[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endoscopic-retrograde-cholangiopancreatography-ercp\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endoscopic-retrograde-cholangiopancreatography-ercp":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100643045","opioid-free-versus-opioid-based-sedation-for-endoscopic-procedures-100643045",false,"NCT07649746","Opioid-Free Versus Opioid-Based Sedation for Endoscopic Procedures","Evaluation of an Opioid-Free Approach in Sedation Method Selection in Endoscopy Units: A Prospective Randomized Observational Double-Blind Comparison of Dexmedetomidine (Opioid-Free) and Remifentanil-Dexmedetomidine (Opioid-Based) Combination","Inclusion Criteria:\n\n* Age 18 to 85 years\n* ASA physical status I-III\n* Scheduled for ERCP, gastroscopy, or colonoscopy\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Inability to communicate\n* Alcohol or substance abuse\n* Neuropsychiatric disease\n* Severe respiratory failure\n* Severe heart failure\n* Pregnancy\n* Body mass index (BMI) \\>30 kg\u002Fm²\n* Hearing impairment\n* History of allergy to study medications\n* Requirement for orotracheal intubation or general anesthesia\n* Procedures lasting less than 20 minutes","ALL","18 Years","85 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will compare two different sedation approaches used during gastroscopy, colonoscopy, and endoscopic retrograde cholangiopancreatography (ERCP). One group will receive dexmedetomidine alone (opioid-free sedation), while the other group will receive dexmedetomidine combined with remifentanil (opioid-based sedation).\n\nThe purpose of the study is to determine whether an opioid-free sedation approach can reduce opioid-related adverse symptoms, such as nausea, vomiting, dizziness, drowsiness, dry mouth, headache, and fatigue. The study will also evaluate quality of recovery, patient and healthcare staff satisfaction, hemodynamic effects, complications, and time to discharge after the procedure.",[27,28,29,30],"Sedation","Endoscopy","Colonoscopy","Endoscopic Retrograde Cholangiopancreatography (ERCP)",[32,33,34,27,28],"Dexmedetomidine","Opioid-Free Sedation","Remifentanil","NOT_YET_RECRUITING","2026-06-10",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":21},"2026-06",{"date":43,"type":21},"2028-02",{"name":45,"class":46},"Bakirkoy Dr. Sadi Konuk Research and Training Hospital","OTHER_GOV",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100637179","a-22-factorial-randomized-controlled-trial-for-ercp-100637179","NCT07584902","A 2×2 Factorial Randomized Controlled Trial for ERCP","Effects of Propofol Versus Ciprofol and Sufentanil Versus Es-ketamine on Intraoperative Desaturation and Hypotension in Elderly Patients Undergoing ERCP: A 2×2 Factorial Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 60 years old.\n* ASA II-III level.\n* BMI\\\u003C30kg\u002Fm2.\n* Patients who require elective therapeutic ERCP.\n* Voluntarily participate in this study and sign an informed consent form. If the subject is unable to read and sign the informed consent form due to reasons such as lack of capacity, their guardian needs to act as a proxy for the informed process and sign the informed consent form. If the subject lacks the ability to read the informed consent form (such as illiterate subjects), a witness is required to witness the informed process and sign the informed consent form.\n\nExclusion Criteria:\n\n* Previous anatomical changes in the gastrointestinal tract, delayed gastric emptying, and gastric outlet obstruction.\n* Coagulation dysfunction or tendency towards nosebleeds.\n* Combined severe heart disease (coronary heart disease, myocardial infarction, congestive heart failure, left ventricular ejection fraction\\\u003C40%, tachyarrhythmia)\n* Have a history of allergies to relevant anesthetic drugs in the past.\n* Severe pulmonary diseases (severe asthma attacks, respiratory failure, severe chronic obstructive pulmonary disease, severe interstitial lung disease, large pleural effusion, severe pulmonary arterial hypertension, etc.).\n* Existing upper respiratory tract infection (within one week).\n* Uncontrolled severe hypertension.\n* Patients with increased intracranial pressure; Cerebral hemorrhage, intracranial space occupying lesions, acute phase of traumatic brain injury.\n* Glaucoma and significant increase in intraocular pressure.\n* Untreated or inadequately treated patients with hyperthyroidism.\n* Serious liver and kidney diseases.\n* Known neurological and psychiatric disorders (Parkinson's disease, epilepsy, or schizophrenia).\n* Difficult airway: The anesthesiologist assessed the presence of difficult airway before surgery.\n* Vulnerable groups other than the elderly\u002Filliterate, including those with mental illness, cognitive impairment, critically ill patients, pregnant women, etc.","60 Years",{"count":56,"type":21},236,[24],"To investigate the effects of propofol vs. cyclopropofol and sufentanil vs. esketamine on intraoperative hypoxemia and hypotension in elderly patients undergoing ERCP, as well as the interaction between these two factors.",[60,30],"Biliary and Pancreatic Diseases","2026-05-07",{"date":63,"type":39},"2026-05-13",{"date":65,"type":21},"2026-04-27",{"date":67,"type":21},"2026-10-31",{"name":69,"class":70},"Gang Chen","OTHER",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},"100594272","effect-of-deep-analgosedation-vs-endotracheal-intubation-general-anesthesia-on-on-perioperative-sedation-related-adverse-events-in-elderly-ercp-patients-100594272","NCT07017283","Effect of Deep Analgosedation vs. Endotracheal Intubation General Anesthesia on on Perioperative Sedation Related Adverse Events in Elderly ERCP Patients","Effect of Deep Analgosedation vs. Endotracheal Intubation General Anesthesia on Perioperative Respiratory Adverse Events in Elderly ERCP Patients: An Open-Label Randomized Controlled Trial","Inclusion criteria：\n\n1. Aged 60 and above;\n2. ASA physical status≤III;\n3. Patients who scheduled for elective therapeutic ERCP (ERCP complexity grading system;\n4. Willing to provide informed consent (or by legal guardian\u002Fwitness if applicable).\n\nExclusion criteria：\n\n1: Altered gastrointestinal anatomy, delayed gastric emptying, or gastric outlet obstruction； 2.Coagulopathy or epistaxis tendency; 3.Cardiac diseases (e.g., coronary artery disease, heart failure, arrhythmias); 4.Pulmonary diseases (e.g., asthma, COPD); 5.Prior hypersensitivity to anesthetic agents; 6.Active upper respiratory infection； 7.Severe liver and kidney diseases； 8.Difficult airway: Preoperative anesthesiologist assessment of difficult airway； 9.Psychiatric disorders, cognitive impairment, critical illness, or pregnancy.",{"count":79,"type":21},170,[24],"This study aims to investigate the impact of deep analgosedation versus endotracheal intubation general anesthesia on perioperative sedation related adverse events in elderly ERCP patients.",[60,30],"RECRUITING","2025-12-10",{"date":86,"type":39},"2025-12-18",{"date":88,"type":39},"2025-11-10",{"date":90,"type":21},"2026-02-28",{"name":69,"class":70},1]