any type of surgical procedures)\n* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that according to the investigator may increase the risk associated with trial participation,\n* Poor compliance","80 Years",{"count":325,"type":20},115,[91],"The endodontic periodontal-disease is characterized by the involvement of the pulp and periodontal disease in the same tooth. The anatomic connections between the dental pulp and the periodontium provide a pathway for perio-endo communication via apical foramina, lateral canals, exposed dentinal tubules, and developmental grooves. These pathways provide an egress for pulpal disease to affect the periodontium and conversely, an ingress for periodontal disease to affect the pulp.\n\nTeeth with endo-perio disease, which are deemed salvageable might require root canal (endodontic) treatment, followed by staged periodontal treatment. Compared to conventional sealers used for endodontic treatment, the hydraulic calcium silicate based sealers (HCSB)s have excellent sealing ability, biocompatibility, regeneration ability, and antimicrobial characteristics. However little is known about its clinical benefits when used to treat endo-perio disease.\n\nThe gold standard treatment for periodontitis affected teeth associated with intrabony lesions is guided tissue regeneration (GTR) which has significant improved clinical outcomes over open flap debridement (Cochrane systematic review 2005). However, the success the of this regenerative technique requires careful case and defect selection. We propose the use of an autologous bioactive scaffold, leukocyte platelet rich fibrin (L-PRF) to achieve regeneration of periodontal soft and hard tissues, resulting in faster healing, greater bone infill and improved predictability of clinical outcomes",[30,329],"Periodontitis",[331],"Endo-perio lesions","2023-01-11",{"date":334,"type":39},"2023-01-12",{"date":336,"type":20},"2023-05",{"date":338,"type":20},"2033-05",{"name":340,"class":46},"King's College London",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":57,"phases":351,"briefSummary":352,"conditions":353,"keywords":354,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":47},"100403106","outcome-of-endodontic-treatment-and-retreatment-with-a-bioceramic-sealer-100403106","NCT04528979","Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer","The Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer: A Prospective Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.\n* Understands and is willing to comply with all study procedures and restrictions.\n* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.\n* Diagnosis of irreversible pulpitis or apical symptomatic \u002F asymptomatic periodontitis.\n* Retreatment cases due to an endodontic failure.\n* Single or bi-radicular teeth.\n\nExclusion Criteria:\n\n* General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.\n* Specific: root resorption, root fractures, impossibility of restoration and cases were primary or secondary root canal treatment is not the treatment of choice.","75 Years",{"count":350,"type":20},220,[91],"This study is a prospective randomized controlled study of patients who come to the University. The aim is to evaluate the success rate of treatment and retreatment of canals using BioRoot ™ RCS cement compared with AH Plus up to 6 years of follow-up. The null hypothesis is that there will be no statistically significant differences in rates of successful treatment of root canals filled with BioRoot ™ RCS compared to gutta-percha and AH Plus sealer.",[30,248],[355,356,357,358],"Primary root canal treatment","Secondary root canal treatment","Outcome","Root canal sealer","2020-08-27",{"date":361,"type":39},"2020-08-31",{"date":363,"type":39},"2019-09-20",{"date":365,"type":20},"2027-01",{"name":367,"class":46},"Juan Gonzalo Olivieri",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":348,"enrollmentInfo":375,"targetDuration":4,"studyType":57,"phases":377,"briefSummary":378,"conditions":379,"keywords":380,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":47},"100403008","outcome-of-endodontic-retreatment-in-one-or-two-visits-100403008","NCT04527705","Outcome of Endodontic Retreatment in One or Two Visits","Clinical and Radiographic Outcome of Endodontic Retreatment in One or Two Visits: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.\n* Understands and is willing to comply with all study procedures and restrictions.\n* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.\n* Retreatment cases due to an endodontic failure.\n* Diagnosis of apical periodontitis.\n* Single or bi-radicular teeth.\n\nExclusion Criteria:\n\n* General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.\n* Specific: root resorption, root fractures, impossibility of restoration and cases were secondary root canal treatment is not the treatment of choice.",{"count":376,"type":20},110,[91],"This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease. The aim is to evaluate the success rate of non-surgical retreatment performed in one compared to two visit treatment up to 10 years of follow-up. The null hypothesis is that there will be no statistically significant differences in rates of success, when performing root canal non-surgical retreatment in one or two visits.",[30,248,63],[355,356,381,357],"Periapical healing","2020-08-23",{"date":384,"type":39},"2020-08-26",{"date":386,"type":39},"2018-09-20",{"date":388,"type":20},"2031-07-20",{"name":390,"class":46},"Universitat Internacional de Catalunya"]