[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endoscopic-sinus-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endoscopic-sinus-surgery":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100634971","in-vivo-imaging-of-the-olfactory-epithelium-using-confocal-laser-endomicroscopy-100634971",false,"NCT07546617","In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy","In Vivo Imaging of Olfactory Epithelium in Humans With Olfactory Impairment Using Confocal Laser Endomicroscopy","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Undergoing endoscopic sinus or endonasal skull base surgery while under - general anesthesia where the nasal turbinate is accessible\n* Able to complete study questionnaires and psychophysical smell testing\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to fluorescein\n* Pregnancy\n* Medical instability precluding participation\n* Severe anatomic obstruction preventing safe access to the olfactory cleft and nasal turbinate\n* Any other safety concern identified by the investigator","ALL","18 Years",{"count":19,"type":20},36,"ESTIMATED","OBSERVATIONAL","This research is being done to better characterize the part of the nose that helps us smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying structures directly. In this study, we will use a special microscope (Confocal Laser Endomicroscopy (CLE)), originally developed for brain tissue, to look at the part of the nose that helps to detects smell. We hope to identify the tiny structures in that area and see how they might be different in people who have smell loss compared to those who do not.",[24,25,26],"Endonasal Surgery","Endoscopic Sinus Surgery","Olfactory Dysfunction",[28,25,29,30,26],"Confocal Laser Endomicroscopy","Smell Loss","Endonasal Skull Base Surgery","NOT_YET_RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-23","ACTUAL",{"date":37,"type":20},"2026-07-01",{"date":39,"type":20},"2027-07-31",{"name":41,"class":42},"Dartmouth-Hitchcock Medical Center","OTHER"]