[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endometriosis-of-colon\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endometriosis-of-colon":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,62],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":4},"100632699","intraoperative-sono-assessment-in-deep-endometriosis-100632699",false,"NCT07517081","Intraoperative Sono-assessment In Deep Endometriosis","Intraoperative Ultrasound in Rectal Shaving for Deep Infiltrating Endometriosis: Evaluation of Residual Disease, Bowel Wall Thickness, and Clinical Outcomes","INSIDE","Inclusion Criteria:\n\n* Female patients aged 20-60 years\n* Rectal or sigmoid nodule with muscularis propria infiltration ≥1 mm and \\\u003C20 mm (assessed by expert transvaginal ultrasound)\n* Indication for surgery agreed upon with the patient\n* Written informed consent\n\nExclusion Criteria:\n\n* Previous major bowel surgery or primary indication for bowel resection\n* Inflammatory bowel disease, malignancy, or severe pelvic pathology\n* Inability to complete study questionnaires","FEMALE","20 Years","60 Years",{"count":21,"type":22},57,"ESTIMATED","OBSERVATIONAL","Deep infiltrating endometriosis (DIE) involving the bowel, particularly the rectosigmoid region, is associated with significant gastrointestinal symptoms and impaired quality of life. Rectal shaving is a conservative surgical technique aimed at removing endometriotic lesions while preserving bowel integrity; however, it may result in residual disease or excessive thinning of the bowel wall, potentially leading to recurrence or complications.\n\nIntraoperative ultrasound (IOUS) allows real-time assessment of residual nodule thickness and bowel wall thickness after shaving. This prospective observational study aims to evaluate the relationship between intraoperative ultrasound measurements and postoperative clinical outcomes, including gastrointestinal symptoms and quality of life.\n\nThe study also seeks to identify ultrasound cut-off values that may guide intraoperative surgical decision-making and optimize the balance between radicality and safety.",[26,27,28,29,30],"Endometriosis","Endometriosis-related Pain","Pelvic Pain Syndrome","Endometriosis, Rectum","Endometriosis of Colon","NOT_YET_RECRUITING","2026-04-01",{"date":34,"type":35},"2026-04-08","ACTUAL",{"date":37,"type":22},"2026-04-07",{"date":39,"type":22},"2028-07-07",{"name":41,"class":42},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":60,"leadSponsor":61,"locationsCount":4},"100632697","intraoperative-vs-transvaginal-ultrasound-in-rectosigmoid-endometriosis-100632697","NCT07517055","Intraoperative vs Transvaginal Ultrasound in Rectosigmoid Endometriosis","Comparative Study of Transvaginal and Intraoperative Ultrasound in Rectosigmoid Deep Infiltrating Endometriosis","INTREND","Inclusion Criteria:\n\n* Women aged 18 to 55 years\n* Clinical and\u002For imaging suspicion of rectal or rectosigmoid deep infiltrating endometriosis (DIE)\n* Indication for laparoscopic or robotic surgery for DIE\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Previous bowel resection for deep infiltrating endometriosis\n* Active inflammatory bowel disease\n* Pregnancy\n* Technical inability to perform transvaginal or intraoperative ultrasound\n* Refusal or withdrawal of informed consent","18 Years","55 Years",{"count":54,"type":22},98,"Deep infiltrating endometriosis (DIE) of the rectum and rectosigmoid colon represents one of the most severe forms of endometriosis and often requires surgical management when symptomatic and unresponsive to medical therapy. Accurate preoperative assessment of lesion size, extent, and depth of bowel infiltration is essential to guide surgical planning and minimize complications. Transvaginal ultrasound (TVUS) is the first-line imaging technique for the diagnosis of pelvic endometriosis and has high diagnostic accuracy for detecting rectosigmoid lesions. However, its ability to precisely assess infiltration depth and guide the choice of surgical technique may be limited by anatomical distortion and technical factors. Intraoperative ultrasound (IO-US) is a real-time imaging modality that can be performed during laparoscopic surgery after adhesiolysis, allowing direct evaluation of bowel lesions. It may improve the assessment of lesion