[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endodontically-treated-teeth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endodontically-treated-teeth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,51,78,109,138,168,190,223,245,270,297,322,349],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100643478","milled-vs-3d-printed-partial-coverage-restorations-in-endodontically-treated-molars-100643478",false,"NCT07643311","Milled vs 3D-Printed Partial-Coverage Restorations in Endodontically Treated Molars","Clinical Performance of CAD\u002FCAM-Milled Versus 3D-Printed Composite Resin Partial-Coverage Restorations for Endodontically Treated Molars: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 70 years\n* Absence of active periodontal disease\n* Good oral hygiene (O'Leary plaque index \\\u003C20%)\n* Absence of parafunctional habits (e.g., bruxism, onychophagia)\n* Endodontically treated first molars (maxillary or mandibular) with extensive Class II cavities and loss of at least one cusp, requiring onlay or overlay restoration\n* Tooth with functional occlusal contact and at least one proximal contact\n* Referred from the Endodontics Department of Hospital San José, with endodontic treatment completed at the same institution\n* Ability to provide written informed consent\n* Ability to attend follow-up visits at 12, 24, and 36 months\n\nExclusion Criteria:\n\n* Untreated active periodontal disease\n* Poor oral hygiene (O'Leary plaque index ≥20%)\n* Generalized active caries\n* Active parafunctional habits\n* Teeth with complete circumferential structural destruction or insufficient coronal tooth structure for onlay\u002Foverlay restoration\n* Subgingival margins compromising the biologic width\n* Known allergy to study materials\n* Pregnancy or breastfeeding","ALL","18 Years","70 Years",{"count":20,"type":21},142,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the clinical performance of Computer-Aided Design and Computer-Aided Manufacturing (CAD\u002FCAM)-milled and 3D-printed composite resin partial-coverage restorations in endodontically treated molars.\n\nThe main questions it aims to answer are:\n\n* Do 3D-printed composite resin partial-coverage restorations show similar clinical performance compared with CAD\u002FCAM-milled composite resin restorations?\n* Are there differences in survival, success rates, and complications between the two types of restorations over a 3-year follow-up period?\n\nResearchers will compare CAD\u002FCAM-milled composite resin restorations with 3D-printed composite resin restorations to evaluate their clinical performance.\n\nParticipants will:\n\n* Receive a partial-coverage restoration (onlay or overlay) in an endodontically treated molar.\n* Be randomly assigned to receive either a CAD\u002FCAM-milled or a 3D-printed composite resin restoration.\n* Attend follow-up visits at 12, 24, and 36 months.\n* Undergo clinical evaluations by two blinded evaluators using the revised FDI criteria and standardized photographic documentation.",[27],"Endodontically Treated Teeth",[29,30,31,32,33,34,35,36,37],"Onlay","Overlay","Milled Composite Resin","3D-Printed Composite Resin","partial coverage restoration","CAD\u002FCAM","3D printing","Indirect restoration","FDI Criteria","RECRUITING","2026-06-09",{"date":41,"type":42},"2026-06-11","ACTUAL",{"date":44,"type":42},"2026-05-29",{"date":46,"type":21},"2030-06-30",{"name":48,"class":49},"Hospital San Jose","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100643699","additive-vs-subtractive-manufacturing-for-endocrown-fabrication-a-24-month-rct-100643699","NCT07633574","Additive vs Subtractive Manufacturing for Endocrown Fabrication: A 24-Month RCT","Additive Versus Subtractive Manufacturing for Endocrown Fabrication: A Clinical Comparison of 3D-Printed Ceramic-Filled Photopolymer Resin and CAD\u002FCAM Milled Resin Nano-Ceramics Endocrowns in Posterior Teeth - A 24-Month Randomized Controlled Trial","ENDO-3D","Inclusion Criteria:\n\n* Age 25-45 years, male or female\n* Endodontically treated molar tooth with radiographically confirmed treatment success and no clinical signs of failure\n* Sufficient remaining coronal structure for endocrown preparation: minimum three walls, wall thickness 1.5 mm or greater, pulp chamber depth 3 mm or greater, supragingival preparation margins\n* Completely erupted tooth with intact periodontal support\n* Minimum of 20 occluding teeth\n* Satisfactory oral hygiene status\n* Capable of providing written informed consent and committed to scheduled follow-up visits\n\nExclusion Criteria:\n\n* Diagnosed parafunctional habit or nocturnal bruxism\n* Uncontrolled systemic illness or physical disability precluding safe participation\n* Heavy tobacco use\n* Current or suspected pregnancy\n* Periapical