[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endodontic-treatment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endodontic-treatment":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,63,93,125],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100589516","clinical-investigation-measuring-the-long-term-clinical-performance-and-safety-of-biodentine-xp-in-patients-treated-for-coronal-restorative-or-endodontic-dental-indications-100589516",false,"NCT06955429","Clinical Investigation Measuring the Long Term Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.","Observational, Prospective, International and Multicenter Clinical Investigation Measuring the Longterm Clinical Performance and Safety of Biodentine™ XP in Patients Treated for Coronal Restorative or Endodontic Dental Indications.","BIOD XP","Inclusion Criteria:\n\n1. Temporary tooth, from a child ≥ 2 years old, requiring dental restorative treatment with Biodentine™ XP, and\u002For, Permanent (mature or immature) tooth, from a child or an adult, requiring a dental restorative and\u002For an endodontic treatment with Biodentine™ XP.\n2. Adult patient with a signed informed consent form; For the minor, if in age to understand, an assent is required, and at least one parent or legal representative must consent.\n3. Only in France: Subject affiliated or benefiting from a social\u002Fhealth insurance system.\n\nExclusion Criteria:\n\n1. Patient with one or more documented contraindication to use Biodentine™ XP (Refer to IFU).\n2. Inadequate expected tooth lifetime as estimated by the investigator:\n\n   * For a Temporary tooth: high probability of tooth loss within 2 years after treatment with Biodentine™ XP.\n   * For a permanent tooth: high probability of tooth loss within 10 years after treatment with Biodentine™ XP.\n3. Patient with any systemic disease that may hinder the normal healing process and\u002For the follow-up.\n4. Adult patient under legal protection measures or unable to express his\u002Fher consent, and individual deprived of liberty by judicial or administrative decision, as well as individual receiving psychiatric care.\n5. Periodontitis (stage 3, 4 or stage 2 grade C).\n6. Inability to comply with study procedures.\n7. Participation in another interventional clinical investigation that can induce bias in the study results.","ALL","2 Years",{"count":20,"type":21},275,"ESTIMATED","OBSERVATIONAL","The aim of this present study is to collect additional data for the post-marketing follow-up of Biodentine™ XP and measure long-term (up to 10 years) performance and safety of the biomaterial in all its indications.",[25,26,27],"Dental Restoration, Permanent","Dental Restorations","Endodontic Treatment",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49],"Dentine restoration","Coronal carious lesions","Restoration of cervical lesion","Restoration of radicular lesion","Pulp capping","Pulpotomy","Apexification","Revitalization","Endodontic treatment","Root","Crown","Pulp","Root perforations","Furcation perforations","Perforating internal resorptions","External resorption","Root-end filling","Permanent dentine restoration","Temporary dentine-enamel restoration","Biodentine","Biodentine XP","RECRUITING","2026-04-30",{"date":53,"type":54},"2026-05-06","ACTUAL",{"date":56,"type":54},"2025-10-23",{"date":58,"type":21},"2037-02-28",{"name":60,"class":61},"Septodont","INDUSTRY",8,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":70,"maxAge":4,"enrollmentInfo":71,"targetDuration":73,"studyType":22,"phases":4,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":4},"100611720","the-present-study-aims-to-follow-up-on-all-root-canal-treatments-performed-during-the-year-2023-within-the-public-dental-services-of-the-counties-of-jnkping-kalmar-and-stergtland-sweden-the-study-is-entirely-observational-in-nature-100611720","NCT07244250","The Present Study Aims to Follow up on All Root Canal Treatments Performed During the Year 2023 Within the Public Dental Services of the Counties of Jönköping, Kalmar, and Östergötland, Sweden. The Study is Entirely Observational in Nature.","Result of Root Canal Treatment in General Dentistry","Inclusion Criteria:\n\n• All patients who have received and completed a root canal treatment in the Public Dental Service in the counties of Jönköping, Kalmar and Östergötland in 2023.\n\nExclusion Criteria:\n\n• All patients who decline participation","20 Years",{"count":72,"type":21},1500,"8 Years","Each year, nearly 200,000 teeth undergo root canal treatment in Sweden, most of them within general dental care. However, studies that evaluate the outcomes of root canal treatments have almost exclusively been conducted at specialist or university clinics, where treatment conditions differ from everyday practice in general dentistry. Moreover, the design of such studies often limits the ability to generalize their findings to routine clinical settings.\n\nThese earlier studies suggest that root canal treatment is a predictable procedure-about 80-90% of treated teeth become free from infection, 90% of patients experience no pain, and approximately 90% of root-filled teeth remain in the mouth six years after treatment. Still, the results from these studies cannot easily be applied to general dental care. This has been confirmed by large-scale epidemiological studies using X-rays to assess the technical quality of performed root fillings and to detect signs of disease. These studies have shown that many root fillings exhibit technical shortcomings, and a significant proportion of root-treated teeth have persistent infections.\n\nThe current study aims to increase understanding of the factors that may explain why the results of root canal treatment in general dental practice appear to differ from those in specialist care. Based on epidemiological data, it is estimated that about 35% of teeth treated with root canal therapy in general dental practice still show signs of disease after treatment. What happens to these patients is largely unknown. Evidence suggests that teeth with persistent apical periodontitis rarely cause discomfort, and the condition often goes unnoticed.