characteristics and support intraoperative decision-making, potentially reducing unnecessary bowel resections. This prospective single-center comparative study aims to evaluate the agreement between preoperative TVUS and intraoperative ultrasound in measuring rectal and rectosigmoid DIE nodules. Secondary objectives include assessing measurement differences, identifying factors associated with discordance, and evaluating the reproducibility of ultrasound measurements. The findings of this study may improve preoperative counseling, optimize surgical planning, and support the integration of intraoperative ultrasound into the management of bowel endometriosis.",[26,30,57,29],"Endometriosis; Bowel",{"date":34,"type":35},{"date":37,"type":22},{"date":39,"type":22},{"name":41,"class":42},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":73,"studyType":23,"phases":4,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":85,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":95},"100491295","the-cost-effectiveness-of-surgical-excision-of-colorectal-endometriosis-compared-to-art-treatment-trajectory-100491295","NCT05677269","The (Cost-)Effectiveness of Surgical Excision of Colorectal Endometriosis Compared to ART Treatment Trajectory","TOSCA","Inclusion Criteria:\n\n* Colorectal endometriosis defined as endometriosis involving the (colo)rectum:\n\n  #Enzian classification score C1,C2,C3 (C=rectum) or FI (F=far locations, I=sigmoid colon) detected with ultrasound or MRI;\n* Women in a heterosexual or in a same-sex relationship;\n* The patient has an active wish to conceive and experiences at least one of the following criteria:\n\n  * At least one year of non-conception (either spontaneous of after intra uterine inseminations)\n  * Inability to have timed intercourse because of pain (dyspareunia and\u002For chronic pelvic pain)\n  * Severe complaints (expectant management is not acceptable (anymore)\n* The patients has an indication for IVF\u002FICSI according to Dutch guidelines (Werkgroep netwerkrichtlijn, december 2010);\n\n  * failed intra uterine insemination\n  * male factor subfertility (oligoasthenoteratozoospermia defined as VCM \\\u003C1 million)\n  * bilateral tubal pathology (e.g. bilateral hydrosalpinx, bilateral tubal occlusion)\n  * age \\> 38 years and (unexplained) subfertility\n  * severe endometriosis in case of subfertility\n* The patient is faces the choice between IVF\u002FICSI or laparoscopic (colorectal) endometriosis or is on the waiting list for a respective treatment at T=0 (at the beginning of the treatment trajectory), T=1 (after one unsuccessful IVF\u002FICSI cycle) or T=2 (after 2 unsuccessful IVF\u002FICSI cycles)\n\nExclusion Criteria:\n\n* Patients with deep endometriosis without colorectal involvement;\n* Patients who conceive spontaneously prior to intervention;\n* Patients requiring surgery on short notice and therefore unable to opt for IVF\u002FICSI (e.g. in case of unilateral or bilateral hydronephrosis, severe bowel stenosis and suspicion of an impending ileus);\n* Patients with a contra-indication for IVF\u002FICSI (e.g. diminished ovarian reserve (premature ovarian failure) (AMH (when available) \\\u003Cp10 adjusted for age), untreated congenital uterine abnormalities, maltreated\u002Funtreated systemic or malignant disease or severe risk factors for oocyte aspiration);\n* Patients diagnosed with other diseases causing infertility (e.g. recurrent miscarriages, antiphospholipid syndrome);\n* Not able to read and understand Dutch or English.","21 Years","40 Years",{"count":72,"type":22},339,"40 Months","To goal of this study is to determine whether laparoscopic resection of colorectal endometriosis results in an increased cumulative live birth rate (CLBR) both spontaneous and after ART (including in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), and better patient reported outcome measures (PROMs) compared to an IVF\u002FICSI treatment trajectory.",[29,30,76],"Subfertility, Female",[78,79,80,81,82,83,84],"Colorectal endometriosis","Subfertility","Surgery","In vitro fertilisation","Live birth rate","Quality of life","Cost-effectiveness","RECRUITING","2024-11-19",{"date":88,"type":35},"2024-11-21",{"date":90,"type":35},"2023-02-17",{"date":92,"type":22},"2029-01-01",{"name":94,"class":42},"Leiden University Medical Center",10]