disease or radiographic signs of endodontic failure\n* Evidence of pathological tooth wear or occlusal erosion\n* Moderate-to-severe periodontitis or tooth with hopeless prognosis\n* Radiographic or clinical evidence of vertical root fracture\n* Impaired decision-making capacity or anticipated non-compliance","25 Years","45 Years",{"count":62,"type":21},60,[24],"This randomized controlled trial (RCT) compares the 24-month clinical performance of endocrown restorations fabricated by two digital manufacturing pathways: additive manufacturing using 3D-printed ceramic-filled photopolymer resin (VarseoSmile TriniQ, BEGO) versus subtractive computer-aided design\u002Fcomputer-aided manufacturing (CAD\u002FCAM) milling from hybrid nano-ceramic blocks (HC Hard Block, Shofu). Sixty endocrowns will be placed in endodontically treated posterior molars and evaluated using modified United States Public Health Service (USPHS) criteria at 6, 12, and 24 months. The trial is conducted at the Conservative Dentistry Department, Faculty of Dentistry, Cairo University.",[66,67,27],"Tooth, Nonvital","Dental Restoration","NOT_YET_RECRUITING","2026-06-04",{"date":71,"type":42},"2026-06-08",{"date":73,"type":21},"2026-06",{"date":75,"type":21},"2028-09",{"name":77,"class":49},"Cairo University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":91,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":95,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":104,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100639862","bite-force-and-occlusal-force-distribution-following-root-canal-treatment-100639862","NCT07626372","Bite Force and Occlusal Force Distribution Following Root Canal Treatment.","Changes in Bite Force and Occlusal Force Distribution Following Root Canal Treatment, Restoration, and Over Time: A Prospective Observational Study","B-FORCE RCT","Inclusion Criteria:\n\n* Premolars or molars diagnosed with pulp necrosis or previously initiate therapy with normal apical tissues, asymptomatic apical periodontitis, or chronic apical abscess without full coverage restoration.\n* Adequate remaining tooth structure for cuspal coverage restoration.\n* Presence of adjacent teeth and functional opposing natural teeth.\n* No analgesics drug effect at the time of investigation or not have taken analgesics 6 hours ago.\n\nExclusion Criteria:\n\n* Patients undergoing other dental treatments during the study period that may interfere with occlusion or bite force distribution, such as orthodontic treatment, jaw surgery, or full mouth restoration.\n* Received treatments that cause weakness of the jaw and facial muscles, such as botox injections.\n* History or symptoms of temporomandibular disorders (TMD)\n* Periodontal disease with second- or third-degree mobility\n* Teeth presenting crack lines extending into the pulp chamber floor or root canal orifices.",true,"20 Years","60 Years",{"count":90,"type":21},70,"4 Years","OBSERVATIONAL","Understanding the changes in bite force and occlusal force distribution in ETT is clinically important, as it can directly influence tooth prognosis, guide restorative treatment planning, and impact the long-term survival of the treated tooth. Therefore, this study aims to further explore changes and possible correlation in maximum bite force (MBF), occlusal force distribution and patients' subjective perception of chewing function of endodontically treated teeth after non-surgical root canal treatment, subsequent restoration, and during long-term follow-up, along with comparing to contralateral vital teeth.\n\nMethods: Patients aged 20-60 years who underwent non-surgical root canal treatment at the Graduate Endodontic Clinic, Faculty of Dentistry, Chulalongkorn University, with the following teeth indicated for endodontic treatment. Measurements of maximum bite force (MBF) of ETT and contralateral vital teeth, relative occlusal force (ROF), and questionnaire responses, are performed at the following time points: before NS-RCT, 1 month after completion of NS-RCT (before doing restoration), 3 months after crown restoration, 1, 2 and 4 years after completion of NS-RCT.