[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endoscopic-ultrasound-guided-radiofrequency-ablation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endoscopic-ultrasound-guided-radiofrequency-ablation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100634161","endoscopic-ultrasound-guided-radiofrequency-ablation-for-pancreatic-cystic-neoplasms-and-pancreatic-neuroendocrine-tumors-100634161",false,"NCT07536087","Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Pancreatic Neuroendocrine Tumors","Endoscopic Ultrasound-Guided Radiofrequency Ablation for Pancreatic Cystic Neoplasms and Neuroendocrine Tumors","Inclusion Criteria:\n\n* Consensual indication to EUS-guided RFA treatment made in a multidisciplinary team\n* Capability of giving informed consent PCN Inoperability or refusal of surgery\n* Branch duct IPMN (BD-IPMN) with worrisome features:\n* Jaundice\n* High grade dysplasia or cancer\n* Solid mass\u002Fnodule \\> 5mm\n* Main pancreatic duct dilation \\> 10mm Or at least one (patients without comorbidities) or at least two (patient with comorbidities) of the following risk features:\n* CA 19-9\\> 37 U\u002Fml\n* Increase in size \\> 5mm\u002Fyear\n* Dilation of the main pancreatic duct between 5-10mm\n* Size ≥ 40mm\n* Symptoms (new onset of diabetes, acute pancreatitis)\n* Nodule \\\u003C 5mm Pancreatic NET\n* Size \\\u003C 2 cm\n* Histological proof in non-functional lesions\u002Fhistological proof or clinical proof in functional lesions\n* 68Ga-DOTATATE PET\u002FCT positive for a pancreatic lesion and negative for lymph nodes, liver, and other distant metastases\n* G1 or G2 (\\\u003C5 %) histology\n\nExclusion Criteria:\n\n* Known bleeding disorder that cannot be sufficiently corrected with medication\n* Use of anticoagulants that cannot be discontinued\n* Physical and\u002For psychological inability to understand the aims of the research and to adequately cooperate\n* Pregnancy\n* Inability to sign the informed consent","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","The primary aim of this study is to evaluate the technical feasibility and effectiveness of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) in the treatment of pancreatic cystic neoplasms (PCNs) and pancreatic neuroendocrine tumors (pNETs) in patients who are not suitable candidates for surgical treatment or who refuse surgery.\n\nEUS-RFA, as a minimally invasive therapeutic option, may potentially reduce the need for intensive imaging surveillance, prevent further progression of these lesions, and serve as a bridging therapy in selected patients for whom surgical intervention may be considered in the future. At the same time, EUS-RFA could contribute to reducing overtreatment, thereby lowering the risk of complications associated with surgical procedures and leading to an overall reduction in healthcare costs.\n\nThe secondary objectives of the study are to evaluate the safety profile of EUS-RFA, including the incidence and severity of adverse events both in the early postoperative period and during the first year of follow-up, as well as to assess the long-term efficacy of EUS-RFA, including disease progression.",[26,27,28],"Endoscopic Ultrasound-Guided Radiofrequency Ablation","Pancreatic Neuroendocrine Tumors (pNET)","Pancreatic Cystic Neoplasms",[30,31,32,33,34,35],"Pancreatic Cystic Neoplasm","Intraductal papillary mucinous neoplasm","EUS-guided RFA","Pancreas","Neuroendocrine tumor","Radiofrequency ablation","RECRUITING","2026-04-11",{"date":39,"type":40},"2026-04-17","ACTUAL",{"date":37,"type":40},{"date":43,"type":20},"2029-12-31",{"name":45,"class":46},"Institute for Clinical and Experimental Medicine","OTHER_GOV"]