[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"endoscopic-vacuum-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:endoscopic-vacuum-therapy":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100608994","pre-emptive-endoscopic-vacuum-therapy-reduces-the-incidence-of-anastomotic-leakage-after-colorectal-cancer-surgery-100608994",false,"NCT07208786","Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery","Randomized Clinical Trial on Pre-emptive Endoscopic Vacuum Therapy Versus Conventional Management for the Prevention of Anastomotic Leakage After Colorectal Cancer Surgery","Inclusion Criteria:\n\n1. Pathologically diagnosed with colorectal cancer, planned for radical surgery (right hemicolectomy, left hemicolectomy, or anterior resection of the rectum, etc.).\n2. Age 18-85 years, American Society of Anesthesiologists (ASA) classification I-III.\n3. Anastomosis to be performed in a single stage (meeting anastomotic criteria).\n4. Patient or legal guardian is able to understand and sign the informed consent form and comply with follow-up.\n\nExclusion Criteria:\n\n1. Preexisting anastomotic leakage or severe intra-abdominal infection before surgery.\n2. Complicated by severe cardiovascular or cerebrovascular diseases (e.g., acute myocardial infarction, acute phase of cerebral infarction).\n3. Severe liver or kidney dysfunction (liver function Child-Pugh class C, creatinine clearance \\\u003C30 ml\u002Fmin).\n4. Coagulation disorders (platelets \\\u003C50×10⁹\u002FL, INR \\>1.5) or receiving anticoagulant therapy that cannot be adjusted.\n5. History of abdominal radiotherapy or multiple abdominal surgeries leading to severe intra-abdominal adhesions.\n6. Complicated by other malignant tumors and currently undergoing radiotherapy or chemotherapy.\n7. Psychiatric illness or cognitive impairment preventing compliance with the study.","ALL","18 Years","85 Years",{"count":20,"type":21},110,"ESTIMATED","INTERVENTIONAL",[24],"NA","Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the differences between the PEVT group and the control group in terms of operation time, length of hospital stay, and total medical costs. Analyze the incidence of other postoperative complications in the two groups, such as wound infection, abdominal abscess, and intestinal obstruction. Assess the impact of PEVT on postoperative recovery indicators, including time to first flatus, time to first defecation, and time to ambulation. Observe the occurrence of PEVT-related adverse events, such as device displacement, bleeding, and infection.",[27,28,29,30,31],"Colorectal Cancer","Colorectal Surgery","Complications","Anastomotic Leakage","Endoscopic Vacuum Therapy","RECRUITING","2026-03-28",{"date":35,"type":36},"2026-04-02","ACTUAL",{"date":38,"type":36},"2025-09-22",{"date":40,"type":21},"2026-12-30",{"name":42,"class":43},"Nanchong Central Hospital","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":44},"100485880","endoscopic-vacuum-therapy-for-transmural-defects-in-the-upper-gastrointestinal-tract-100485880","NCT05606822","Endoscopic Vacuum Therapy for Transmural Defects in the Upper Gastrointestinal Tract","Endoscopic Vacuum Therapy for Anastomotic Leakage After Upper Gastrointestinal Surgery \u002F Endoscopic Vacuum Therapy for Esophageal Perforation: A Multicenter Retrospective Cohort Study","Inclusion Criteria:\n\n* Treated with EVT for anastomotic leakage after esophago-gastric surgery\n* Signed informed consent form\n* 18 years or older\n\nExclusion Criteria:\n\n* No signed informed consent",{"count":53,"type":21},200,"6 Months","OBSERVATIONAL","The goal of this observational study is to learn about the best indications and techniques regarding endoscopic vacuum therapy (EVT) in patients with a transmural defect in the upper gastrointestinal (GI) tract (e.g. anastomotic leakage, Boerhaave syndrome, iatrogenic perforation, other). The main questions it aims to answer are:\n\n* What is the success rate of EVT for transmural defects in the upper GI tract?\n* What are the best indications for EVT in the upper GI tract? (e.g. etiology, patient characteristics, defect characteristics)\n* What are the best techniques for EVT in the upper GI tract? (e.g. EsoSponge, VACStent, vacuum pressure, intraluminal\u002Fintracavitary) Participants will be asked for informed consent to retrospectively and prospectively collect data on EVT.",[31,58,59,60,61,62],"Anastomotic Leak","Esophageal Perforation","Esophageal Perforation, Traumatic","EsoSponge","VACStent","2024-07-19",{"date":65,"type":36},"2024-07-23",{"date":67,"type":36},"2021-10-01",{"date":69,"type":21},"2030-10-01",{"name":71,"class":72},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)","OTHER"]