\n\nDifferences in MBF and ROF over time points within subjects and differences in MBF and ROF between ETT and their contralateral vital teeth were statistically analyzed.",[27],[96,97,98,99,100,101],"Bite force","occlusal force distribution","Endodontically treated teeth","Chewing side preference","Endodontic restoration","Prospective study","2026-05-31",{"date":69,"type":42},{"date":71,"type":21},{"date":106,"type":21},"2030-10-31",{"name":108,"class":49},"Chulalongkorn University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":50},"100628771","clinical-performance-of-printed-hybrid-resin-in-indirect-restorations-100628771","NCT07465978","Clinical Performance of Printed Hybrid Resin in Indirect Restorations","Clinical Behavior of 3D-Printed VarseoSmile TriniQ Resin Versus CAD\u002FCAM Cerasmart in Indirect Restorations for Endodontically Treated Teeth: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age ≥18 years\n* Signed informed consent\n* Need to restore an endodontically treated molar with an indirect adhesive overlay\n* Physically and psychologically able to tolerate conventional restorative procedures\n* No high caries risk\n* No active periodontal disease\n* Natural antagonist tooth present\n* Need for full cuspal coverage restoration (overlay)\n* Remaining wall thickness \\\u003C3 mm in the endodontically treated tooth\n* Occlusal thickness of the restoration ≥1 mm\n* Willing and able to attend follow-up visits\n\nExclusion Criteria:\n\n* Poor oral hygiene\n* Uncontrolled parafunctional habits (e.g., bruxism)\n* High caries risk\n* Active periodontal disease\n* Active pulpal disease\n* Absence of natural antagonist tooth\n* Need for partial cuspal coverage restoration (inlay or onlay)\n* Insufficient interarch space for restoration\n* Teeth planned as abutments for removable or fixed prostheses\n* Known allergy to any materials used in the study",{"count":62,"type":21},[24],"This randomized clinical trial aims to evaluate the clinical performance of a 3D-printed hybrid resin (VarseoSmile TriniQ) used for indirect restorations in endodontically treated teeth, compared with a CAD\u002FCAM composite block (Cerasmart). In addition, two different luting protocols will be compared: a preheated microhybrid composite (Enamel Plus HRi) and a resin cement (RelyX Universal).\n\nSixty patients requiring restoration of an endodontically treated molar with an indirect adhesive overlay will be recruited at the University Dental Clinic of the Universitat Internacional de Catalunya (Barcelona, Spain). Participants will be randomly assigned to receive restorations fabricated either using the printed hybrid resin or the CAD\u002FCAM composite material. Each material group will be further divided according to the cementation technique used.\n\nAll restorations will be fabricated following a digital workflow that includes intraoral scanning, CAD design, and either additive manufacturing (3D printing) or subtractive milling. Adhesive luting procedures will be performed according to standardized clinical protocols.\n\nClinical evaluations will be performed at baseline, 3 months, 6 months, and 12 months, and annually thereafter. The clinical performance of the restorations will be assessed using modified United States Public Health Service (USPHS) criteria, including parameters such as marginal adaptation, contact points, color stability, wear, fracture occurrence, secondary caries, and patient comfort.\n\nThe results of this study will provide clinical evidence regarding the behavior of 3D-printed hybrid resin restorations and their potential use as an alternative to conventional CAD\u002FCAM composite materials for indirect restorations in endodontically treated teeth.",[27,120],"Indirect Restoration",[36,122,123,124,125,126,127,128],"CAD-CAM dentistry","3D printing dentistry","Hybrid resin restoration","Overlay restoration","Digital dentistry","VarseoSmile TriniQ","cerasmart","2026-03-11",{"date":131,"type":42},"2026-03-16",{"date":133,"type":42},"2024-12-13",{"date":135,"type":21},"2027-06-01",{"name":137,"class":49},"Universitat Internacional de Catalunya",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":4,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100589873","clinical-success-of-onlays-fabricated-with-different-types-of-resin-100589873","NCT06960070","Clinical Success of Onlays Fabricated With Different Types of Resin","One-year Clinical Evaluation of Onlay Restorations Fabricated With Three Different Additive Manufacturing Resins in Endodontically Treated Teeth: A Prospective Study","Inclusion Criteria:\n\n* Molar teeth that have undergone root canal treatment\n* Teeth with proximal defects located above the gingival margin\n* Defects limited to the occlusal surface and a single adjacent surface\n* Presence of an occlusal defect extending over one-third of the distance between the fissure and the cusp tip and involving one or more cusps\n* Presence of an opposing tooth or a fixed prosthetic restoration against the tooth to be restored\n* Presence of adjacent teeth next to the tooth to be restored\n\nExclusion Criteria:\n\n* Fractured or cracked teeth\n* Patients with temporomandibular joint disorders\n* Patients with bruxism (teeth grinding)\n* Molar teeth without an opposing tooth or fixed prosthetic restoration\n* Molar teeth without adjacent teeth\n* Vital teeth\n* Patients with a history of allergy to the components of the resins","84 Years",{"count":147,"type":21},48,[24],"Additive manufacturing, also referred to as \"3D printing\" or \"rapid prototyping,\" is defined as the process of joining materials layer by layer to create an object based on 3D model data. In this method, a digital data set is first created on a computer (computer-aided design, CAD) and then transferred to a 3D printer. The designed object is produced by printing it in successive layers.