\n\nIn the first part of the study, only patients who have already received treatment will be invited to participate, making this a retrospective study. Because it takes several years to evaluate the outcome of a root canal treatment, all patients aged 20 years and older who had a tooth root-filled in 2023 within the Public Dental Services of Jönköping, Kalmar, or Östergötland counties will be offered a free clinical and radiological examination-thus a three-year follow-up. The examination is entirely painless.\n\nIn the second part of the study, patients with a root-filled tooth showing persistent disease will be offered a five-year follow-up (2026-2031). They will be grouped according to whether they choose to have further treatment or leave the condition untreated. This second phase will therefore constitute a prospective follow-up.",[27,76,77],"Apical Periodontitis","Quality",[79,80,81],"Root canal treatment","Apical periodontitis","Root filling","NOT_YET_RECRUITING","2025-12-15",{"date":85,"type":54},"2025-12-16",{"date":87,"type":21},"2026-03-01",{"date":89,"type":21},"2027-12-31",{"name":91,"class":92},"Region Jönköping County","OTHER_GOV",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":11,"sex":17,"minAge":100,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":4},"100584800","early-phase-1-intracanal-dexamethasone-extrusion-and-postoperative-endodontic-pain-100584800","NCT06894069","Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain","Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n* A diagnosis of irreversible pulpits with symptomatic apical periodontitis\n* Adult patients (aged 18 - 70)\n* Healthy patients or those with a well-controlled disease (ASA I \\& II)\n\nExclusion Criteria:\n\n* A diagnosis of necrotic pulp, or normal apical tissues\n* Patients with a severe systemic disease (ASA III or higher)\n* Patients who received analgesics12 hours before presentation\n* Previously treated\u002Finitiated Endodontics treatment on the same tooth\n* Unopposed teeth\n* Third molar teeth\n* Non-restorable teeth\n* Periodontally compromised teeth\n* Pregnant or lactating patients","18 Years","70 Years",{"count":103,"type":21},80,"INTERVENTIONAL",[106],"EARLY_PHASE1","The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP\u002FSAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP\u002FSAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.",[109,27],"Post Operative Pain Control",[79,111,112,113,114],"Post-operative pain","Corticosteroids","Dexamethasone","Randomised controlled trial","2025-03-25",{"date":117,"type":54},"2025-03-26",{"date":119,"type":21},"2025-03",{"date":121,"type":21},"2025-05",{"name":123,"class":124},"University of Jordan","OTHER",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":17,"minAge":100,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":104,"phases":136,"briefSummary":138,"conditions":139,"keywords":140,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":151},"100540072","a-study-to-assess-the-clinical-success-of-root-canal-treatment-using-novel-obturation-material-100540072","NCT06312085","A Study to Assess the Clinical Success of Root Canal Treatment Using Novel Obturation Material.","A Prospective, Single-arm, Non-randomized Controlled Trial to Test the Effectiveness, Safety and Performance of a Novel Dental Obturation Material","Inclusion Criteria:\n\n• Patients aged 18-75 years with ASA (American Society of Anesthesiologists) classification 1 and 2.\n\nASA 1: A normal healthy patient. Example: Fit, non-obese BMI (Body Mass Index) under 30, a non-smoking patient with good exercise tolerance.\n\nASA 2: A patient with mild systemic disease. Example: Patient with no functional limitations and a well-controlled disease (e.g., treated hypertension, obesity with BMI under 35, frequent social drinker, or cigarette smoker).\n\n* Patients who agreed to participate and who have signed the informed consent.\n* Patients presenting with symptomatic and\u002For asymptomatic apical periodontitis and radiographic evidence of apical periodontitis in anterior or posterior teeth larger than 1.5 mm in diameter.\n* Mature tooth with closed apices.\n* Tooth that has never been treated with root canal therapy.\n\nExclusion Criteria:\n\n* Patients who have pre-existing health or oral conditions that placed them at risk during the trial.\n* Patients with generalized untreated periodontal disease.\n* Patients with a history of analgesic intake within the past 3 days or antibiotics in the last 1 month.\n* Uncooperative patients.\n* Teeth with immature apices, root resorption, or requiring extensive prosthetic rehabilitation.\n* Teeth that cannot be made functional nor restored or difficult to access teeth with no importance (wisdom teeth).\n* Teeth with insufficient periodontal support.\n* Teeth with poor prognosis for root canal treatment, for example due to deep root caries, large root resorption or open apex cases.\n* Fractured teeth\n* Local anatomical factors such as an inaccessible root end\n* Presence of fractured instrument in the root canal\n* Pregnant women\n* Patients unable to understand the study procedure.",true,"75 Years",{"count":135,"type":21},63,[137],"NA","The goal of this study is prospective, single-arm, non-randomized controlled trial to test the effectiveness, safety and performance of a novel dental obturation material. The main question sit answers is\n\n1. To test the effectiveness of the Endofill device for root canal obturation up to 12-month follow-up period.\n2. To test the performance of the Endofill device evaluated with periapical radiographs immediately on completion of procedure.\n\nThe participants requiring root canal treatment will be treated with obturated using Endofill material and post-treatment follow-up vistis will be conducted for 1 year. This is a single-arm study with no comparison groups.",[27],[141],"Root Canal Treatment","2024-07-11",{"date":144,"type":54},"2024-07-12",{"date":146,"type":54},"2024-06-07",{"date":148,"type":21},"2026-12",{"name":150,"class":61},"Lumendo AG",1]