[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endonasal-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endonasal-surgery":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100634971","in-vivo-imaging-of-the-olfactory-epithelium-using-confocal-laser-endomicroscopy-100634971",false,"NCT07546617","In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy","In Vivo Imaging of Olfactory Epithelium in Humans With Olfactory Impairment Using Confocal Laser Endomicroscopy","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Undergoing endoscopic sinus or endonasal skull base surgery while under - general anesthesia where the nasal turbinate is accessible\n* Able to complete study questionnaires and psychophysical smell testing\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to fluorescein\n* Pregnancy\n* Medical instability precluding participation\n* Severe anatomic obstruction preventing safe access to the olfactory cleft and nasal turbinate\n* Any other safety concern identified by the investigator","ALL","18 Years",{"count":19,"type":20},36,"ESTIMATED","OBSERVATIONAL","This research is being done to better characterize the part of the nose that helps us smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying structures directly. In this study, we will use a special microscope (Confocal Laser Endomicroscopy (CLE)), originally developed for brain tissue, to look at the part of the nose that helps to detects smell. We hope to identify the tiny structures in that area and see how they might be different in people who have smell loss compared to those who do not.",[24,25,26],"Endonasal Surgery","Endoscopic Sinus Surgery","Olfactory Dysfunction",[28,25,29,30,26],"Confocal Laser Endomicroscopy","Smell Loss","Endonasal Skull Base Surgery","NOT_YET_RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-23","ACTUAL",{"date":37,"type":20},"2026-07-01",{"date":39,"type":20},"2027-07-31",{"name":41,"class":42},"Dartmouth-Hitchcock Medical Center","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100634446","phase-2-efficacy-and-safety-evaluation-of-absorbable-and-moldable-skull-base-support-plates-in-extended-endoscopic-endonasal-transsphenoidal-surgery-a-prospective-randomized-controlled-study-100634446","NCT07539792","Efficacy and Safety Evaluation of Absorbable and Moldable Skull Base Support Plates in Extended Endoscopic Endonasal Transsphenoidal Surgery: A Prospective, Randomized, Controlled Study","EEEA-AMSBP","Inclusion Criteria:\n\n1. Aged 1-80 years, regardless of gender;\n2. Diagnosed with sellar region tumors confirmed by clinical symptoms, endocrine examinations, and imaging data;\n3. Planned to undergo extended endoscopic endonasal transsphenoidal approach surgery as determined by departmental discussion;\n4. Karnofsky Performance Status score ≥ 70, with an expected survival period ≥ 24 months;\n5. Laboratory indicators (such as liver and kidney function, blood routine, etc.) within the normal range or controllable range;\n6. Sign the informed consent form and are willing to participate in the study.\n\nExclusion Criteria:\n\n1. Patients with other concurrent intracranial tumors or severe brain lesions;\n2. Patients scheduled to undergo craniotomy or non-extended endoscopic endonasal transsphenoidal surgery;\n3. Patients with uncontrolled severe heart, lung, kidney, or liver diseases;\n4. Pregnant or lactating women;\n5. Patients who have previously received radiotherapy or chemotherapy;\n6. Patients with active nasal infections, inflammation, or severe nasal diseases;\n7. Patients with a history of severe allergies to drugs or synthetic materials;\n8. Patients with extensive skull base bone destruction evaluated by preoperative imaging, for whom it is estimated that support materials cannot be used during surgery;\n9. Patients with mental illness or cognitive impairment who are unable to complete follow-up or understand the purpose of the study.","1 Year","80 Years",{"count":54,"type":20},126,"INTERVENTIONAL",[57],"PHASE2","Primary objective: To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the incidence of cerebrospinal fluid (CSF) rhinorrhea within 1 month after surgery.