\n\nIn contrast, in subtractive manufacturing, restorations are produced by milling homogeneous blocks based on computer-designed models. Compared to subtractive manufacturing technology, additive manufacturing allows for the production of more complex, detailed, and larger structures with much less material waste and without excessive use of force.\n\nIt is thought that additive manufacturing has the potential to overcome the disadvantages of subtractive manufacturing. Over the past decade, global sales of industrial and personal 3D printers, materials, and services have increased by more than 33% annually.\n\nDue to its success in the production of surgical guides, temporary and permanent restorations, crowns and bridges, occlusal splints, frameworks, and orthodontic appliances, this technology has attracted significant interest in the field of dentistry.\n\nAlthough additive manufacturing has started to be used as an alternative to subtractive manufacturing in many applications, there is still a lack of information regarding the chemical composition, mechanical, and physical properties of printable resins. Moreover, clinical data on the use of these resins in permanent restorations are quite limited.\n\nTherefore, the aim of this study is to clinically evaluate and monitor for one year the performance of onlay restorations fabricated with three different resins of varying compositions in endodontically treated teeth.",[151],"Endodontically-Treated Teeth",[153,154,155,156,157],"onlay","endodontically -reated teeth","indirect restoration","additively manufactured","hybrid resin","2025-09-09",{"date":160,"type":42},"2025-09-10",{"date":162,"type":42},"2025-06-18",{"date":164,"type":21},"2027-06-18",{"name":166,"class":49},"Mersin University",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":86,"sex":16,"minAge":175,"maxAge":4,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":167},"100571206","digital-conventional-and-biomimetic-approaches-for-restoring-endodontically-treated-teeth-100571206","NCT06717230","Digital, Conventional, And Biomimetic Approaches for Restoring Endodontically Treated Teeth","Evaluating The Clinical Success And Patient Satisfaction of Digital, Conventional, And Biomimetic Approaches For Restoring Endodontically Treated Teeth: Randomized Controlled Trial.","Inclusion Criteria:\n\n* Endodontically-treated molar tooth with significant loss of tooth structure (both marginal ridges lost) requiring cuspal coverage.\n* Patients aged ≥15 years.\n* Controlled dental disease - no active caries or periodontal diseases\n* Patients will be available to be clinically reviewed up to 1 year\n\nExclusion Criteria:\n\n* Patients with poor oral hygiene.\n* Teeth with extensive cracks or fractures.\n* Deep subgingival margins (\\>0.5mm subgingival).\n* Non-restorable teeth.\n* Non-functional teeth (no opposing dentition).\n* Pocket probing depth \\> 3mm.\n* Mobility.\n* Patients with bruxism.","15 Years",{"count":177,"type":21},42,[24],"Endocrowns are preferred over the post-retained crown, especially at a young age for many reasons; they allow better gingival health and care due to placement of the supragingival margin, have greater fracture resistance limiting the risk for root fracture, thus improving the long-term prognosis of ETMs and has a superior ability to restore ETMs with short crowns, calcified root canals, and thin roots. Furthermore, using CAD\u002FCAM technology facilitates Endocrowns preparation making it simpler with less invasive techniques that can be prepared, fabricated, and cemented in a single visit. The high demand for permanent, esthetic, and conservative restorations has directed clinicians to restore permanent ETMs at a young age with Endo crowns as final coronal restorations.\n\nIn addition, Biomimetic dentistry leverages modern materials to replicate the biological and mechanical functions of natural teeth, presenting a distinct approach that minimizes the need for extensive tooth reduction and post-placement, particularly advantageous for endodontically treated teeth. Utilizing fiber-reinforced composites, this technique aims to strengthen the dentin-resin bond and evenly distribute occlusal forces across the restoration. By closely adhering to the intact tooth's natural contours and functionality, biomimetic restorations not only preserve more of the natural tooth structure but also reduce stress and strain within the restored tooth. This approach enhances longevity and minimizes the risk of bond failure, with any necessary repairs being straightforward and contributing to the restoration's sustainability. This study explores the application of fiber-reinforced composites within a biomimetic framework for restoring endodontically treated teeth, aiming to achieve durable and biologically compatible outcomes.",[27],"2024-12-10",{"date":183,"type":42},"2024-12-16",{"date":185,"type":42},"2024-09-01",{"date":187,"type":21},"2025-10-01",{"name":189,"class":49},"October University for Modern Sciences and Arts",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":208,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":50},"100560208","effect-of-photobiomodulation-on-pain-and-healing-of-the-vertical-releasing-incision-after-endodontic-microsurgery-100560208","NCT06574152","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery","Effect of Photobiomodulation on Pain and Healing of the Vertical Releasing Incision After Endodontic Microsurgery: A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) I or II.\n* At least one tooth will receive EMS.\n* Flap design that includes at least one VRI (triangular, rectangular, papilla base or submarginal rectangular).\n\nExclusion Criteria:\n\n* ASA III or IV.\n* Current heavy smokers (\\>10 cigarettes\u002Fday)\n* Uncontrolled diabetes (HbA1c ≥ 7%) or other uncontrolled systemic diseases that may comprise healing, such as vitamin C deficiency, neutrophil deficiencies, immunodeficiency syndromes, or leukemia.\n* Surgical access on the palatal surface.\n* Acute swelling or abscess present on the day of the surgery.\n* Any event or condition that would make continued participation in the study not in the best interest of the subject, as determined by the investigator.\n* Pregnancy.\n* Development of any medical condition that might affect the treatment and clinical outcomes, as determined by the investigator.\n* Initiation of any treatment or exposure that might affect therapy's healing, as determined by the investigator.",{"count":198,"type":21},40,[24],"The purpose of this study is to evaluate the effect of Photobiomodulation (PBM) in postoperative pain after endodontic microsurgery (EMS) in patients from the University of Texas Health Science Center at Houston, School of Dentistry Graduate Endodontic Clinic and to assess the soft tissue healing of the vertical releasing incision (VRI) after PBM",[202,27,203,204,205,206,207],"Apical Periodontitis","Endodontic Disease","Apical Cyst","Apical Granuloma","Periradicular Disease","Previous Endodontic Treatment",[209,210,211,212,213],"vertical incision","photobiomodulation","apicoectomy","endodontic microsurgery","laser therapy","2024-08-27",{"date":216,"type":42},"2024-08-29",{"date":218,"type":42},"2024-08-20",{"date":220,"type":21},"2025-07-31",{"name":222,"class":49},"The University of Texas Health Science Center, Houston",{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":86,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":241,"leadSponsor":243,"locationsCount":50},"100555916","effectiveness-of-gentlewave-system-in-endodontic-treatment-100555916","NCT06518304","Effectiveness of GentleWave System in Endodontic Treatment","Randomized Controlled Trial: Effectiveness of GentleWave System in Endodontic Treatment and Its Impact on Reducing Post- Operative Pain.","Inclusion Criteria:\n\n* Male and female patients from 18 years age or older (maximum of 80 years of age), both genders.\n* The patients in need of an endodontic intervention.\n* All dental groups in both arches were eligible.\n* Patients who do or do not experience symptoms after the endodontic intervention.\n* Patient-signed informed consent\u002Fassent form\n\nExclusion Criteria:\n\n* Patients\\\u003C 18 years old.\n* fractured teeth.\n* Patients who were recommended extraction after the endodontic evaluation.","80 Years",{"count":90,"type":21},[24],"This study aims to evaluate the efficacy of the GentleWave® System compared to conventional methods in reducing postoperative pain in patients with necrotic pulp or requiring endodontic retreatment.",[235,236,27],"Pain, Postoperative","Root Canal Infection","2024-08-19",{"date":239,"type":42},"2024-08-21",{"date":218,"type":21},{"date":242,"type":21},"2024-09-20",{"name":244,"class":49},"University of Salamanca",{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":88,"enrollmentInfo":252,"targetDuration":4,"studyType":22,"phases":254,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100557548","shade-matching-and-patient-satisfaction-of-yttria-stabilized-multilayered-zirconia-and-lithium-disilicate-restorations-100557548","NCT06539546","Shade Matching and Patient Satisfaction of Yttria Stabilized Multilayered Zirconia and Lithium Disilicate Restorations","Shade Matching and Patient Satisfaction of Yttria Stabilized Multilayered Zirconia and Lithium Disilicate Restorations: a Randomized Controlled Clinical Trial","Inclusion criteria:\n\n1. Age range of the patients from 20-60 years old; able to read and sign the informed consent document, illiterate patient will be avoided.