\n\nSecondary objectives:\n\n1. To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the incidence of intracranial infection within 1 months after surgery;\n2. To evaluate the effect of absorbable and moldable skull base support plates used in extended endoscopic endonasal transsphenoidal surgery on the duration of the surgery and length of postoperative hospital stay;\n3. To monitor and evaluate the safety of absorbable and moldable skull base support plates, especially the occurrence of nasal complications.",[60,24,61],"Sellar Tumor","Csf Leakage",[60,63,64,65],"Extended Endoscopic Endonasal Transsphenoidal Surgery","Cerebrospinal Fluid Rhinorrhea","Skull Base Reconstruction","RECRUITING","2026-04-13",{"date":69,"type":35},"2026-04-20",{"date":71,"type":35},"2026-04-01",{"date":73,"type":20},"2030-02-28",{"name":75,"class":42},"Nanfang Hospital, Southern Medical University",8,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":55,"phases":86,"briefSummary":88,"conditions":89,"keywords":97,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100562265","effect-of-passive-music-therapy-via-an-app-on-anxiety-prevention-in-ent-surgery-100562265","NCT06600919","Effect of Passive Music Therapy Via an App on Anxiety Prevention in ENT Surgery","MUSICORL","Inclusion Criteria:\n\n* Male or female, aged 18 years or older\n* Patient has signed informed consent\n* Patient scheduled to undergo ENT surgery (cervical, endonasal, otologic, oropharyngeal-laryngeal) at the participating facility\n* Patient is affiliated with or a beneficiary of a social security system\n\nExclusion Criteria:\n\n* Refusal to provide consent\n* Patient with severe bilateral hearing loss (\\> 70 dB HL)\n* Patient unable to read, write, or understand French\n* Vulnerable patient as defined by Article L1121-6 of the French Public Health Code (CSP)\n* Adult patient under guardianship, curatorship, or judicial protection\n* Patient unable to personally provide consent as per Article L1121-8 of the CSP or an adult under legal protection\n* Pregnant or breastfeeding women as per Article L1121-5 of the CSP\n* Patient who has already participated in the current study",{"count":85,"type":20},500,[87],"NA","Music therapy is a controlled method of listening to music, utilizing its physiological, psychological, and emotional effects on humans during the treatment of illness or trauma. It is considered active when it involves playing musical instruments and passive when it involves listening to music (via headphones, television, stereo systems, etc.).\n\nThe benefits of this technique in treating chronic pain (i.e., pain lasting several weeks, such as chronic back pain, osteoarthritis, etc.) have been demonstrated. Numerous studies have also examined the effect of music therapy on acute postoperative pain and anxiety related to surgical interventions. These studies suggest, though without conclusive evidence, that a single session of music therapy just before entering the operating room may reduce postoperative pain and anxiety.\n\nHowever, all of these studies were limited by relatively small sample sizes (a few hundred patients), leaving some scientific uncertainty regarding the effectiveness of music therapy in the context of surgical interventions.\n\nThis research will therefore evaluate the impact of preoperative passive music therapy on perioperative anxiety and postoperative pain, with a larger number of patients included in the study than has been previously reported in the scientific literature.\n\nThe primary objective of this study is to assess the impact of preoperative passive music therapy on perioperative anxiety in patients undergoing ENT surgery. MUSICORL is an interventional, randomized study (the assignment to receive or not receive music therapy will be determined by randomization) with two parallel arms. This is a single-center study, conducted at a single French site: Clinique Saint Vincent. A total of 500 subjects will participate in this study. Your participation will last for 2 days; the overall study duration will be 27 months.\n\nTo participate in this research, you must be affiliated with a social security system, be over 18 years old, have signed informed consent, and be scheduled for ENT surgery (cervical, endonasal, otologic, oropharyngeal-laryngeal).",[90,24,91,92,93,94,95,96],"Cervical Surgery","Otologic Disease","Oropharyngeal Disease","Laryngeal Disease","ENT Surgery","Musical Therapy","Laryngeal Surgery",[98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116],"Music therapy","Preoperative anxiety","ENT surgery","Passive music therapy","Randomized controlled trial","Perioperative anxiety","Postoperative pain","Patient care improvement","Clinical research","Music Care® application","Music Care®","Surgical intervention","Anxiety prevention","Music therapy session","Cervical surgery","Endonasal surgery","Otologic surgery","Oropharyngolaryngeal surgery","Musical therapy","2026-03-17",{"date":119,"type":35},"2026-03-18",{"date":121,"type":35},"2024-11-15",{"date":123,"type":20},"2027-02",{"name":125,"class":42},"Clinique Saint-Vincent"]