\n2. Patients able physically and psychologically to tolerate conventional restorative procedures.\n3. Patients with no active periodontal or pulpal diseases, having teeth with good restorations.\n4. Patients with teeth problems indicated for full coverage restoration (coronal fracture where partial coverage would lack retention, malposed or malformed teeth).\n5. Patients with root canal treated teeth requiring full coverage restorations.\n6. Patients willing to return for follow-up examinations and evaluation.\n\nExclusion Criteria:\n\n1. Patients in the growth stage with partially erupted teeth.\n2. Patients with poor oral hygiene and motivation.\n3. Patients with psychiatric problems or unrealistic expectations (patient that has phobia from dental treatments or needle bunch).\n4. Patients suffer from parafunctional habits.",{"count":253,"type":21},22,[24],"The aim of the study is to determine whether Yttria stabilized multilayered zirconia restorations will differ from lithium disilicate restorations in shade matching and patient satisfaction in patients requiring full coverage restorations.",[257,27],"Mutilated Teeth",[259,260,261,262],"Shade match","patient satisfaction","Yttria stabilized multilayered zirconia","Lithium disilicate","2024-08-07",{"date":265,"type":42},"2024-08-09",{"date":185,"type":21},{"date":268,"type":21},"2025-09-01",{"name":77,"class":49},{"id":271,"slug":272,"hasResults":11,"nctId":273,"briefTitle":274,"officialTitle":275,"acronym":4,"eligibilityCriteria":276,"healthyVolunteers":86,"sex":16,"minAge":277,"maxAge":88,"enrollmentInfo":278,"targetDuration":4,"studyType":22,"phases":280,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":50},"100557061","antimicrobial-efficacy-of-nano-based-icm-on-ef-100557061","NCT06533215","Antimicrobial Efficacy of Nano-Based ICM on E.F","Antimicrobial Efficacy of Nano-Based Intracanal Medications on Enterococcus Faecalis","Inclusion Criteria:\n\n* Single rooted, single canal premolar teeth.\n* Teeth indicated for non-surgical root canal retreatment.\n* Teeth have signs and\u002For symptoms of post-treatment disease manifested by recurrent acute and\u002For chronic periapical abscess.\n* Teeth have clinical signs and symptoms of endodontic failure as sensitivity to percussion, pain, swelling or fistula.\n* Teeth with radiographic features of endodontic failure as persistent periapical lesion or widening of periodontal ligament.\n* Symptomatic or asymptomatic teeth with short root canal filling indicated for prosthetic restoration\n\nExclusion Criteria:\n\n* Patients with any systemic diseases.\n* Pregnant or lactating patients.\n* Immunocompromised patients.\n* Non-restorable tooth.\n* Calcified root canal.\n* Teeth with root fracture.\n* Teeth with periodontal pocket deeper than 4mm.\n* Teeth have procedural error like ledge, broken instrument, or perforation","19 Years",{"count":279,"type":21},30,[24],"This in-vivo study aims to evaluate the antimicrobial effect of nano based intracanal medications (Triple antibiotic-loaded chitosan nanoparticles and chlorohexidine loaded by silver nanoparticles) on Enterococcus faecalis count reduction in secondary endodontic infection cases.",[283,27,203],"Enterococcus Faecalis Infection",[285,286,287],"intracanal medication","Enterococcus Faecalis","secondary endodontic infection cases.","2024-07-30",{"date":290,"type":42},"2024-08-01",{"date":292,"type":42},"2024-01-02",{"date":294,"type":21},"2025-03-02",{"name":296,"class":49},"Tanta University",{"id":298,"slug":299,"hasResults":11,"nctId":300,"briefTitle":301,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":86,"sex":16,"minAge":87,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":22,"phases":307,"briefSummary":308,"conditions":309,"keywords":312,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":315,"lastUpdatePostDateStruct":316,"startDateStruct":318,"completionDateStruct":319,"leadSponsor":320,"locationsCount":4},"100550735","no-code-artificial-intelligence-to-detect-radiographic-features-associated-with-unsatisfactory-endodontic-treatment-100550735","NCT06450938","No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Treatment","Implementing a Corrective Annotation No Code Artificial Intelligence-based Software to Detect Several Radiographic Features Associated With Unsatisfactory Endodontic Treatment: A Randomized Controlled Trial","Inclusion Criteria:\n\n1.Being a last year dental student at the university of Copenhagen\n\nExclusion Criteria:\n\n1. Having any previous AI-related experiences\n2. Not accepting to sign the informed consent","40 Years",{"count":306,"type":21},80,[24],"Developing neural network-based models for image analysis can be time-consuming, requiring dataset design and model training. No-code AI platforms allow users to annotate object features without coding. Corrective annotation, a \"human-in-the-loop\" approach, refines AI segmentations iteratively. Dentistry has seen success with no-code AI for segmenting dental restorations. This study aims to assess radiographic features related to root canal treatment quality using a \"human-in-the-loop\" approach.",[27,310,311,202],"Endodontic Underfill","Endodontic Overfill",[313,314],"Artificial Intelligence","Endodontic treatment","2024-06-24",{"date":317,"type":42},"2024-06-25",{"date":288,"type":21},{"date":133,"type":21},{"name":321,"class":49},"University of Copenhagen",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":86,"sex":16,"minAge":17,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":22,"phases":332,"briefSummary":333,"conditions":334,"keywords":335,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":50},"100403106","outcome-of-endodontic-treatment-and-retreatment-with-a-bioceramic-sealer-100403106","NCT04528979","Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer","The Outcome of Endodontic Treatment and Retreatment With a Bioceramic Sealer: A Prospective Randomized Controlled Clinical Study","Inclusion Criteria:\n\n* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.\n* Understands and is willing to comply with all study procedures and restrictions.\n* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.\n* Diagnosis of irreversible pulpitis or apical symptomatic \u002F asymptomatic periodontitis.\n* Retreatment cases due to an endodontic failure.\n* Single or bi-radicular teeth.\n\nExclusion Criteria:\n\n* General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.\n* Specific: root resorption, root fractures, impossibility of restoration and cases were primary or secondary root canal treatment is not the treatment of choice.","75 Years",{"count":331,"type":21},220,[24],"This study is a prospective randomized controlled study of patients who come to the University. The aim is to evaluate the success rate of treatment and retreatment of canals using BioRoot ™ RCS cement compared with AH Plus up to 6 years of follow-up. The null hypothesis is that there will be no statistically significant differences in rates of successful treatment of root canals filled with BioRoot ™ RCS compared to gutta-percha and AH Plus sealer.",[203,27],[336,337,338,339],"Primary root canal treatment","Secondary root canal treatment","Outcome","Root canal sealer","2020-08-27",{"date":342,"type":42},"2020-08-31",{"date":344,"type":42},"2019-09-20",{"date":346,"type":21},"2027-01",{"name":348,"class":49},"Juan Gonzalo Olivieri",{"id":350,"slug":351,"hasResults":11,"nctId":352,"briefTitle":353,"officialTitle":354,"acronym":4,"eligibilityCriteria":355,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":329,"enrollmentInfo":356,"targetDuration":4,"studyType":22,"phases":358,"briefSummary":359,"conditions":360,"keywords":361,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":50},"100403008","outcome-of-endodontic-retreatment-in-one-or-two-visits-100403008","NCT04527705","Outcome of Endodontic Retreatment in One or Two Visits","Clinical and Radiographic Outcome of Endodontic Retreatment in One or Two Visits: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.\n* Understands and is willing to comply with all study procedures and restrictions.\n* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.\n* Retreatment cases due to an endodontic failure.\n* Diagnosis of apical periodontitis.\n* Single or bi-radicular teeth.\n\nExclusion Criteria:\n\n* General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.\n* Specific: root resorption, root fractures, impossibility of restoration and cases were secondary root canal treatment is not the treatment of choice.",{"count":357,"type":21},110,[24],"This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease. The aim is to evaluate the success rate of non-surgical retreatment performed in one compared to two visit treatment up to 10 years of follow-up. The null hypothesis is that there will be no statistically significant differences in rates of success, when performing root canal non-surgical retreatment in one or two visits.",[203,27,236],[336,337,362,338],"Periapical healing","2020-08-23",{"date":365,"type":42},"2020-08-26",{"date":367,"type":42},"2018-09-20",{"date":369,"type":21},"2031-07-20",{"name":137,"class":49}]